{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:32:37Z","timestamp":1790303557055,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1025,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"crossref","award":["HD24374"],"award-info":[{"award-number":["HD24374"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.ydbio.2010.08.026","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T05:14:23Z","timestamp":1283318063000},"page":"279-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance"],"prefix":"10.1016","volume":"347","author":[{"given":"Weipeng","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Munroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Schimenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2010.08.026_bb0005","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1073\/pnas.042702599","article-title":"The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis","volume":"99","author":"Baron","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0010","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1073\/pnas.0701770104","article-title":"Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas","volume":"104","author":"Baron","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0015","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2005.08.020","article-title":"Core transcriptional regulatory circuitry in human embryonic stem cells","volume":"122","author":"Boyer","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0020","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/genetics\/160.2.675","article-title":"A haplolethal locus uncovered by deletions in the mouse T complex","volume":"160","author":"Browning","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0025","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1146\/annurev.bi.65.070196.004101","article-title":"Structure and functions of the 20S and 26S proteasomes","volume":"65","author":"Coux","year":"1996","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0030","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1128\/MCB.25.16.6990-7004.2005","article-title":"The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development","volume":"25","author":"Cowley","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0035","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1101\/gad.1286905","article-title":"mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival","volume":"19","author":"Dannenberg","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0040","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1073\/pnas.0710285105","article-title":"Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation","volume":"105","author":"David","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0045","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.cell.2008.05.047","article-title":"Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells","volume":"133","author":"Dejosez","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0050","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2443.2005.00873.x","article-title":"GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis","volume":"10","author":"Delehouzee","year":"2005","journal-title":"Genes Cells"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0055","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/00365520310008809","article-title":"Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line","volume":"39","author":"Fan","year":"2004","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0060","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1128\/MCB.18.12.7185","article-title":"Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO","volume":"18","author":"Gelmetti","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0065","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0014-5793(99)01175-8","article-title":"Accumulation of mature mRNA in the nuclear fraction of mammalian cells","volume":"458","author":"Gondran","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0070","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1101\/gad.11.6.726","article-title":"A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function","volume":"11","author":"Goto","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng866","article-title":"Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis","volume":"31","author":"Gottlieb","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0080","doi-asserted-by":"crossref","first-page":"8507","DOI":"10.1128\/MCB.25.19.8507-8519.2005","article-title":"Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation","volume":"25","author":"Gu","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0085","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1083\/jcb.110.3.569","article-title":"Core filaments of the nuclear matrix","volume":"110","author":"He","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0090","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nature01156","article-title":"N-CoR controls differentiation of neural stem cells into astrocytes","volume":"419","author":"Hermanson","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0095","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s00335-005-0045-8","article-title":"Transgenic rescue of the mouse t complex haplolethal locus Thl1","volume":"16","author":"Howell","year":"2005","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-5793(02)03121-6","article-title":"Preimplantation-embryo-specific cell cycle regulation is attributed to the low expression level of retinoblastoma protein","volume":"526","author":"Iwamori","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0105","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0092-8674(00)00064-7","article-title":"Combinatorial roles of the nuclear receptor corepressor in transcription and development","volume":"102","author":"Jepsen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0110","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature06270","article-title":"SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron","volume":"450","author":"Jepsen","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000134058","article-title":"Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death","volume":"71","author":"Kawakami","year":"1995","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0120","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1101\/gad.12.15.2278","article-title":"Inhibition of DNA synthesis by RB: effects on G1\/S transition and S-phase progression","volume":"12","author":"Knudsen","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.onc.1204048","article-title":"BS69, an adenovirus E1A-associated protein, inhibits the transcriptional activity of c-Myb","volume":"20","author":"Ladendorff","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0130","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng1760","article-title":"The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells","volume":"38","author":"Loh","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0135","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1093\/hmg\/ddn149","article-title":"Epigenetic regulation of stem cell fate","volume":"17","author":"Lunyak","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1242\/dev.043943","article-title":"Hematopoietic stem cells in Drosophila","volume":"137","author":"Minakhina","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0145","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1242\/dev.003616","article-title":"Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation","volume":"134","author":"Minakhina","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0150","first-page":"2391","article-title":"Production of homozygous mutant ES cells with a single targeting construct","volume":"12","author":"Mortensen","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0155","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1128\/MCB.00727-08","article-title":"An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development","volume":"28","author":"Mu","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0160","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/MCB.11.8.4177","article-title":"Identification of mRNAs associated with programmed cell death in immature thymocytes","volume":"11","author":"Owens","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0165","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1242\/dev.038828","article-title":"Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2","volume":"137","author":"Ralston","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0170","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1072530","article-title":"\"Stemness\": transcriptional profiling of embryonic and adult stem cells","volume":"298","author":"Ramalho-Santos","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0175","first-page":"809","article-title":"Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts","volume":"9","author":"Savatier","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0180","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1038\/sj.onc.1205647","article-title":"PDCD2 is a negative regulator of HCF-1 (C1)","volume":"21","author":"Scarr","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0185","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sherr","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0190","doi-asserted-by":"crossref","first-page":"26524","DOI":"10.1074\/jbc.M204121200","article-title":"m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor","volume":"277","author":"Sims","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0195","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1634\/stemcells.2004-0341","article-title":"Gene expression signatures of seven individual human embryonic stem cell lines","volume":"23","author":"Skottman","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0200","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/gcc.10231","article-title":"Identification of candidate tumor-suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasms","volume":"37","author":"Steinemann","year":"2003","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0205","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"Su","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molcel.2007.05.030","article-title":"E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases","volume":"27","author":"Tyagi","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0215","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ydbio.2005.03.018","article-title":"Mouse cPLA2gamma, a novel oocyte and early embryo-abundant phospholipase A2 gamma-like protein, is targeted to the nuclear envelope during germinal vesicle breakdown","volume":"282","author":"Vitale","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0220","doi-asserted-by":"crossref","first-page":"10860","DOI":"10.1073\/pnas.95.18.10860","article-title":"ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR\/mSin3\/HDAC1 complex","volume":"95","author":"Wang","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.08.026_bb0225","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/dbio.2000.9814","article-title":"Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse","volume":"225","author":"Welsh","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.08.026_bb0230","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.febslet.2004.10.109","article-title":"Acquisition of essential somatic cell cycle regulatory protein expression and implied activity occurs at the second to third cell division in mouse preimplantation embryos","volume":"579","author":"Xie","year":"2005","journal-title":"FEBS Lett."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160610010377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160610010377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:20:46Z","timestamp":1757910046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160610010377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0012160610010377"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2010.08.026","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2010.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}