{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:11:30Z","timestamp":1789819890325,"version":"4.0.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GM08107"],"award-info":[{"award-number":["01GM08107"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ydbio.2012.09.003","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:06:59Z","timestamp":1347926819000},"page":"55-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome"],"prefix":"10.1016","volume":"372","author":[{"given":"Tracie","family":"Pennimpede","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Proske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana A.","family":"Vidigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Morkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper B.","family":"Bramsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard G.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wittler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2012.09.003_bib1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1101\/gad.303504","article-title":"The mouse homeobox gene not is required for caudal notochord development and affected by the truncate mutation","volume":"18","author":"Abdelkhalek","year":"2004","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1101\/gad.855001","article-title":"The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures","volume":"15","author":"Abu-Abed","year":"2001","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mod.2010.11.005","article-title":"The floor plate is sufficient for development of the sclerotome and spine without the notochord","volume":"128","author":"Ando","year":"2011","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/dbio.1998.9050","article-title":"Apoptosis of epaxial myotome in Danforth\u2019s short-tail (Sd) mice in somites that form following notochord degeneration","volume":"203","author":"Asakura","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/ANC.0b013e31819de44f","article-title":"Recognition of caudal regression syndrome","volume":"9","author":"Boulas","year":"2009","journal-title":"Adv. Neonatal Care"},{"key":"10.1016\/j.ydbio.2012.09.003_bib6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/dbio.1996.0326","article-title":"Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation","volume":"180","author":"Chapman","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35624","article-title":"Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6","volume":"391","author":"Chapman","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2012.09.003_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/jez.1400700306","article-title":"Development of the short-tailed mutant in the house mouse","volume":"70","author":"Chesley","year":"1935","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.ydbio.2012.09.003_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2012.09.003_bib10","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1073\/pnas.1007566108","article-title":"Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs","volume":"108","author":"Choi","year":"2011","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2012.09.003_bib11","first-page":"61","article-title":"Expression analysis of murine genes using in situ hybridization with radioactive and nonradioactively labeled RNA probes","volume":"326","author":"Chotteau-Lelievre","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0925-4773(96)00520-5","article-title":"Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation","volume":"56","author":"Clements","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/tera.1420340314","article-title":"Diplomyelia: caudal duplication of the neural tube in mice","volume":"34","author":"Cogliatti","year":"1986","journal-title":"Teratology"},{"key":"10.1016\/j.ydbio.2012.09.003_bib14","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1242\/dev.124.19.3895","article-title":"Control of dorsoventral pattern in the chick paraxial mesoderm","volume":"124","author":"Dietrich","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib15","first-page":"114","article-title":"Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l\u2019existence d\u2019un caractere (facteur) hereditaire \u201cnon-viable\u201d","volume":"97","author":"Dobrovolska\u00efa-Zavadska\u00efa","year":"1927","journal-title":"C. R. Seances Soc. Biol. Fil."},{"key":"10.1016\/j.ydbio.2012.09.003_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/adc.36.186.152","article-title":"From the mermaid to anal imperforation: the syndrome of caudal regression","volume":"36","author":"Duhamel","year":"1961","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ydbio.2012.09.003_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jez.1401040103","article-title":"A new complex of hereditary abnormalities in the house mouse","volume":"104","author":"Dunn","year":"1947","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.ydbio.2012.09.003_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0092-8674(95)90398-4","article-title":"Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway","volume":"81","author":"Fan","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2012.09.003_bib19","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0092-8674(94)90009-4","article-title":"Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog","volume":"79","author":"Fan","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2012.09.003_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ajmg.c.30317","article-title":"Cloacal exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research","volume":"157C","author":"Feldkamp","year":"2011","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.ydbio.2012.09.003_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1432-0436.1984.tb01336.x","article-title":"Defects in the archenteron of mouse embryos homozygous for the T-mutation","volume":"25","author":"Fujimoto","year":"1983","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2012.09.003_bib22","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1359\/jbmr.080503","article-title":"A missense T (Brachyury) mutation contributes to vertebral malformations","volume":"23","author":"Ghebranious","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ydbio.2012.09.003_bib23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/genetics\/23.6.573","article-title":"The development of two tailless mutants in the house mouse","volume":"23","author":"Gluecksohn-Schoenheimer","year":"1938","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2012.09.003_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/genetics\/28.4.341","article-title":"The morphological manifestations of a dominant mutation in mice affecting tail and urogenital system","volume":"28","author":"Gluecksohn-Schoenheimer","year":"1943","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2012.09.003_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1073\/pnas.30.6.134","article-title":"The development of normal and homozygous Brachy (T\/T) mouse embryos in the extraembryonic coelom of the chick","volume":"30","author":"Gluecksohn-Schoenheimer","year":"1944","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2012.09.003_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/gad.10.3.313","article-title":"Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development","volume":"10","author":"Greco","year":"1996","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib27","series-title":"The Genetics of the Mouse","author":"Gruneberg","year":"1952"},{"key":"10.1016\/j.ydbio.2012.09.003_bib28","first-page":"424","article-title":"Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury","volume":"6","author":"Gruneberg","year":"1958","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dev.02736","article-title":"Molecular analysis of coordinated bladder and urogenital organ formation by hedgehog signaling","volume":"134","author":"Haraguchi","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1242\/dev.113.3.913","article-title":"Expression pattern of the Brachyury gene in whole-mount TWis\/TWis mutant embryos","volume":"113","author":"Herrmann","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/343617a0","article-title":"Cloning of the T gene required in mesoderm formation in the mouse","volume":"343","author":"Herrmann","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2012.09.003_bib32","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0092-8674(92)90387-R","article-title":"Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene","volume":"71","author":"Jegalian","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2012.09.003_bib33","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0092-8674(94)90008-6","article-title":"Ectopic expression of Sonic hedgehog alters dorsal\u2013ventral patterning of somites","volume":"79","author":"Johnson","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2012.09.003_bib34","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1002\/j.1460-2075.1993.tb06179.x","article-title":"The Brachyury gene encodes a novel DNA binding protein","volume":"12","author":"Kispert","year":"1993","journal-title":"Embo. J."},{"key":"10.1016\/j.ydbio.2012.09.003_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/dbio.1994.1019","article-title":"Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos","volume":"161","author":"Kispert","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0925-4773(01)00463-4","article-title":"Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development","volume":"107","author":"MacLean","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib37","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1242\/dev.122.11.3343","article-title":"Targeted disruption of the Wnt2 gene results in placentation defects","volume":"122","author":"Monkley","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1203\/PDR.0b013e3181aa304a","article-title":"Induction of Wnt5a-expressing mesenchymal cells adjacent to the cloacal plate is an essential process for its proximodistal elongation and subsequent anorectal development","volume":"66","author":"Nakata","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2012.09.003_bib39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0890-6238(97)00153-6","article-title":"Retinoic acid-induced caudal regression syndrome in the mouse fetus","volume":"12","author":"Padmanabhan","year":"1998","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib40","first-page":"208","article-title":"A genetic study of the human T gene and its exclusion as a major candidate gene for sacral agenesis with anorectal atresia","volume":"36","author":"Papapetrou","year":"1999","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2012.09.003_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/dbio.2002.0668","article-title":"Sonic hedgehog signaling from the urethral epithelium controls external genital development","volume":"247","author":"Perriton","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib42","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1073\/pnas.90.11.5242","article-title":"Control of dorsoventral patterning of somitic derivatives by notochord and floor plate","volume":"90","author":"Pourquie","year":"1993","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2012.09.003_bib43","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/353348a0","article-title":"A cell autonomous function of Brachyury in T\/T embryonic stem cell chimaeras","volume":"353","author":"Rashbass","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2012.09.003_bib44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2106\/00004623-197860030-00020","article-title":"Sacral agenesis","volume":"60","author":"Renshaw","year":"1978","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.ydbio.2012.09.003_bib45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(94)90514-2","article-title":"Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord","volume":"76","author":"Roelink","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2012.09.003_bib46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1101\/gad.851501","article-title":"The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio\u2013posterior axis within the mouse embryo","volume":"15","author":"Sakai","year":"2001","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib47","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1017\/S0016672300009496","article-title":"Curtailed, a new dominant T-allele in the house mouse","volume":"7","author":"Searle","year":"1966","journal-title":"Genet. Res."},{"key":"10.1016\/j.ydbio.2012.09.003_bib48","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1242\/dev.042291","article-title":"Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development","volume":"136","author":"Seifert","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/dvdy.10480","article-title":"T-box genes in early embryogenesis","volume":"229","author":"Showell","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2012.09.003_bib50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ajmg.c.30316","article-title":"Bladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature","volume":"157C","author":"Siffel","year":"2011","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.ydbio.2012.09.003_bib51","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00383-005-1451-4","article-title":"Caudal regression syndrome\u2014case report and review of literature","volume":"21","author":"Singh","year":"2005","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.ydbio.2012.09.003_bib52","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1542\/peds.78.3.451","article-title":"Vascular steal: the pathogenetic mechanism producing sirenomelia and associated defects of the viscera and soft tissues","volume":"78","author":"Stevenson","year":"1986","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2012.09.003_bib53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejmg.2007.04.002","article-title":"Associated malformations in patients with anorectal anomalies","volume":"50","author":"Stoll","year":"2007","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2012.09.003_bib54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1101\/gad.7.2.197","article-title":"Rescue of the tail defect of Brachyury mice","volume":"7","author":"Stott","year":"1993","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib55","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/aja.1002010309","article-title":"Morphogenesis of the murine node and notochordal plate","volume":"201","author":"Sulik","year":"1994","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2012.09.003_bib56","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1242\/dev.99.1.109","article-title":"The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis","volume":"99","author":"Tam","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib57","first-page":"27","article-title":"Establishment and organization of germ layers in the gastrulating mouse embryo","volume":"165","author":"Tam","year":"1992","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.ydbio.2012.09.003_bib58","first-page":"1","article-title":"Early events of somitogenesis in higher vertebrates: allocation of precursor cells during gastrulation and the organization of a meristic pattern in the paraxial mesoderm","volume":"47","author":"Tam","year":"2000","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib59","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1242\/dev.115.3.703","article-title":"The somitogenetic potential of cells in the primitive streak and the tail bud of the organogenesis-stage mouse embryo","volume":"115","author":"Tam","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib60","doi-asserted-by":"crossref","first-page":"11733","DOI":"10.1073\/pnas.95.20.11733","article-title":"The relationships between notochord and floor plate in vertebrate development revisited","volume":"95","author":"Teillet","year":"1998","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2012.09.003_bib61","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0012-1606(83)90349-4","article-title":"Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo","volume":"98","author":"Teillet","year":"1983","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib62","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1242\/dev.066118","article-title":"Concerted involvement of Cdx\/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone","volume":"138","author":"van de Ven","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.09.003_bib63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01744261","article-title":"Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo","volume":"184","author":"van Straaten","year":"1991","journal-title":"Anat. Embryol. (Berl)"},{"key":"10.1016\/j.ydbio.2012.09.003_bib64","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1093\/nar\/gkq199","article-title":"An inducible RNA interference system for the functional dissection of mouse embryogenesis","volume":"38","author":"Vidigal","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2012.09.003_bib65","first-page":"180","article-title":"Development of structures and transport functions in the mouse placenta","volume":"20","author":"Watson","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.ydbio.2012.09.003_bib66","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/343657a0","article-title":"Expression pattern of the mouse T gene and its role in mesoderm formation","volume":"343","author":"Wilkinson","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2012.09.003_bib67","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1534\/genetics.107.079715","article-title":"Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury","volume":"177","author":"Wu","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2012.09.003_bib68","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1101\/gad.13.24.3185","article-title":"T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification","volume":"13","author":"Yamaguchi","year":"1999","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ydbio.2012.09.003_bib69","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1266\/jjg.65.287","article-title":"Does the T gene determine the anteroposterior axis of a mouse embryo?","volume":"65","author":"Yanagisawa","year":"1990","journal-title":"Jpn. J. Genet."},{"key":"10.1016\/j.ydbio.2012.09.003_bib70","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0012-1606(81)90147-0","article-title":"Effects of the brachyury (T) mutation on morphogenetic movement in the mouse embryo","volume":"87","author":"Yanagisawa","year":"1981","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib71","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1006\/dbio.2001.0173","article-title":"Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse","volume":"232","author":"Ying","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.09.003_bib72","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/dbio.1997.8502","article-title":"Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse","volume":"183","author":"Yoshikawa","year":"1997","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160612005076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160612005076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:28:49Z","timestamp":1757910529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160612005076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0012160612005076"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2012.09.003","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2012.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}