{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:43:18Z","timestamp":1789807398073,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"NIH Office of Research Infrastructure Programs","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ydbio.2012.11.019","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T05:16:13Z","timestamp":1354166173000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2\/Mid1, regulates anchor cell invasion during vulval development"],"prefix":"10.1016","volume":"374","author":[{"given":"Matthias K.","family":"Morf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Rimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hajnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2012.11.019_bib1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.devcel.2010.05.016","article-title":"MADD-2, a homolog of the Opitz syndrome protein MID1, regulates guidance to the midline through UNC-40 in Caenorhabditis elegans","volume":"18","author":"Alexander","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2012.11.019_bib2","doi-asserted-by":"crossref","first-page":"e3507","DOI":"10.1371\/journal.pone.0003507","article-title":"Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A","volume":"3","author":"Aranda-Orgill\u00e9s","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2012.11.019_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00439-007-0456-6","article-title":"The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex","volume":"123","author":"Aranda-Orgill\u00e9s","year":"2008","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ydbio.2012.11.019_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/sj.bjc.6605994","article-title":"Gene expression profiles of human melanoma cells with different invasive potential reveal TSPAN8 as a novel mediator of invasion","volume":"104","author":"Berthier-Vergnes","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ydbio.2012.11.019_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2012.11.019_bib6","series-title":"Current Protocols in Molecular Biology","author":"Edelstein","year":"2001"},{"key":"10.1016\/j.ydbio.2012.11.019_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/biomet\/68.3.589","article-title":"Nonparametric estimates of standard error: the jackknife, the bootstrap and other methods","volume":"68","author":"Efron","year":"1981","journal-title":"Biometrika"},{"key":"10.1016\/j.ydbio.2012.11.019_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0012-1606(03)00131-3","article-title":"The Opitz syndrome gene MID1 is essential for establishing asymmetric gene expression in Hensen\u2019s node","volume":"258","author":"Granata","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.11.019_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.devcel.2009.06.006","article-title":"Integrin acts upstream of netrin signaling to regulate formation of the anchor cell\u2019s invasive membrane in C. elegans","volume":"17","author":"Hagedorn","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2012.11.019_bib10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.devcel.2010.02.019","article-title":"The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in netrin-mediated axon attraction and branching","volume":"18","author":"Hao","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2012.11.019_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0896-6273(90)90444-K","article-title":"The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans","volume":"4","author":"Hedgecock","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2012.11.019_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-4598-10-22","article-title":"Metastasis: new perspectives on an old problem","volume":"10","author":"Kraljevic Pavelic","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ydbio.2012.11.019_bib13","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1523\/JNEUROSCI.4196-09.2010","article-title":"Lack of Mid1, the mouse ortholog of the opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis","volume":"30","author":"Lancioni","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2012.11.019_bib14","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1523\/JNEUROSCI.0346-04.2004","article-title":"A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization","volume":"24","author":"Li","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2012.11.019_bib15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.1439807","article-title":"Cytoskeleton-plasma membrane interactions","volume":"258","author":"Luna","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2012.11.019_bib16","doi-asserted-by":"crossref","first-page":"ra35","DOI":"10.1126\/scisignal.2000654","article-title":"In vivo identification of regulators of cell invasion across basement membranes","volume":"3","author":"Matus","year":"2010","journal-title":"Sci. Signaling"},{"key":"10.1016\/j.ydbio.2012.11.019_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng1197-285","article-title":"Opitz G\/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22","volume":"17","author":"Quaderi","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2012.11.019_bib18","unstructured":"Rimann, I., 2008. Screen for components of the lin-12 Notch pathway during vulval development. Ph.D. thesis. University of Zurich, pp. 87\u2013104."},{"key":"10.1016\/j.ydbio.2012.11.019_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ydbio.2007.05.023","article-title":"Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans","volume":"308","author":"Rimann","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2012.11.019_bib20","doi-asserted-by":"crossref","unstructured":"Schindler, A.J., Sherwood, D.R., 2011. The transcription factor HLH-2\/E\/Daughterless regulates anchor cell invasion across basement membrane in C. elegans. Dev. Biol..357(2):380-391","DOI":"10.1016\/j.ydbio.2011.07.012"},{"key":"10.1016\/j.ydbio.2012.11.019_bib21","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1073\/pnas.96.6.2794","article-title":"The Opitz syndrome gene product, MID1, associates with microtubules","volume":"96","author":"Schweiger","year":"1999","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2012.11.019_bib22","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.cell.2005.03.031","article-title":"FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans","volume":"121","author":"Sherwood","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2012.11.019_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1534-5807(03)00168-0","article-title":"Anchor cell invasion into the vulval epithelium in C. elegans","volume":"5","author":"Sherwood","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2012.11.019_bib24","doi-asserted-by":"crossref","unstructured":"Sternberg, P.W., 2005. Vulval development. WormBook: The Online Review of C Elegans Biology. pp. 1\u201328.","DOI":"10.1895\/wormbook.1.6.1"},{"key":"10.1016\/j.ydbio.2012.11.019_bib25","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1242\/dev.048769","article-title":"MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization","volume":"137","author":"Suzuki","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.11.019_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ng762","article-title":"MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation","volume":"29","author":"Trockenbacher","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2012.11.019_bib27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1242\/dev.128.6.883","article-title":"Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions","volume":"128","author":"Vogel","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2012.11.019_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ncb1825","article-title":"UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans","volume":"11","author":"Ziel","year":"2009","journal-title":"Nat. Cell Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160612006380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160612006380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:30:12Z","timestamp":1757910612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160612006380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0012160612006380"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2012.11.019","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2\/Mid1, regulates anchor cell invasion during vulval development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2012.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}