{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:55:42Z","timestamp":1791298542581,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003179","name":"Alberta Heritage Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.ydbio.2013.07.025","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T16:16:18Z","timestamp":1375373778000},"page":"470-481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer"],"prefix":"10.1016","volume":"382","author":[{"given":"Dong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Snider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Geary-Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2013.07.025_bib1","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1128\/MCB.18.10.5670","article-title":"Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding","volume":"18","author":"Abu Hatoum","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib2","doi-asserted-by":"crossref","first-page":"8219","DOI":"10.1128\/MCB.19.12.8219","article-title":"Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner","volume":"19","author":"Asahara","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib3","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1101\/gad.1202604","article-title":"In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis","volume":"18","author":"Aubin","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2013.07.025_bib4","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1128\/MCB.22.13.4952-4964.2002","article-title":"Promoter specificity and biological activity of tethered AP-1 dimers","volume":"22","author":"Bakiri","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib5","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1242\/dev.128.16.3145","article-title":"Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development","volume":"128","author":"Castanon","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2013.07.025_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0169-328X(94)00236-8","article-title":"Differential expression and distinct DNA-binding specificity of ME1a and ME2 suggest a unique role during differentiation and neuronal plasticity","volume":"29","author":"Chiaramello","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.ydbio.2013.07.025_bib7","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1242\/dev.121.8.2513","article-title":"Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development","volume":"121","author":"Cross","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2013.07.025_bib8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1006\/dbio.1995.1245","article-title":"Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development","volume":"170","author":"Cserjesi","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ng0398-266","article-title":"Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1","volume":"18","author":"Firulli","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2013.07.025_bib10","doi-asserted-by":"crossref","first-page":"33567","DOI":"10.1074\/jbc.M005888200","article-title":"The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function","volume":"275","author":"Firulli","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2013.07.025_bib11","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S1097-2765(03)00425-8","article-title":"PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation","volume":"12","author":"Firulli","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2013.07.025_bib12","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/dvdy.22402","article-title":"Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability","volume":"239","author":"Firulli","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2013.07.025_bib13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ydbio.2004.03.040","article-title":"Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells","volume":"271","author":"Hemberger","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib14","doi-asserted-by":"crossref","first-page":"9835","DOI":"10.1128\/MCB.24.22.9835-9847.2004","article-title":"Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2","volume":"24","author":"Hill","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib15","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1128\/MCB.15.7.3813","article-title":"Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system","volume":"15","author":"Hollenberg","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/gb-2004-5-6-226","article-title":"An overview of the basic helix-loop-helix proteins","volume":"5","author":"Jones","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib17","series-title":"Gene Targeting: A Practical Approach","author":"Joyner","year":"1993"},{"key":"10.1016\/j.ydbio.2013.07.025_bib18","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/emboj\/17.5.1412","article-title":"The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD","volume":"17","author":"Lemercier","year":"1998","journal-title":"Embo J."},{"key":"10.1016\/j.ydbio.2013.07.025_bib19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ncb1633","article-title":"Nucleolar release of Hand1 acts as a molecular switch to determine cell fate","volume":"9","author":"Martindill","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/dvg.20644","article-title":"A Tlx2-Cre mouse line uncovers essential roles for hand1 in extraembryonic and lateral mesoderm","volume":"48","author":"Maska","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2013.07.025_bib21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1128\/MCB.20.2.429-440.2000","article-title":"Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms","volume":"20","author":"Massari","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.01562","article-title":"The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner","volume":"132","author":"McFadden","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2013.07.025_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1139\/o95-080","article-title":"Determination versus differentiation and the MyoD family of transcription factors","volume":"73","author":"Megeney","year":"1995","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib24","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1242\/dev.01091","article-title":"Extra-embryonic vasculature development is regulated by the transcription factor HAND1","volume":"131","author":"Morikawa","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2013.07.025_bib25","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(93)90725-6","article-title":"HLH forced dimers: tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id","volume":"74","author":"Neuhold","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2013.07.025_bib26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/dvdy.23734","article-title":"Distinct Caenorhabditis elegans HLH-8\/twist-containing dimers function in the mesoderm","volume":"241","author":"Philogene","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2013.07.025_bib27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng0398-271","article-title":"The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis","volume":"18","author":"Riley","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2013.07.025_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/dbio.2000.9864","article-title":"Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos","volume":"227","author":"Riley","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1021\/bi9521194","article-title":"Covalent attachment of Arc repressor subunits by a peptide linker enhances affinity for operator DNA","volume":"35","author":"Robinson","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.ydbio.2013.07.025_bib30","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1128\/MCB.20.2.530-541.2000","article-title":"The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms","volume":"20","author":"Scott","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/nar\/26.6.1408","article-title":"Single chain dimers of MASH-1 bind DNA with enhanced affinity","volume":"26","author":"Sieber","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2013.07.025_bib32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"Simmons","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/1471-2164-9-352","article-title":"Spatial and temporal expression of the 23 murine Prolactin\/Placental Lactogen-related genes is not associated with their position in the locus","volume":"9","author":"Simmons","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ydbio.2013.07.025_bib34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/dbio.1997.8685","article-title":"Mash2 acts cell autonomously in mouse spongiotrophoblast development","volume":"190","author":"Tanaka","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib35","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1523\/JNEUROSCI.3584-11.2012","article-title":"A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis","volume":"32","author":"Vincentz","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2013.07.025_bib36","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1073\/pnas.87.12.4722","article-title":"Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains","volume":"87","author":"Voronova","year":"1990","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2013.07.025_bib37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ydbio.2008.02.020","article-title":"Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis","volume":"317","author":"Wong","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2013.07.025_bib38","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1021\/bi015795g","article-title":"The affinity-enhancing roles of flexible linkers in two-domain DNA-binding proteins","volume":"40","author":"Zhou","year":"2001","journal-title":"Biochemistry"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216061300393X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216061300393X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:30:42Z","timestamp":1757910642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216061300393X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S001216061300393X"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2013.07.025","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2013.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}