{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:28:42Z","timestamp":1769635722502,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":600,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministry of Science and Innovation to M.A.R","award":["BFU2011-24972"],"award-info":[{"award-number":["BFU2011-24972"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.ydbio.2014.06.004","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T14:33:37Z","timestamp":1402583617000},"page":"454-465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Long bone development requires a threshold of Hox function"],"prefix":"10.1016","volume":"392","author":[{"given":"M\u00aa Carmen","family":"Gonz\u00e1lez-Mart\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Mallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian A.","family":"Ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2014.06.004_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0925-4773(01)00639-6","article-title":"The synpolydactyly homolog (spdh) mutation in the mouse\u2014a defect in patterning and growth of limb cartilage elements","volume":"112","author":"Albrecht","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1242\/dev.00936","article-title":"Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod","volume":"131","author":"Boulet","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/dvdy.24037","article-title":"Joining the fingers\u2014a HOXD13 story","author":"Brison","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2014.06.004_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/dbio.2001.0382","article-title":"The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes","volume":"237","author":"Bruneau","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib5","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1242\/dev.02395","article-title":"Pbx1\/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression","volume":"133","author":"Capellini","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib6","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1242\/dev.01115","article-title":"Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh","volume":"131","author":"Chen","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/dbio.2001.0346","article-title":"Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function","volume":"236","author":"Chiang","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1172\/JCI11706","article-title":"Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development","volume":"107","author":"Chung","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2014.06.004_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jor.20954","article-title":"Axin2 regulates chondrocyte maturation and axial skeletal development","volume":"28","author":"Dao","year":"2009","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.ydbio.2014.06.004_bib10","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1242\/dev.120.8.2187","article-title":"Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11","volume":"120","author":"Davis","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib11","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.122.4.1175","article-title":"A mutational analysis of the 5\u2032 HoxD genes: dissection of genetic interactions during limb development in the mouse","volume":"122","author":"Davis","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0955-0674(00)00276-3","article-title":"Regulatory mechanisms in the pathways of cartilage and bone formation","volume":"13","author":"de Crombrugghe","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib13","first-page":"11","article-title":"Hox genes and the morphogenesis of the vertebrate limb","volume":"383A","author":"Dolle","year":"1993","journal-title":"Prog. Clin. Biol. Res"},{"key":"10.1016\/j.ydbio.2014.06.004_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(95)90487-5","article-title":"Toward a molecular understanding of skeletal development","volume":"80","author":"Erlebacher","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2014.06.004_bib15","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1242\/dev.122.10.2997","article-title":"Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod","volume":"122","author":"Fromental-Ramain","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.orthres.2005.02.005","article-title":"Reactivation of Hox gene expression during bone regeneration","volume":"23","author":"Gersch","year":"2005","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.ydbio.2014.06.004_bib17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1242\/dev.124.3.627","article-title":"Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth","volume":"124","author":"Goff","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib18","doi-asserted-by":"crossref","first-page":"e43553","DOI":"10.1371\/journal.pone.0043553","article-title":"Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice","volume":"7","author":"Gross","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2014.06.004_bib19","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1128\/MCB.01544-06","article-title":"HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes","volume":"27","author":"Hassan","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib20","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1242\/dev.02025","article-title":"Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development","volume":"132","author":"Hilton","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng0393-241","article-title":"A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene","volume":"3","author":"Hui","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2014.06.004_bib22","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1242\/dev.041624","article-title":"The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization","volume":"136","author":"Joeng","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib23","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/hmg\/7.6.1033","article-title":"A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly","volume":"7","author":"Johnson","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2014.06.004_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1242\/dev.127.3.543","article-title":"Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways","volume":"127","author":"Karp","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1172\/JCI12294","article-title":"Chondrogenesis just ain\u2019t what it used to be","volume":"107","author":"Karsenty","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2014.06.004_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.genom.9.081307.164437","article-title":"Transcriptional control of skeletogenesis","volume":"9","author":"Karsenty","year":"2008","journal-title":"Annu. Rev. Genomics Hum. Genet"},{"key":"10.1016\/j.ydbio.2014.06.004_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.cellbio.042308.113308","article-title":"Genetic control of bone formation","volume":"25","author":"Karsenty","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.ydbio.2014.06.004_bib700","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1002\/dvdy.22301","article-title":"Gli2 activator function in preosteoblasts is sufficient to mediate Ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification","volume":"239","author":"Kesper","year":"2010","journal-title":"Dev. Dyn."},{"issue":"2","key":"10.1016\/j.ydbio.2014.06.004_bib701","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0925-4773(98)00210-X","article-title":"Regulation of chondrocyte differentiation by Cbfa1","volume":"80","author":"Kim","year":"1999","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib28","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1242\/dev.01327","article-title":"HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis","volume":"131","author":"Knosp","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-62703-989-5_1","article-title":"Overview of skeletal development","volume":"1130","author":"Kobayashi","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib30","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1242\/dev.02097","article-title":"Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation","volume":"132","author":"Koziel","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","article-title":"Hox genes in vertebrate development","volume":"78","author":"Krumlauf","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2014.06.004_bib32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ydbio.2013.10.013","article-title":"Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A","volume":"385","author":"Kuss","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib33","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.273.5275.663","article-title":"PTH\/PTHrP receptor in early development and Indian hedgehog-regulated bone growth","volume":"273","author":"Lanske","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2014.06.004_bib34","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1210\/endo.137.11.8895385","article-title":"Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development","volume":"137","author":"Lee","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2014.06.004_bib35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1242\/dev.01006","article-title":"Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton","volume":"131","author":"Long","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib36","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1242\/dev.128.24.5099","article-title":"Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation","volume":"128","author":"Long","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib37","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1242\/dev.018044","article-title":"Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy","volume":"135","author":"Mak","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ydbio.2010.04.024","article-title":"Hox genes and regional patterning of the vertebrate body plan","volume":"344","author":"Mallo","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib39","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1432-0436.2006.00132.x","article-title":"Expression of Hoxa2 in cells entering chondrogenesis impairs overall cartilage development","volume":"75","author":"Massip","year":"2007","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2014.06.004_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tera.1420220306","article-title":"Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S","volume":"22","author":"McLeod","year":"1980","journal-title":"Teratology"},{"key":"10.1016\/j.ydbio.2014.06.004_bib41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.modgep.2005.04.012","article-title":"Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification","volume":"6","author":"Minina","year":"2005","journal-title":"Gene Expression Patterns"},{"key":"10.1016\/j.ydbio.2014.06.004_bib42","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1101\/gad.1631708","article-title":"Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness","volume":"22","author":"Montavon","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/358236a0","article-title":"Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations","volume":"358","author":"Morgan","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2014.06.004_bib44","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1242\/dev.02480","article-title":"Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors","volume":"133","author":"Rodda","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/dvdy.24019","article-title":"\u201cSelf-regulation,\u201d a new facet of Hox genes\u2019 function","author":"Sheth","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2014.06.004_bib46","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ydbio.2007.07.023","article-title":"Hoxd and Gli3 interactions modulate digit number in the amniote limb","volume":"310","author":"Sheth","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib47","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1242\/dev.089409","article-title":"Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth","volume":"140","author":"Sheth","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib48","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1126\/science.1226804","article-title":"Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism","volume":"338","author":"Sheth","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2014.06.004_bib49","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1242\/dev.02471","article-title":"Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis","volume":"133","author":"Spater","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.06.004_bib50","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/dbio.2002.0640","article-title":"Role of Runx genes in chondrocyte differentiation","volume":"245","author":"Stricker","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib52","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1677\/joe.0.1770413","article-title":"Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes","volume":"177","author":"Takamoto","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/jez.b.21051","article-title":"The digits of the wing of birds are 1, 2, and 3. A review","volume":"304","author":"Vargas","year":"2005","journal-title":"J. Exp. Zool. B: Mol. Dev. Evol"},{"key":"10.1016\/j.ydbio.2014.06.004_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1525-142X.2009.00317.x","article-title":"Frame-shifts of digit identity in bird evolution and Cyclopamine-treated wings","volume":"11","author":"Vargas","year":"2009","journal-title":"Evol. Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib55","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1172\/JCI41554","article-title":"Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation","volume":"120","author":"Villavicencio-Lorini","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2014.06.004_bib56","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein","volume":"273","author":"Vortkamp","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2014.06.004_bib57","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/MCB.01089-09","article-title":"Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation","volume":"30","author":"Wen","year":"2010","journal-title":"Mol. Cell. Biol."},{"issue":"5631","key":"10.1016\/j.ydbio.2014.06.004_bib800","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1126\/science.1085672","article-title":"Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton","volume":"18;301","author":"Wellik","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2014.06.004_bib58","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.devcel.2010.04.002","article-title":"The origin of digits: expression patterns versus regulatory mechanisms","volume":"18","author":"Woltering","year":"2010","journal-title":"Dev. Cell."},{"key":"10.1016\/j.ydbio.2014.06.004_bib59","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1101\/gad.9.20.2509","article-title":"Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds","volume":"9","author":"Yokouchi","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib60","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1101\/gad.1174704","article-title":"Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog","volume":"18","author":"Yoshida","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2014.06.004_bib61","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00256-005-0928-5","article-title":"Radiographic evaluation and unusual bone formations in different genetic patterns in synpolydactyly","volume":"34","author":"Yucel","year":"2005","journal-title":"Skeletal Radiol."},{"key":"10.1016\/j.ydbio.2014.06.004_bib62","doi-asserted-by":"crossref","first-page":"9956","DOI":"10.1073\/pnas.95.17.9956","article-title":"Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8","volume":"95","author":"Yueh","year":"1998","journal-title":"Proc. Nat. Acad. Sci. U.S.A"},{"key":"10.1016\/j.ydbio.2014.06.004_bib63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/384069a0","article-title":"Synpolydactyly in mice with a targeted deficiency in the HoxD complex","volume":"384","author":"Zakany","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2014.06.004_bib64","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.gde.2007.05.011","article-title":"The role of Hox genes during vertebrate limb development","volume":"17","author":"Zakany","year":"2007","journal-title":"Curr. Opin. Genet. Dev"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160614003005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160614003005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T17:59:55Z","timestamp":1716832795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160614003005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0012160614003005"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2014.06.004","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long bone development requires a threshold of Hox function","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2014.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}