{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:47:32Z","timestamp":1790948852225,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HD040307 HD052937"],"award-info":[{"award-number":["HD040307 HD052937"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ydbio.2014.07.016","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T21:33:19Z","timestamp":1407015199000},"page":"129-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Steroid signaling promotes stem cell maintenance in the Drosophila testis"],"prefix":"10.1016","volume":"394","author":[{"given":"Yijie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.","family":"Matunis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2014.07.016_bib1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.stem.2010.10.001","article-title":"The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila","volume":"7","author":"Ables","year":"2010","journal-title":"Cell stem cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0168-9525(92)90371-A","article-title":"Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone","volume":"8","author":"Andres","year":"1992","journal-title":"Trends Genet.: TIG"},{"key":"10.1016\/j.ydbio.2014.07.016_bib3","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1101\/gad.1342605","article-title":"The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis","volume":"19","author":"Badenhorst","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2014.07.016_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1520-6327(1996)33:3\/4<231::AID-ARCH5>3.0.CO;2-V","article-title":"Ecdysone signaling cascade and regulation of Drosophila metamorphosis","volume":"33","author":"Baehrecke","year":"1996","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(03)00420-3","article-title":"The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway","volume":"113","author":"Baker","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib6","first-page":"11","article-title":"The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae","author":"Baldini","year":"2013","journal-title":"Plos Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0022-1910(84)90019-2","article-title":"Ecdysteroids in adult males and females of Drosophila-Melanogaster","volume":"30","author":"Bownes","year":"1984","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.psyneuen.2005.02.010","article-title":"Depression and cortisol responses to psychological stress: a meta-analysis","volume":"30","author":"Burke","year":"2005","journal-title":"Psychoneuroendocrino"},{"key":"10.1016\/j.ydbio.2014.07.016_bib9","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1242\/dev.126.20.4581","article-title":"Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila","volume":"126","author":"Buszczak","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib10","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1101\/gad.2064111","article-title":"Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75","volume":"25","author":"Caceres","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2014.07.016_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1091\/mbc.E12-04-0267","article-title":"Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr","volume":"24","author":"Carbonell","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib12","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/genetics\/154.3.1203","article-title":"The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis","volume":"154","author":"Carney","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2014.07.016_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.stem.2010.04.018","article-title":"Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF","volume":"6","author":"Cherry","year":"2010","journal-title":"Cell stem cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib14","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1073\/pnas.89.23.11503","article-title":"DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1\/ultraspiracle","volume":"89","author":"Christianson","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2014.07.016_bib15","doi-asserted-by":"crossref","first-page":"e1004287","DOI":"10.1371\/journal.pgen.1004287","article-title":"Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing","volume":"10","author":"Claudius","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2014.07.016_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.1119432","article-title":"Antagonistic actions of ecdysone and insulins determine final size in Drosophila","volume":"310","author":"Colombani","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2014.07.016_bib17","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1242\/dev.056242","article-title":"The stem cell niche: lessons from the Drosophila testis","volume":"138","author":"de Cuevas","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib18","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1534\/genetics.108.098244","article-title":"Stem cells, their niches and the systemic environment: an aging network","volume":"180","author":"Drummond-Barbosa","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2014.07.016_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/dbio.2000.0135","article-title":"Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis","volume":"231","author":"Drummond-Barbosa","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib20","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1073\/pnas.0709128105","article-title":"Drosophila, germ-line modulation of insulin signaling and lifespan","volume":"105","author":"Flatt","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2014.07.016_bib21","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.cub.2010.08.055","article-title":"dDOR Is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling","volume":"20","author":"Francis","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/cr.2010.64","article-title":"Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq","volume":"20","author":"Gan","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.ydbio.2014.07.016_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-cellbio-101512-122331","article-title":"Hormonal control of stem cell systems","volume":"29","author":"Gancz","year":"2013","journal-title":"Annu. Rev. Cell and Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib24","first-page":"9","article-title":"Coordinated regulation of niche and stem cell precursors by hormonal signaling","author":"Gancz","year":"2011","journal-title":"Plos Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib25","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.74.11.5099","article-title":"Roles of ecdysone in Drosophila development","volume":"74","author":"Garen","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2014.07.016_bib26","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1242\/dev.01143","article-title":"Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis","volume":"131","author":"Gaziova","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1146\/annurev.ento.47.091201.145302","article-title":"Control and biochemical nature of the ecdysteroidogenic pathway","volume":"47","author":"Gilbert","year":"2002","journal-title":"Annu Rev. Entomol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib28","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/dvdy.21140","article-title":"Ras signaling modulates activity of the ecdysone receptor EcR during cell migration in the Drosophila ovary","volume":"236","author":"Hackney","year":"2007","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.ydbio.2014.07.016_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0012-1606(82)90240-8","article-title":"Ecdysteroid titers during pupal and adult development in Drosophila melanogaster","volume":"93","author":"Handler","year":"1982","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-5320(79)90108-4","article-title":"The germinal proliferation center in the testis of Drosophila melanogaster","volume":"69","author":"Hardy","year":"1979","journal-title":"J. Ultrastruct. Res."},{"key":"10.1016\/j.ydbio.2014.07.016_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0022-1910(99)00038-4","article-title":"Ecdysteroid titers in mated and unmated Drosophila melanogaster females","volume":"45","author":"Harshman","year":"1999","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s004270050290","article-title":"The sequence of Locusta RXR, homologous to Drosophila ultraspiracle, and its evolutionary implications","volume":"209","author":"Hayward","year":"1999","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0012-1606(77)90128-2","article-title":"Ecdysone titers during postembryonic development of Drosophila melanogaster","volume":"60","author":"Hodgetts","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib34","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ydbio.2007.11.006","article-title":"Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila","volume":"313","author":"Hsu","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1673-8527(08)60001-6","article-title":"New players in the regulation of ecdysone biosynthesis","volume":"35","author":"Huang","year":"2008","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.ydbio.2014.07.016_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1534\/genetics.110.114587","article-title":"The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster","volume":"185","author":"Ishimoto","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2014.07.016_bib37","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1073\/pnas.0810213106","article-title":"Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster","volume":"106","author":"Ishimoto","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2014.07.016_bib38","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature02989","article-title":"Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells","volume":"431","author":"Ito","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2014.07.016_bib39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ncb1863","article-title":"Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt","volume":"11","author":"Jang","year":"2009","journal-title":"Nature Cell biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0965-1748(01)00077-7","article-title":"Juvenile hormone III-dependent conformational changes of the nuclear receptor ultraspiracle","volume":"32","author":"Jones","year":"2001","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib41","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1073\/pnas.0830856100","article-title":"An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells","volume":"100","author":"Kai","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2014.07.016_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrg1581","article-title":"Nuclear receptors\u2014a perspective from Drosophila","volume":"6","author":"King-Jones","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2014.07.016_bib43","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/emboj.2011.73","article-title":"Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation","volume":"30","author":"Konig","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2014.07.016_bib44","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S1043-2760(00)00282-4","article-title":"Steroid regulation of postembryonic development and reproduction in Drosophila","volume":"11","author":"Kozlova","year":"2000","journal-title":"Trends Endocrinol. Metabol.: TEM"},{"key":"10.1016\/j.ydbio.2014.07.016_bib45","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1242\/dev.129.7.1739","article-title":"Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorphosis","volume":"129","author":"Kozlova","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib46","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1087419","article-title":"Essential roles for ecdysone signaling during Drosophila mid-embryonic development","volume":"301","author":"Kozlova","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2014.07.016_bib47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.stem.2008.05.001","article-title":"Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal","volume":"3","author":"Leatherman","year":"2008","journal-title":"Cell stem cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2014.07.016_bib49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev.cellbio.21.012704.131525","article-title":"Stem cell niche: structure and function","volume":"21","author":"Li","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib50","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1242\/dev.124.21.4383","article-title":"Punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline","volume":"124","author":"Matunis","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.27.070203.144157","article-title":"The amygdala modulates the consolidation of memories of emotionally arousing experiences","volume":"27","author":"McGaugh","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2014.07.016_bib52","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.cub.2010.10.038","article-title":"Stem cell dynamics in response to nutrient availability","volume":"20","author":"McLeod","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib53","doi-asserted-by":"crossref","first-page":"e46109","DOI":"10.1371\/journal.pone.0046109","article-title":"Steroid signaling within Drosophila ovarian epithelial cells sex-specifically modulates early germ cell development and meiotic entry","volume":"7","author":"Morris","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.ydbio.2014.07.016_bib54","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1242\/dev.02512","article-title":"Dynamic regulation of Drosophila nuclear receptor activity in vivo","volume":"133","author":"Palanker","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib55","first-page":"11","article-title":"Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila","author":"Parisi","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ydbio.2014.07.016_bib56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/arch.20081","article-title":"Heterodimerization of ecdysone receptor and ultraspiracle on symmetric and asymmetric response elements","volume":"60","author":"Perera","year":"2005","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib57","doi-asserted-by":"crossref","first-page":"13773","DOI":"10.1073\/pnas.2336088100","article-title":"Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone","volume":"100","author":"Petryk","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2014.07.016_bib58","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1023\/A:1026610425973","article-title":"Role of the ecdysteroid system in the regulation of Drosophila reproduction under environmental stress","volume":"375","author":"Rauschenbach","year":"2000","journal-title":"Dokl. Biol. Sci.: Proc. Acad. Sci. USSR"},{"key":"10.1016\/j.ydbio.2014.07.016_bib59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2005.07.005","article-title":"The Drosophila nuclear receptor e75 contains heme and is gas responsive","volume":"122","author":"Reinking","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib60","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0965-1748(99)00084-3","article-title":"Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti","volume":"29","author":"Riehle","year":"1999","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib61","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1091\/mbc.E11-12-0999","article-title":"Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells","volume":"23","author":"Roth","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib70","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1247\/csf.08042","article-title":"Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila","volume":"34","author":"Satoru","year":"2009","journal-title":"Cell structure and function Struct. Funct."},{"key":"10.1016\/j.ydbio.2014.07.016_bib62","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0022-1910(85)90029-0","article-title":"The Effects of nutrition and methoprene treatment on ovarian ecdysteroid synthesis in Drosophila-Melanogaster","volume":"31","author":"Schwartz","year":"1985","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib63","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jinsphys.2012.01.013","article-title":"Ecdysone signaling in adult Drosophila melanogaster","volume":"58","author":"Schwedes","year":"2012","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2009.05.024","article-title":"Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis","volume":"5","author":"Sheng","year":"2009","journal-title":"Cell stem cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib65","doi-asserted-by":"crossref","first-page":"a002642","DOI":"10.1101\/cshperspect.a002642","article-title":"Germline stem cells","volume":"3","author":"Spradling","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib66","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0092-8674(93)90359-X","article-title":"Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms","volume":"73","author":"Talbot","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib67","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.mad.2009.05.004","article-title":"The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner","volume":"130","author":"Tricoire","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ydbio.2014.07.016_bib68","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1097-2765(00)80365-2","article-title":"SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development","volume":"4","author":"Tsai","year":"1999","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ydbio.2014.07.016_bib69","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1474-9728.2002.00016.x","article-title":"Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants","volume":"1","author":"Tu","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.ydbio.2014.07.016_bib71","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.4161\/cc.10.16.17059","article-title":"Regulation of adult stem cell behavior by nutrient signaling","volume":"10","author":"Wang","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ydbio.2014.07.016_bib72","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1242\/dev.01413","article-title":"Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch","volume":"131","author":"Wang","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib73","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","article-title":"Analysis of genetic mosaics in developing and adult Drosophila tissues","volume":"117","author":"Xu","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib74","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev-ento-120811-153608","article-title":"Ecdysone control of developmental transitions: lessons from Drosophila research","volume":"58","author":"Yamanaka","year":"2013","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ydbio.2014.07.016_bib75","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1242\/dev.083030","article-title":"Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis","volume":"139","author":"Zeng","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2014.07.016_bib76","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ydbio.2013.08.029","article-title":"Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles","volume":"383","author":"Zirin","year":"2013","journal-title":"Dev Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160614003522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160614003522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:24:41Z","timestamp":1649859881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160614003522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0012160614003522"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2014.07.016","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steroid signaling promotes stem cell maintenance in the Drosophila testis","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2014.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}