{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:25:36Z","timestamp":1789410336047,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Xenopus Resource and its staff"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ydbio.2015.02.012","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T04:30:17Z","timestamp":1424838617000},"page":"328-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients"],"prefix":"10.1016","volume":"408","author":[{"given":"Takuya","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinleye O.","family":"Odeleye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith B.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret B.","family":"Fish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Yaoita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jena L.","family":"Chojnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Lauderdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Netland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Grainger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.02.012_bib1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1534-5807(03)00160-6","article-title":"The protooncogene c-Myc is an essential regulator of neural crest formation in Xenopus","volume":"4","author":"Bellmeyer","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2015.02.012_bib2","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1242\/dev.128.20.3987","article-title":"Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium","volume":"128","author":"Bernier","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/dvg.22719","article-title":"Biallelic genome modification in F0 Xenopus tropicalis embryos using the CRISPR\/Cas system","volume":"51","author":"Blitz","year":"2013","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.012_bib4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molcel.2011.04.018","article-title":"Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay","volume":"42","author":"Bruno","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2015.02.012_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.neuro.20.1.483","article-title":"PAX-6 in development and evolution","volume":"20","author":"Callaerts","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2015.02.012_bib6","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/cercor\/bhn123","article-title":"Differential regulation of telencephalic pallial\u2013subpallial boundary patterning by Pax6 and Gsh2","volume":"19","author":"Carney","year":"2009","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.ydbio.2015.02.012_bib7","doi-asserted-by":"crossref","first-page":"e87182","DOI":"10.1371\/journal.pone.0087182","article-title":"c-myc regulates cell proliferation during lens development","volume":"9","author":"Cavalheiro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.02.012_bib8","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1093\/nar\/gkr218","article-title":"Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting","volume":"39","author":"Cermak","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2015.02.012_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.biochem.76.050106.093909","article-title":"The nonsense-mediated decay RNA surveillance pathway","volume":"76","author":"Chang","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ydbio.2015.02.012_bib10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1101\/gr.124115.111","article-title":"Discovery and assessment of conserved Pax6 target genes and enhancers","volume":"21","author":"Coutinho","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.ydbio.2015.02.012_bib11","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1242\/dev.126.16.3585","article-title":"Role of Pax6 in development of the cerebellar system","volume":"126","author":"Engelkamp","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib12","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1534\/genetics.108.088591","article-title":"Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus","volume":"179","author":"Favor","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.02.012_bib13","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1093\/genetics\/159.4.1689","article-title":"Molecular characterization of Pax62Neu through Pax610Neu: an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus","volume":"159","author":"Favor","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.02.012_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ydbio.2014.09.004","article-title":"Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character","volume":"395","author":"Fish","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/dvg.20819","article-title":"Simple, fast, tissue-specific bacterial artificial chromosome transgenesis in Xenopus","volume":"50","author":"Fish","year":"2012","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.012_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0168-9525(99)01776-X","article-title":"Pax 6: mastering eye morphogenesis and eye evolution","volume":"15","author":"Gehring","year":"1999","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib17","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/dneu.20895","article-title":"The role of Pax6 in forebrain development","volume":"71","author":"Georgala","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng0894-463","article-title":"PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects","volume":"7","author":"Glaser","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1567-133X(02)00015-7","article-title":"Expression pattern of the homeobox proteinNKX2-1 in the developing Xenopus forebrain.","volume":"1","author":"Gonz\u00e1lez","year":"2002","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.ydbio.2015.02.012_bib20","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1242\/dev.099853","article-title":"Efficient RNA\/Cas9-mediated genome editing in Xenopus tropicalis","volume":"141","author":"Guo","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib21","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.tig.2011.08.003","article-title":"Xenopus research: metamorphosed by genetics and genomics","volume":"27","author":"Harland","year":"2011","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib22","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.1076231","article-title":"Genomics. Vertebrate genomes compared","volume":"297","author":"Hedges","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.02.012_bib23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.1183670","article-title":"The genome of the Western clawed frog Xenopus tropicalis","volume":"328","author":"Hellsten","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.02.012_bib24","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/mend.13.9.0340","article-title":"Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription","volume":"13","author":"Hill","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/354522a0","article-title":"Mouse Small eye results from mutations in a paired-like homeobox-containing gene","volume":"354","author":"Hill","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.02.012_bib26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ejhg.2012.100","article-title":"Aniridia","volume":"20","author":"Hingorani","year":"2012","journal-title":"Eur. J. Human Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/(SICI)1097-4695(199701)32:1<45::AID-NEU5>3.0.CO;2-E","article-title":"Xenopus Pax-6 and retinal development","volume":"32","author":"Hirsch","year":"1997","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/dvdy.10188","article-title":"Xenopus tropicalis transgenic lines and their use in the study of embryonic induction","volume":"225","author":"Hirsch","year":"2002","journal-title":"Dev. Dyn."},{"issue":"Suppl.","key":"10.1016\/j.ydbio.2015.02.012_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/dev.103.Supplement.115","article-title":"Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities","volume":"103","author":"Hogan","year":"1988","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib30","first-page":"95","article-title":"Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse","volume":"97","author":"Hogan","year":"1986","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0161-6420(02)01451-3","article-title":"Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique","volume":"110","author":"Holland","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ydbio.2015.02.012_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mcn.2006.10.008","article-title":"Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon","volume":"34","author":"Holm","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ydbio.2015.02.012_bib33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/dvdy.21816","article-title":"Cloning and expression analysis of the anterior parahox genes, Gsh1 and Gsh2 from Xenopus tropicalis","volume":"238","author":"Illes","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.02.012_bib34","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1242\/bio.20123228","article-title":"Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis","volume":"1","author":"Ishibashi","year":"2012","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2015.02.012_bib35","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ydbio.2005.12.041","article-title":"Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb","volume":"292","author":"Kim","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib36","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ydbio.2007.10.043","article-title":"Overexpression of pairedless Pax6 in the retina disrupts corneal development and affects lens cell survival","volume":"313","author":"Kim","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1399-0004.2010.01372.x","article-title":"Clinical and molecular aspects of aniridia","volume":"77","author":"Kokotas","year":"2010","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib38","doi-asserted-by":"crossref","first-page":"17484","DOI":"10.1073\/pnas.1215421109","article-title":"Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)","volume":"109","author":"Lei","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2015.02.012_bib39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.brainresbull.2005.02.006","article-title":"Role of Pax6 in forebrain regionalization","volume":"66","author":"Manuel","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ydbio.2015.02.012_bib40","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1242\/dev.124.10.1985","article-title":"Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain","volume":"124","author":"Mastick","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng0493-299","article-title":"A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells","volume":"3","author":"Matsuo","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S1542-0124(12)70130-1","article-title":"Keratopathy in congenital aniridia","volume":"1","author":"Mayer","year":"2003","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.ydbio.2015.02.012_bib43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2008.08.052","article-title":"Spatio-temporal expression of Pax6 in Xenopus forebrain","volume":"1239","author":"Moreno","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ydbio.2015.02.012_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2108\/zsj.30.455","article-title":"Targeted gene disruption in the Xenopus tropicalis genome using designed TALE nucleases","volume":"30","author":"Nakajima","year":"2013","journal-title":"Zool. Sci."},{"key":"10.1016\/j.ydbio.2015.02.012_bib45","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1242\/bio.20136676","article-title":"Comparison of TALEN scaffolds in Xenopus tropicalis","volume":"2","author":"Nakajima","year":"2013","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2015.02.012_bib46","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/dvg.22720","article-title":"Simple and efficient CRISPR\/Cas9-mediated targeted mutagenesis in Xenopus tropicalis","volume":"51","author":"Nakayama","year":"2013","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.012_bib47","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jaapos.2011.07.009","article-title":"Ocular and systemic findings in a survey of aniridia subjects","volume":"15","author":"Netland","year":"2011","journal-title":"J. AAPOS"},{"key":"10.1016\/j.ydbio.2015.02.012_bib48","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1261\/rna.2401811","article-title":"Mechanism of escape from nonsense-mediated mRNA decay of human \u00df-globin transcripts with nonsense mutations in the first exon","volume":"17","author":"Neu-Yilik","year":"2011","journal-title":"RNA"},{"key":"10.1016\/j.ydbio.2015.02.012_bib49","series-title":"Normal Table of Xenopus laevis","author":"Nieuwkoop","year":"1994"},{"key":"10.1016\/j.ydbio.2015.02.012_bib50","doi-asserted-by":"crossref","unstructured":"Numayama-Tsuruta, K., Arai, Y., Osumi, N., 2007. The rat Small eye homozygote (rSey2\/rSey2) can be regarded as a Pax6 null mutant. In: Esashi, M., Ishii, K., Ohuchi, N., Osumi, N., Sato, M., Yamaguchi, T. (Eds.), Future Medical Engineering Based on Bionanotechnology: Proceedings of the Final Symposium of the Tohoku University 21st Century Center for Excellence Program. Imperial College Press, pp. 151-161.","DOI":"10.1142\/9781860948800_0017"},{"key":"10.1016\/j.ydbio.2015.02.012_bib51","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/nprot.2006.208","article-title":"High-throughput transgenesis in Xenopus using I-SceI meganuclease","volume":"1","author":"Ogino","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ydbio.2015.02.012_bib52","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1242\/dev.124.15.2961","article-title":"Pax-6 is involved in the specification of hindbrain motor neuron subtype","volume":"124","author":"Osumi","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib53","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1634\/stemcells.2007-0884","article-title":"Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator","volume":"26","author":"Osumi","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ydbio.2015.02.012_bib54","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/dvdy.21935","article-title":"Xenopus pancreas development","volume":"238","author":"Pearl","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.02.012_bib55","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1242\/dev.102186","article-title":"Making designer mutants in model organisms","volume":"141","author":"Peng","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ydbio.2012.03.014","article-title":"Induction of the neural crest state: control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions","volume":"366","author":"Prasad","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/(SICI)1098-1004(1998)11:2<93::AID-HUMU1>3.0.CO;2-M","article-title":"PAX6 mutations reviewed","volume":"11","author":"Prosser","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ydbio.2015.02.012_bib58","doi-asserted-by":"crossref","first-page":"e1003177","DOI":"10.1371\/journal.pgen.1003177","article-title":"Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences","volume":"9","author":"Ravi","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European molecular biology open software suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1017\/S0016672300010387","article-title":"Small eyes\u2014a new dominant mutation in the mouse","volume":"9","author":"Roberts","year":"1967","journal-title":"Genet. Res. Camb."},{"key":"10.1016\/j.ydbio.2015.02.012_bib61","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0896-6273(92)90123-U","article-title":"A labile period in the determination of the anterior\u2013posterior axis during early neural development in Xenopus","volume":"8","author":"Saha","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2015.02.012_bib62","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1101\/gad.11.13.1662","article-title":"Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development","volume":"11","author":"Sander","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2015.02.012_bib63","doi-asserted-by":"crossref","first-page":"e1000511","DOI":"10.1371\/journal.pgen.1000511","article-title":"The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis","volume":"5","author":"Sansom","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib64","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1242\/dev.00539","article-title":"Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6","volume":"130","author":"Scardigli","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0092-8674(00)80078-1","article-title":"Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities","volume":"86","author":"Schedl","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.02.012_bib66","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.preteyeres.2012.04.002","article-title":"Pax6: a multi-level regulator of ocular development","volume":"31","author":"Shaham","year":"2012","journal-title":"Prog. Retinal Eye Res."},{"key":"10.1016\/j.ydbio.2015.02.012_bib67","series-title":"Early Development of Xenopus laevis: A Laboratory Manual","author":"Sive","year":"2000"},{"key":"10.1016\/j.ydbio.2015.02.012_bib68","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2217\/rme.10.79","article-title":"Myc transcription factors: key regulators behind establishment and maintenance of pluripotency","volume":"5","author":"Smith","year":"2010","journal-title":"Regen. Med."},{"key":"10.1016\/j.ydbio.2015.02.012_bib69","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/387406a0","article-title":"Pax6 is required for differentiation of glucagon-producing \u03b1-cells in mouse pancreas","volume":"387","author":"St-Onge","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.02.012_bib70","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1242\/dev.122.11.3453","article-title":"Forebrain patterning defects in Small eye mutant mice","volume":"122","author":"Stoykova","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib786","doi-asserted-by":"crossref","first-page":"8042","DOI":"10.1523\/JNEUROSCI.20-21-08042.2000","article-title":"Pax6 modulates the dorsoventral patterning of the mammalian telencephalon","volume":"20","author":"Stoykova","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.02.012_bib71","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1073\/pnas.37.7.405","article-title":"A map of the fourth chromosome of Drosophila melanogaster, based on crossing over in triploid females","volume":"37","author":"Sturtevant","year":"1951","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2015.02.012_bib72","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1242\/dev.126.15.3359","article-title":"Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum","volume":"126","author":"Sussel","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib73","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1242\/bio.20133855","article-title":"High efficiency TALENs enable F0 functional analysis by targeted gene disruption in Xenopus laevis embryos","volume":"2","author":"Suzuki","year":"2013","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2015.02.012_bib74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00315732","article-title":"Development of Dickie\u2019s Small eye, a mutation in the house mouse","volume":"155","author":"Theiler","year":"1978","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib75","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1242\/dev.127.20.4361","article-title":"Genetic control of dorsal\u2013ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2","volume":"127","author":"Toresson","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib76","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/hmg\/11.10.1161","article-title":"PAX6 in sensory development","volume":"11","author":"van Heyningen","year":"2002","journal-title":"Hum. Mol. Gen."},{"key":"10.1016\/j.ydbio.2015.02.012_bib77","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.ejhg.5200940","article-title":"Screening for PAX6 gene mutations is consistent with haploinsufficiency as the main mechanism leading to various ocular defects","volume":"11","author":"Vincent","year":"2003","journal-title":"Eur. J. Human Genet."},{"key":"10.1016\/j.ydbio.2015.02.012_bib78","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1242\/dev.113.4.1435","article-title":"Pax-6, a murine paired box gene, is expressed in the developing CNS","volume":"113","author":"Walther","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib79","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/dbio.1998.9153","article-title":"BMP7 acts in murine lens placode development","volume":"207","author":"Wawersik","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib80","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/dbio.1994.1289","article-title":"Nonsense-mediated mRNA decay in Xenopus oocytes and embryos","volume":"165","author":"Whitfield","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.012_bib81","doi-asserted-by":"crossref","first-page":"e4159","DOI":"10.1371\/journal.pone.0004159","article-title":"Identification of Pax6-dependent gene regulatory networks in the mouse lens","volume":"4","author":"Wolf","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.02.012_bib82","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1242\/dev.00399","article-title":"Cell-autonomous involvement of Mab21l1 is essential for lens placode development","volume":"130","author":"Yamada","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.012_bib83","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dev.128.2.193","article-title":"Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon","volume":"128","author":"Yun","year":"2001","journal-title":"Development"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615000809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615000809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:12:38Z","timestamp":1747699958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615000809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0012160615000809"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.02.012","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}