{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:36:26Z","timestamp":1790472986643,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T00:00:00Z","timestamp":1463270400000},"content-version":"vor","delay-in-days":380,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["5-FY12-59"],"award-info":[{"award-number":["5-FY12-59"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01HL115447"],"award-info":[{"award-number":["K01HL115447"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL110964"],"award-info":[{"award-number":["U01 HL110964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.ydbio.2015.02.014","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T19:47:45Z","timestamp":1424980065000},"page":"264-275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall"],"prefix":"10.1016","volume":"401","author":[{"given":"John","family":"Snowball","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Ambalavanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Cornett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Whitsett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Sinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.02.014_bib1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1084\/jem.20121871","article-title":"Loss of epidermal Evi\/Wls results in a phenotype resembling psoriasiform dermatitis","volume":"210","author":"Augustin","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ydbio.2015.02.014_bib2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cell.2006.02.049","article-title":"Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells","volume":"125","author":"Banziger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.02.014_bib3","doi-asserted-by":"crossref","first-page":"12752","DOI":"10.1073\/pnas.1006437108","article-title":"Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia\/Goltz syndrome","volume":"108","author":"Barrott","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.02.014_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2003.11.021","article-title":"Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure","volume":"267","author":"Brewer","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib5","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1091\/mbc.E08-07-0711","article-title":"The extracellular domain of Lrp5\/6 inhibits noncanonical Wnt signaling in vivo","volume":"20","author":"Bryja","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2015.02.014_bib6","first-page":"602","article-title":"A syndrome of congenital defects involving the abdominal wall, sternum, diaphragm, pericardium, and heart","volume":"107","author":"Cantrell","year":"1958","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1016\/j.ydbio.2015.02.014_bib8","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/dvg.20651","article-title":"Generation of mice with a conditional null allele for Wntless","volume":"48","author":"Carpenter","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.014_bib9","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1242\/dev.076463","article-title":"Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation","volume":"139","author":"Chen","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.014_bib10","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1242\/jcs.072132","article-title":"Wls-dependent secretion of WNT3A requires ser209 acylation and vacuolar acidification","volume":"123","author":"Coombs","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2015.02.014_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ydbio.2013.03.010","article-title":"Wntless is required for peripheral lung differentiation and pulmonary vascular development","volume":"379","author":"Cornett","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/dbio.2002.0620","article-title":"Programmed cell death is required for palate shelf fusion and is regulated by retinoic acid","volume":"245","author":"Cuervo","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib13","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/jid.2012.407","article-title":"Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis","volume":"133","author":"Fu","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib14","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature02033","article-title":"A gene expression atlas of the central nervous system based on bacterial artificial chromosomes","volume":"425","author":"Gong","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.02.014_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI12466","article-title":"c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis","volume":"108","author":"Han","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ydbio.2015.02.014_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrm2141","article-title":"Helping wingless take flight: how WNT proteins are secreted","volume":"8","author":"Hausmann","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib17","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ydbio.2011.11.003","article-title":"Porcupine-mediated lipidation is required for Wnt recognition by Wls","volume":"361","author":"Herr","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35017574","article-title":"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation","volume":"406","author":"Hoeflich","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.02.014_bib19","doi-asserted-by":"crossref","first-page":"e45904","DOI":"10.1371\/journal.pone.0045904","article-title":"Wls is expressed in the epidermis and regulates embryonic hair follicle induction in mice","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.02.014_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2011.08.020","article-title":"Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo","volume":"359","author":"Joeng","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/gene.10050","article-title":"Conditional inactivation of Sox9: a mouse model for campomelic dysplasia","volume":"32","author":"Kist","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.014_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2443.2007.01068.x","article-title":"Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a","volume":"12","author":"Komekado","year":"2007","journal-title":"Genes Cells"},{"key":"10.1016\/j.ydbio.2015.02.014_bib22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1006\/dbio.1995.0023","article-title":"Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis","volume":"172","author":"Li","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.mod.2008.11.003","article-title":"Body wall morphogenesis: limb-genesis interferes with body wall-genesis via its influence on the abaxial somite derivatives","volume":"126","author":"Liem","year":"2009","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2015.02.014_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nature05557","article-title":"Chemical rescue of cleft palate and midline defects in conditional GSK-3[bgr] mice","volume":"446","author":"Liu","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.02.014_bib25","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/MCB.22.4.1184-1193.2002","article-title":"Negative feedback loop of Wnt signaling through upregulation of conductin\/axin2 in colorectal and liver tumors","volume":"22","author":"Lustig","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/jmg.2009.068403","article-title":"Phenotype and genotype in 17 patients with Goltz\u2013Gorlin syndrome","volume":"46","author":"Maas","year":"2009","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2015.02.014_bib27","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1073\/pnas.0434590100","article-title":"Mapping Wnt\/beta-catenin signaling during mouse development and in colorectal tumors","volume":"100","author":"Maretto","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.02.014_bib28","doi-asserted-by":"crossref","first-page":"40231","DOI":"10.1074\/jbc.M305892200","article-title":"beta-Catenin is required for specification of proximal\/distal cell fate during lung morphogenesis","volume":"278","author":"Mucenski","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2015.02.014_bib29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.014_bib30","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s00246-009-9410-9","article-title":"Outcome of children with Pentalogy of Cantrell following cardiac surgery","volume":"30","author":"O\u2019Gorman","year":"2009","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib31","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1242\/dev.021170","article-title":"beta-Catenin has sequential roles in the survival and specification of ventral dermis","volume":"135","author":"Ohtola","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.014_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C","article-title":"Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice","volume":"26","author":"Ovchinnikov","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.02.014_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.sempedsurg.2010.03.006","article-title":"The embryologic origin of ventral body wall defects","volume":"19","author":"Sadler","year":"2010","journal-title":"Semin. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2015.02.014_bib34","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/ajmg.a.33895","article-title":"Co-occurrence of severe Goltz\u2013Gorlin syndrome and pentalogy of Cantrell \u2013 case report and review of the literature","volume":"155A","author":"Smigiel","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ydbio.2015.02.014_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(03)00002-3","article-title":"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity","volume":"112","author":"Sosic","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.02.014_bib36","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/0006-291X(91)92031-E","article-title":"The newly synthesized selective Ca2+\/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells","volume":"181","author":"Sumi","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2015.02.014_bib37","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1083\/jcb.200303158","article-title":"Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation","volume":"162","author":"Topol","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ydbio.2012.06.020","article-title":"Wnt5a can both activate and repress Wnt\/beta-catenin signaling during mouse embryonic development","volume":"369","author":"van Amerongen","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.02.014_bib39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.ydbio.2015.02.014_bib40","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/ng2057","article-title":"Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia","volume":"39","author":"Wang","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.02.014_bib41","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1242\/dev.00491","article-title":"Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth","volume":"130","author":"Yu","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.02.014_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ydbio.2013.12.027","article-title":"Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development","volume":"387","author":"Zhang","year":"2014","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615000834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615000834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T20:54:48Z","timestamp":1537822488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615000834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0012160615000834"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.02.014","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}