{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:38:18Z","timestamp":1791509898077,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RDE023553A"],"award-info":[{"award-number":["RDE023553A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30CA16059"],"award-info":[{"award-number":["P30CA16059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ydbio.2015.07.001","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T17:12:36Z","timestamp":1436029956000},"page":"108-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["The role of folate metabolism in orofacial development and clefting"],"prefix":"10.1016","volume":"405","author":[{"given":"Stacey E.","family":"Wahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson E.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent H.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah E.","family":"Pridgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"Mavila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.G.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.07.001_bib1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/carcin\/bgh347","article-title":"Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts","volume":"26","author":"Andersen","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ydbio.2015.07.001_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2008.07.073","article-title":"Induction of oxidative stress and DNA damage in rat brain by a folate\/methyl-deficient diet","volume":"1237","author":"Bagnyukova","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ydbio.2015.07.001_bib3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/bdra.20553","article-title":"Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview","volume":"85","author":"Beaudin","year":"2009","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"issue":"3","key":"10.1016\/j.ydbio.2015.07.001_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/gepi.20376","article-title":"Oral facial clefts and gene polymorphisms in metabolism of folate\/one-carbon and vitamin A: a pathway-wide association study","volume":"33","author":"Boyles","year":"2009","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4081\/cp.2014.608","article-title":"Assessment of folic Acid and DNA damage in cleft lip and cleft palate","volume":"4","author":"Brooklyin","year":"2014","journal-title":"Clin. Pract."},{"key":"10.1016\/j.ydbio.2015.07.001_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/tera.10040","article-title":"Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model","volume":"65","author":"Burgoon","year":"2002","journal-title":"Teratology"},{"key":"10.1016\/j.ydbio.2015.07.001_bib7","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jnutbio.2010.10.003","article-title":"Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects","volume":"22","author":"Chang","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ydbio.2015.07.001_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1079\/BJN20041283","article-title":"Folate supplementation increases genomic DNA methylation in the liver of elder rats","volume":"93","author":"Choi","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ydbio.2015.07.001_bib9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jnutbio.2007.05.003","article-title":"Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines","volume":"19","author":"Crott","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ydbio.2015.07.001_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1073\/pnas.1010740107","article-title":"Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network","volume":"108","author":"de Croze","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.07.001_bib11","unstructured":"Dhawan, A., Bajpayee, M., Pandey, A.K., D., P., Protocol for the single cell gel electrophoresis\/comet assay for rapid genotoxicity assessment. Indian Institute of Toxicology Research, India, 2009."},{"key":"10.1016\/j.ydbio.2015.07.001_bib12","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ydbio.2006.03.054","article-title":"Development of the primary mouth in Xenopus laevis","volume":"295","author":"Dickinson","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1242\/dev.032912","article-title":"The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth","volume":"136","author":"Dickinson","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.07.001_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/10454411980090010201","article-title":"Neural tube and craniofacial defects with special emphasis on folate pathway genes","volume":"9","author":"Finnell","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.ydbio.2015.07.001_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.taap.2003.09.031","article-title":"Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis","volume":"198","author":"Finnell","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/cyto.a.20048","article-title":"Distinguishing modes of cell death using the ImageStream multispectral imaging flow cytometer","volume":"59","author":"George","year":"2004","journal-title":"Cytometry A"},{"key":"10.1016\/j.ydbio.2015.07.001_bib18","first-page":"52","article-title":"Folic acid supplementation and pregnancy: more than just neural tube defect prevention","volume":"4","author":"Greenberg","year":"2011","journal-title":"Rev. Obstet. Gynecol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib19","doi-asserted-by":"crossref","first-page":"e4381","DOI":"10.1371\/journal.pone.0004381","article-title":"Relationship between neural crest cells and cranial mesoderm during head muscle development","volume":"4","author":"Grenier","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.07.001_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0955-2863(02)00178-X","article-title":"Involvement of DNA mismatch repair in folate deficiency-induced apoptosis small star, filled","volume":"13","author":"Gu","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ydbio.2015.07.001_bib21","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1038\/sj.onc.1204326","article-title":"Histone H3 phosphorylation and cell division","volume":"20","author":"Hans","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2015.07.001_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0969-9961(03)00070-6","article-title":"Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine","volume":"14","author":"Ho","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2015.07.001_bib23","doi-asserted-by":"crossref","first-page":"36922","DOI":"10.1074\/jbc.M110.126714","article-title":"Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development","volume":"285","author":"Ichi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2015.07.001_bib24","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.celrep.2014.06.026","article-title":"The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling","volume":"8","author":"Jacox","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2015.07.001_bib25","doi-asserted-by":"crossref","DOI":"10.3791\/50697","article-title":"Facial transplants in Xenopus laevis embryos","author":"Jacox","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2015.07.001_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.nbd.2014.08.004","article-title":"Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish--implication in neural tube defects and Alzheimer's diseases","volume":"71","author":"Kao","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2015.07.001_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ydbio.2012.02.033","article-title":"Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes","volume":"365","author":"Kennedy","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib28","first-page":"e52062","article-title":"Quantification of orofacial phenotypes in Xenopus","author":"Kennedy","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2015.07.001_bib29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/ar.22864","article-title":"Quantitative analysis of orofacial development and median clefts in Xenopus laevis","volume":"297","author":"Kennedy","year":"2014","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.ydbio.2015.07.001_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-213X-12-12","article-title":"Disruption of the folate pathway in zebrafish causes developmental defects","volume":"12","author":"Lee","year":"2012","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0955-2863(03)00115-3","article-title":"Folate deficiency, mismatch repair-dependent apoptosis, and human disease","volume":"14","author":"Li","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ydbio.2015.07.001_bib32","doi-asserted-by":"crossref","first-page":"e27198","DOI":"10.1371\/journal.pone.0027198","article-title":"Xenopus reduced folate carrier regulates neural crest development epigenetically","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.07.001_bib33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","article-title":"Folic acid: nutritional biochemistry, molecular biology, and role in disease processes","volume":"71","author":"Lucock","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ydbio.2015.07.001_bib34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/emmm.200900040","article-title":"Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2","volume":"1","author":"Martin","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ydbio.2015.07.001_bib35","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1093\/hmg\/ddr289","article-title":"Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival","volume":"20","author":"Marean","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2015.07.001_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmg.2013.12.002","article-title":"Evidence of the involvement of the DHFR gene in nonsyndromic cleft lip with or without cleft palate","volume":"57","author":"Martinelli","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2015.07.001_bib37","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1177\/15648265080292S114","article-title":"Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development","volume":"29","author":"Molloy","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.ydbio.2015.07.001_bib38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1073\/pnas.1211199110","article-title":"Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice","volume":"110","author":"Momb","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.07.001_bib39","series-title":"Normal Table of Xenopus Laevis (Daudin)","author":"Nieuwkoop","year":"1967"},{"key":"10.1016\/j.ydbio.2015.07.001_bib40","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/dvdy.20697","article-title":"The differentiation and morphogenesis of craniofacial muscles","volume":"235","author":"Noden","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.07.001_bib41","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/carcin\/bgi312","article-title":"Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells","volume":"27","author":"Novakovic","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ydbio.2015.07.001_bib42","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nsmb.1897","article-title":"Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres","volume":"17","author":"O\u2019Sullivan","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","article-title":"Emerging roles of caspase-3 in apoptosis","volume":"6","author":"Porter","year":"1999","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.ydbio.2015.07.001_bib44","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1158\/0008-5472.CAN-05-4048","article-title":"Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates","volume":"66","author":"Qi","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ydbio.2015.07.001_bib45","doi-asserted-by":"crossref","first-page":"13481","DOI":"10.1073\/pnas.172501499","article-title":"Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics","volume":"99","author":"Rajagopalan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.07.001_bib46","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMc066569","article-title":"Folate deficiency and plasma homocysteine during increased oxidative stress","volume":"357","author":"Rogers","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2015.07.001_bib47","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1469-7580.2012.01541.x","article-title":"Cranial muscles in amphibians: development, novelties and the role of cranial neural crest cells","volume":"222","author":"Schmidt","year":"2013","journal-title":"J. Anat."},{"key":"10.1016\/j.ydbio.2015.07.001_bib48","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/dvg.20623","article-title":"A new perspective on neural tube defects: folic acid and microRNA misexpression","volume":"48","author":"Shookhoff","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.07.001_bib49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1242\/dev.105445","article-title":"Establishing neural crest identity: a gene regulatory recipe","volume":"142","author":"Simoes-Costa","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.07.001_bib50","series-title":"Early development of Xenopus laevis: a laboratory manual","author":"Sive","year":"2000"},{"key":"10.1016\/j.ydbio.2015.07.001_bib51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/bj20031522","article-title":"Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum","volume":"379","author":"Soto","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2015.07.001_bib52","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1292\/jvms.13-0457","article-title":"Effect of methotrexate on neuroepithelium in the rat fetal brain","volume":"76","author":"Sun","year":"2014","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.ydbio.2015.07.001_bib53","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/abbs\/gmr098","article-title":"Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish","volume":"43","author":"Sun","year":"2011","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.ydbio.2015.07.001_bib54","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/00029330-200707010-00010","article-title":"Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development","volume":"120","author":"Sun","year":"2007","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.ydbio.2015.07.001_bib55","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2009.11.021","article-title":"New directions in craniofacial morphogenesis","volume":"341","author":"Szabo-Rogers","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.30053","article-title":"Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies","volume":"135C","author":"Tang","year":"2005","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.ydbio.2015.07.001_bib57","first-page":"107","article-title":"Revised procedures for staining and clearing small fishes and other vertebrates for bone and cartilage study","volume":"9","author":"Taylor","year":"1985","journal-title":"Cybium"},{"key":"10.1016\/j.ydbio.2015.07.001_bib58","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/jat.2901","article-title":"Role of methotrexate exposure in apoptosis and proliferation during early neurulation","volume":"34","author":"Wang","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1601-0825.2009.01587.x","article-title":"Folic acid and orofacial clefts: a review of the evidence","volume":"16","author":"Wehby","year":"2010","journal-title":"Oral Dis."},{"key":"10.1016\/j.ydbio.2015.07.001_bib60","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/dvdy.21967","article-title":"Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus","volume":"238","author":"Wheeler","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.07.001_bib61","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/bmj.39079.618287.0B","article-title":"Folic acid supplements and risk of facial clefts: national population based case-control study","volume":"334","author":"Wilcox","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.ydbio.2015.07.001_bib62","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1093\/nar\/19.13.3709","article-title":"Developmental regulation of transcription factor AP-2 during Xenopus laevis embryogenesis","volume":"19","author":"Winning","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2015.07.001_bib63","doi-asserted-by":"crossref","first-page":"12001","DOI":"10.1074\/jbc.M109219200","article-title":"Apoptotic release of histones from nucleosomes","volume":"277","author":"Wu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2015.07.001_bib64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3164\/jcbn.08-223","article-title":"Folate deficiency induces neural stem cell apoptosis by increasing homocysteine in vitro","volume":"45","author":"Zhang","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.ydbio.2015.07.001_bib65","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jat.2769","article-title":"Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability","volume":"33","author":"Zhao","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ydbio.2015.07.001_bib66","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1038\/sj.onc.1206946","article-title":"Resistance to antifolates","volume":"22","author":"Zhao","year":"2003","journal-title":"Oncogene"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615300282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615300282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T17:15:49Z","timestamp":1717953349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615300282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0012160615300282"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.07.001","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of folate metabolism in orofacial development and clefting","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}