{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:25:32Z","timestamp":1768317932235,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"University of Louisville School of Dentistry"},{"DOI":"10.13039\/100007924","name":"University of Louisville","doi-asserted-by":"crossref","award":["P20 RR017702"],"award-info":[{"award-number":["P20 RR017702"]}],"id":[{"id":"10.13039\/100007924","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cardiovascular Innovation Institute in Louisville","award":["GM103507"],"award-info":[{"award-number":["GM103507"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ydbio.2015.08.008","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T18:32:37Z","timestamp":1439490757000},"page":"57-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Retinoic acid regulates embryonic development of mammalian submandibular salivary glands"],"prefix":"10.1016","volume":"407","author":[{"given":"Diana M.","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna E.","family":"Buenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur M.","family":"Abashev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa L.","family":"Sandell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.08.008_bib1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/bdra.20338","article-title":"Rhabdomyomatous hamartomata of the pharyngeal region with bilateral microtia and aural atresia: a new association?","volume":"79","author":"Adam","year":"2007","journal-title":"Birth Defects Res. Part A: Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib2","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1194\/jlr.R030833","article-title":"Vitamin A and retinoid signaling: genomic and nongenomic effects: thematic review series: fat-soluble vitamins: vitamin A","volume":"54","author":"Al Tanoury","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ydbio.2015.08.008_bib3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/jn\/111.3.496","article-title":"Impaired salivary gland secretory function following the induction of rapid, synchronous vitamin A deficiency in rats","volume":"111","author":"Anzano","year":"1981","journal-title":"J. Nutr."},{"key":"10.1016\/j.ydbio.2015.08.008_bib4","first-page":"717","article-title":"Morphologic alterations in the trachea and the salivary gland following the induction of rapid synchronous vitamin A deficiency in rats","volume":"98","author":"Anzano","year":"1980","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib5","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1096\/fj.13-227967","article-title":"The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development","volume":"27","author":"Billings","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.ydbio.2015.08.008_bib6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/nu3040385","article-title":"Vitamin A in reproduction and development","volume":"3","author":"Clagett-Dame","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.ydbio.2015.08.008_bib7","first-page":"1","article-title":"Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid","volume":"9","author":"D\u2019Aniello","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.08.008_bib8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/dvdy.24232","article-title":"Input overload: contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis","volume":"244","author":"D\u2019Aniello","year":"2015","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.08.008_bib9","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1002\/dvdy.22479","article-title":"Fate of retinoic acid-activated embryonic cell lineages","volume":"239","author":"Doll\u00e9","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.08.008_bib10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1242\/dev.110.4.1133","article-title":"Retinoic acid receptors and cellular retinoid binding proteins I. A systematic study of their differential pattern of transcription during mouse organogenesis","volume":"110","author":"Dolle","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.08.008_bib11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis","volume":"134","author":"Duester","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.08.008_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2009.10.029","article-title":"Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism","volume":"338","author":"Feng","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib13","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3109\/02841869109088252","article-title":"Acute radiation effects on saliva composition in rats with different vitamin a levels in serum","volume":"30","author":"Funeg\u00e5rd","year":"1991","journal-title":"Acta Oncol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib14","doi-asserted-by":"crossref","first-page":"16700","DOI":"10.1016\/S0021-9258(19)84762-2","article-title":"Universality and structure of the N-end rule","volume":"264","author":"Gonda","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2015.08.008_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000358776","article-title":"Anatomy, biogenesis and regeneration of salivary glands","volume":"24","author":"Holmberg","year":"2014","journal-title":"Monogr. Oral Sci."},{"key":"10.1016\/j.ydbio.2015.08.008_bib16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0003-9969(96)00069-6","article-title":"Response of rat salivary glands to mastication of pelleted vitamin A-deficient diet","volume":"41","author":"Horn","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/00220345940730010101","article-title":"Saliva composition in Indian children with chronic protein-energy malnutrition","volume":"73","author":"Johansson","year":"1994","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ydbio.2015.08.008_bib18","first-page":"263","article-title":"Effect of a moderate vitamin A deficiency on saliva secretion rate and some salivary glycoproteins in adult rat","volume":"97","author":"Johansson","year":"1989","journal-title":"Scand. J. Dent. Res."},{"key":"10.1016\/j.ydbio.2015.08.008_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/wdev.4","article-title":"Salivary gland organogenesis","volume":"1","author":"Knosp","year":"2012","journal-title":"Wiley Interdiscip. Rev.: Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.devcel.2015.01.023","article-title":"Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors","volume":"32","author":"Knosp","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2015.08.008_bib21","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ncomms2493","article-title":"Parasympathetic stimulation improves epithelial organ regeneration","volume":"4","author":"Knox","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2015.08.008_bib22","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.1192046","article-title":"Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis","volume":"329","author":"Knox","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.08.008_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0012-1606(69)90004-9","article-title":"Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse","volume":"20","author":"Kratochwil","year":"1969","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0012-1606(85)90097-1","article-title":"A pituitary-salivary mixed gland induced by tissue recombination of embryonic pituitary epithelium and embryonic submandibular gland mesenchyme in mice","volume":"110","author":"Kusakabe","year":"1985","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib25","doi-asserted-by":"crossref","first-page":"13668","DOI":"10.1073\/pnas.1200872109","article-title":"A paradoxical teratogenic mechanism for retinoic acid","volume":"109","author":"Lee","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ydbio.2015.08.008_bib26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0960-0760(95)00094-G","article-title":"Developmental roles of the retinoic acid receptors","volume":"53","author":"Lohnes","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib27","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1242\/dev.120.10.2723","article-title":"Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants","volume":"120","author":"Lohnes","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.08.008_bib28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.gde.2004.07.012","article-title":"Retinoic acid signalling in the development of branchial arches","volume":"14","author":"Mark","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2015.08.008_bib29","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.07002","article-title":"Function of retinoic acid receptors during embryonic development","volume":"7","author":"Mark","year":"2009","journal-title":"Nucl. Recept. Signal"},{"key":"10.1016\/j.ydbio.2015.08.008_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1741-7007-8-89","article-title":"Characterization of a heat resistant SZ-glucosidase as a new reporter in cells and mice","volume":"8","author":"McCutcheon","year":"2010","journal-title":"BMC Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg2340","article-title":"Retinoic acid in development: towards an integrated view","volume":"9","author":"Niederreither","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2015.08.008_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcdb.2013.12.001","article-title":"Salivary gland development: a template for regeneration","volume":"25\u201326","author":"Patel","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib33","doi-asserted-by":"crossref","first-page":"16687","DOI":"10.1073\/pnas.1103877108","article-title":"Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment","volume":"108","author":"Rhinn","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.08.008_bib34","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1101\/gad.5.8.1333","article-title":"Expression of retinoic acid response element-hsp lacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis","volume":"5","author":"Rossant","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2015.08.008_bib35","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ydbio.2013.11.009","article-title":"Cochleovestibular nerve development is integrated with migratory neural crest cells","volume":"385","author":"Sandell","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib36","doi-asserted-by":"crossref","first-page":"e30698","DOI":"10.1371\/journal.pone.0030698","article-title":"RDH10 oxidation of vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis","volume":"7","author":"Sandell","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.08.008_bib37","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.1533407","article-title":"RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development","volume":"21","author":"Sandell","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2015.08.008_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ydbio.2007.10.018","article-title":"A nutritional model of late embryonic vitamin A deficiency produces defects in organogenesis at a high penetrance and reveals new roles for the vitamin in skeletal development","volume":"316","author":"See","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib39","doi-asserted-by":"crossref","first-page":"891-IN812","DOI":"10.1016\/0003-9969(69)90267-2","article-title":"Salivary gland changes in vitamin-A-deficient rats","volume":"14","author":"Trowbridge","year":"1969","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.semcdb.2007.01.006","article-title":"Salivary gland development","volume":"18","author":"Tucker","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.08.008_bib41","doi-asserted-by":"crossref","first-page":"D552","DOI":"10.1093\/nar\/gkh029","article-title":"GenePaint.org: an atlas of gene expression patterns in the mouse embryo","volume":"32","author":"Visel","year":"2004","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.ydbio.2015.08.008_bib42","doi-asserted-by":"crossref","unstructured":"Wells, K.L., Gaete, M., Matalova, E., Deutsch, D., Rice, D., Tucker, A.S., 2013. Dynamic relationship of the epithelium and mesenchyme during salivary gland initiation: the role of Fgf10. Biology Open.","DOI":"10.1242\/bio.20135306"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615301214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615301214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T11:35:03Z","timestamp":1653046503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615301214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0012160615301214"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.08.008","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoic acid regulates embryonic development of mammalian submandibular salivary glands","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}