{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:12:10Z","timestamp":1791249130706,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T00:00:00Z","timestamp":1484438400000},"content-version":"vor","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Irma and Norman Braman Endowment"},{"name":"Suzi and Scott Lustgarten Center Endowment"},{"name":"The Children\u2019s Hospital of Philadelphia Research Institute"},{"name":"The Children\u2019s Discovery Institute of Washington University"},{"name":"St. Louis Children\u2019s Hospital","award":["CH-II-1008-123"],"award-info":[{"award-number":["CH-II-1008-123"]}]},{"name":"St. Louis Children\u2019s Hospital","award":["CH-II-2010-390"],"award-info":[{"award-number":["CH-II-2010-390"]}]},{"name":"St. Louis Children\u2019s Hospital","award":["MD-II-2013-269"],"award-info":[{"award-number":["MD-II-2013-269"]}]},{"DOI":"10.13039\/100000002","name":"United States National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["RO1 DK087715"],"award-info":[{"award-number":["RO1 DK087715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"United States National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["R01 GM059688"],"award-info":[{"award-number":["R01 GM059688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"United States National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["R37 DK33165"],"award-info":[{"award-number":["R37 DK33165"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"United States National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["RO1 DK080914"],"award-info":[{"award-number":["RO1 DK080914"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"United States National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["F30 DK100101"],"award-info":[{"award-number":["F30 DK100101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Burroughs Wellcome Fund Clinical Scientist Award","award":["1008525"],"award-info":[{"award-number":["1008525"]}]},{"name":"NIH Medical Scientist Training Program","award":["T32 GM07200"],"award-info":[{"award-number":["T32 GM07200"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.ydbio.2015.09.023","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T08:15:14Z","timestamp":1447488914000},"page":"473-488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse"],"prefix":"10.1016","volume":"409","author":[{"given":"Ellen Merrick","family":"Schill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Tusheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandor","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saya K.","family":"Bery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Avetisyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Stenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Heuckeroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.09.023_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","article-title":"The GDNF family: signalling, biological functions and therapeutic value","volume":"3","author":"Airaksinen","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0731-7085(93)80072-9","article-title":"Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine","volume":"11","author":"Aluri","year":"1993","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ydbio.2015.09.023_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"Amiel","year":"2008","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2015.09.023_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-0-387-46954-6_11","article-title":"Neural crest and the development of the enteric nervous system","volume":"589","author":"Anderson","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/humu.20944","article-title":"Interaction between a chromosome 10 RET enhancer and chromosome 21 in the Down syndrome-Hirschsprung disease association","volume":"30","author":"Arnold","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ydbio.2015.09.023_bib6","series-title":"Disposition of Toxic Drugs and Chemicals in Man","author":"Baselt","year":"1982"},{"key":"10.1016\/j.ydbio.2015.09.023_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1101\/gad.186601","article-title":"The transcription factor Sox10 is a key regulator of peripheral glial development","volume":"15","author":"Britsch","year":"2001","journal-title":"Genes. Dev."},{"key":"10.1016\/j.ydbio.2015.09.023_bib8","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.febslet.2004.12.074","article-title":"Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth","volume":"579","author":"Bryan","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2015.09.023_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ng998","article-title":"Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease","volume":"32","author":"Carrasquillo","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.09.023_bib10","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1067\/j.cpsurg.2004.09.004","article-title":"Hirschsprung disease","volume":"41","author":"Dasgupta","year":"2004","journal-title":"Curr. Probl. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000109851","article-title":"Functions of Rac GTPases during neuronal development","volume":"30","author":"de Curtis","year":"2008","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1523\/JNEUROSCI.5045-09.2010","article-title":"A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons","volume":"30","author":"Dill","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpedsurg.2012.10.028","article-title":"Probiotic prophylaxis after pullthrough for Hirschsprung disease to reduce incidence of enterocolitis: a prospective, randomized, double-blind, placebo-controlled, multicenter trial","volume":"48","author":"El-Sawaf","year":"2013","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib14","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1242\/dev.128.20.3963","article-title":"RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons","volume":"128","author":"Enomoto","year":"2001","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.ydbio.2015.09.023_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1470320314528364","article-title":"Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration","volume":"16","author":"Ferri","year":"2014","journal-title":"J. Renin Angiotensin Aldosterone Syst.: JRAAS"},{"issue":"12","key":"10.1016\/j.ydbio.2015.09.023_bib16","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1172\/JCI67653","article-title":"Retinoblastoma protein loss in the enteric nervous system causes selective defects and early death","volume":"123","author":"Fu","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ydbio.2015.09.023_bib17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1242\/dev.040550","article-title":"Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation","volume":"137","author":"Fu","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.09.023_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00429-003-0371-0","article-title":"Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study","volume":"208","author":"Fu","year":"2004","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib19","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1523\/JNEUROSCI.4353-06.2007","article-title":"Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition","volume":"27","author":"Fu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib20","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0955-0674(03)00097-8","article-title":"Roles of Rho-family GTPases in cell polarisation and directional migration","volume":"15","author":"Fukata","year":"2003","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/0091270008328096","article-title":"Single-dose pharmacokinetic study of clomiphene citrate isomers in anovular patients with polycystic ovary disease","volume":"49","author":"Ghobadi","year":"2009","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/cge.12054","article-title":"Building a brain in the gut: development of the enteric nervous system","volume":"83","author":"Goldstein","year":"2013","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2015.09.023_bib24","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1523\/JNEUROSCI.4828-12.2013","article-title":"GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1","volume":"33","author":"Goto","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00609837","article-title":"In-vitro effect of phalloidin on plasma membrane preparation from rat liver","volume":"59","author":"Govindan","year":"1972","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.ydbio.2015.09.023_bib26","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.tcb.2011.08.002","article-title":"Rho protein crosstalk: another social network?","volume":"21","author":"Guilluy","year":"2011","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib27","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jpedsurg.2014.04.011","article-title":"Effects of RET and NRG1 polymorphisms in Indonesian patients with Hirschsprung disease","volume":"49","author":"Gunadi","year":"2014","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib28","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST0330891","article-title":"Rho GTPases and the control of cell behaviour","volume":"33","author":"Hall","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ydbio.2015.09.023_bib29","series-title":"Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children","first-page":"271","article-title":"Hirschsprung disease","author":"Heuckeroth","year":"2013"},{"key":"10.1016\/j.ydbio.2015.09.023_bib30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/dbio.1998.8955","article-title":"Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro","volume":"200","author":"Heuckeroth","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/030006058801600106","article-title":"The pharmacokinetics of loratadine in normal geriatric volunteers","volume":"16","author":"Hilbert","year":"1988","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.ydbio.2015.09.023_bib32","first-page":"1","article-title":"Stuhltr\u00e4gheit neugeborener in folge von dilatation und hypertrophie des colons","volume":"27","author":"Hirschsprung","year":"1888","journal-title":"Jahrb. Kinderheilkd. Phys. Erzieh."},{"key":"10.1016\/j.ydbio.2015.09.023_bib33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/dbio.2000.9886","article-title":"Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model","volume":"227","author":"Kapur","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/dev.116.1.167","article-title":"A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice","volume":"116","author":"Kapur","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.09.023_bib35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000101527","article-title":"Rho GTPases and their regulators in neuronal functions and development","volume":"15","author":"Koh","year":"2006","journal-title":"Neurosignals"},{"key":"10.1016\/j.ydbio.2015.09.023_bib36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/dvdy.21033","article-title":"Genetic screen for mutations affecting development and function of the enteric nervous system","volume":"236","author":"Kuhlman","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.09.023_bib37","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00452.2012","article-title":"Enteric nervous system development: migration, differentiation, and disease","volume":"305","author":"Lake","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib38","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1172\/JCI69781","article-title":"Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis","volume":"123","author":"Lake","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.ydbio.2015.09.023_bib39","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0092-8674(95)90126-4","article-title":"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration","volume":"83","author":"Langenbach","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.09.023_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.autneu.2009.09.001","article-title":"Enteric nervous system development: Recent progress and future challenges","volume":"151","author":"Laranjeira","year":"2009","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib41","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0896-6273(02)00621-9","article-title":"Regulation of rho GTPases by crosstalk and neuronal activity in vivo","volume":"33","author":"Li","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2015.09.023_bib42","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","article-title":"Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease","volume":"20","author":"Lim","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib43","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1530-0277.2011.01468.x","article-title":"Ethanol alters BDNF-induced Rho GTPase activation in axonal growth cones","volume":"35","author":"Lindsley","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ydbio.2015.09.023_bib44","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1073\/pnas.0337540100","article-title":"Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb","volume":"100","author":"McCallion","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.09.023_bib45","first-page":"113","article-title":"Hirschsprung disease: a developmental disorder of the enteric nervous system. Wiley interdisciplinary reviews","volume":"2","author":"McKeown","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-12-391857-4.00009-4","article-title":"Methods for cell and particle tracking","volume":"504","author":"Meijering","year":"2012","journal-title":"Methods Enzym."},{"key":"10.1016\/j.ydbio.2015.09.023_bib47","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.jpedsurg.2008.01.072","article-title":"Long-term clinical outcome in patients with total colonic aganglionosis: a 31-year review","volume":"43","author":"Menezes","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib48","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90125-6","article-title":"Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse","volume":"83","author":"Morham","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.09.023_bib49","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/sj.npp.1300668","article-title":"Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models","volume":"30","author":"Morihara","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ydbio.2015.09.023_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ymeth.2005.09.019","article-title":"Small molecule screening in the zebrafish","volume":"39","author":"Murphey","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.ydbio.2015.09.023_bib51","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/dvdy.23767","article-title":"Immunophenotypic characterization of enteric neural crest cells in the developing avian colorectum","volume":"241","author":"Nagy","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.09.023_bib52","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.devcel.2007.11.021","article-title":"Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation","volume":"14","author":"Nakayama","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2015.09.023_bib53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ab.2009.11.011","article-title":"Accurate and reproducible measurements of RhoA activation in small samples of primary cells","volume":"398","author":"Nini","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ydbio.2015.09.023_bib54","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.119.4.1005","article-title":"Expression of the c-ret proto-oncogene during mouse embryogenesis","volume":"119","author":"Pachnis","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.09.023_bib55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1478-811X-8-23","article-title":"Rac and Rho GTPases in cancer cell motility control","volume":"8","author":"Parri","year":"2010","journal-title":"Cell. Commun. Signal"},{"key":"10.1016\/j.ydbio.2015.09.023_bib56","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0092-8674(93)80057-L","article-title":"Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products","volume":"74","author":"Peppelenbosch","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2015.09.023_bib57","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/jhg.2012.18","article-title":"Association of genetic polymorphisms in the RET-protooncogene and NRG1 with Hirschsprung disease in Thai patients","volume":"57","author":"Phusantisampan","year":"2012","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2015.09.023_bib58","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2015.09.023_bib59","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/archsurg.1992.01420080068011","article-title":"Hirschsprung's disease. Evaluation of mortality and long-term function in 260 cases","volume":"127","author":"Rescorla","year":"1992","journal-title":"Arch. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib60","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","article-title":"Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking","volume":"16","author":"Ridley","year":"2006","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib61","series-title":"Handbook of Basic Pharmacokinetics. Including Clinical Applications","author":"Ritschel","year":"2009"},{"key":"10.1016\/j.ydbio.2015.09.023_bib62","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ydbio.2012.01.012","article-title":"The enteric nervous system","volume":"366","author":"Sasselli","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ydbio.2008.05.524","article-title":"Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro","volume":"320","author":"Sato","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib64","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2015.09.023_bib65","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret","volume":"367","author":"Schuchardt","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.09.023_bib66","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0011-3840(96)80009-8","article-title":"Hirschsprung\u2019s disease","volume":"33","author":"Skinner","year":"1996","journal-title":"Curr. Probl. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib67","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.devcel.2008.01.015","article-title":"Dialogue between RhoA\/ROCK and members of the Par complex in cell polarity","volume":"14","author":"Sordella","year":"2008","journal-title":"Dev. Cell."},{"key":"10.1016\/j.ydbio.2015.09.023_bib68","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ydbio.2007.04.024","article-title":"Effects of pharmacological inhibition of small GTPases on axon extension and migration of enteric neural crest-derived cells","volume":"307","author":"Stewart","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib69","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpedsurg.2004.09.052","article-title":"Hirschsprung\u2019s disease in Japan: analysis of 3852 patients based on a nationwide survey in 30 years","volume":"40","author":"Suita","year":"2005","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2015.09.023_bib70","first-page":"212","article-title":"Resection of rectum and rectosigmoid with preservation of the sphincter for benign spastic lesions producing megacolon; an experimental study","volume":"24","author":"Swenson","year":"1948","journal-title":"Surgery"},{"key":"10.1016\/j.ydbio.2015.09.023_bib71","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","article-title":"Cyclooxygenase-independent actions of cyclooxygenase inhibitors","volume":"15","author":"Tegeder","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.ydbio.2015.09.023_bib72","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/pds.3495","article-title":"Medications in the first trimester of pregnancy: most common exposures and critical gaps in understanding fetal risk","volume":"22","author":"Thorpe","year":"2013","journal-title":"Pharmacoepidemiol. Drug. Saf."},{"key":"10.1016\/j.ydbio.2015.09.023_bib73","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat. New. Biol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib74","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1523\/JNEUROSCI.0870-07.2007","article-title":"Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity","volume":"27","author":"Vohra","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/dvdy.21028","article-title":"Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis","volume":"236","author":"Vohra","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.09.023_bib76","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.3748\/wjg.v17.i45.4937","article-title":"Genetic interactions and modifier genes in Hirschsprung\u2019s disease","volume":"17","author":"Wallace","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ydbio.2015.09.023_bib77","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1523\/JNEUROSCI.3861-09.2010","article-title":"The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function","volume":"30","author":"Wang","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2015.09.023_bib78","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1090772","article-title":"Regulation of cell polarity and protrusion formation by targeting RhoA for degradation","volume":"302","author":"Wang","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.09.023_bib79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/neu.2007.0464","article-title":"Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth","volume":"26","author":"Wang","year":"2009","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ydbio.2015.09.023_bib80","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1053\/j.gastro.2011.06.002","article-title":"Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo","volume":"141","author":"Wang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2015.09.023_bib81","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08241","article-title":"A genetically encoded photoactivatable Rac controls the motility of living cells","volume":"461","author":"Wu","year":"2009","journal-title":"Nature"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615300877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615300877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T16:06:02Z","timestamp":1638633962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615300877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0012160615300877"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.09.023","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726111773.793513997","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}