{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:10:55Z","timestamp":1790395855322,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Center for Cancer Research of the Intramural Research Program"},{"name":"National Institutes of Health through the National Cancer Institute"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ydbio.2015.12.016","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T23:02:02Z","timestamp":1453935722000},"page":"266-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["BMPs are direct triggers of interdigital programmed cell death"],"prefix":"10.1016","volume":"411","author":[{"given":"Maria M.","family":"Kaltcheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Harfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lewandoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.12.016_bib1","doi-asserted-by":"crossref","first-page":"e62479","DOI":"10.1371\/journal.pone.0062479","article-title":"TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud","volume":"8","author":"Anderson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.12.016_bib2","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1371\/journal.pgen.0020216","article-title":"Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis","volume":"2","author":"Bandyopadhyay","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.12.016_bib3","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.devcel.2012.04.018","article-title":"FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man","volume":"22","author":"Barak","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2015.12.016_bib4","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/dvg.22412","article-title":"Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds","volume":"51","author":"Benazet","year":"2013","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.12.016_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4614-3209-8_2","article-title":"Programmed cell death during retinal development of the mouse eye","volume":"801","author":"Braunger","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib6","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1242\/dev.01390","article-title":"A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos","volume":"131","author":"Brugger","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib7","doi-asserted-by":"crossref","first-page":"e1000050","DOI":"10.1371\/journal.pgen.1000050","article-title":"Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements","volume":"4","author":"Chang","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.12.016_bib8","doi-asserted-by":"crossref","first-page":"e37826","DOI":"10.1371\/journal.pone.0037826","article-title":"Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth","volume":"7","author":"Choi","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ydbio.2015.12.016_bib9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.genet.42.110807.091533","article-title":"Genetic control of programmed cell death during animal development","volume":"43","author":"Conradt","year":"2009","journal-title":"Ann. Rev. Genet."},{"key":"10.1016\/j.ydbio.2015.12.016_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1242\/dev.126.3.535","article-title":"BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo","volume":"126","author":"Coucouvanis","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.289.5478.438","article-title":"Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling","volume":"289","author":"Dahn","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.12.016_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/j.1460-2075.1989.tb03394.x","article-title":"Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes","volume":"8","author":"de The","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2015.12.016_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/dbio.1998.9176","article-title":"Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods","volume":"208","author":"Dupe","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jmor.1051620203","article-title":"A comparative study of the differentiation and involution of the Mullerian duct and Wolffian duct in the male and female fetal mouse","volume":"162","author":"Dyche","year":"1979","journal-title":"J. Morphol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ydbio.2006.09.002","article-title":"The CNTF\/LIF signaling pathway regulates developmental programmed cell death and differentiation of rod precursor cells in the mouse retina in vivo","volume":"300","author":"Elliott","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1242\/dev.120279","article-title":"Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism","volume":"142","author":"Eshkar-Oren","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib17","first-page":"425","article-title":"Role of the retinoic acid receptor beta (RARbeta) during mouse development","volume":"41","author":"Ghyselinck","year":"1997","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib18","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1242\/dev.127.10.2113","article-title":"Fate and function of the ventral ectodermal ridge during mouse tail development","volume":"127","author":"Goldman","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib19","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/372684a0","article-title":"The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest","volume":"372","author":"Graham","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.12.016_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/dvg.20366","article-title":"A Cre transgene active in developing endodermal organs, heart, limb, and extra-ocular muscle","volume":"46","author":"Grieshammer","year":"2008","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.12.016_bib21","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1242\/dev.01944","article-title":"FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons","volume":"132","author":"Grieshammer","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/dbio.2002.0752","article-title":"In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb","volume":"249","author":"Guha","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib23","doi-asserted-by":"crossref","first-page":"150845","DOI":"10.1155\/2014\/150845","article-title":"Apoptosis and molecular targeting therapy in cancer","volume":"2014","author":"Hassan","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ydbio.2015.12.016_bib24","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1242\/dev.041954","article-title":"Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid","volume":"136","author":"Hernandez-Martinez","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1440-169X.2010.01246.x","article-title":"Interdigital cell death function and regulation: new insights on an old programmed cell death model","volume":"53","author":"Hernandez-Martinez","year":"2011","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.ydbio.2015.12.016_bib26","doi-asserted-by":"crossref","first-page":"e0123325","DOI":"10.1371\/journal.pone.0123325","article-title":"Tamoxifen-dependent, inducible Bmp2CreER drives selective recombinase activity in early interdigital mesenchyme and digit collateral ligaments","volume":"10","author":"Huang","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.ydbio.2015.12.016_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.125.2.161","article-title":"The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot","volume":"125","author":"Jernvall","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib28","doi-asserted-by":"crossref","unstructured":"Joyner, A., Wall, N., 2008. Immunohistochemistry of whole-mount mouse embryos. CSH Protoc 2008, pdb prot4820.","DOI":"10.1101\/pdb.prot4820"},{"key":"10.1016\/j.ydbio.2015.12.016_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1242\/dev.124.2.313","article-title":"Genetic evidence that the retinoid signal is transduced by heterodimeric RXR\/RAR functional units during mouse development","volume":"124","author":"Kastner","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1387\/ijdb.150065jh","article-title":"Interdigital tissue regression in the developing limb of vertebrates","volume":"59","author":"Lorda-Diez","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib31","first-page":"367","article-title":"Apoptosis of the cerebellar neurons","volume":"23","author":"Lossi","year":"2008","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1242\/dev.02172","article-title":"Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function","volume":"133","author":"Lu","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib33","first-page":"555","article-title":"Interdigital soft tissue separation induced by retinoic acid in mouse limbs cultured in vitro","volume":"37","author":"Lussier","year":"1993","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/gene.20132","article-title":"Generation of a Bmp2 conditional null allele","volume":"42","author":"Ma","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.12.016_bib35","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ydbio.2009.01.004","article-title":"In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth","volume":"327","author":"Maatouk","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00187925","article-title":"In vivo inhibition of programmed cell death by local administration of FGF-2 and FGF-4 in the interdigital areas of the embryonic chick leg bud","volume":"193","author":"Macias","year":"1996","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib37","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1242\/dev.124.6.1109","article-title":"Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development","volume":"124","author":"Macias","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib38","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1242\/dev.126.23.5515","article-title":"The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb","volume":"126","author":"Merino","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib39","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1242\/dev.01251","article-title":"Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis","volume":"131","author":"Michos","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/gene.10038","article-title":"Generation of Bmpr\/Alk3 conditional knockout mice","volume":"32","author":"Mishina","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.12.016_bib41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10495-009-0444-5","article-title":"Sculpturing digit shape by cell death","volume":"15","author":"Montero","year":"2010","journal-title":"Apoptosis: Int. J. Program. Cell Death"},{"key":"10.1016\/j.ydbio.2015.12.016_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00441-011-1201-y","article-title":"Non-Smad signaling pathways","volume":"347","author":"Mu","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2015.12.016_bib43","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2015.12.016_bib44","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.1007417108","article-title":". FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis","volume":"108","author":"Naiche","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.12.016_bib45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/dbio.2000.9612","article-title":"Influence of FGF4 on digit morphogenesis during limb development in the mouse","volume":"219","author":"Ngo-Muller","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib46","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1242\/dev.001677","article-title":"BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling","volume":"134","author":"Pajni-Underwood","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib47","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2015.12.016_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1440-169X.2007.00946.x","article-title":"Bone morphogenetic protein signaling in limb outgrowth and patterning","volume":"49","author":"Robert","year":"2007","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.ydbio.2015.12.016_bib49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/10098","article-title":"Retinoic acid regulates programmed cell death through BMP signalling","volume":"1","author":"Rodriguez-Leon","year":"1999","journal-title":"Nature Cell Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib50","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/excr.1997.3828","article-title":"Reactive oxygen species participate in the control of mouse embryonic cell death","volume":"238","author":"Salas-Vidal","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2015.12.016_bib51","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/dvdy.1108","article-title":"Differential tissue growth and patterns of cell death in mouse limb autopod morphogenesis","volume":"220","author":"Salas-Vidal","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.12.016_bib52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2005.12.023","article-title":"Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death","volume":"291","author":"Schnabel","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nature Gen."},{"key":"10.1016\/j.ydbio.2015.12.016_bib54","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1242\/dev.00846","article-title":"Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]","volume":"130","author":"Suzuki","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib55","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/dgd.12022","article-title":"How is digit identity determined during limb development?","volume":"55","author":"Suzuki","year":"2013","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.ydbio.2015.12.016_bib56","doi-asserted-by":"crossref","first-page":"11272","DOI":"10.1073\/pnas.0504783102","article-title":"Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease","volume":"102","author":"Takeuchi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.12.016_bib57","first-page":"657","article-title":"Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications","volume":"22","author":"Teixeira","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ydbio.2015.12.016_bib58","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.arr.2015.04.002","article-title":"Programmed cell death in aging","volume":"23","author":"Tower","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ydbio.2015.12.016_bib59","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00277-005-1065-x","article-title":"Apoptosis: mechanisms and relevance in cancer","volume":"84","author":"Vermeulen","year":"2005","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib60","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ydbio.2004.01.016","article-title":"Function of BMPs in the apical ectoderm of the developing mouse limb","volume":"269","author":"Wang","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib61","doi-asserted-by":"crossref","first-page":"15103","DOI":"10.1073\/pnas.0604934103","article-title":"Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification","volume":"103","author":"Weatherbee","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.12.016_bib62","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ajmg.10775","article-title":"FGFs, their receptors, and human limb malformations: clinical and molecular correlations","volume":"112","author":"Wilkie","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2015.12.016_bib63","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ydbio.2011.12.037","article-title":"Smad1\/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death","volume":"363","author":"Wong","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib64","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1242\/dev.122.12.3725","article-title":"BMP-2\/-4 mediate programmed cell death in chicken limb buds","volume":"122","author":"Yokouchi","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.016_bib65","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/cne.902290307","article-title":"Cell death during differentiation of the retina in the mouse","volume":"229","author":"Young","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1387\/ijdb.150220zz","article-title":"What cell death does in development","volume":"59","author":"Zakeri","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib67","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/dvdy.22188","article-title":"Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction","volume":"239","author":"Zhao","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2015.12.016_bib68","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cub.2009.04.059","article-title":"Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning","volume":"19","author":"Zhao","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib69","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1126\/science.272.5262.738","article-title":"Requirement for BMP signaling in interdigital apoptosis and scale formation","volume":"272","author":"Zou","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.12.016_bib70","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1387\/ijdb.082648vz","article-title":"Generation and functional characterization of mice with a conditional BMP7 allele","volume":"53","author":"Zouvelou","year":"2009","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib71","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1097-0320(19981101)33:3<348::AID-CYTO9>3.0.CO;2-C","article-title":"Confocal laser scanning microscopy of apoptosis in organogenesis-stage mouse embryos","volume":"33","author":"Zucker","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.ydbio.2015.12.016_bib72","first-page":"871","article-title":"Programmed cell death in the developing limb","volume":"46","author":"Zuzarte-Luis","year":"2002","journal-title":"In. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib73","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.semcdb.2004.12.004","article-title":"Programmed cell death in the embryonic vertebrate limb","volume":"16","author":"Zuzarte-Luis","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.016_bib74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ydbio.2004.04.015","article-title":"A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways","volume":"272","author":"Zuzarte-Luis","year":"2004","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615302037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615302037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:35:59Z","timestamp":1718325359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615302037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0012160615302037"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.12.016","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BMPs are direct triggers of interdigital programmed cell death","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}