{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:50:16Z","timestamp":1770292216861,"version":"3.49.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NSF DEB","award":["9707665"],"award-info":[{"award-number":["9707665"]}]},{"name":"NSF DEB","award":["1257053"],"award-info":[{"award-number":["1257053"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 GM70026"],"award-info":[{"award-number":["R01 GM70026"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008522","name":"University of Illinois at Chicago","doi-asserted-by":"crossref","award":["LYNCH 2013"],"award-info":[{"award-number":["LYNCH 2013"]}],"id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ydbio.2015.12.022","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T04:15:58Z","timestamp":1450844158000},"page":"391-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dissection of the complex genetic basis of craniofacial anomalies using haploid genetics and interspecies hybrids in Nasonia wasps"],"prefix":"10.1016","volume":"415","author":[{"given":"John H.","family":"Werren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Gadau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Ponce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Baudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy A.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2015.12.022_bib1","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1242\/dev.126.23.5453","article-title":"The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis","volume":"126","author":"Agnes","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib2","doi-asserted-by":"crossref","first-page":"14217","DOI":"10.1073\/pnas.1008623107","article-title":"Live imaging of Drosophila imaginal disc development","volume":"107","author":"Aldaz","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.12.022_bib3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1101\/gr.115402.110","article-title":"Multiplexed shotgun genotyping for rapid and efficient genetic mapping","volume":"21","author":"Andolfatto","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.ydbio.2015.12.022_bib4","series-title":"The Cuvier-Geoffroy Debate: French Biology in the Decades before Darwin","author":"Appel","year":"1987"},{"key":"10.1016\/j.ydbio.2015.12.022_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/ede.12027","article-title":"Genetic and developmental analysis of differences in eye and face morphology between Drosophila simulans and Drosophila mauritiana","volume":"15","author":"Arif","year":"2013","journal-title":"Evol. Dev."},{"key":"10.1016\/j.ydbio.2015.12.022_bib6","doi-asserted-by":"crossref","first-page":"1241006","DOI":"10.1126\/science.1241006","article-title":"Fine tuning of craniofacial morphology by distant-acting enhancers","volume":"342","author":"Attanasio","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.12.022_bib7","doi-asserted-by":"crossref","first-page":"R860","DOI":"10.1016\/j.cub.2003.10.042","article-title":"Nasonia","volume":"13","author":"Beukeboom","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1558-5646.1995.tb02307.x","article-title":"Hybrid breakdown between two haplodiploid species-the role of nuclear and cytoplasmic genes","volume":"49","author":"Breeuwer","year":"1995","journal-title":"Evolution"},{"key":"10.1016\/j.ydbio.2015.12.022_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ydbio.2013.05.026","article-title":"Patterning the dorsal-ventral axis of the wasp Nasonia vitripennis","volume":"381","author":"Buchta","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s00427-005-0488-7","article-title":"Expression of defective proventriculus during head capsule development is conserved in Drosophila and stalk-eyed flies (Diopsidae)","volume":"215","author":"Carr","year":"2005","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/jmg.19.5.329","article-title":"A family study of isolated cleft palate","volume":"19","author":"Carter","year":"1982","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s001220050471","article-title":"Epistat: A computer program for identifying and testing interactions between pairs of quantitative trait loci","volume":"94","author":"Chase","year":"1997","journal-title":"Theor. Appl. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib13","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","article-title":"Empirical threshold values for quantitative trait mapping","volume":"138","author":"Churchill","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.12.022_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0169-5347(97)01029-X","article-title":"The genetic and molecular basis of developmental stability: the Lucilia story","volume":"12","author":"Clarke","year":"1997","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/aesa\/83.3.352","article-title":"Biosystematics of Nasonia (Hymenoptera, Pteromalidae)-2 New Species Reared from Birds Nests in North-America","volume":"83","author":"Darling","year":"1990","journal-title":"Ann. Entomol. Soc. Am."},{"key":"10.1016\/j.ydbio.2015.12.022_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1534\/g3.112.004739","article-title":"Fine-scale mapping Nasonia genome chromosomes using a high-density genotyping microarray","volume":"3","author":"Desjardins","year":"2013","journal-title":"G3"},{"key":"10.1016\/j.ydbio.2015.12.022_bib17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/hdy.2009.145","article-title":"The genetic basis of interspecies host preference differences in the model parasitoid Nasonia","volume":"104","author":"Desjardins","year":"2010","journal-title":"Heredity"},{"key":"10.1016\/j.ydbio.2015.12.022_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib19","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/j.1420-9101.2006.01175.x","article-title":"Fluctuating asymmetry and developmental instability in evolutionary biology: past, present and future","volume":"19","author":"Dongen","year":"2006","journal-title":"J. Evol. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib20","first-page":"223","article-title":"Differences in mating behaviour and sex ratio between three sibling species of Nasonia","volume":"1","author":"Drapeau","year":"1999","journal-title":"Evol. Ecol. Res."},{"key":"10.1016\/j.ydbio.2015.12.022_bib21","article-title":"TWIST mutations disrupting the b-HLH domain are specific to Saethre-Chotzen syndrome","volume":"61","author":"El Ghouzzi","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib22","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/hmg\/ddt664","article-title":"An etiologic regulatory mutation in IRF6 with loss- and gain-of-function effects","volume":"23","author":"Fakhouri","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1242\/dev.112.4.899","article-title":"The molecular-genetics of head development in Drosophila-Melanogaster","volume":"112","author":"Finkelstein","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib24","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/genetics\/153.4.1731","article-title":"Mapping of hybrid incompatibility loci in Nasonia","volume":"153","author":"Gadau","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.12.022_bib25","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/genetics\/161.2.673","article-title":"The genetic basis of the interspecific differences in wing size in Nasonia (Hymenoptera; Pteromalidae): Major quantitative trait loci and epistasis","volume":"161","author":"Gadau","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.12.022_bib26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/bies.1098","article-title":"Drosophila peripodial cells, more than meets the eye?","volume":"23","author":"Gibson","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.ydbio.2015.12.022_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/bdrc.20180","article-title":"Palate morphogenesis: current understanding and future directions","volume":"90","author":"Greene","year":"2010","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.ydbio.2015.12.022_bib28","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1534\/genetics.114.161661","article-title":"Complex craniofacial changes in blind cave-dwelling fish are mediated by genetically symmetric and asymmetric loci","volume":"196","author":"Gross","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.12.022_bib29","doi-asserted-by":"crossref","first-page":"e1004724","DOI":"10.1371\/journal.pgen.1004724","article-title":"Let\u2019s face it \u2013 complex traits are just not that simple","volume":"10","author":"Hallgrimsson","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib30","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1242\/dev.129.18.4347","article-title":"Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice","volume":"129","author":"Hide","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib31","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/hdy.2014.66","article-title":"Introgression study reveals two quantitative trait loci involved in interspecific variation in memory retention among Nasonia wasp species","volume":"113","author":"Hoedjes","year":"2014","journal-title":"Heredity"},{"key":"10.1016\/j.ydbio.2015.12.022_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng0197-36","article-title":"Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome","volume":"15","author":"Howard","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrg2829","article-title":"Evolution and development of shape: integrating quantitative approaches","volume":"11","author":"Klingenberg","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib34","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/j.0014-3820.2002.tb00117.x","article-title":"Shape analysis of symmetric structures: quantifying variation among individuals and asymmetry","volume":"56","author":"Klingenberg","year":"2002","journal-title":"Evolution"},{"key":"10.1016\/j.ydbio.2015.12.022_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng985","article-title":"Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes","volume":"32","author":"Kondo","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib36","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1073\/pnas.92.10.4656","article-title":"Interactions between quantitative trait loci in soybean in which trait variation at one locus is conditional upon a specific allele at another","volume":"92","author":"Lark","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.12.022_bib37","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1242\/dev.02807","article-title":"The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development","volume":"134","author":"Lee","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib38","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/gim.2012.141","article-title":"Comparative analysis of IRF6 variants in families with Van der Woude syndrome and popliteal pterygium syndrome using public whole-exome databases","volume":"15","author":"Leslie","year":"2013","journal-title":"Genet. Med."},{"key":"10.1016\/j.ydbio.2015.12.022_bib39","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ajhg.2015.01.004","article-title":"Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci","volume":"96","author":"Leslie","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/01.mop.0000185138.65820.7f","article-title":"Progress toward discerning the genetics of cleft lip","volume":"17","author":"Lidral","year":"2005","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.ydbio.2015.12.022_bib41","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/hdy.2009.146","article-title":"Evolution of sex-specific wing shape at the widerwing locus in four species of Nasonia","volume":"104","author":"Loehlin","year":"2010","journal-title":"Heredity"},{"key":"10.1016\/j.ydbio.2015.12.022_bib42","doi-asserted-by":"crossref","first-page":"e1000821","DOI":"10.1371\/journal.pgen.1000821","article-title":"Non-coding changes cause sex-specific wing size differences between closely related species of Nasonia","volume":"6","author":"Loehlin","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib43","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.1215193","article-title":"Evolution of shape by multiple regulatory changes to a growth gene","volume":"335","author":"Loehlin","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2015.12.022_bib44","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/0022034514523987","article-title":"Strong association of variants around FOXE1 and orofacial clefting","volume":"93","author":"Ludwig","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ydbio.2015.12.022_bib45","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1534\/genetics.112.147512","article-title":"The expanding genetic toolbox of the wasp Nasonia vitripennis and its relatives","volume":"199","author":"Lynch","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.12.022_bib46","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nprot.2006.70","article-title":"A method for parental RNA interference in the wasp Nasonia vitripennis","volume":"1","author":"Lynch","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ydbio.2015.12.022_bib47","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1242\/dev.054213","article-title":"Novel modes of localization and function of nanos in the wasp Nasonia","volume":"137","author":"Lynch","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib48","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1073\/pnas.97.14.7888","article-title":"JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila","volume":"97","author":"Martin-Blanco","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2015.12.022_bib49","series-title":"Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders","author":"McKusick","year":"1994"},{"key":"10.1016\/j.ydbio.2015.12.022_bib50","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/ajmg.a.33703","article-title":"Genetic basis of potential therapeutic strategies for craniosynostosis","volume":"152A","author":"Melville","year":"2010","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ydbio.2015.12.022_bib51","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/ede.12125","article-title":"The significance and scope of evolutionary developmental biology: a vision for the 21st century","volume":"17","author":"Moczek","year":"2015","journal-title":"Evol. Dev."},{"key":"10.1016\/j.ydbio.2015.12.022_bib52","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s000360050009","article-title":"Developmental instability is heritable \u2013 reply","volume":"10","author":"Moller","year":"1997","journal-title":"J. Evol. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib53","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/molbev\/msp167","article-title":"Dynamic evolution of immune system regulators: the history of the interferon regulatory factor family","volume":"26","author":"Nehyba","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib54","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature11838","article-title":"Behavioural and genetic analyses of Nasonia shed light on the evolution of sex pheromones","volume":"494","author":"Niehuis","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2015.12.022_bib55","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/j.cub.2014.08.035","article-title":"Dorsoventral polarity of the Nasonia embryo primarily relies on a BMP gradient formed without input from Toll","volume":"24","author":"Ozuak","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.es.17.110186.002135","article-title":"Fluctuating asymmetry-measurement, analysis, patterns","volume":"17","author":"Palmer","year":"1986","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"10.1016\/j.ydbio.2015.12.022_bib57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s000360050005","article-title":"Fluctuating asymmetry and developmental stability: heritability of observable variation vs. heritability of inferred cause","volume":"10","author":"Palmer","year":"1997","journal-title":"J. Evol. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ajhg.2013.11.009","article-title":"Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development","volume":"94","author":"Peyrard-Janvid","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib59","doi-asserted-by":"crossref","first-page":"e37346","DOI":"10.1371\/journal.pone.0037346","article-title":"Evolution of eye morphology and rhodopsin expression in the Drosophila melanogaster species subgroup","volume":"7","author":"Posnien","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.12.022_bib60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1469-1809.2001.6560505.x","article-title":"Nonsyndromic cleft lip and palate: complex genetics and environmental effects","volume":"65","author":"Prescott","year":"2001","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib61","doi-asserted-by":"crossref","first-page":"e01440","DOI":"10.7554\/eLife.01440","article-title":"Dual mode of embryonic development is highlighted by expression and function of Nasonia pair-rule genes","volume":"3","author":"Rosenberg","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2015.12.022_bib62","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1242\/dev.124.23.4793","article-title":"Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog","volume":"124","author":"Royet","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib63","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ng.2531","article-title":"Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis","volume":"45","author":"Sharma","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1399-0004.1981.tb01800.x","article-title":"Cleft palate: a genetic and epidemiologic investigation","volume":"20","author":"Shields","year":"1981","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib65","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1242\/dev.129.8.1839","article-title":"A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila","volume":"129","author":"Shyamala","year":"2002","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ydbio.2015.12.022_bib66","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1093\/hmg\/ddh052","article-title":"Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts","volume":"113","author":"Stanier","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib67","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ydbio.2006.05.034","article-title":"Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head","volume":"296","author":"Stultz","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib68","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ydbio.2012.07.012","article-title":"Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila","volume":"369","author":"Stultz","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib69","unstructured":"Team, R.C., 2014. R: A language and environment for statistical computing. Vienna, Austria."},{"key":"10.1016\/j.ydbio.2015.12.022_bib70","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1093\/hmg\/ddv228","article-title":"New insights into craniofacial malformations","volume":"24","author":"Twigg","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib71","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1558-5646.2007.00096.x","article-title":"What do we know about the heritability of developmental instability? Answers from a Bayesian model","volume":"61","author":"Van Dongen","year":"2007","journal-title":"Evolution"},{"key":"10.1016\/j.ydbio.2015.12.022_bib72","unstructured":"van Ooijen, J.W., Boer, M.P., Jansen, R.C., Maliepaard, C., 2000. MapQTL 4.0: Software for the calculation of QTL positions on genetic maps."},{"key":"10.1016\/j.ydbio.2015.12.022_bib73","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1242\/dev.085423","article-title":"Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila","volume":"140","author":"Weasner","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib74","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.ento.42.1.587","article-title":"Biology of Wolbachia","volume":"42","author":"Werren","year":"1997","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ydbio.2015.12.022_bib75","first-page":"1","article-title":"The parasitoid wasp Nasonia: an emerging model system with haploid male genetics","volume":"4","author":"Werren","year":"2009","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.ydbio.2015.12.022_bib76","first-page":"343","article-title":"Functional and evolutionary insights from the genomes of three parasitoid Nasonia species","volume":"327","author":"Werren","year":"2010"},{"key":"10.1016\/j.ydbio.2015.12.022_bib77","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/hmg\/6.10.1647","article-title":"Craniosynostosis: genes and mechanisms","volume":"6","author":"Wilkie","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib78","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35076601","article-title":"Genetics of craniofacial development and malformation","volume":"2","author":"Wilkie","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib79","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1534\/genetics.104.038885","article-title":"Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice","volume":"171","author":"Wolf","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2015.12.022_bib80","doi-asserted-by":"crossref","first-page":"e1005059","DOI":"10.1371\/journal.pgen.1005059","article-title":"Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate","volume":"11","author":"Wolf","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib81","doi-asserted-by":"crossref","first-page":"e1004257","DOI":"10.1371\/journal.pgen.1004257","article-title":"A LINE-1 insertion in DLX6 is responsible for cleft palate and mandibular abnormalities in a canine model of Pierre Robin sequence","volume":"10","author":"Wolf","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2015.12.022_bib82","doi-asserted-by":"crossref","first-page":"e0121999","DOI":"10.1371\/journal.pone.0121999","article-title":"Cell type-specific responses to wingless, hedgehog and decapentaplegic are essential for patterning early eye-antenna disc in Drosophila","volume":"10","author":"Won","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2015.12.022_bib83","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1597\/1545-1569(1996)033<0406:GONOCR>2.3.CO;2","article-title":"Genetics of nonsyndromic oral clefts revisited","volume":"33","author":"Wyszynski","year":"1996","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.ydbio.2015.12.022_bib84","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/10454411000110030201","article-title":"Genetic and teratogenic approaches to craniofacial development","volume":"11","author":"Young","year":"2000","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.ydbio.2015.12.022_bib85","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1242\/dev.126.17.3947","article-title":"Thorax closure in Drosophila: involvement of Fos and the JNK pathway","volume":"126","author":"Zeitlinger","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2015.12.022_bib86","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1242\/dev.129.17.4135","article-title":"Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis","volume":"129","author":"Zhang","year":"2002","journal-title":"Development"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615303705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615303705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T13:25:32Z","timestamp":1653917132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615303705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0012160615303705"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.12.022","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissection of the complex genetic basis of craniofacial anomalies using haploid genetics and interspecies hybrids in Nasonia wasps","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2015.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}