{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:46:09Z","timestamp":1776260769165,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,15]],"date-time":"2017-04-15T00:00:00Z","timestamp":1492214400000},"content-version":"vor","delay-in-days":379,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"S.M.S."}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ydbio.2016.02.025","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T04:08:15Z","timestamp":1456891695000},"page":"234-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Epithelial Wnt\/\u03b2catenin signalling is essential for epididymal coiling"],"prefix":"10.1016","volume":"412","author":[{"given":"Manish","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafiq M.","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto M.","family":"Taketo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep S.","family":"Tanwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2016.02.025_bib1","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1056\/NEJMoa040533","article-title":"A WNT4 mutation associated with M\u00fcllerian-duct regression and virilization in a 46, XX woman","volume":"351","author":"Biason-Lauber","year":"2004","journal-title":"NewEngland J. Med."},{"key":"10.1016\/j.ydbio.2016.02.025_bib2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"Carroll","year":"2005","journal-title":"Dev. Cell."},{"key":"10.1016\/j.ydbio.2016.02.025_bib3","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1242\/dev.01200","article-title":"Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development","volume":"131","author":"Chi","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.02.025_bib4","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1095\/biolreprod.109.078360","article-title":"Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment","volume":"81","author":"De Gendt","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ydbio.2016.02.025_bib5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/jmor.1051620203","article-title":"A comparative study of the differentiation and involution of the M\u00fcllerian duct and Wolffian duct in the male and female mouse","volume":"162","author":"Dyche","year":"1979","journal-title":"J. Morphol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/1471-213X-10-121","article-title":"A sensitive and bright single-cell resolution live imaging reporter of Wnt\/ss-catenin signaling in the mouse","volume":"10","author":"Ferrer-Vaquer","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib7","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1210\/en.2014-1226","article-title":"Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ER\u03b1 expression, and Wnt\/\u03b2-catenin signaling in female mice","volume":"155","author":"Gao","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2016.02.025_bib8","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.1093\/emboj\/18.21.5931","article-title":"Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene","volume":"18","author":"Harada","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2016.02.025_bib9","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.celrep.2014.09.041","article-title":"Pattern formation of an epithelial tubule by mechanical instability during epididymal development","volume":"9","author":"Hirashima","year":"2014","journal-title":"Cell. Rep."},{"key":"10.1016\/j.ydbio.2016.02.025_bib10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nrg840","article-title":"Organogenesis: molecular mechanisms of tubulogenesis","volume":"3","author":"Hogan","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2016.02.025_bib11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"\u03b2-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.02.025_bib12","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ydbio.2008.10.012","article-title":"Development and morphogenesis of the Wolffian\/epididymal duct, more twists and turns","volume":"325","author":"Joseph","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib13","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1210\/en.2014-1341","article-title":"ROS1 signaling regulates epithelial differentiation in the epididymis","volume":"155","author":"Jun","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2016.02.025_bib14","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nrd4233","article-title":"Can we safely target the WNT pathway?","volume":"13","author":"Kahn","year":"2014","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ydbio.2016.02.025_bib15","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1002\/dvdy.22340","article-title":"Tankyrase Is Necessary for Canonical Wnt Signaling During Kidney Development","volume":"239","author":"Karner","year":"2010","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2016.02.025_bib16","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.242","article-title":"The Androgen Receptor Antagonizes Wnt\/\u03b2-Catenin Signaling in Epidermal Stem Cells","author":"Kretzschmar","year":"2015","journal-title":"J. Invest. Dermatol. Print."},{"key":"10.1016\/j.ydbio.2016.02.025_bib17","doi-asserted-by":"publisher","first-page":"e1002428","DOI":"10.1371\/journal.pgen.1002428","article-title":"Ror2 enhances polarity and directional migration of primordial germ cells","volume":"7","author":"Laird","year":"2011","journal-title":"Plos. Genet."},{"key":"10.1016\/j.ydbio.2016.02.025_bib18","doi-asserted-by":"publisher","first-page":"15710","DOI":"10.1073\/pnas.1218168110","article-title":"Inhibition of androgen receptor and beta-catenin activity in prostate cancer","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.02.025_bib19","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1007\/s10637-009-9311-z","article-title":"Antitumor activity of natural compounds, curcumin and PKF118\u2013310, as Wnt\/\u03b2-catenin antagonists against human osteosarcoma cells","volume":"28","author":"Leow","year":"2010","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.ydbio.2016.02.025_bib20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.stemcr.2015.01.021","article-title":"The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through beta-catenin signaling","volume":"4","author":"Lindstrom","year":"2015","journal-title":"Stem Cell. Rep."},{"key":"10.1016\/j.ydbio.2016.02.025_bib21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ydbio.2005.11.043","article-title":"Defective postnatal development of the male reproductive tract in LGR4 knockout mice","volume":"290","author":"Mendive","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib22","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1210\/me.2008-0478","article-title":"Genetic interactions of the androgen and Wnt\/beta-catenin pathways for the masculinization of external genitalia","volume":"23","author":"Miyagawa","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib23","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1210\/en.2010-1121","article-title":"Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation","volume":"152","author":"Murashima","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2016.02.025_bib24","doi-asserted-by":"crossref","first-page":"749","DOI":"10.4103\/1008-682X.155540","article-title":"Understanding normal and abnormal development of the Wolffian\/epididymal duct by using transgenic mice","volume":"17","author":"Murashima","year":"2015","journal-title":"Asian J Androl."},{"key":"10.1016\/j.ydbio.2016.02.025_bib25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ydbio.2015.01.023","article-title":"Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development","volume":"400","author":"Okazawa","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1681\/ASN.2010030316","article-title":"The GDNF target Vsnl1 marks the ureteric tip","volume":"22","author":"Ola","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib27","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.1158\/0008-5472.CAN-10-3978","article-title":"Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations","volume":"71","author":"Osada","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.ydbio.2016.02.025_bib28","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/27221","article-title":"Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a","volume":"395","author":"Parr","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.02.025_bib29","unstructured":"Robaire, B., Hinton, B.T., 2015. Knobil and Neill Physiology of Reproduction. In: Plant, T.M., Zeleznik, A.J. (Eds.)."},{"key":"10.1016\/j.ydbio.2016.02.025_bib30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ydbio.2012.08.016","article-title":"Wnt signaling though beta-catenin is required for prostate lineage specification","volume":"371","author":"Simons","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.02.025_bib32","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ydbio.2012.07.003","article-title":"Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud","volume":"369","author":"Stulberg","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/aja.1001540104","article-title":"Development of cell types and of regional differences in the postnatal rat epididymis","volume":"154","author":"Sun","year":"1979","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.ydbio.2016.02.025_bib34","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1093\/carcin\/bgs405","article-title":"PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression","volume":"34","author":"Tanwar","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ydbio.2016.02.025_bib35","doi-asserted-by":"publisher","first-page":"e1002906","DOI":"10.1371\/journal.pgen.1002906","article-title":"Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1","volume":"8","author":"Tanwar","year":"2012","journal-title":"PLOS Genet."},{"key":"10.1016\/j.ydbio.2016.02.025_bib36","doi-asserted-by":"publisher","first-page":"16142","DOI":"10.1073\/pnas.1011606107","article-title":"Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme","volume":"107","author":"Tanwar","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.02.025_bib37","doi-asserted-by":"publisher","first-page":"16142","DOI":"10.1073\/pnas.1011606107","article-title":"Focal M\u00fcllerian duct retention in male mice with constitutively activated \u03b2-catenin expression in the M\u00fcllerian duct mesenchyme","volume":"107","author":"Tanwar","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ydbio.2016.02.025_bib38","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1210\/me.2011-0057","article-title":"Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium","volume":"25","author":"Tanwar","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib39","doi-asserted-by":"publisher","first-page":"11322","DOI":"10.1073\/pnas.0703445104","article-title":"Essential roles of inhibin beta A in mouse epididymal coiling","volume":"104","author":"Tomaszewski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.02.025_bib40","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nm.1865","article-title":"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice","volume":"14","author":"Traykova-Brauch","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.ydbio.2016.02.025_bib41","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/17068","article-title":"Female development in mammals is regulated by Wnt-4 signalling","volume":"397","author":"Vainio","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.02.025_bib42","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.157396","article-title":"Comparison of gene expression of the oncogenic Wnt\/beta-catenin signaling pathway components in the mouse and human epididymis","author":"Wang","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.ydbio.2016.02.025_bib43","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ydbio.2008.11.023","article-title":"Sfrp1 and Sfrp2 are required for normal male sexual development in mice","volume":"326","author":"Warr","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.02.025_bib44","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1210\/en.2006-0149","article-title":"Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide","volume":"147","author":"Welsh","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2016.02.025_bib45","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1210\/en.2008-0529","article-title":"New insights into the role of androgens in wolffian duct stabilization in male and female rodents","volume":"150","author":"Welsh","year":"2009","journal-title":"Endocrinology"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615302554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615302554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T02:50:03Z","timestamp":1692240603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615302554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0012160615302554"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.02.025","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial Wnt\/\u03b2catenin signalling is essential for epididymal coiling","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}