{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:00:35Z","timestamp":1791327635991,"version":"4.3.1"},"reference-count":91,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":379,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ydbio.2016.03.019","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T09:27:30Z","timestamp":1458638850000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Roof plate mediated morphogenesis of the forebrain: New players join the game"],"prefix":"10.1016","volume":"413","author":[{"given":"Sandeep","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonaki","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2016.03.019_bib1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1074\/jbc.271.2.1043","article-title":"The mouse Zic gene family: homologues of the Drosophila pair-rule gene odd-paired","volume":"271","author":"Aruga","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.03.019_bib2","doi-asserted-by":"crossref","first-page":"31178","DOI":"10.1074\/jbc.270.52.31178","article-title":"A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif","volume":"270","author":"Bertolino","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.03.019_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ydbio.2007.10.041","article-title":"Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling","volume":"313","author":"Bonner","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.ne.14.030191.002151","article-title":"Genetic and molecular bases of neurogenesis in Drosophila melanogaster","volume":"14","author":"Campos-Ortega","year":"1991","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2016.03.019_bib5","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1242\/dev.076018","article-title":"Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling","volume":"139","author":"Carlin","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib6","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1523\/JNEUROSCI.0714-06.2006","article-title":"Central roles of the roof plate in telencephalic development and holoprosencephaly","volume":"26","author":"Cheng","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.03.019_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0896-6273(94)90308-5","article-title":"The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system","volume":"12","author":"Cheyette","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2016.03.019_bib8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.03.019_bib9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nrn1520","article-title":"Mechanisms of roof plate formation in the vertebrate CNS","volume":"5","author":"Chizhikov","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2016.03.019_bib10","doi-asserted-by":"crossref","first-page":"e86025","DOI":"10.1371\/journal.pone.0086025","article-title":"Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline","volume":"9","author":"Choe","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2016.03.019_bib11","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/bdra.20295","article-title":"Holoprosencephaly: clinical, anatomic, and molecular dimensions","volume":"76","author":"Cohen","year":"2006","journal-title":"Birth Defects Res. Part A: Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib12","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.semcdb.2009.05.009","article-title":"Neural crest contribution to forebrain development","volume":"20","author":"Creuzet","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib13","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1073\/pnas.0605899103","article-title":"The cephalic neural crest exerts a critical effect on forebrain and midbrain development","volume":"103","author":"Creuzet","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.03.019_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0306-4522(01)00411-0","article-title":"Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles","volume":"108","author":"Crossley","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.ydbio.2016.03.019_bib15","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1242\/dev.00834","article-title":"Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation","volume":"130","author":"Dahlqvist","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","article-title":"Mechanisms underlying differential responses to FGF signaling","volume":"16","author":"Dailey","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib17","doi-asserted-by":"crossref","first-page":"L510","DOI":"10.1152\/ajplung.00144.2002","article-title":"Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?","volume":"283","author":"Demayo","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib18","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1210\/endo.136.6.7750489","article-title":"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis","volume":"136","author":"Dewulf","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2016.03.019_bib19","doi-asserted-by":"crossref","first-page":"e44009","DOI":"10.1371\/journal.pone.0044009","article-title":"A Bmp reporter with ultrasensitive characteristics reveals that high bmp signaling is not required for cortical hem fate","volume":"7","author":"Doan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2016.03.019_bib20","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/hmg\/ddn294","article-title":"Mutations in the human SIX3 gene in holoprosencephaly are loss of function","volume":"17","author":"Domene","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1172-2-8","article-title":"Holoprosencephaly","volume":"2","author":"Dubourg","year":"2007","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.ydbio.2016.03.019_bib22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/bdra.20380","article-title":"Single median maxillary central incisor: new data and mutation review","volume":"79","author":"El-Jaick","year":"2007","journal-title":"Birth Defects Res. Part A, Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib23","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1242\/dev.004325","article-title":"Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly","volume":"134","author":"Fernandes","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1399-0004.2008.00994.x","article-title":"The ups and downs of holoprosencephaly: dorsal versus ventral patterning forces","volume":"73","author":"Fernandes","year":"2008","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000147600","article-title":"Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain","volume":"150","author":"Franz","year":"1994","journal-title":"Acta Anat."},{"key":"10.1016\/j.ydbio.2016.03.019_bib26","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1126\/science.1064252","article-title":"Neocortex patterning by the secreted signaling molecule FGF8","volume":"294","author":"Fukuchi-Shimogori","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2016.03.019_bib27","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1242\/dev.124.11.2203","article-title":"Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development","volume":"124","author":"Furuta","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1242\/dev.127.3.469","article-title":"Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1","volume":"127","author":"Galceran","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib29","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.devcel.2008.07.003","article-title":"Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly","volume":"15","author":"Geng","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.03.019_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/76074","article-title":"Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination","volume":"25","author":"Gripp","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib31","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1242\/dev.125.12.2315","article-title":"The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice","volume":"125","author":"Grove","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nn1068","article-title":"Specification of dorsal telencephalic character by sequential Wnt and FGF signaling","volume":"6","author":"Gunhaga","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2016.03.019_bib33","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1242\/dev.122390","article-title":"Retinoic acid signaling regulates development of the dorsal forebrain midline and the choroid plexus in the chick","volume":"142","author":"Gupta","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib34","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3174\/ajnr.A2123","article-title":"Septopreoptic holoprosencephaly: a mild subtype associated with midline craniofacial anomalies","volume":"31","author":"Hahn","year":"2010","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.semcdb.2014.04.036","article-title":"Dpp\/BMP signaling in flies: from molecules to biology","volume":"32","author":"Hamaratoglu","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib36","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/gene.10183","article-title":"BMP ligands act redundantly to pattern the dorsal telencephalic midline","volume":"35","author":"H\u00e9bert","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2016.03.019_bib37","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0896-6273(02)00900-5","article-title":"BMP signaling is required locally to pattern the dorsal telencephalic midline","volume":"35","author":"H\u00e9bert","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2016.03.019_bib38","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1242\/dev.021535","article-title":"Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline","volume":"135","author":"Imayoshi","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/dvdy.20642","article-title":"Expression and functional analysis of Tgif during mouse midline development","volume":"235","author":"Jin","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2016.03.019_bib40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s004410051180","article-title":"Identification of early postmitotic cells in distinct embryonic sites and their possible roles in morphogenesis","volume":"294","author":"Kahane","year":"1998","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2016.03.019_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-5793(96)00899-X","article-title":"Identification and expression of six family genes in mouse retina","volume":"393","author":"Kawakami","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2016.03.019_bib42","first-page":"43","article-title":"Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly","volume":"154C","author":"Klingensmith","year":"2010","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ydbio.2016.03.019_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1242\/dev.129.1.83","article-title":"Early subdivisions in the neural plate define distinct competence for inductive signals","volume":"129","author":"Kobayashi","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib44","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1242\/dev.125.15.2973","article-title":"Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish","volume":"125","author":"Kobayashi","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib45","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1101\/gad.1059403","article-title":"Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development","volume":"17","author":"Lagutin","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib46","first-page":"10","article-title":"RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking","author":"Lake","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib47","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/35001507","article-title":"Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification","volume":"403","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.03.019_bib48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.neuro.22.1.261","article-title":"The specification of dorsal cell fates in the vertebrate central nervous system","volume":"22","author":"Lee","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2016.03.019_bib49","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.127.3.457","article-title":"A local Wnt-3a signal is required for development of the mammalian hippocampus","volume":"127","author":"Lee","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0092-8674(01)80015-5","article-title":"A Role for the roof plate and its resident TGF\u03b2-related proteins in neuronal patterning in the dorsal spinal cord","volume":"91","author":"Liem","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.03.019_bib51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0306-4522(03)00519-0","article-title":"Role of \u03b2-catenin in the developing cortical and hippocampal neuroepithelium","volume":"122","author":"Machon","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.ydbio.2016.03.019_bib52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.1151695","article-title":"Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate","volume":"319","author":"Mangale","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2016.03.019_bib53","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1242\/dev.01308","article-title":"Retinoic acid signalling specifies intermediate character in the developing telencephalon","volume":"131","author":"Marklund","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib54","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/dvdy.20128","article-title":"Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation","volume":"231","author":"Mic","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2016.03.019_bib55","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ydbio.2004.03.008","article-title":"Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse","volume":"270","author":"Millen","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib56","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ydbio.2006.11.035","article-title":"Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone","volume":"303","author":"Molotkova","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib57","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/nen.0b013e3180986e1b","article-title":"The morphogen signaling network in forebrain development and holoprosencephaly","volume":"66","author":"Monuki","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib58","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1101\/gad.937102","article-title":"Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord","volume":"16","author":"Muroyama","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib59","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1073\/pnas.97.4.1618","article-title":"Zic2 regulates the kinetics of neurulation","volume":"97","author":"Nagai","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.03.019_bib60","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/dbio.1996.8449","article-title":"The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation","volume":"182","author":"Nagai","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib61","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ydbio.2010.01.032","article-title":"Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus","volume":"340","author":"Nielsen","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib62","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.celrep.2013.12.003","article-title":"Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling","volume":"6","author":"Niewiadomski","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2016.03.019_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(01)00616-9","article-title":"Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles","volume":"111","author":"Ohkubo","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.ydbio.2016.03.019_bib64","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ydbio.2008.04.034","article-title":"FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development","volume":"320","author":"Okada","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib65","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1242\/dev.121.12.4045","article-title":"Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development","volume":"121","author":"Oliver","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib66","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1101\/gad.894701","article-title":"Sequential actions of BMP receptors control neural precursor cell production and fate","volume":"15","author":"Panchision","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib67","doi-asserted-by":"crossref","first-page":"37732","DOI":"10.1074\/jbc.M111.242826","article-title":"Transcription factor Zic2 inhibits Wnt\/\u03b2-catenin protein signaling","volume":"286","author":"Pourebrahim","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.03.019_bib68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1749-8104-4-35","article-title":"Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain","volume":"4","author":"Quinlan","year":"2009","journal-title":"Neural Dev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib69","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ydbio.2008.01.041","article-title":"Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification","volume":"316","author":"Rajaii","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib70","doi-asserted-by":"crossref","first-page":"11595","DOI":"10.1523\/JNEUROSCI.3204-07.2007","article-title":"Patterning the dorsal telencephalon: a role for sonic hedgehog?","volume":"27","author":"Rash","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.03.019_bib71","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00401-013-1104-y","article-title":"Hand in glove: brain and skull in development and dysmorphogenesis","volume":"125","author":"Richtsmeier","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib72","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1196-357","article-title":"Mutations in the human Sonic Hedgehog gene cause holoprosencephaly","volume":"14","author":"Roessler","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib73","first-page":"389","article-title":"MR evaluation of the hippocampus in patients with congenital malformations of the brain","volume":"22","author":"Sato","year":"2001","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib74","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/hmg\/5.2.223","article-title":"Molecular characterization of breakpoints in patients with holoprosencephaly and definition of the HPE2 critical region 2p21","volume":"5","author":"Schell","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0925-4773(98)00028-8","article-title":"Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordia","volume":"73","author":"Seo","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib76","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1128\/MCB.25.9.3639-3647.2005","article-title":"Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice","volume":"25","author":"Shen","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib77","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1242\/dev.01428","article-title":"Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex","volume":"131","author":"Shimogori","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib78","doi-asserted-by":"crossref","first-page":"e1003463","DOI":"10.1371\/journal.pcbi.1003463","article-title":"A BMP\u2013FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain","volume":"10","author":"Srinivasan","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib79","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1073\/pnas.0337736100","article-title":"Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain","volume":"100","author":"Storm","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.03.019_bib80","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/35017617","article-title":"Initiation of neural induction by FGF signalling before gastrulation","volume":"406","author":"Streit","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.03.019_bib81","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1371\/journal.pgen.1002524","article-title":"Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway","volume":"8","author":"Taniguchi","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib82","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1242\/dev.126.16.3561","article-title":"Gli3 is required for Emx gene expression during dorsal telencephalon development","volume":"126","author":"Theil","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib83","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ydbio.2005.10.020","article-title":"Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum","volume":"289","author":"Tole","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib84","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/dbio.1999.9509","article-title":"Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes (J)","volume":"217","author":"Tole","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.03.019_bib85","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1101\/gad.1693608","article-title":"Hedgehog: functions and mechanisms","volume":"22","author":"Varjosalo","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.03.019_bib86","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/9718","article-title":"Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly","volume":"22","author":"Wallis","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib87","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1093\/hmg\/ddn197","article-title":"Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation","volume":"17","author":"Warr","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2016.03.019_bib88","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)80712-6","article-title":"A Smad transcriptional corepressor","volume":"97","author":"Wotton","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.03.019_bib89","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dev.127.3.621","article-title":"The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb","volume":"127","author":"Yi","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib90","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.122.10.2977","article-title":"Mice deficient for BMP2 are nonviable and have defects in amnion\/chorion and cardiac development","volume":"122","author":"Zhang","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.03.019_bib91","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1523\/JNEUROSCI.4071-03.2004","article-title":"Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities","volume":"24","author":"Zhou","year":"2004","journal-title":"J. Neurosci."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615302207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615302207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:46:24Z","timestamp":1655333184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615302207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":91,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0012160615302207"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.03.019","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roof plate mediated morphogenesis of the forebrain: New players join the game","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}