{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:33:52Z","timestamp":1790760832766,"version":"4.1.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ydbio.2016.06.006","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T17:17:24Z","timestamp":1465319844000},"page":"230-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["hPSC-derived lung and intestinal organoids as models of human fetal tissue"],"prefix":"10.1016","volume":"420","author":[{"given":"Megan","family":"Aurora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Spence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2016.06.006_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005496.pub4","article-title":"Probiotics for prevention of necrotizing enterocolitis in preterm infants","volume":"4","author":"AlFaleh","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ydbio.2016.06.006_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.95.1.133","article-title":"Historical overview of antenatal steroid use","volume":"95","author":"Avery","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2016.06.006_bib3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0002-9378(95)90210-4","article-title":"Scientific basis and therapeutic regimens for use of antenatal glucocorticoids","volume":"173","author":"Ballard","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","article-title":"In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection","volume":"148","author":"Bartfeld","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2016.06.006_bib5","doi-asserted-by":"crossref","DOI":"10.3791\/4279","article-title":"Tissue engineering of the intestine in a murine model","author":"Barthel","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2016.06.006_bib6","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1164\/ajrccm.157.6.9707011","article-title":"Number and proliferation of basal and parabasal cells in normal human airway epithelium","volume":"157","author":"Boers","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jpeds.2012.03.052","article-title":"The EPICure study: association between hemodynamics and lung function at 11 years after extremely preterm birth","volume":"161","author":"Bolton","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ydbio.2016.06.006_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ajog.2008.12.011","article-title":"Antenatal corticosteroid treatment: what\u2019s happened since Drs Liggins and Howie?","volume":"200","author":"Bonanno","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9378(84)80177-5","article-title":"Triamcinolone-induced structural alterations in the development of the lung of the fetal rhesus macaque","volume":"148","author":"Bunton","year":"1984","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib10","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/SLA.0000000000000374","article-title":"Genome-wide expression profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in human intestinal tissues: dysregulation of functional pathways","volume":"260","author":"Chan","year":"2014","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ydbio.2016.06.006_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biomaterials.2015.02.016","article-title":"Design and validation of a clinical-scale bioreactor for long-term isolated lung culture","volume":"52","author":"Charest","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ydbio.2016.06.006_bib12","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0041-1345(96)00164-9","article-title":"Preliminary studies of tissue-engineered intestine using isolated epithelial organoid units on tubular synthetic biodegradable scaffolds","volume":"29","author":"Choi","year":"1997","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.ydbio.2016.06.006_bib13","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1073\/pnas.92.17.7794","article-title":"Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice","volume":"92","author":"Clark","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.06.006_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2307\/30145489","article-title":"Intravascular catheter colonization and related bloodstream infection in critically ill neonates","volume":"11","author":"Cronin","year":"1990","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003935.pub4","article-title":"Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes","volume":"7","author":"Crowther","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ydbio.2016.06.006_bib16","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nbt1163","article-title":"Efficient differentiation of human embryonic stem cells to definitive endoderm","volume":"23","author":"D\u2019Amour","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib17","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","article-title":"Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells","volume":"24","author":"D\u2019Amour","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib18","article-title":"Organoid models of human gastrointestinal development and disease","volume":"0","author":"Dedhia","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2016.06.006_bib19","doi-asserted-by":"crossref","first-page":"35574","DOI":"10.1074\/jbc.M304885200","article-title":"TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression","volume":"278","author":"DeFelice","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.06.006_bib20","first-page":"1","article-title":"How to grow a lung: applying principles of developmental biology to generate lung lineages from human pluripotent stem cells","author":"Dye","year":"2016","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib21","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.7554\/eLife.05098","article-title":"In vitro generation of human pluripotent stem cell derived lung organoids","volume":"4","author":"Dye","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2016.06.006_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ncb3312","article-title":"Organoids as an in vitro model of human development and disease","volume":"18","author":"Fatehullah","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1113\/jphysiol.2008.162719","article-title":"Dissociation of E-cadherin and beta-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy","volume":"587","author":"Feng","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib24","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1242\/bio.013235","article-title":"Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids","volume":"4","author":"Finkbeiner","year":"2015","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2016.06.006_bib25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.stemcr.2015.04.010","article-title":"Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo","volume":"4","author":"Finkbeiner","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib26","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jpedsurg.2009.02.013","article-title":"Mortality of necrotizing enterocolitis expressed by birth weight categories","volume":"44","author":"Fitzgibbons","year":"2009","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2016.06.006_bib27","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1128\/IAI.00161-15","article-title":"Interaction of Salmonella enterica Serovar Typhimurium with intestinal organoids derived from human induced pluripotent stem cells","volume":"83","author":"Forbester","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ydbio.2016.06.006_bib28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jpedsurg.2005.11.003","article-title":"Mechanism of nitric oxide-mediated intestinal barrier failure: insight into the pathogenesis of necrotizing enterocolitis","volume":"41","author":"Ford","year":"2006","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2016.06.006_bib29","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.stem.2013.09.015","article-title":"Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury","volume":"13","author":"Fordham","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib30","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.stemcr.2014.05.001","article-title":"Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells","volume":"2","author":"Forster","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib31","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1101\/gad.245233.114","article-title":"Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon","volume":"28","author":"Fukuda","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.06.006_bib32","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.1172\/JCI68793","article-title":"Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix","volume":"123","author":"Ghaedi","year":"2013","journal-title":"J. Clin. Investig."},{"issue":"Suppl 1","key":"10.1016\/j.ydbio.2016.06.006_bib33","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1513\/AnnalsATS.201408-366MG","article-title":"Using nature\u2019s platform to engineer bio-artificial lungs","volume":"12","author":"Gilpin","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.ydbio.2016.06.006_bib34","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.healun.2013.10.030","article-title":"Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale","volume":"33","author":"Gilpin","year":"2014","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ydbio.2016.06.006_bib35","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.athoracsur.2014.05.080","article-title":"Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix","volume":"98","author":"Gilpin","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ydbio.2016.06.006_bib36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stemcr.2014.07.005","article-title":"Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells","volume":"3","author":"Gotoh","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.sempedsurg.2013.01.008","article-title":"Tissue engineering \u2013 a promising therapeutic approach to necrotizing enterocolitis","volume":"22","author":"Grant","year":"2013","journal-title":"Semin. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2016.06.006_bib38","doi-asserted-by":"crossref","first-page":"G664","DOI":"10.1152\/ajpgi.00111.2014","article-title":"Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function","volume":"308","author":"Grant","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1387\/ijdb.041946ag","article-title":"Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin\u2019s PhD thesis","volume":"49","author":"Grapin-Botton","year":"2005","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nbt.1788","article-title":"Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells","volume":"29","author":"Green","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-3476(05)72461-6","article-title":"Prenatal and postnatal corticosteroid therapy to prevent neonatal necrotizing enterocolitis: a controlled trial","volume":"117","author":"Halac","year":"1990","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ydbio.2016.06.006_bib42","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1089\/scd.2014.0512","article-title":"Generation of distal airway epithelium from multipotent human foregut stem cells","volume":"24","author":"Hannan","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ydbio.2016.06.006_bib43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.stemcr.2013.09.003","article-title":"Generation of multipotent foregut stem cells from human pluripotent stem cells","volume":"1","author":"Hannan","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib44","doi-asserted-by":"crossref","unstructured":"Hay, W.W., Lucas, A., Heird, W.C., Ziegler, E., Levin, E., Grave, G.D., Catz, C.S., Yaffe, S.J., 1999. Workshop summary: nutrition of the extremely low birth weight infant., in: Presented at the Pediatrics, pp. 1360\u20131368.","DOI":"10.1542\/peds.104.6.1360"},{"key":"10.1016\/j.ydbio.2016.06.006_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/pr.2016.67","article-title":"Paneth cells in the developing gut: when do they arise and when are they immune competent?","author":"Heida","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2016.06.006_bib46","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1242\/dev.098186","article-title":"Lung development: orchestrating the generation and regeneration of a complex organ","volume":"141","author":"Herriges","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.06.006_bib47","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1073\/pnas.1400709111","article-title":"Differentiated human stem cells resemble fetal, not adult, \u03b2 cells","volume":"111","author":"Hrvatin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.06.006_bib48","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1203\/PDR.0b013e31815ed64c","article-title":"Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC)","volume":"63","author":"Hunter","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2016.06.006_bib49","doi-asserted-by":"crossref","first-page":"L468","DOI":"10.1152\/ajplung.2000.279.3.L468","article-title":"Surfactant metabolism in SP-D gene-targeted mice","volume":"279","author":"Ikegami","year":"2000","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib50","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1097\/00007890-200005150-00031","article-title":"Long-term follow-up of tissue-engineered intestine after anastomosis to native small bowel","volume":"69","author":"Kaihara","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.ydbio.2016.06.006_bib51","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1073\/pnas.1113890109","article-title":"Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells","volume":"109","author":"Kim","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.06.006_bib52","doi-asserted-by":"crossref","unstructured":"Kliegman, R.M., Walker, W.A., Yolken, R.H., 1993. Necrotizing enterocolitis: research agenda for a disease of unknown etiology and pathogenesis, in: Presented at the Pediatric research, Nature Publishing Group, pp. 701\u2013708. Doi:10.1203\/00006450-199312000-00001","DOI":"10.1203\/00006450-199312000-00001"},{"key":"10.1016\/j.ydbio.2016.06.006_bib53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.stemcr.2015.11.010","article-title":"Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent","volume":"6","author":"Konishi","year":"2016","journal-title":"Stem Cells Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib54","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/0148607192016004386","article-title":"Parenteral nutrition-related bone disease","volume":"16","author":"Koo","year":"1992","journal-title":"J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.ydbio.2016.06.006_bib55","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo","volume":"26","author":"Kroon","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/MPG.0000000000000586","article-title":"Intestinal failure-associated liver disease: a position paper of the ESPGHAN Working Group of Intestinal Failure and Intestinal Transplantation","volume":"60","author":"Lacaille","year":"2015","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.ydbio.2016.06.006_bib57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.06.006_bib58","first-page":"295","article-title":"Congenital diaphragmatic hernia","volume":"8","author":"Langer","year":"1998","journal-title":"Chest Surg. Clin. N. Am."},{"key":"10.1016\/j.ydbio.2016.06.006_bib59","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2013.12.039","article-title":"Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis","volume":"156","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.anaerobe.2015.10.016","article-title":"A whole new ball game: stem cell-derived epithelia in the study of host-microbe interactions","volume":"37","author":"Leslie","year":"2016","journal-title":"Anaerobe"},{"key":"10.1016\/j.ydbio.2016.06.006_bib61","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/IAI.02561-14","article-title":"Persistence and toxin production by clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function","volume":"83","author":"Leslie","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ydbio.2016.06.006_bib62","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jpedsurg.2012.10.029","article-title":"Human tissue-engineered small intestine forms from postnatal progenitor cells","volume":"48","author":"Levin","year":"2013","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2016.06.006_bib63","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0140-6736(06)69525-1","article-title":"Necrotising enterocolitis","volume":"368","author":"Lin","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ydbio.2016.06.006_bib64","first-page":"2015","article-title":"BMP signaling is essential in neonatal surfactant production during respiratory adaptation","author":"Luo","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib65","article-title":"Cystic lung disease: The importance of a multidisciplinary approach","author":"Marchiori","year":"2015","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib66","first-page":"1","article-title":"Births: final data for 2013","volume":"64","author":"Martin","year":"2015","journal-title":"Natl. Vital Stat. Rep."},{"key":"10.1016\/j.ydbio.2016.06.006_bib67","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature13863","article-title":"Modelling human development and disease in pluripotent stem-cell-derived gastric organoids","volume":"516","author":"McCracken","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.06.006_bib68","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1542\/peds.2009-3149","article-title":"Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis","volume":"125","author":"Morowitz","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2016.06.006_bib69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.devcel.2009.12.010","article-title":"Preparing for the first breath: genetic and cellular mechanisms in lung development","volume":"18","author":"Morrisey","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib70","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1513\/AnnalsATS.201207-036OT","article-title":"Molecular determinants of lung development","volume":"10","author":"Morrisey","year":"2013","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.ydbio.2016.06.006_bib71","article-title":"Organoids as a model system for studying human lung development and disease","author":"Nadkarni","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2016.06.006_bib72","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1440-1827.1998.tb03865.x","article-title":"Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways","volume":"48","author":"Nakajima","year":"1998","journal-title":"Pathol. Int."},{"key":"10.1016\/j.ydbio.2016.06.006_bib73","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2012.05.009","article-title":"Self-formation of optic cups and storable stratified neural retina from human ESCs","volume":"10","author":"Nakano","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib74","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0031-3955(05)70413-2","article-title":"Necrotizing enterocolitis: the search for a unifying pathogenic theory leading to prevention","volume":"43","author":"Neu","year":"1996","journal-title":"Pediatr. Clin. N. Am."},{"key":"10.1016\/j.ydbio.2016.06.006_bib75","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"Neu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib76","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia","volume":"276","author":"Northway","year":"1967","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib77","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1542\/peds.68.6.781","article-title":"Lung surfactant in an era of replacement therapy","volume":"68","author":"Notter","year":"1981","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2016.06.006_bib78","first-page":"345","article-title":"Immature epithelial Na+ channel expression is one of the pathogenetic mechanisms leading to human neonatal respiratory distress syndrome","volume":"108","author":"O\u2019Brodovich","year":"1996","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"10.1016\/j.ydbio.2016.06.006_bib79","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nm.1951","article-title":"Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche","volume":"15","author":"Ootani","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib80","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/pr.2015.97","article-title":"Intestinal microbiota and its relationship with necrotizing enterocolitis","volume":"78","author":"Patel","year":"2015","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2016.06.006_bib81","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1534-5807(02)00321-0","article-title":"Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks","volume":"3","author":"Perea-Gomez","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib82","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nbt.3354","article-title":"Engineering pulmonary vasculature in decellularized rat and human lungs","volume":"33","author":"Ren","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib83","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1242\/dmm.006031","article-title":"Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling","volume":"3","author":"Rock","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ydbio.2016.06.006_bib224","unstructured":"Rodriguez, RJ., Martin, RJ., Fanaroff, AA., 2002. Respiratory distress syndrome and its management. In Fanaroff, Avroy A; Martin, Richard J. Neonatal-perinatal medicine: diseases of the fetus and infant. St. Louis: Mosby. pp. 1001-1011. ISBN 978-0-323-00929-4."},{"key":"10.1016\/j.ydbio.2016.06.006_bib84","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.06.006_bib85","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJMoa1410689","article-title":"Between-hospital variation in treatment and outcomes in extremely preterm infants","volume":"372","author":"Rysavy","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib222","unstructured":"Sadler, T W (Thomas W) (2012) Langman Medical embryology. 12th ed. ISBN: 9781451113426"},{"key":"10.1016\/j.ydbio.2016.06.006_bib86","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1542\/peds.2014-2651","article-title":"Lung function in very low birth weight adults","volume":"136","author":"Saarenp\u00e4\u00e4","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2016.06.006_bib87","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.06.006_bib88","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/hel.12152","article-title":"Helicobacter pylori-Induced Sonic Hedgehog Expression is regulated by NF\u03baB Pathway activation: the use of a novel in vitro model to study epithelial response to infection","volume":"20","author":"Schumacher","year":"2015","journal-title":"Helicobacter"},{"key":"10.1016\/j.ydbio.2016.06.006_bib89","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ydbio.2008.03.017","article-title":"Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum","volume":"318","author":"Seifert","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib90","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1242\/dev.036830","article-title":"Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development","volume":"136","author":"Seifert","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.06.006_bib91","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1242\/dev.042291","article-title":"Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development","volume":"136","author":"Seifert","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.06.006_bib92","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.15252\/embj.201490686","article-title":"Generating human intestinal tissues from pluripotent stem cells to study development and disease","volume":"34","author":"Sinagoga","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2016.06.006_bib93","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","article-title":"Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells","volume":"51","author":"Si-Tayeb","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ydbio.2016.06.006_bib94","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature09691","article-title":"Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro","volume":"470","author":"Spence","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.06.006_bib95","doi-asserted-by":"crossref","first-page":"e1002149","DOI":"10.1371\/journal.pbio.1002149","article-title":"The renaissance of developmental biology","volume":"13","author":"St. Johnston","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib96","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1651-2227.2012.02801.x","article-title":"The preterm gut microbiota: changes associated with necrotizing enterocolitis and infection","volume":"101","author":"Stewart","year":"2012","journal-title":"Acta Paediatr."},{"issue":"Suppl 2","key":"10.1016\/j.ydbio.2016.06.006_bib97","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1038\/sj.jp.7211320","article-title":"Overview of surfactant replacement trials","volume":"25","author":"Suresh","year":"2005","journal-title":"J. Perinatol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib98","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib99","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.06.006_bib100","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature15695","article-title":"Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis","volume":"526","author":"Takasato","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.06.006_bib101","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2016.06.006_bib102","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0925-4773(02)00252-6","article-title":"BMP signalling regulates anteroposterior endoderm patterning in zebrafish","volume":"118","author":"Tiso","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2016.06.006_bib103","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/bies.201500111","article-title":"Organoids and the genetically encoded self-assembly of embryonic stem cells","volume":"38","author":"Turner","year":"2016","journal-title":"Bioessays"},{"key":"10.1016\/j.ydbio.2016.06.006_bib104","first-page":"630","article-title":"Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates","volume":"119","author":"Uauy","year":"1991","journal-title":"Natl. Inst. Child. Health Hum. Dev. Neonatal Res. Netw. J. Pediatr."},{"key":"10.1016\/j.ydbio.2016.06.006_bib105","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ajog.2012.06.012","article-title":"Effects of antenatal corticosteroids on the hypothalamic-pituitary-adrenocortical axis of the fetus and newborn: experimental findings and clinical considerations","volume":"207","author":"Waffarn","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib106","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ydbio.2006.05.019","article-title":"Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives","volume":"297","author":"Wang","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib107","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nm.3737","article-title":"An in vivo model of human small intestine using pluripotent stem cells","volume":"20","author":"Watson","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib108","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1242\/dev.097386","article-title":"How to make an intestine","volume":"141","author":"Wells","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.06.006_bib109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2350\/09-01-0586.1","article-title":"Genetic disorders of surfactant dysfunction","volume":"12","author":"Wert","year":"2009","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1053\/j.semperi.2007.02.009","article-title":"Nutritional management of infants with short bowel syndrome","volume":"31","author":"Wessel","year":"2007","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2015-0128PS","article-title":"Alveolar development and disease","volume":"53","author":"Whitsett","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ydbio.2016.06.006_bib112","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.med.60.041807.123500","article-title":"Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease","volume":"61","author":"Whitsett","year":"2010","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib113","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature02418","article-title":"Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo","volume":"428","author":"Yamamoto","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.06.006_bib114","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nm.2695","article-title":"Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5\u207a stem cell","volume":"18","author":"Yui","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ydbio.2016.06.006_bib115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00431-007-0492-1","article-title":"Inherited renal tubular dysgenesis: the first patients surviving the neonatal period","volume":"167","author":"Zingg-Schenk","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ydbio.2016.06.006_bib116","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.cellbio.042308.113344","article-title":"Vertebrate endoderm development and organ formation","volume":"25","author":"Zorn","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0012160616301889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0012160616301889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T05:12:06Z","timestamp":1656652326000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160616301889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":118,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0012160616301889"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.06.006","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"hPSC-derived lung and intestinal organoids as models of human fetal tissue","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ydbio.2016.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}