{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:16:21Z","timestamp":1791389781807,"version":"4.3.3"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K08 DK105326"],"award-info":[{"award-number":["K08 DK105326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 GM007226"],"award-info":[{"award-number":["T32 GM007226"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01DK090311"],"award-info":[{"award-number":["R01DK090311"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R24OD017870"],"award-info":[{"award-number":["R24OD017870"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01GM088041"],"award-info":[{"award-number":["R01GM088041"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["T32 NS077984"],"award-info":[{"award-number":["T32 NS077984"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003183","name":"National Pancreas Foundation","doi-asserted-by":"publisher","award":["108244"],"award-info":[{"award-number":["108244"]}],"id":[{"id":"10.13039\/100003183","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Harvard Digestive Diseases Center","award":["P30 DK034854"],"award-info":[{"award-number":["P30 DK034854"]}]},{"name":"Anna Fuller Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.ydbio.2016.07.019","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T22:39:53Z","timestamp":1469659193000},"page":"108-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development"],"prefix":"10.1016","volume":"418","author":[{"given":"Sahar","family":"Nissim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Weeks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared C.","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Hedgepeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wucherpfennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schatzman-Bone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Swinburne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Alexa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Megason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trista E.","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Amacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Goessling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2016.07.019_bib1","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1038\/sj.onc.1208950","article-title":"The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene","volume":"24","author":"Annicotte","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2016.07.019_bib2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ncb1621","article-title":"Genetic control of single lumen formation in the zebrafish gut","volume":"9","author":"Bagnat","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib3","doi-asserted-by":"crossref","first-page":"16927","DOI":"10.1073\/pnas.1112047108","article-title":"Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation","volume":"108","author":"Benod","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.07.019_bib4","doi-asserted-by":"crossref","first-page":"19830","DOI":"10.1074\/jbc.M112.411686","article-title":"Structure-based discovery of antagonists of nuclear receptor LRH-1","volume":"288","author":"Benod","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.07.019_bib5","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1371\/journal.pgen.0030188","article-title":"Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression","volume":"3","author":"Bertrand","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2016.07.019_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/dbio.2000.0103","article-title":"Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet","volume":"230","author":"Biemar","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2006.06.049","article-title":"Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network","volume":"126","author":"Bookout","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.molcel.2004.07.009","article-title":"Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation","volume":"15","author":"Botrugno","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib9","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1242\/dev.068080","article-title":"Rapid BAC selection for tol2-mediated transgenesis in zebrafish","volume":"138","author":"Bussmann","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.07.019_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkr739","article-title":"Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting","volume":"39","author":"Cermak","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2016.07.019_bib11","first-page":"13","article-title":"Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR","author":"Chong","year":"2012","journal-title":"BMC Genom."},{"key":"10.1016\/j.ydbio.2016.07.019_bib12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.devcel.2008.08.019","article-title":"Bmp2 signaling regulates the hepatic versus pancreatic fate decision","volume":"15","author":"Chung","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib13","first-page":"8","article-title":"Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome","author":"Dahlem","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2016.07.019_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.21952","article-title":"Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate","volume":"47","author":"Decaens","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.ydbio.2016.07.019_bib15","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1242\/dev.128.6.871","article-title":"A bipotential precursor population for pancreas and liver within the embryonic endoderm","volume":"128","author":"Deutsch","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.07.019_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ng1961","article-title":"Fgf10 regulates hepatopancreatic ductal system patterning and differentiation","volume":"39","author":"Dong","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.07.019_bib17","doi-asserted-by":"crossref","first-page":"250260","DOI":"10.1016\/j.tcb.2004.03.008","article-title":"LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis","volume":"14","author":"Fayard","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0012-1606(03)00308-7","article-title":"Formation of the digestive system in zebrafish. II. Pancreas morphogenesis","volume":"261","author":"Field","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0012-1606(02)00017-9","article-title":"Formation of the digestive system in zebrafish. I. Liver morphogenesis","author":"Field","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ydbio.2008.05.526","article-title":"APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development","author":"Goessling","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.biocel.2004.07.010","article-title":"Ductal cells of the pancreas","volume":"37","author":"Grapin-Botton","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib22","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/MCB.25.9.3492-3505.2005","article-title":"Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development","volume":"25","author":"Gu","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib23","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1242\/dev.109405","article-title":"The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis","volume":"141","author":"Hale","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.07.019_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.stem.2009.12.009","article-title":"The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells","volume":"6","author":"Heng","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.stem.2009.12.009","article-title":"The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells","volume":"6","author":"Heng","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-5793(03)00157-1","article-title":"In vivo studies of liver-type fatty acid binding protein (l-FABP) gene expression in liver of transgenic zebrafish (Danio rerio)","volume":"538","author":"Her","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2016.07.019_bib27","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1101\/gad.16860911","article-title":"LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function","author":"Holmstrom","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.07.019_bib28","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1101\/gad.390906","article-title":"Plasticity and expanding complexity of the hepatic transcription factor network during liver development","volume":"20","author":"Kyrmizi","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.07.019_bib29","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1002\/dvdy.20996","article-title":"Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis","volume":"235","author":"Labelle-Dumais","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2016.07.019_bib30","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1210\/me.2007-0565","article-title":"Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis","volume":"22","author":"Lee","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ydbio.2004.07.001","article-title":"Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas","volume":"274","author":"Lin","year":"2004","journal-title":"Dev. Biol."},{"issue":"Pt 2","key":"10.1016\/j.ydbio.2016.07.019_bib32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1042\/bj3480439","article-title":"Zebrafish ftz-f1 gene has two promoters, is alternatively spliced, and is expressed in digestive organs","volume":"348","author":"Lin","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2016.07.019_bib33","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1242\/dev.001230","article-title":"Repression of Wnt\/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development","volume":"134","author":"McLin","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.07.019_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/dvdy.20032","article-title":"Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas","volume":"230","author":"Mudumana","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2016.07.019_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/org.4.2.5853","article-title":"The what, where, when and how of Wnt\/beta-catenin signaling in pancreas development","volume":"4","author":"Murtaugh","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.ydbio.2016.07.019_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/gutjnl-2013-305030","article-title":"Putting GWAS to the functional test: NR5A2 and pancreatic cancer risk","volume":"63","author":"Murtaugh","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ydbio.2016.07.019_bib37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.devcel.2014.01.006","article-title":"Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth","volume":"28","author":"Nissim","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/B978-0-12-387036-0.00010-4","article-title":"Endoderm specification, liver development, and regeneration","volume":"101","author":"North","year":"2011","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib39","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nature05883","article-title":"Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis","volume":"447","author":"North","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.07.019_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0925-4773(02)00327-1","article-title":"From endoderm formation to liver and pancreas development in zebrafish","author":"Ober","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2016.07.019_bib41","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature04888","article-title":"Mesodermal Wnt2b signalling positively regulates liver specification","volume":"442","author":"Ober","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.07.019_bib42","doi-asserted-by":"crossref","first-page":"13136","DOI":"10.1074\/jbc.M010737200","article-title":"The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promoters","volume":"276","author":"Par\u00e9","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.07.019_bib43","doi-asserted-by":"crossref","first-page":"21206","DOI":"10.1074\/jbc.M401523200","article-title":"The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element","volume":"279","author":"Par\u00e9","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.07.019_bib44","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ng.522","article-title":"A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33","volume":"42","author":"Petersen","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.07.019_bib45","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1242\/dev.055921","article-title":"Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development","volume":"138","author":"Poulain","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.07.019_bib46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0925-4773(99)00209-9","article-title":"The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3beta in the developing murine liver, intestine and pancreas","volume":"89","author":"Rausa","year":"1999","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2016.07.019_bib47","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1101\/gad.904601","article-title":"Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm","volume":"15","author":"Rossi","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.07.019_bib48","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nbt.1934","article-title":"Targeted gene disruption in somatic zebrafish cells using engineered TALENs","volume":"29","author":"Sander","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1242\/dev.099481","article-title":"Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment","volume":"141","author":"Seth","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.07.019_bib50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/76996","article-title":"Hepatocyte migration during liver development requires Prox1","volume":"25","author":"Sosa-Pineda","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.07.019_bib51","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/hep.22225","article-title":"Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development","volume":"47","author":"Tan","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.ydbio.2016.07.019_bib52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2009.04.018","article-title":"Zebrafish pancreas development","volume":"312","author":"Tiso","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib53","article-title":"Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese","volume":"5","author":"Ueno","year":"2015","journal-title":"Nat. Sci. Rep."},{"key":"10.1016\/j.ydbio.2016.07.019_bib54","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/gutjnl-2012-304287","article-title":"Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation","volume":"63","author":"von Figura","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ydbio.2016.07.019_bib55","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/stem.502","article-title":"Canonical Wnt\/ catenin regulation of liver receptor homolog 1 mediates pluripotency gene expression","volume":"28","author":"Wagner","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.ydbio.2016.07.019_bib56","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.yexcr.2006.01.016","article-title":"Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter","volume":"312","author":"Wan","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2016.07.019_bib57","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1174497","article-title":"Dynamic signaling network for the specification of embryonic pancreas and liver progenitors","volume":"324","author":"Wandzioch","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2016.07.019_bib58","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.stem.2015.02.013","article-title":"Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates","volume":"16","author":"Wang","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2016.07.019_bib59","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ydbio.2005.07.021","article-title":"Prox1 activity controls pancreas morphogenesis and participates in the production of \u201csecondary transition\u201d pancreatic endocrine cells","author":"Wang","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib60","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/j.gastro.2011.12.007","article-title":"Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas","volume":"142","author":"Westmoreland","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2016.07.019_bib61","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2005.04.035","article-title":"Exocrine pancreas development in zebrafish","volume":"284","author":"Yee","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.07.019_bib62","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.1161431","article-title":"Generation and regeneration of cells of the liver and pancreas","volume":"322","author":"Zaret","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2016.07.019_bib63","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ydbio.2003.12.016","article-title":"Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates","volume":"268","author":"Zecchin","year":"2004","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615303377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160615303377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:11:37Z","timestamp":1656893497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160615303377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0012160615303377"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.07.019","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}