{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:32:38Z","timestamp":1778941958807,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":379,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute, United States,","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Eye Institute (NIH), United States,","award":["1R01EY018637"],"award-info":[{"award-number":["1R01EY018637"]}]},{"name":"National Institute of Neurologic Disease and Stroke","award":["1R01NS098590-01"],"award-info":[{"award-number":["1R01NS098590-01"]}]},{"name":"Actions de Recherches Concert\u00e9es","award":["ARC-10\/15-026"],"award-info":[{"award-number":["ARC-10\/15-026"]}]},{"name":"Interuniversity Poles of Attraction","award":["PDR-FNRS T0002.13"],"award-info":[{"award-number":["PDR-FNRS T0002.13"]}]},{"name":"R\u00e9gion Wallonne","award":["WELBIO-CR-2012A-07"],"award-info":[{"award-number":["WELBIO-CR-2012A-07"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ydbio.2016.09.004","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T00:03:38Z","timestamp":1473465818000},"page":"298-310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling"],"prefix":"10.1016","volume":"419","author":[{"given":"Yanshu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Rattner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G.","family":"Bassuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre M.","family":"Goffinet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Nathans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2016.09.004_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1534-5807(02)00176-4","article-title":"Planar signaling and morphogenesis in Drosophila","volume":"2","author":"Adler","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.09.004_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/dvg.1020080206","article-title":"Allelic variation at the frizzled locus of Drosophila","volume":"8","author":"Adler","year":"1987","journal-title":"Dev. Genet."},{"key":"10.1016\/j.ydbio.2016.09.004_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fninf.2014.00044","article-title":"The Insight ToolKit image registration framework","volume":"8","author":"Avants","year":"2014","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.ydbio.2016.09.004_bib4","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1128\/MCB.25.16.7249-7259.2005","article-title":"Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice","volume":"25","author":"Bianchi","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2016.09.004_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature05634","article-title":"The delayed rise of present-day mammals","volume":"446","author":"Bininda-Emonds","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.09.004_bib6","doi-asserted-by":"crossref","first-page":"E3129","DOI":"10.1073\/pnas.1404988111","article-title":"A dual role for planar cell polarity genes in ciliated cells","volume":"111","author":"Boutin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.09.004_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ydbio.2015.10.027","article-title":"The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation","volume":"409","author":"Chang","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.09.004_bib8","doi-asserted-by":"crossref","first-page":"14001","DOI":"10.1523\/JNEUROSCI.1307-13.2013","article-title":"Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2","volume":"33","author":"Copley","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.09.004_bib9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0960-9822(03)00374-9","article-title":"Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse","volume":"13","author":"Curtin","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2016.09.004_bib10","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","author":"Dassule","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.09.004_bib11","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1523\/JNEUROSCI.5151-06.2007","article-title":"Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear","volume":"27","author":"Deans","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.09.004_bib12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/ncb1784","article-title":"Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles","volume":"10","author":"Devenport","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.09.004_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000144377","article-title":"Review of the evolution and phylogeny of the mammalian tongue","volume":"91","author":"Doran","year":"1975","journal-title":"Acta Anat."},{"key":"10.1016\/j.ydbio.2016.09.004_bib14","doi-asserted-by":"crossref","first-page":"e10566","DOI":"10.7554\/eLife.10566","article-title":"A platform for brain-wide imaging and reconstruction of individual neurons","volume":"5","author":"Economo","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2016.09.004_bib15","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1242\/dev.054080","article-title":"Principles of planar polarity in animal development","volume":"128","author":"Goodrich","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.09.004_bib16","doi-asserted-by":"crossref","first-page":"9277","DOI":"10.1073\/pnas.0402802101","article-title":"Frizzled6 controls hair patterning in mice","volume":"101","author":"Guo","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.09.004_bib17","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1242\/dev.110189","article-title":"Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance","volume":"141","author":"Hua","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.09.004_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.2002.00073.x","article-title":"Evolution of the structure and function of the vertebrate tongue","volume":"201","author":"Iwasaki","year":"2002","journal-title":"J. Anat."},{"key":"10.1016\/j.ydbio.2016.09.004_bib19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ar.1091100302","article-title":"The filiform and conical papillae of the tongue in the white rat","volume":"110","author":"Kutuzov","year":"1951","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ydbio.2016.09.004_bib20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ar.1091160403","article-title":"Comparative anatomy of the mucosa of the tongue and the palate of the laboratory mouse","volume":"116","author":"Kutuzov","year":"1953","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ydbio.2016.09.004_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrg2125","article-title":"Planar cell polarity: one or two pathways?","volume":"8","author":"Lawrence","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2016.09.004_bib22","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1101\/gad.228098.113","article-title":"Regulation of PCP by the Fat signaling pathway","volume":"27","author":"Matis","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.09.004_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature01618","article-title":"Identification of Vangl2 and Scrb1 as planar polarity genes in mammals","volume":"423","author":"Montcouquiol","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.09.004_bib24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/gene.10022","article-title":"Embryonic expression of an Nkx2-5\/Cre gene using ROSA26 reporter mice","volume":"31","author":"Moses","year":"2001","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2016.09.004_bib25","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/hmg\/10.22.2593","article-title":"Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification","volume":"10","author":"Murdoch","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2016.09.004_bib26","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.neuron.2014.06.022","article-title":"Inactivation of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus","volume":"83","author":"Ohata","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2016.09.004_bib27","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.1523\/JNEUROSCI.0124-10.2010","article-title":"Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice","volume":"30","author":"Qu","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.09.004_bib28","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1038\/jid.2009.84","article-title":"Planar cell polarity cadherin Celsr1 regulates skin patterning in the mouse","volume":"129","author":"Ravni","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ydbio.2016.09.004_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1242\/bio.016162","article-title":"Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms","volume":"5","author":"Sharp","year":"2016","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2016.09.004_bib30","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1242\/dev.115659","article-title":"Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct","volume":"141","author":"Shi","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.09.004_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/oxfordjournals.jhered.a105976","article-title":"Hereditary loop-tail in the house mouse accompanied by imperforate vagina and with lethal craniorachischisis when homozygous","volume":"40","author":"Strong","year":"1949","journal-title":"J. Hered."},{"key":"10.1016\/j.ydbio.2016.09.004_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ajhg.2010.12.012","article-title":"Mutations in prickle orthologs cause seizures in flies, mice, and humans","volume":"88","author":"Tao","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2016.09.004_bib33","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.2555","article-title":"Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus","volume":"13","author":"Tissir","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2016.09.004_bib34","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.0712126105","article-title":"Genetic interaction between members of the Vangl family causes neural tube defects in mice","volume":"105","author":"Torban","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.09.004_bib35","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/j.cub.2012.09.046","article-title":"Microtubules enable the planar cell polarity of airway cilia","volume":"22","author":"Vladar","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2016.09.004_bib36","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/ng1622","article-title":"Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway","volume":"37","author":"Wang","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2016.09.004_bib37","doi-asserted-by":"crossref","first-page":"19800","DOI":"10.1073\/pnas.0609712104","article-title":"Order from disorder: self-organization in mammalian hair patterning","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.09.004_bib38","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1523\/JNEUROSCI.4698-05.2005","article-title":"The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells","volume":"26","author":"Wang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.09.004_bib39","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1242\/dev.057455","article-title":"When whorls collide: the development of hair patterns in frizzled 6 mutant mice","volume":"137","author":"Wang","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.09.004_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuron.2013.10.051","article-title":"Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease","volume":"81","author":"Wu","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2016.09.004_bib41","doi-asserted-by":"crossref","first-page":"e31988","DOI":"10.1371\/journal.pone.0031988","article-title":"Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development","volume":"7","author":"Yin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2016.09.004_bib42","series-title":"Biostatistical Analysis","author":"Zar","year":"1999"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160616304390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160616304390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T02:37:56Z","timestamp":1657247876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160616304390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0012160616304390"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.09.004","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}