{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:01:28Z","timestamp":1789941688642,"version":"4.0.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"vor","delay-in-days":379,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["13BGIA14470002"],"award-info":[{"award-number":["13BGIA14470002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ydbio.2016.12.012","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:45:25Z","timestamp":1481676325000},"page":"271-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development"],"prefix":"10.1016","volume":"421","author":[{"given":"Jieli","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"VanBuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Dostal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyuan L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2016.12.012_bib1","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1242\/dev.125260","article-title":"Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice","volume":"142","author":"Barry","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.12.012_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/BJ20031481","article-title":"Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes","volume":"382","author":"Bicknell","year":"2004","journal-title":"Biochem J."},{"key":"10.1016\/j.ydbio.2016.12.012_bib3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nature06801","article-title":"The developmental genetics of congenital heart disease","volume":"451","author":"Bruneau","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.12.012_bib4","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/nn1744","article-title":"The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface","volume":"9","author":"Cappello","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2016.12.012_bib5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tcb.2004.01.008","article-title":"Cdc42: new roads to travel","volume":"14","author":"Cerione","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib6","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0960-9822(00)00571-6","article-title":"Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability","volume":"10","author":"Chen","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib7","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00246-009-9406-5","article-title":"Analysis of ventricular hypertrabeculation and noncompaction using genetically engineered mouse models","volume":"30","author":"Chen","year":"2009","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib8","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1083\/jcb.200403043","article-title":"Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42","volume":"167","author":"Chu","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nm0502-459","article-title":"ErbB2 is essential in the prevention of dilated cardiomyopathy","volume":"8","author":"Crone","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.ydbio.2016.12.012_bib10","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.yexcr.2008.11.012","article-title":"Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1","volume":"315","author":"Du","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2016.12.012_bib11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2016.12.012_bib12","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1242\/jcs.109.13.2989","article-title":"Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin","volume":"109","author":"Fassler","year":"1996","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2016.12.012_bib13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncb1453","article-title":"Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth","volume":"8","author":"Feng","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1083\/jcb.145.2.347","article-title":"Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility","volume":"145","author":"Fukata","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib15","doi-asserted-by":"crossref","first-page":"51885","DOI":"10.1074\/jbc.M308015200","article-title":"Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells","volume":"278","author":"Fukuhara","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.12.012_bib16","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.cub.2008.09.029","article-title":"Cdc42, Par6, and aPKC regulate Arp2\/3-mediated endocytosis to control local adherens junction stability","volume":"18","author":"Georgiou","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib17","doi-asserted-by":"crossref","first-page":"18505","DOI":"10.1073\/pnas.1010249107","article-title":"Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis","volume":"107","author":"Guo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.12.012_bib18","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.200807020","article-title":"Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis","volume":"183","author":"Harris","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.devcel.2008.12.007","article-title":"Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling","volume":"16","author":"Ieda","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2016.12.012_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1083\/jcb.200401078","article-title":"Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments","volume":"166","author":"Izumi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib21","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1128\/MCB.00650-13","article-title":"Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis","volume":"33","author":"Jin","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/01.RES.0000111522.02730.56","article-title":"Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes","volume":"94","author":"Ke","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ydbio.2016.12.012_bib23","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.cell.2009.08.049","article-title":"Cdc42-mediated tubulogenesis controls cell specification","volume":"139","author":"Kesavan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.12.012_bib24","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.yjmcc.2003.10.001","article-title":"Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models","volume":"35","author":"Liang","year":"2003","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib25","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0960-9822(06)00338-1","article-title":"A novel Cdc42Hs mutant induces cellular transformation","volume":"7","author":"Lin","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ydbio.2013.09.013","article-title":"Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects","author":"Liu","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jcp.20098","article-title":"Interactions among IQGAP1, Cdc42, and the cadherin\/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis","volume":"202","author":"Lui","year":"2005","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1242\/dev.128.4.459","article-title":"Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin","volume":"128","author":"Luo","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.12.012_bib29","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1172\/JCI37694","article-title":"Cdc42 is an antihypertrophic molecular switch in the mouse heart","volume":"119","author":"Maillet","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ydbio.2016.12.012_bib30","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1074\/jbc.R110.200329","article-title":"Signaling role of Cdc42 in regulating mammalian physiology","volume":"286","author":"Melendez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.12.012_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20040176","article-title":"Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2\/3 complex","volume":"380","author":"Millard","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2016.12.012_bib32","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00006.2003","article-title":"Cardiac chamber formation: development, genes, and evolution","volume":"83","author":"Moorman","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ydbio.2016.12.012_bib33","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0006-291X(03)00838-6","article-title":"Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes","volume":"305","author":"Nagai","year":"2003","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2016.12.012_bib34","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1523\/JNEUROSCI.18-07-02506.1998","article-title":"Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Muller cells and fibrous astrocytes","volume":"18","author":"Nagelhus","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2016.12.012_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2009.03.016","article-title":"Cardiac cell-cell junctions in health and disease: electrical versus mechanical coupling","volume":"47","author":"Noorman","year":"2009","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib36","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1091\/mbc.E03-08-0582","article-title":"Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact","volume":"15","author":"Noritake","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2016.12.012_bib37","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1242\/jcs.02379","article-title":"IQGAP1: a key regulator of adhesion and migration","volume":"118","author":"Noritake","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2016.12.012_bib38","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1101\/gad.1110103","article-title":"Sizing up the heart: development redux in disease","volume":"17","author":"Olson","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2016.12.012_bib39","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1126\/science.7652575","article-title":"An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1","volume":"269","author":"Olson","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2016.12.012_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.200605012","article-title":"Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells","volume":"175","author":"Otani","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s13238-012-2098-2","article-title":"Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice","volume":"4","author":"Peng","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.ydbio.2016.12.012_bib42","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1073\/pnas.0802319105","article-title":"Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice","volume":"105","author":"Peng","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2016.12.012_bib43","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/eurheartj\/ehs011","article-title":"Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia\/reperfusion injury","volume":"34","author":"Pu","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ydbio.2016.12.012_bib44","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1083\/jcb.201006114","article-title":"Tinman\/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species","volume":"193","author":"Qian","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-394311-8.00012-1","article-title":"N-cadherin-mediated adhesion and signaling from development to disease: lessons from mice","volume":"116","author":"Radice","year":"2013","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ydbio.2016.12.012_bib46","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics-2012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ydbio.2016.12.012_bib47","first-page":"797","article-title":"Cerebello-extrapyramidal syndrome as the only manifestation of poisoning with tricyclic antidepressives","volume":"98","author":"Roquer","year":"1992"},{"key":"10.1016\/j.ydbio.2016.12.012_bib48","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/bies.950180714","article-title":"Trabeculation in the embryonic heart","volume":"18","author":"Sedmera","year":"1996","journal-title":"Bioessays"},{"key":"10.1016\/j.ydbio.2016.12.012_bib49","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bbrc.2008.08.074","article-title":"RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells","volume":"375","author":"Shan","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2016.12.012_bib50","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tcm.2009.12.001","article-title":"Cell-cell connection to cardiac disease","volume":"19","author":"Sheikh","year":"2009","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ydbio.2016.12.012_bib51","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1083\/jcb.200411155","article-title":"Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis","volume":"169","author":"Shen","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib52","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1074\/jbc.M703300200","article-title":"Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway","volume":"283","author":"Shen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2016.12.012_bib53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.pathol.1.110304.100039","article-title":"Genetic regulation of cardiogenesis and congenital heart disease","volume":"1","author":"Srivastava","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib54","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1053\/j.gastro.2008.01.002","article-title":"Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver","volume":"134","author":"van Hengel","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2016.12.012_bib55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1083\/jcb.201405075","article-title":"Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis","volume":"206","author":"Vogler","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2016.12.012_bib56","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1093\/bioinformatics\/btm290","article-title":"VISDA: an open-source caBIG analytical tool for data clustering and beyond","volume":"23","author":"Wang","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2016.12.012_bib57","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1242\/jcs.044644","article-title":"IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway","volume":"122","author":"Wang","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2016.12.012_bib58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1182\/blood-2005-05-2171","article-title":"Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem\/progenitor cell survival, adhesion, and engraftment","volume":"107","author":"Wang","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ydbio.2016.12.012_bib59","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1242\/dev.129.7.1705","article-title":"Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation","volume":"129","author":"Wei","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2016.12.012_bib60","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm1101-1236","article-title":"Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq\/Galpha11 in cardiomyocytes","volume":"7","author":"Wettschureck","year":"2001","journal-title":"Nat. Med"},{"key":"10.1016\/j.ydbio.2016.12.012_bib61","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0092-8674(03)00688-3","article-title":"Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2016.12.012_bib62","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/dvdy.21309","article-title":"Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development","volume":"236","author":"Wu","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2016.12.012_bib63","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1101\/gad.361406","article-title":"Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin","volume":"20","author":"Wu","year":"2006","journal-title":"Genes Dev."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160616303396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160616303396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T23:03:22Z","timestamp":1658012602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160616303396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0012160616303396"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.12.012","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2016.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}