{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:50:59Z","timestamp":1785923459807,"version":"3.56.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.ydbio.2017.04.012","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T01:00:55Z","timestamp":1493427655000},"page":"165-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration"],"prefix":"10.1016","volume":"427","author":[{"given":"Carolyn E.","family":"Adler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"S\u00e1nchez Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2017.04.012_bib1","doi-asserted-by":"crossref","first-page":"e02238","DOI":"10.7554\/eLife.02238","article-title":"Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria","volume":"3","author":"Adler","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2017.04.012_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jez.1401950107","article-title":"Mitosis in the intact and regenerating planarian Dugesia mediterranea n.sp. II. Mitotic studies during regeneration, and a possible mechanism of blastema formation","volume":"195","author":"Bagu\u00f1\u00e0","year":"1976","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.ydbio.2017.04.012_bib3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1101\/gr.6943508","article-title":"Evolution of protein domain promiscuity in eukaryotes","volume":"18","author":"Basu","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.ydbio.2017.04.012_bib4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1242\/dev.082982","article-title":"PBX\/extradenticle is required to re-establish axial structures and polarity during planarian regeneration","volume":"140","author":"Blassberg","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.04.012_bib5","doi-asserted-by":"crossref","first-page":"D764","DOI":"10.1093\/nar\/gkv1148","article-title":"PlanMine--a mineable resource of planarian biology and biodiversity","volume":"44","author":"Brandl","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2017.04.012_bib6","first-page":"5","article-title":"The evolutionary origin of bilaterian smooth and striated myocytes","author":"Brunet","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2017.04.012_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s004180050098","article-title":"Cell-, tissue-, and position-specific monoclonal antibodies against the planarian Dugesia (Girardia) tigrina","volume":"107","author":"Bueno","year":"1997","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neures.2008.04.005","article-title":"Organization of the nervous system in the model planarian Schmidtea mediterranea: an immunocytochemical study","volume":"61","author":"Cebri\u00e0","year":"2008","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ydbio.2017.04.012_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fcell.2016.00008","article-title":"Planarian Body-Wall Muscle: regeneration and Function beyond a Simple Skeletal Support","volume":"4","author":"Cebri\u00e0","year":"2016","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib10","first-page":"131","article-title":"Body-wall muscle restoration dynamics are different in dorsal and ventral blastemas during planarian anterior regeneration","author":"Cebri\u00e0","year":"2001","journal-title":"Belg. J. Zool."},{"key":"10.1016\/j.ydbio.2017.04.012_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s004270050118","article-title":"Myocyte differentiation and body wall muscle regeneration in the planarian Girardia tigrina","volume":"207","author":"Cebri\u00e0","year":"1997","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1440-169X.1979.00195.x","article-title":"The dynamics of wound closure and its role in the programming of planarian regeneration. I - Blastema emergence","volume":"21","author":"Chandebois","year":"1979","journal-title":"Dev., Growth Differ."},{"key":"10.1016\/j.ydbio.2017.04.012_bib13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1242\/dev.083741","article-title":"pbx is required for pole and eye regeneration in planarians","volume":"140","author":"Chen","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.04.012_bib14","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1242\/dev.098616","article-title":"Genome-wide analysis of the bHLH gene family in planarians identifies factors required for adult neurogenesis and neuronal regeneration","volume":"140","author":"Cowles","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.04.012_bib15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/dvdy.24428","article-title":"Muscle-derived matrix metalloproteinase regulates stem cell proliferation in planarians","volume":"245","author":"Dingwall","year":"2016","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.04.012_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.stem.2008.07.002","article-title":"Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea","volume":"3","author":"Eisenhoffer","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2017.04.012_bib17","doi-asserted-by":"crossref","first-page":"e1000915","DOI":"10.1371\/journal.pgen.1000915","article-title":"The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration","volume":"6","author":"Felix","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2017.04.012_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ydbio.2011.05.669","article-title":"Stem cell-based growth, regeneration, and remodeling of the planarian intestine","volume":"356","author":"Forsthoefel","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ydbio.2010.08.007","article-title":"Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response","volume":"347","author":"Gurley","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0045-6039(83)90005-2","article-title":"Differentiation of myoblasts in the regenerating planarian Dugesia japonica","volume":"12","author":"Hori","year":"1983","journal-title":"Cell Differ."},{"key":"10.1016\/j.ydbio.2017.04.012_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000546","article-title":"Eukaryotic protein domains as functional units of cellular evolution","author":"Jin","year":"2009","journal-title":"Sci. Signal. 2, ra76"},{"key":"10.1016\/j.ydbio.2017.04.012_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-213X-13-8","article-title":"In situ hybridization protocol for enhanced detection of gene expression in the planarian Schmidtea mediterranea","volume":"13","author":"King","year":"2013","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2108\/zsj.15.861","article-title":"Identification of two distinct muscles in the planarian Dugesia japonica by their expression of myosin heavy chain genes","volume":"15","author":"Kobayashi","year":"1998","journal-title":"Zool. Sci."},{"key":"10.1016\/j.ydbio.2017.04.012_bib24","first-page":"5","article-title":"Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration","author":"Lander","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2017.04.012_bib25","doi-asserted-by":"crossref","first-page":"D257","DOI":"10.1093\/nar\/gku949","article-title":"SMART: recent updates, new developments and status in 2015","volume":"43","author":"Letunic","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2017.04.012_bib26","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1083\/jcb.18.3.651","article-title":"Observations on the fine structure of pharyngeal muscle in the planarian Dugesia tigrina","volume":"18","author":"Macrae","year":"1963","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib27","doi-asserted-by":"crossref","first-page":"e1000537","DOI":"10.1371\/journal.pgen.1000537","article-title":"An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans","volume":"5","author":"Meissner","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2017.04.012_bib28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/dbio.2000.9645","article-title":"Bromodeoxyuridine specifically labels the regenerative stem cells of planarians","volume":"220","author":"Newmark","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2108\/zsj.22.535","article-title":"Neural projections in planarian brain revealed by fluorescent dye tracing","volume":"22","author":"Okamoto","year":"2005","journal-title":"Zool. Sci."},{"key":"10.1016\/j.ydbio.2017.04.012_bib30","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2108\/zsj.19.1123","article-title":"Anatomy of the planarian Dugesia japonica I. The muscular system revealed by antisera against myosin heavy chains","volume":"19","author":"Orii","year":"2002","journal-title":"Zool. Sci."},{"key":"10.1016\/j.ydbio.2017.04.012_bib31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/dvdy.21849","article-title":"Formaldehyde-based whole-mount in situ hybridization method for planarians","volume":"238","author":"Pearson","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.04.012_bib32","doi-asserted-by":"crossref","unstructured":"Petersen, C.P., Reddien, P.W., 2009. A wound-induced Wnt expression program controls planarian regeneration polarity. Proceedings of the National Academy of Sciences 106, 17061\u201317066. doi:10.1073\/pnas.0906823106.","DOI":"10.1073\/pnas.0906823106"},{"key":"10.1016\/j.ydbio.2017.04.012_bib33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1126\/science.1202143","article-title":"Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration","volume":"332","author":"Petersen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2017.04.012_bib34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1146\/annurev.cellbio.20.010403.095114","article-title":"Fundamentals of planarian regeneration","volume":"20","author":"Reddien","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib35","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.devcel.2005.02.014","article-title":"Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria","volume":"8","author":"Reddien","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2017.04.012_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00427-012-0426-4","article-title":"Stem cell systems and regeneration in planaria","volume":"223","author":"Rink","year":"2013","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.gde.2015.01.009","article-title":"On the organ trail: insights into organ regeneration in the planarian","volume":"32","author":"Roberts-Galbraith","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2017.04.012_bib38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12861-014-0050-9","article-title":"Novel monoclonal antibodies to study tissue regeneration in planarians","volume":"15","author":"Ross","year":"2015","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib39","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/dvdy.23950","article-title":"RNA interference by feeding in vitro-synthesized double-stranded RNA to planarians: methodology and dynamics","volume":"242","author":"Rouhana","year":"2013","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.04.012_bib40","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1073\/pnas.96.9.5049","article-title":"Double-stranded RNA specifically disrupts gene expression during planarian regeneration","volume":"96","author":"S\u00e1nchez Alvarado","year":"1999","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"10.1016\/j.ydbio.2017.04.012_bib41","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1073\/pnas.95.11.5857","article-title":"SMART, a simple modular architecture research tool: identification of signaling domains","volume":"95","author":"Schultz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"10.1016\/j.ydbio.2017.04.012_bib42","doi-asserted-by":"crossref","first-page":"e1003999","DOI":"10.1371\/journal.pgen.1003999","article-title":"A forkhead transcription factor is wound-induced at the planarian midline and required for anterior pole regeneration","volume":"10","author":"Scimone","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2017.04.012_bib43","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.stemcr.2014.06.001","article-title":"Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea","volume":"3","author":"Scimone","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2017.04.012_bib44","first-page":"5","article-title":"Two FGFRL-Wnt circuits organize the planarian anteroposterior axis","author":"Scimone","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2017.04.012_bib45","doi-asserted-by":"crossref","first-page":"E5660","DOI":"10.1073\/pnas.1513439112","article-title":"An invertebrate smooth muscle with striated muscle myosin filaments","volume":"112","author":"Sulbar\u00e1n","year":"2015","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"10.1016\/j.ydbio.2017.04.012_bib46","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.cell.2016.05.038","article-title":"The molecular and cellular choreography of appendage regeneration","volume":"165","author":"Tanaka","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2017.04.012_bib47","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1242\/dev.01874","article-title":"The circuitry of a master switch: MyoD and the regulation of skeletal muscle gene transcription","volume":"132","author":"Tapscott","year":"2005","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.ydbio.2017.04.012_bib48","doi-asserted-by":"crossref","first-page":"e1004452","DOI":"10.1371\/journal.pgen.1004452","article-title":"zic-1 Expression in Planarian neoblasts after injury controls anterior pole regeneration","volume":"10","author":"V\u00e1squez-Doorman","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2017.04.012_bib49","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ydbio.2014.03.016","article-title":"Stem cell-dependent formation of a functional anterior regeneration pole in planarians requires Zic and Forkhead transcription factors","volume":"390","author":"Vogg","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib50","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ydbio.2010.06.017","article-title":"Planarian regeneration involves distinct stem cell responses to wounds and tissue absence","volume":"344","author":"Wenemoser","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.04.012_bib51","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1101\/gad.187377.112","article-title":"A molecular wound response program associated with regeneration initiation in planarians","volume":"26","author":"Wenemoser","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2017.04.012_bib52","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.celrep.2013.07.022","article-title":"Muscle cells provide instructions for planarian regeneration","volume":"4","author":"Witchley","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2017.04.012_bib53","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.devcel.2015.11.004","article-title":"A generic and cell-type-specific wound response precedes regeneration in planarians","volume":"35","author":"Wurtzel","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2017.04.012_bib54","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s13238-011-1018-1","article-title":"Structure and function of WD40 domain proteins","volume":"2","author":"Xu","year":"2011","journal-title":"Protein Cell"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160617300295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160617300295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T03:29:14Z","timestamp":1535858954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160617300295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0012160617300295"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2017.04.012","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/131789","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2017.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}