{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:46:03Z","timestamp":1790711163717,"version":"4.1.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T00:00:00Z","timestamp":1535846400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["11GRNT7770002"],"award-info":[{"award-number":["11GRNT7770002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY022098-01"],"award-info":[{"award-number":["EY022098-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ydbio.2017.07.003","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T14:45:57Z","timestamp":1499352357000},"page":"92-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis"],"prefix":"10.1016","volume":"429","author":[{"given":"Irina","family":"Sedykh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baul","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Roberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Moskvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin N.","family":"Dewey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgenya","family":"Grinblat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2017.07.003_bib1","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1523\/JNEUROSCI.14-06-03475.1994","article-title":"Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head","volume":"14","author":"Akimenko","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2017.07.003_bib2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/dvg.22767","article-title":"The Zic2 gene directs the formation and function of node cilia to control cardiac situs","volume":"52","author":"Barratt","year":"2014","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2017.07.003_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gde.2015.02.004","article-title":"Watching eyes take shape","volume":"32","author":"Bazin-Lopez","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ygeno.2007.09.001","article-title":"Expression profiling identifies novel Hh\/Gli-regulated genes in developing zebrafish embryos","volume":"91","author":"Bergeron","year":"2008","journal-title":"Genomics"},{"key":"10.1016\/j.ydbio.2017.07.003_bib5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/ajmg.a.35762","article-title":"Vertical transmission of a frontonasal phenotype caused by a novel ALX4 mutation","volume":"161A","author":"Bertola","year":"2013","journal-title":"Am. J. Med. Genet. Part A"},{"key":"10.1016\/j.ydbio.2017.07.003_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<713::AID-JNR8>3.0.CO;2-K","article-title":"Oligodendrocyte-specific protein (OSP) is a major component of CNS myelin","volume":"50","author":"Bronstein","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ydbio.2017.07.003_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/hmg\/ddi037","article-title":"In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation","volume":"14","author":"Brown","year":"2005","journal-title":"Human. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1567-133X(03)00043-7","article-title":"Immunolocalization of Zic2 expression in the developing mouse forebrain","volume":"3","author":"Brown","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.ydbio.2017.07.003_bib9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/hmg\/10.8.791","article-title":"Holoprosencephaly due to mutations in ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination","volume":"10","author":"Brown","year":"2001","journal-title":"Human. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/2484","article-title":"Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired","volume":"20","author":"Brown","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib11","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/hmg\/ddq030","article-title":"A primary cilia-dependent etiology for midline facial disorders","volume":"19","author":"Brugmann","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mod.2012.10.002","article-title":"Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development","volume":"130","author":"Cannon","year":"2013","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nmeth.1606","article-title":"In vivo protein trapping produces a functional expression codex of the vertebrate proteome","volume":"8","author":"Clark","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2017.07.003_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/dev.129.4.1061","article-title":"Interactions between Hox-negative cephalic neural crest cells and the foregut endoderm in patterning the facial skeleton in the vertebrate head","volume":"129","author":"Couly","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1756-0500-3-73","article-title":"RNA isolation method for single embryo transcriptome analysis in zebrafish","volume":"3","author":"de Jong","year":"2010","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.ydbio.2017.07.003_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/hmg\/dds423","article-title":"Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia","volume":"22","author":"Dee","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-213X-13-31","article-title":"The role of Zic transcription factors in regulating hindbrain retinoic acid signaling","volume":"13","author":"Drummond","year":"2013","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ng.82","article-title":"MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis","volume":"40","author":"Eberhart","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib19","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0960-9822(95)00185-0","article-title":"Patterning activities of vertebrate hedgehog proteins in the developing eye and brain","volume":"5","author":"Ekker","year":"1995","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.ydbio.2017.07.003_bib20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.modgep.2004.03.003","article-title":"Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation","volume":"4","author":"Elms","year":"2004","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.ydbio.2017.07.003_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ydbio.2003.09.005","article-title":"Zic2 is required for neural crest formation and hindbrain patterning during mouse development","volume":"264","author":"Elms","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ydbio.2007.12.006","article-title":"Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis","volume":"314","author":"Elsen","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib23","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.neuron.2013.10.007","article-title":"Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS","volume":"80","author":"Escalante","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2017.07.003_bib24","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1093\/hmg\/ddi365","article-title":"Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development","volume":"14","author":"Evans","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nn.3995","article-title":"Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum","volume":"18","author":"Frank","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2017.07.003_bib26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ydbio.2011.10.026","article-title":"Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt\/beta-catenin signaling pathway","volume":"361","author":"Fujimi","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib27","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1242\/dev.020693","article-title":"Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms","volume":"135","author":"Garcia-Frigola","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib28","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/dneu.20919","article-title":"The visual system of zebrafish and its use to model human ocular diseases","volume":"72","author":"Gestri","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/dvdy.20060","article-title":"Two Frodo\/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish","volume":"230","author":"Gillhouse","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib30","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.bbadis.2010.09.005","article-title":"Aberrant forebrain signaling during early development underlies the generation of holoprosencephaly and coloboma","volume":"1812","author":"Gongal","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2017.07.003_bib31","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/jmg.2004.025494","article-title":"Ocular coloboma: a reassessment in the age of molecular neuroscience","volume":"41","author":"Gregory-Evans","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib32","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/dvdy.1221","article-title":"zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula","volume":"222","author":"Grinblat","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib33","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1073\/pnas.0501061102","article-title":"Tbx2b is essential for neuronal differentiation along the dorsal\/ventral axis of the zebrafish retina","volume":"102","author":"Gross","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2017.07.003_bib34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/srep00016","article-title":"Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients","volume":"1","author":"Hatayama","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2017.07.003_bib35","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(03)00684-6","article-title":"Zic2 patterns binocular vision by specifying the uncrossed retinal projection","volume":"114","author":"Herrera","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2017.07.003_bib36","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1093\/hmg\/ddw235","article-title":"Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling","volume":"25","author":"Houtmeyers","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib37","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/dvdy.20001","article-title":"nlz gene family is required for hindbrain patterning in the zebrafish","volume":"229","author":"Hoyle","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ydbio.2017.07.003_bib39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ydbio.2007.04.003","article-title":"Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo","volume":"306","author":"Inoue","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ajmg.a.34375","article-title":"Duplication of the ZIC2 gene is not associated with holoprosencephaly","volume":"158A","author":"Jobanputra","year":"2012","journal-title":"Am. J. Med. Genet. Part A"},{"key":"10.1016\/j.ydbio.2017.07.003_bib41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/dbio.1998.9016","article-title":"The shaping of pharyngeal cartilages during early development of the zebrafish","volume":"203","author":"Kimmel","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/dvg.20716","article-title":"The eye as an organizer of craniofacial development","volume":"49","author":"Kish","year":"2011","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2017.07.003_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.devcel.2014.11.018","article-title":"Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish","volume":"32","author":"Kok","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2017.07.003_bib45","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/dvdy.24162","article-title":"Coming into focus: the role of extracellular matrix in vertebrate optic cup morphogenesis","volume":"243","author":"Kwan","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib46","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ydbio.2010.06.002","article-title":"Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects","volume":"344","author":"Lakhwani","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib47","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/dvdy.21577","article-title":"The eye organizes neural crest cell migration","volume":"237","author":"Langenberg","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib48","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainresrev.2007.06.023","article-title":"Role of the neural crest in face and brain development","volume":"55","author":"Le Douarin","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ydbio.2008.03.035","article-title":"Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye","volume":"319","author":"Lee","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib51","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1523\/JNEUROSCI.0632-08.2008","article-title":"Zic2 regulates retinal ganglion cell axon avoidance of ephrinB2 through inducing expression of the guidance receptor EphB1. The","volume":"28","author":"Lee","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2017.07.003_bib52","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/bioinformatics\/btt087","article-title":"EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments","volume":"29","author":"Leng","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2017.07.003_bib53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.ydbio.2017.07.003_bib54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1097>3.0.CO;2-1","article-title":"Specific pan-neural crest expression of zebrafish Crestin throughout embryonic development","volume":"220","author":"Luo","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib55","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.molcel.2015.01.007","article-title":"Zic2 is an enhancer-binding factor required for embryonic stem cell specification","volume":"57","author":"Luo","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2017.07.003_bib56","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1073\/pnas.1103802108","article-title":"Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme","volume":"108","author":"Lupo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2017.07.003_bib57","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1242\/dev.01726","article-title":"Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling","volume":"132","author":"Lupo","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib58","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1242\/dev.121.10.3267","article-title":"Midline signalling is required for Pax gene regulation and patterning of the eyes","volume":"121","author":"Macdonald","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0896-6273(00)00034-9","article-title":"Midline signals regulate retinal neurogenesis in zebrafish","volume":"27","author":"Masai","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2017.07.003_bib60","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1242\/dev.129.13.3055","article-title":"Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development","volume":"129","author":"Mathieu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ydbio.2008.04.039","article-title":"Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis","volume":"320","author":"Matt","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib62","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1101\/gad.517009","article-title":"Zic-associated holoprosencephaly: zebrafish Zic1 controls midline formation and forebrain patterning by regulating Nodal, Hedgehog, and retinoic acid signaling","volume":"23","author":"Maurus","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib63","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ydbio.2009.05.577","article-title":"Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish","volume":"332","author":"McMahon","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib64","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.145.3.579","article-title":"Claudin-11\/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis","volume":"145","author":"Morita","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib65","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1101\/gad.1276605","article-title":"Vax genes ventralize the embryonic eye","volume":"19","author":"Mui","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib66","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.devcel.2015.04.018","article-title":"Atypical transcriptional activation by TCF via a zic transcription factor in C. elegans neuronal precursors","volume":"33","author":"Murgan","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2017.07.003_bib67","doi-asserted-by":"crossref","first-page":"11266","DOI":"10.1523\/JNEUROSCI.0779-15.2015","article-title":"Zic2 controls the migration of specific neuronal populations in the developing forebrain","volume":"35","author":"Murillo","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2017.07.003_bib68","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1073\/pnas.97.4.1618","article-title":"Zic2 regulates the kinetics of neurulation","volume":"97","author":"Nagai","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2017.07.003_bib69","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/dbio.1996.8449","article-title":"The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation","volume":"182","author":"Nagai","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib70","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1073\/pnas.94.22.11980","article-title":"Xenopus Zic3, a primary regulator both in neural and neural crest development","volume":"94","author":"Nakata","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2017.07.003_bib71","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0925-4773(98)00073-2","article-title":"Xenopus Zic family and its role in neural and neural crest development","volume":"75","author":"Nakata","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib72","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1242\/jcs.043471","article-title":"A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation","volume":"122","author":"Nyholm","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2017.07.003_bib73","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1242\/dev.02756","article-title":"The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum","volume":"134","author":"Nyholm","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib74","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0039-6257(00)00151-X","article-title":"Ocular colobomata","volume":"45","author":"Onwochei","year":"2000","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib75","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ydbio.2010.12.037","article-title":"A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis","volume":"351","author":"Pan","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib76","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1242\/dev.124.20.4153","article-title":"Patterning of the chick forebrain anlage by the prechordal plate","volume":"124","author":"Pera","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib77","doi-asserted-by":"crossref","first-page":"e1004491","DOI":"10.1371\/journal.pgen.1004491","article-title":"Sox11 is required to maintain proper levels of Hedgehog signaling during vertebrate ocular morphogenesis","volume":"10","author":"Pillai-Kastoori","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib78","doi-asserted-by":"crossref","first-page":"37732","DOI":"10.1074\/jbc.M111.242826","article-title":"Transcription factor Zic2 inhibits Wnt\/beta-catenin protein signaling","volume":"286","author":"Pourebrahim","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2017.07.003_bib79","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1242\/dev.126.2.359","article-title":"Physical and genetic interactions between Alx4 and Cart1","volume":"126","author":"Qu","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib80","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/bdra.23047","article-title":"Comparison of mutation findings in ZIC2 between microform and classical holoprosencephaly in a Brazilian cohort","volume":"94","author":"Ribeiro","year":"2012","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib81","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2017.07.003_bib82","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1196-357","article-title":"Mutations in the human Sonic Hedgehog gene cause holoprosencephaly","volume":"14","author":"Roessler","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib83","doi-asserted-by":"crossref","first-page":"E541","DOI":"10.1002\/humu.20982","article-title":"The full spectrum of holoprosencephaly-associated mutations within the ZIC2 gene in humans predicts loss-of-function as the predominant disease mechanism","volume":"30","author":"Roessler","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ydbio.2017.07.003_bib84","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ajmg.c.30236","article-title":"The molecular genetics of holoprosencephaly","volume":"154C","author":"Roessler","year":"2010","journal-title":"Am. J. Med. Genet. Part C. Semin. Med. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib85","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature14580","article-title":"Genetic compensation induced by deleterious mutations but not gene knockdowns","volume":"524","author":"Rossi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2017.07.003_bib86","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev.neuro.21.1.445","article-title":"Regionalization of the prosencephalic neural plate","volume":"21","author":"Rubenstein","year":"1998","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2017.07.003_bib87","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ydbio.2008.02.029","article-title":"A novel role for zebrafish zic2a during forebrain development","volume":"317","author":"Sanek","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib88","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1242\/dev.037820","article-title":"Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression","volume":"136","author":"Sanek","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib89","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/dbio.1999.9214","article-title":"Regulation of left-right asymmetries in the zebrafish by Shh and BMP4","volume":"210","author":"Schilling","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib90","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ajmg.a.10884","article-title":"Novel mutation in sonic hedgehog in non-syndromic colobomatous microphthalmia","volume":"116A","author":"Schimmenti","year":"2003","journal-title":"Am. J. Med. Genet. Part A"},{"key":"10.1016\/j.ydbio.2017.07.003_bib91","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.903440404","article-title":"Early eye morphogenesis in the zebrafish, Brachydanio rerio","volume":"344","author":"Schmitt","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib92","doi-asserted-by":"crossref","first-page":"34437","DOI":"10.1038\/srep34437","article-title":"Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia","volume":"6","author":"Sedykh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2017.07.003_bib93","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ydbio.2008.03.041","article-title":"Ectopic Pax2 expression in chick ventral optic cup phenocopies loss of Pax2 expression","volume":"319","author":"Sehgal","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib94","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1242\/dev.124.14.2709","article-title":"Inductive interactions direct early regionalization of the mouse forebrain","volume":"124","author":"Shimamura","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib95","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/jmedgenet-2012-101008","article-title":"Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog","volume":"49","author":"Solomon","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib96","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/jmg.2009.073049","article-title":"Mutations in ZIC2 in human holoprosencephaly: description of a novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals","volume":"47","author":"Solomon","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib97","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/dvdy.22713","article-title":"Examination of a palatogenic gene program in zebrafish","volume":"240","author":"Swartz","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2017.07.003_bib98","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1242\/dev.00305","article-title":"Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity","volume":"130","author":"Take-uchi","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib99","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ydbio.2013.04.033","article-title":"Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development","volume":"380","author":"Teslaa","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib100","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.modgep.2003.09.011","article-title":"Sequence relationships and expression patterns of zebrafish zic2 and zic5 genes","volume":"4","author":"Toyama","year":"2004","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.ydbio.2017.07.003_bib101","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ajhg.2010.04.002","article-title":"Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia","volume":"86","author":"Uz","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib102","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1242\/dev.128.18.3497","article-title":"Zebrafish smoothened functions in ventral neural tube specification and axon tract formation","volume":"128","author":"Varga","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib103","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1242\/dev.01943","article-title":"Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull","volume":"132","author":"Wada","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib104","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13064-015-0035-9","article-title":"Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling","volume":"10","author":"Wang","year":"2015","journal-title":"Neural Dev."},{"key":"10.1016\/j.ydbio.2017.07.003_bib105","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1093\/hmg\/ddn197","article-title":"Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation","volume":"17","author":"Warr","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib106","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ydbio.2014.12.026","article-title":"Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis","volume":"399","author":"Wen","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2017.07.003_bib107","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio)","author":"Westerfield","year":"1993"},{"key":"10.1016\/j.ydbio.2017.07.003_bib108","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ejmg.2014.05.002","article-title":"The genetic architecture of microphthalmia, anophthalmia and coloboma","volume":"57","author":"Williamson","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib109","doi-asserted-by":"crossref","first-page":"e1003852","DOI":"10.1371\/journal.pgen.1003852","article-title":"Genome wide analysis reveals Zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish","volume":"9","author":"Winata","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2017.07.003_bib110","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1002\/ajmg.a.31963","article-title":"Subtypes of frontonasal dysplasia are useful in determining clinical prognosis","volume":"143A","author":"Wu","year":"2007","journal-title":"Am. J. Med. Genet. Part A"},{"key":"10.1016\/j.ydbio.2017.07.003_bib111","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1242\/dev.008177","article-title":"Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling","volume":"134","author":"Ybot-Gonzalez","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib112","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1242\/dev.052340","article-title":"Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape","volume":"137","author":"Young","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2017.07.003_bib113","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.devcel.2011.12.023","article-title":"Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia","volume":"22","author":"Zhao","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2017.07.003_bib114","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng0796-275","article-title":"Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene","volume":"13","author":"Zhao","year":"1996","journal-title":"Nat. Genet."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160617301768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160617301768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T22:50:04Z","timestamp":1762123804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160617301768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0012160617301768"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2017.07.003","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2017.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}