{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:38:38Z","timestamp":1770417518681,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.ydbio.2018.01.016","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T12:11:03Z","timestamp":1517573463000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues"],"prefix":"10.1016","volume":"435","author":[{"given":"Sandra C.P.","family":"De Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline S.","family":"Hirst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Savery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Lickert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogi","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Copp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas D.E.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2018.01.016_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00418-016-1487-7","article-title":"Grhl3 modulates epithelial structure formation of the circumvallate papilla during mouse development","volume":"147","author":"Adhikari","year":"2017","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.bbagrm.2015.01.005","article-title":"Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition","volume":"1849","author":"Alotaibi","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2018.01.016_bib3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1242\/dev.113.2.671","article-title":"Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo","volume":"113","author":"Brook","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib4","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/hmg\/ddr031","article-title":"Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse","volume":"20","author":"Brouns","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.devcel.2009.11.014","article-title":"Local protease signalling contributes to neural tube closure in the mouse embryo","volume":"18","author":"Camerer","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2018.01.016_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/hmg\/ddh003","article-title":"Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol","volume":"13","author":"Cogram","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib7","first-page":"39","article-title":"Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture","volume":"88","author":"Copp","year":"1985","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1242\/dev.104.2.285","article-title":"A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects","volume":"104","author":"Copp","year":"1988","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1242\/dev.104.2.297","article-title":"Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation","volume":"104","author":"Copp","year":"1988","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(13)70110-8","article-title":"Neural tube defects: recent advances, unsolved questions, and controversies","author":"Copp","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib11","doi-asserted-by":"crossref","first-page":"e1003059","DOI":"10.1371\/journal.pgen.1003059","article-title":"Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice","volume":"8","author":"de Castro","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/dvg.20540","article-title":"Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells","volume":"47","author":"Engert","year":"2009","journal-title":"Genesis."},{"key":"10.1016\/j.ydbio.2018.01.016_bib13","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1172\/JCI77138","article-title":"A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia","volume":"124","author":"Gordon","year":"2014","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.ydbio.2018.01.016_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-neuro-062012-170354","article-title":"Neural tube defects","volume":"37","author":"Greene","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2018.01.016_bib15","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/bdra.20494","article-title":"Grainyhead genes and mammalian neural tube closure","volume":"82","author":"Gustavsson","year":"2008","journal-title":"Birth Defects Res. A Clin Mol. Teratol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib16","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/hmg\/ddm221","article-title":"Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model","volume":"16","author":"Gustavsson","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib17","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1242\/dev.119768","article-title":"Neuromesodermal progenitors and the making of the spinal cord","volume":"142","author":"Henrique","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib18","doi-asserted-by":"crossref","first-page":"e1002829","DOI":"10.1371\/journal.pgen.1002829","article-title":"GRHL3\/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program","volume":"8","author":"Hopkin","year":"2012","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ng747","article-title":"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer","volume":"29","author":"Jonkers","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ebiom.2015.04.012","article-title":"Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure","volume":"2","author":"Kimura-Yoshida","year":"2015","journal-title":"EBioMedicine."},{"key":"10.1016\/j.ydbio.2018.01.016_bib21","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1073\/pnas.0611376104","article-title":"p63 induces key target genes required for epidermal morphogenesis","volume":"104","author":"Koster","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ydbio.2018.01.016_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/dvdy.10255","article-title":"Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor","volume":"226","author":"Kudryavtseva","year":"2003","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2018.01.016_bib23","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1006\/geno.1995.9946","article-title":"A curly-tail modifier locus, mct1, on mouse chromosome 17","volume":"29","author":"Letts","year":"1995","journal-title":"Genomics"},{"key":"10.1016\/j.ydbio.2018.01.016_bib24","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1093\/brain\/awt209","article-title":"Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse","volume":"136","author":"Leung","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.ydbio.2018.01.016_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng0494-357","article-title":"Multifactorial inheritance of neural tube defects: Localization of the major gene and recognition of modifiers in ct mutant mice","volume":"6","author":"Neumann","year":"1994","journal-title":"Nature Genet."},{"key":"10.1016\/j.ydbio.2018.01.016_bib26","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1242\/dev.145904","article-title":"Neural tube closure: cellular, molecular and biomechanical mechanisms","volume":"144","author":"Nikolopoulou","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1242\/dev.99.4.509","article-title":"Differential deposition of basement membrane components during formation of the caudal neural tube in the mouse embryo","volume":"99","author":"O'Shea","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/bdra.23072","article-title":"Epithelial fusion during neural tube morphogenesis","volume":"94","author":"Pai","year":"2012","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib29","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1242\/dev.068338","article-title":"Mechanisms of tissue fusion during development","volume":"139","author":"Ray","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.01.016_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ydbio.2016.06.030","article-title":"Dynamic behaviors of the non-neural ectoderm during mammalian cranial neural tube closure","volume":"416","author":"Ray","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13273","article-title":"Regulation of cell protrusions by small GTPases during fusion of the neural folds","volume":"5","author":"Rolo","year":"2016","journal-title":"Elife."},{"key":"10.1016\/j.ydbio.2018.01.016_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev. Biol"},{"key":"10.1016\/j.ydbio.2018.01.016_bib33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1107511","article-title":"A homolog of Drosophila grainy head is essential for epidermal integrity in mice","volume":"308","author":"Ting","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2018.01.016_bib34","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/nm961","article-title":"Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3","volume":"9","author":"Ting","year":"2003","journal-title":"Nature Med."},{"key":"10.1016\/j.ydbio.2018.01.016_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1042\/bj20021476","article-title":"The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors","volume":"370","author":"Ting","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2018.01.016_bib36","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.1128\/MCB.17.11.6727","article-title":"Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead","volume":"17","author":"Uv","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s004290100169","article-title":"Curly tail: a 50-year history of the mouse spina bifida model","volume":"203","author":"Van Straaten","year":"2001","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.ydbio.2018.01.016_bib38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ydbio.2006.07.015","article-title":"The Grainyhead-like epithelial transactivator Get-1\/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4","volume":"299","author":"Yu","year":"2006","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160617308060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160617308060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T20:41:37Z","timestamp":1660423297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160617308060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0012160617308060"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2018.01.016","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2018.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}