{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:49:02Z","timestamp":1790844542206,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Irma and Norman Braman Endowment"},{"name":"Scott Lustgarten Center Endowment"},{"name":"Children\u2019s Hospital of Philadelphia Research Institute"},{"name":"St. Louis Children\u2019s Hospital","award":["MD-II2013-269"],"award-info":[{"award-number":["MD-II2013-269"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1 DK087715"],"award-info":[{"award-number":["RO1 DK087715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HD046767"],"award-info":[{"award-number":["R01 HD046767"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes","doi-asserted-by":"publisher","award":["6-FY15-235"],"award-info":[{"award-number":["6-FY15-235"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basil O\u2019Connor Award"},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1008525"],"award-info":[{"award-number":["1008525"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["20150331717"],"award-info":[{"award-number":["20150331717"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ydbio.2018.09.017","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T03:36:38Z","timestamp":1538710598000},"page":"S337-S351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"S1","title":["Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit"],"prefix":"10.1016","volume":"444","author":[{"given":"Silvia Huerta","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Avetisyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Mesbah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Heuckeroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2018.09.017_bib1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1161\/CIRCRESAHA.108.192450","article-title":"The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle","volume":"104","author":"Aanhaanen","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"Amiel","year":"2008","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2018.09.017_bib3","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.107.169565","article-title":"Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system","volume":"102","author":"Bakker","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng0797-311","article-title":"Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome","volume":"16","author":"Bamshad","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2018.09.017_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/cge.12032","article-title":"The developmental genetics of Hirschsprung\u2019s disease","volume":"83","author":"Bergeron","year":"2013","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2018.09.017_bib6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cne.23423","article-title":"Birthdating of myenteric neuron subtypes in the small intestine of the mouse","volume":"522","author":"Bergner","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib7","first-page":"12","article-title":"Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma","author":"Burgucu","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ydbio.2018.09.017_bib8","doi-asserted-by":"crossref","DOI":"10.1242\/dev.067082","article-title":"Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development","volume":"139","author":"Bush","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2006.11.002","article-title":"A novel method for oral delivery of drug compounds to the neonatal SMNDelta7 mouse model of spinal muscular atrophy","author":"Butchbach","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ydbio.2018.09.017_bib10","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2018.09.017_bib11","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib12","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/dvdy.20833","article-title":"Recent advances in craniofacial morphogenesis","volume":"235","author":"Chai","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2018.09.017_bib13","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1523\/JNEUROSCI.3688-03.2004","article-title":"Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset","volume":"24","author":"Chalazonitis","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2018.09.017_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/23262133.2017.1293958","article-title":"Toward a better understanding of enteric gliogenesis","author":"Charrier","year":"2017","journal-title":"Neurogenesis"},{"key":"10.1016\/j.ydbio.2018.09.017_bib15","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1053\/j.gastro.2011.04.059","article-title":"Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice","volume":"141","author":"D\u2019Autr\u00e9aux","year":"2011","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.ydbio.2018.09.017_bib16","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1242\/dev.00431","article-title":"Mammary gland, limb and yolk sac defects in mice lacking\u00a0Tbx3, the gene mutated in human ulnar mammary syndrome","volume":"130","author":"Davenport","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10911-013-9282-8","article-title":"The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer","volume":"18","author":"Douglas","year":"2013","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"1","key":"10.1016\/j.ydbio.2018.09.017_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Acids Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.07897","article-title":"T-box 3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number","volume":"5","author":"Emechebe","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2018.09.017_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.103.Supplement.41","article-title":"Palate development","volume":"103","author":"Ferguson","year":"1988","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib22","doi-asserted-by":"crossref","first-page":"E154","DOI":"10.1073\/pnas.1115165109","article-title":"Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis","volume":"109","author":"Frank","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ydbio.2018.09.017_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0067841","article-title":"Mouse Tbx3 mutants suggest novel molecular mechanisms for ulnar-mammary syndrome","volume":"8","author":"Frank","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2018.09.017_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ydbio.2006.07.016","article-title":"BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition","volume":"299","author":"Fu","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib25","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1177\/0022034517719749","article-title":"Identification of Osr2 transcriptional target genes in palate development","volume":"96","author":"Fu","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib26","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/dev.00433","article-title":"GDNF availability determines enteric neuron number by controlling precursor proliferation","author":"Gianino","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib28","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.mod.2005.03.003","article-title":"BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system","volume":"122","author":"Goldstein","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2018.09.017_bib29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/cge.12054","article-title":"Building a brain in the gut: development of the enteric nervous system","volume":"83","author":"Goldstein","year":"2013","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2018.09.017_bib30","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.mod.2010.03.001","article-title":"Tbx1 is necessary for palatal elongation and elevation","volume":"127","author":"Goudy","year":"2010","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2018.09.017_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-017-1174-6","article-title":"Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes","volume":"18","author":"Gui","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib32","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1242\/dev.01378","article-title":"Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development","volume":"131","author":"Harrelson","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib33","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1073\/pnas.0602152103","article-title":"Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes","volume":"103","author":"Heanue","year":"2006","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"10.1016\/j.ydbio.2018.09.017_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/dvdy.20989","article-title":"Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system","volume":"236","author":"Hendershot","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2018.09.017_bib35","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1101\/gad.416007","article-title":"Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria","volume":"21","author":"Hoogaars","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2018.09.017_bib36","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/dvdy.21714","article-title":"Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development","volume":"237","author":"Huang","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2018.09.017_bib37","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1242\/dev.00708","article-title":"Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects","volume":"130","author":"Ito","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/dbio.2001.0487","article-title":"Tissue origins and interactions in the mammalian skull vault","volume":"241","author":"Jiang","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00441-008-0612-x","article-title":"Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion","volume":"333","author":"Jin","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib40","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/hmg\/ddv051","article-title":"Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms","volume":"24","author":"Kapoor","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2018.09.017_bib41","first-page":"10","article-title":"TBX3 Regulates splicing In vivo: a novel Molecular mechanism for ulnar-mammary syndrome","author":"Kumar","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2018.09.017_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.02805","article-title":"Coordinated control of senescence by lncRNA and a novel T-box 3 co-repressor complex","volume":"3","author":"Kumar P","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2018.09.017_bib43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ydbio.2015.11.004","article-title":"Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton","volume":"409","author":"Lake","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib44","first-page":"G1","article-title":"Enteric nervous system development: migration, differentiation, and disease. AJP Gastrointest","volume":"305","author":"Lake","year":"2013","journal-title":"Liver Physiol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib45","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1172\/JCI69781","article-title":"Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis","volume":"123","author":"Lake","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2018.09.017_bib46","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1242\/dev.01175","article-title":"Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis","volume":"131","author":"Lan","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib47","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1242\/dev.028167","article-title":"Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth","volume":"136","author":"Lan","year":"2009","journal-title":"Development"},{"issue":"80-.","key":"10.1016\/j.ydbio.2018.09.017_bib48","article-title":"Instructive role of Wnt\/\u03b2-Catenin in sensory fate specification in neural crest stem cells","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2018.09.017_bib49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00441-006-0271-8","article-title":"Modulation of cell proliferation during palatogenesis by the interplay between Tbx3 and Bmp4","volume":"327","author":"Lee","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep16473","article-title":"Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease","volume":"5","author":"Luz\u00f3n-Toro","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2018.09.017_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/wdev.57","article-title":"Hirschsprung disease: a developmental disorder of the enteric nervous system","volume":"2","author":"Mckeown","year":"2013","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tera.1420220306","article-title":"Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S","volume":"22","author":"McLeod","year":"1980","journal-title":"Teratology"},{"key":"10.1016\/j.ydbio.2018.09.017_bib53","first-page":"1","article-title":"Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system","author":"Memic","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2018.09.017_bib54","first-page":"624","article-title":"Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system","author":"Memic","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2018.09.017_bib55","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCRESAHA.108.172858","article-title":"Tbx3 is required for outflow tract development","volume":"103","author":"Mesbah","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ydbio.2018.09.017_bib56","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0160-5402(81)90110-8","article-title":"Accurate measurement of intestinal transit in the rat","volume":"6","author":"Miller","year":"1981","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.ydbio.2018.09.017_bib57","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/dev.124.1.113","article-title":"Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development","volume":"124","author":"Mo","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib58","doi-asserted-by":"crossref","DOI":"10.1172\/JCI43737","article-title":"Hedgehog\/notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans","author":"Ngan","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2018.09.017_bib59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrgastro.2012.234","article-title":"Development and developmental disorders of the enteric nervous system","volume":"10","author":"Obermayr","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib60","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.devcel.2014.09.018","article-title":"HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme","volume":"31","author":"Osterwalder","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2018.09.017_bib61","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1172\/JCI39929","article-title":"Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction","volume":"119","author":"Puig","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2018.09.017_bib62","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1242\/dev.01787","article-title":"Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo","volume":"132","author":"Rallis","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib63","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.07.002","article-title":"Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice","author":"Rao","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ydbio.2018.09.017_bib64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/B:JOMG.0000037156.64331.3f","article-title":"The role of Tbx2 and Tbx3 in mammary development and tumorigenesis","volume":"9","author":"Rowley","year":"2004","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.ydbio.2018.09.017_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ydbio.2012.01.012","article-title":"The enteric nervous system","volume":"366","author":"Sasselli","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib66","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00018-011-0884-2","article-title":"Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation","volume":"69","author":"Singh","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ydbio.2018.09.017_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1534-5807(03)00401-5","article-title":"Tbx genes specify posterior digit identity through Shh and BMP signaling","volume":"6","author":"Suzuki","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2018.09.017_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1440-169x.2001.00556.x","article-title":"T-targets: clues to understanding the functions of T-box proteins","volume":"43","author":"Tada","year":"2001","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.ydbio.2018.09.017_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00040.2007","article-title":"Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases","volume":"89","author":"Turgeon","year":"2009","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.ydbio.2018.09.017_bib71","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/dbio.2002.0762","article-title":"Regulation of\u00a0Tbx3\u00a0expression by anteroposterior signalling in vertebrate limb development","volume":"250","author":"T\u00fcmpel","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib72","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1172\/JCI62613","article-title":"Genetic variation in T-box binding element functionally affects SCN5A\/SCN10A enhancer","volume":"122","author":"Van Den Boogaard","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2018.09.017_bib73","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ydbio.2006.06.033","article-title":"Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis","volume":"298","author":"Vohra","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib74","first-page":"176","article-title":"Closure of the secondary palate in three strains of mice","volume":"4","author":"Walker","year":"1956","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.ydbio.2018.09.017_bib75","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.stemcr.2013.08.002","article-title":"TBX3 directs cell-fate decision toward mesendoderm","volume":"1","author":"Weidgang","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ydbio.2018.09.017_bib76","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/BF03401719","article-title":"Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation","volume":"3","author":"Yang","year":"1997","journal-title":"Mol. Med."},{"key":"10.1016\/j.ydbio.2018.09.017_bib77","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1242\/dev.129.17.4135","article-title":"Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis","volume":"129","author":"Zhang","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2018.09.017_bib78","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1038\/onc.2015.486","article-title":"TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle","volume":"35","author":"Zhu","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2018.09.017_bib79","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2009.09.020","article-title":"Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse","volume":"336","author":"Zirzow","year":"2009","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160618302355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160618302355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T09:41:56Z","timestamp":1662198116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160618302355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":79,"alternative-id":["S0012160618302355"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2018.09.017","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2018.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}