{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:53:04Z","timestamp":1790819584337,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["#I-1906"],"award-info":[{"award-number":["#I-1906"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["-1906"],"award-info":[{"award-number":["-1906"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10RR029731"],"award-info":[{"award-number":["S10RR029731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01GM113023"],"award-info":[{"award-number":["1R01GM113023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ydbio.2019.03.011","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T11:32:30Z","timestamp":1553340750000},"page":"47-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities"],"prefix":"10.1016","volume":"450","author":[{"given":"Issei S.","family":"Shimada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandarigoda N.","family":"Somatilaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley G.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Rajaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Konopka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2019.03.011_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1242\/dev.02238","article-title":"The interpretation of morphogen gradients","volume":"133","author":"Ashe","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib2","doi-asserted-by":"crossref","first-page":"7786","DOI":"10.1073\/pnas.1608061113","article-title":"Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling","volume":"113","author":"Bachmann","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2019.03.011_bib3","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1126\/science.1244392","article-title":"Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning","volume":"343","author":"Bae","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2019.03.011_bib4","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1242\/dev.128.24.5161","article-title":"Gli1 can rescue the in vivo function of Gli2","volume":"128","author":"Bai","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib5","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1242\/dev.02153","article-title":"Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus","volume":"132","author":"Banizs","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/ng.423","article-title":"Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies","volume":"41","author":"Bielas","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib7","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1242\/dev.02339","article-title":"Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid\/hindbrain region","volume":"133","author":"Blaess","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.conb.2014.02.007","article-title":"Role of radial glial cells in cerebral cortex folding","volume":"27","author":"Borrell","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ajhg.2008.06.023","article-title":"Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome","volume":"83","author":"Cantagrel","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/hmg\/ddr531","article-title":"A\u00a0glial origin for periventricular nodular heterotopia caused by impaired expression of filamin-A","volume":"21","author":"Carabalona","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.devcel.2007.03.004","article-title":"The graded response to Sonic Hedgehog depends on cilia architecture","volume":"12","author":"Caspary","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2019.03.011_bib12","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/cercor\/13.6.592","article-title":"Cell output, cell cycle duration and neuronal specification: a model of integrated mechanisms of the neocortical proliferative process","volume":"13","author":"Caviness","year":"2003","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.ydbio.2019.03.011_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(95)93933-O","article-title":"Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model","volume":"18","author":"Caviness","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1126\/science.1074192","article-title":"Regulation of cerebral cortical size by control of cell cycle exit in neural precursors","volume":"297","author":"Chenn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2019.03.011_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014680","article-title":"Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors","volume":"6","author":"Dave","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2019.03.011_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nrm1855","article-title":"Spemann's organizer and self-regulation in amphibian embryos","volume":"7","author":"De Robertis","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib17","doi-asserted-by":"crossref","first-page":"19836","DOI":"10.1073\/pnas.0609628104","article-title":"Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis","volume":"103","author":"Feng","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2019.03.011_bib18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/hmg\/ddn377","article-title":"Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia","volume":"18","author":"Ferland","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib19","first-page":"201","article-title":"mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis","volume":"144","author":"Foerster","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib20","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.cell.2015.05.041","article-title":"Embryonic origin of postnatal neural stem cells","volume":"161","author":"Fuentealba","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2019.03.011_bib21","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/nn1340","article-title":"GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain","volume":"7","author":"Garcia","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg2774","article-title":"The primary cilium: a signalling centre during vertebrate development","volume":"11","author":"Goetz","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11859","article-title":"A\u00a0G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins","volume":"4","author":"Gotthardt","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2019.03.011_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","article-title":"The cell biology of neurogenesis","volume":"6","author":"Gotz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrn3586","article-title":"Molecular logic of neocortical projection neuron specification, development and diversity","volume":"14","author":"Greig","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib26","series-title":"Gli3 Controls the Onset of Cortical Neurogenesis by Regulating the Radial Glial Cell Cycle through Cdk 6 Expression","first-page":"145","author":"Hasenpusch-Theil","year":"2018"},{"key":"10.1016\/j.ydbio.2019.03.011_bib27","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.devcel.2012.09.019","article-title":"Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex","volume":"23","author":"Higginbotham","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2019.03.011_bib28","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/nn.3451","article-title":"Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation","volume":"16","author":"Higginbotham","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-213X-10-118","article-title":"Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures","volume":"10","author":"Himmelstein","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib30","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/hmg\/ddm096","article-title":"Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly","volume":"16","author":"Huang","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1101\/gad.1902910","article-title":"The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins","volume":"24","author":"Humke","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2019.03.011_bib32","series-title":"The G Protein-Coupled Receptor Gpr161 Regulates Forelimb Formation, Limb Patterning and Skeletal Morphogenesis in a Primary Cilium-dependent Manner","first-page":"145","author":"Hwang","year":"2018"},{"key":"10.1016\/j.ydbio.2019.03.011_bib33","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/hmg\/ddh219","article-title":"Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation","volume":"13","author":"Ibanez-Tallon","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ydbio.2009.04.009","article-title":"Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia","volume":"330","author":"Jia","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib35","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1523\/JNEUROSCI.2166-10.2011","article-title":"Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor","volume":"31","author":"Kim","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib36","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1242\/dev.015891","article-title":"Hedgehog signaling is involved in development of the neocortex","volume":"135","author":"Komada","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib37","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1242\/dev.069963","article-title":"Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex","volume":"139","author":"Kwan","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cne.10964","article-title":"Neural stem and progenitor cells in nestin-GFP transgenic mice","volume":"469","author":"Mignone","year":"2004","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.semcdb.2014.05.002","article-title":"G-protein-coupled receptors, Hedgehog signaling and primary cilia","volume":"33","author":"Mukhopadhyay","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2012.12.026","article-title":"The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling","volume":"152","author":"Mukhopadhyay","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2019.03.011_bib41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.neuron.2014.06.022","article-title":"Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus","volume":"83","author":"Ohata","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2019.03.011_bib42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/embr.201438447","article-title":"Neurogenesis during development of the vertebrate central nervous system","volume":"15","author":"Paridaen","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ydbio.2019.03.011_bib43","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1093\/brain\/awl125","article-title":"Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations","volume":"129","author":"Parrini","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.ydbio.2019.03.011_bib44","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fnana.2017.00102","article-title":"Transcriptional and post-transcriptional mechanisms of the development of neocortical lamination","volume":"11","author":"Popovitchenko","year":"2017","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.ydbio.2019.03.011_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cne.901450105","article-title":"Mode of cell migration to the superficial layers of fetal monkey neocortex","volume":"145","author":"Rakic","year":"1972","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0166-2236(95)93934-P","article-title":"A\u00a0small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution","volume":"18","author":"Rakic","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/ncb3512","article-title":"Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division","volume":"19","author":"Saade","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib48","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.celrep.2013.06.038","article-title":"Sonic hedgehog signaling switches the mode of division in the developing nervous system","volume":"4","author":"Saade","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2019.03.011_bib49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuron.2009.06.006","article-title":"Fgf 10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors","volume":"63","author":"Sahara","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2019.03.011_bib50","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuron.2006.10.024","article-title":"MEKK4 signaling regulates filamin expression and neuronal migration","volume":"52","author":"Sarkisian","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2019.03.011_bib51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ydbio.2010.10.014","article-title":"Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages","volume":"349","author":"Shikata","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib52","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1101\/gad.291773.116","article-title":"Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells","volume":"31","author":"Shimada","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2019.03.011_bib53","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.celrep.2018.01.018","article-title":"Basal suppression of the sonic hedgehog pathway by the G-protein-coupled receptor Gpr161 restricts medulloblastoma pathogenesis","volume":"22","author":"Shimada","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2019.03.011_bib54","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1242\/dev.121.12.3923","article-title":"Longitudinal organization of the anterior neural plate and neural tube","volume":"121","author":"Shimamura","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ydbio.2008.02.026","article-title":"Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool","volume":"317","author":"Spassky","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1523\/JNEUROSCI.1108-04.2005","article-title":"Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis","volume":"25","author":"Spassky","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrn3707","article-title":"Growth and folding of the mammalian cerebral cortex: from molecules to malformations","volume":"15","author":"Sun","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib58","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2019.03.011_bib59","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1242\/dev.070805","article-title":"Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube","volume":"138","author":"Tuson","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.03.011_bib60","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1523\/JNEUROSCI.4892-10.2011","article-title":"Gli3 is required for maintenance and fate specification of cortical progenitors","volume":"31","author":"Wang","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib61","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.celrep.2014.07.006","article-title":"Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche","volume":"8","author":"Wang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2019.03.011_bib62","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nn.4307","article-title":"Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex","volume":"19","author":"Wang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib63","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1750-3639.1992.tb00704.x","article-title":"Pathways of fluid drainage from the brain--morphological aspects and immunological significance in rat and man","volume":"2","author":"Weller","year":"1992","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib64","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/MCB.01089-09","article-title":"Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation","volume":"30","author":"Wen","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib65","doi-asserted-by":"crossref","first-page":"12887","DOI":"10.1523\/JNEUROSCI.2084-08.2008","article-title":"A\u00a0crucial role for primary cilia in cortical morphogenesis","volume":"28","author":"Willaredt","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2019.03.011_bib66","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/dneu.20985","article-title":"Primary cilia and Gli3 activity regulate cerebral cortical size","volume":"72","author":"Wilson","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5193(69)80016-0","article-title":"Positional information and the spatial pattern of cellular differentiation","volume":"25","author":"Wolpert","year":"1969","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib68","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.celrep.2015.08.031","article-title":"Suppressor of fused is critical for maintenance of neuronal progenitor identity during corticogenesis","volume":"12","author":"Yabut","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2019.03.011_bib69","article-title":"Loss of suppressor of fused in mid-corticogenesis leads to the expansion of intermediate progenitors","volume":"4","author":"Yabut","year":"2016","journal-title":"J.\u00a0Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib70","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ydbio.2009.07.026","article-title":"Patterning of ventral telencephalon requires positive function of Gli transcription factors","volume":"334","author":"Yu","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.03.011_bib71","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gene.10008","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160618307723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160618307723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:55:54Z","timestamp":1777402554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160618307723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0012160618307723"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2019.03.011","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2019.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}