{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:36:38Z","timestamp":1789688198522,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0901899"],"award-info":[{"award-number":["G0901899"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ydbio.2019.12.015","type":"journal-article","created":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T01:17:37Z","timestamp":1577236657000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction"],"prefix":"10.1016","volume":"460","author":[{"given":"James","family":"Pegge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold Junior","family":"Tatsinkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ydbio.2019.12.015_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0012-1606(03)00161-1","article-title":"Sox10 regulates the development of neural crest-derived melanocytes in Xenopus","volume":"259","author":"Aoki","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/dbio.1999.9319","article-title":"Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm","volume":"212","author":"Bang","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib38","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1242\/dev.124.10.2075","article-title":"Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm","volume":"124","author":"Bang","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib2","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1242\/dev.126.22.4977","article-title":"Bmp activity establishes a gradient of positional information throughout the entire neural plate","volume":"126","author":"Barth","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcb.2014.12.004","article-title":"BMP signalling: agony and antagony in the family","volume":"25","author":"Brazil","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/dbio.1997.8820","article-title":"Neural crest induction by Xwnt7B in Xenopus","volume":"194","author":"Chang","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib6","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1161\/ATVBAHA.111.235184","article-title":"Heparan sulfate proteoglycans mediate the angiogenic activity of the vascular endothelial growth factor receptor-2 agonist gremlin","volume":"31","author":"Chiodelli","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib7","doi-asserted-by":"crossref","first-page":"15774","DOI":"10.1073\/pnas.0906072106","article-title":"Regulation of pre-otic brain development by the cephalic neural crest","volume":"106","author":"Creuzet","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2019.12.015_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1073\/pnas.1010740107","article-title":"Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network","volume":"108","author":"de Croze","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2019.12.015_bib9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1070824","article-title":"Ectodermal Wnt function as a neural crest inducer","volume":"297","author":"Garcia-Castro","year":"2002","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ydbio.2019.12.015_bib31","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0092-8674(89)90612-0","article-title":"A\u00a0Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest","volume":"59","author":"Hopwood","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2019.12.015_bib10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1097-2765(00)80067-2","article-title":"The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities","volume":"1","author":"Hsu","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2019.12.015_bib11","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1242\/dev.125.13.2403","article-title":"Neural crest induction in Xenopus: evidence for a two-signal model","volume":"125","author":"LaBonne","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0012-1606(98)80008-0","article-title":"The inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradient","volume":"198","author":"Marchant","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2015.08.011","article-title":"VEGF signals induce trailblazer cell identity that drives neural crest migration","volume":"407","author":"McLennan","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib14","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1073\/pnas.1219124110","article-title":"Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos","volume":"110","author":"Milet","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2019.12.015_bib36","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1242\/dev.125.4.579","article-title":"Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction","volume":"125","author":"Mizuseki","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib15","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1242\/dev.00531","article-title":"Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals","volume":"130","author":"Monsoro-Burq","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2004.12.017","article-title":"Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction","volume":"8","author":"Monsoro-Burq","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2019.12.015_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/dbio.1998.8927","article-title":"Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b\/swirl pathway of genes","volume":"199","author":"Nguyen","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ydbio.2008.08.003","article-title":"Hairy2-Id3 interactions play an essential role in Xenopus neural crest progenitor specification","volume":"322","author":"Nichane","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0925-4773(98)00034-3","article-title":"The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals","volume":"73","author":"Pannese","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2019.12.015_bib34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1242\/dev.121.3.707","article-title":"The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions","volume":"121","author":"Pannese","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib20","volume":"vol. 22","author":"Rider","year":"2017"},{"key":"10.1016\/j.ydbio.2019.12.015_bib21","doi-asserted-by":"crossref","first-page":"13713","DOI":"10.1073\/pnas.94.25.13713","article-title":"Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a","volume":"94","author":"Saint-Jeannet","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ydbio.2019.12.015_bib33","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/dev.128.13.2525","article-title":"Requirement of FoxD3-class signaling for neural crest determination in Xenopus","volume":"128","author":"Sasai","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib22","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1242\/dev.01823","article-title":"Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm","volume":"132","author":"Sato","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature19840","article-title":"Genome evolution in the allotetraploid frog Xenopus laevis","volume":"538","author":"Session","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2019.12.015_bib24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1242\/dev.105445","article-title":"Establishing neural crest identity: a gene regulatory recipe","volume":"142","author":"Simoes-Costa","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(91)90573-H","article-title":"Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction","volume":"67","author":"Smith","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2019.12.015_bib37","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/dev.124.16.3037","article-title":"Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4","volume":"124","author":"Suzuki","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/BJ20150228","article-title":"Mapping the heparin-binding site of the BMP antagonist gremlin by site-directed mutagenesis based on predictive modelling","volume":"470","author":"Tatsinkam","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2019.12.015_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biocel.2016.12.006","article-title":"The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: such binding is not essential for BMP antagonism","volume":"83","author":"Tatsinkam","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ydbio.2019.12.015_bib27","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1242\/dev.00878","article-title":"Regulation of Msx genes by a Bmp gradient is essential for neural crest specification","volume":"130","author":"Tribulo","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2019.12.015_bib28","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1101\/gad.1154103","article-title":"Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle","volume":"17","author":"Tzahor","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2019.12.015_bib29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.devcel.2011.03.015","article-title":"Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility","volume":"20","author":"Yanai","year":"2011","journal-title":"Dev. Cell"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216061930171X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216061930171X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:41:41Z","timestamp":1757911301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216061930171X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S001216061930171X"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2019.12.015","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2019.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}