{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:26:38Z","timestamp":1777519598071,"version":"3.51.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15NS104976"],"award-info":[{"award-number":["1R15NS104976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS080685"],"award-info":[{"award-number":["NS080685"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ydbio.2021.01.011","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T09:31:07Z","timestamp":1611739867000},"page":"15-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging"],"prefix":"10.1016","volume":"473","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3844-6433","authenticated-orcid":false,"given":"M. Brandon","family":"Titus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-3884","authenticated-orcid":false,"given":"Ethan G.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy M.","family":"Bono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-3611","authenticated-orcid":false,"given":"Andrea K.","family":"Poliakon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-3238","authenticated-orcid":false,"given":"Brandon R.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-1521","authenticated-orcid":false,"given":"Meg K.","family":"Super","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-8707","authenticated-orcid":false,"given":"Lauren A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melpomeni","family":"Manaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-5928","authenticated-orcid":false,"given":"Morgan","family":"Litchford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noreen E.","family":"Reist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-433X","authenticated-orcid":false,"given":"Darrell J.","family":"Killian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia C.","family":"Olesnicky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2021.01.011_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0896-6273(02)00589-5","article-title":"Wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila","volume":"33","author":"Aberle","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2021.01.011_bib2","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1093\/nar\/gkw508","article-title":"RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals","volume":"44","author":"Ahmad","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib3","doi-asserted-by":"crossref","first-page":"E4494","DOI":"10.1073\/pnas.1608423113","article-title":"Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106","volume":"113","author":"Anderson","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ydbio.2021.01.011_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2010.03.008","article-title":"Aberrant RNA processing events in neurological disorders","volume":"1338","author":"Anthony","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1534\/g3.115.017327","article-title":"Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons","volume":"5","author":"Antonacci","year":"2015","journal-title":"G3 Genes, Genomes, Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib6","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1523\/JNEUROSCI.6369-09.2010","article-title":"Short-and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein","volume":"30","author":"Banerjee","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib7","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.neuron.2006.10.028","article-title":"Staufen-and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies","volume":"52","author":"Barbee","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2021.01.011_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2021.01.011_bib9","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1101\/gr.192518.115","article-title":"Regulation of alternative splicing in Drosophila by 56 RNA binding proteins","volume":"25","author":"Brooks","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib10","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1534\/genetics.106.065961","article-title":"The carnegie protein trap library: a versatile tool for drosophila developmental studies","volume":"175","author":"Buszczak","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2021.01.011_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A\u00a0transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2012.03.042","article-title":"Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain","volume":"1462","author":"Callan","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib13","first-page":"6886","article-title":"Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation","volume":"24","author":"Coyne","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib14","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1006\/bbrc.2002.6768","article-title":"Species-specific and isoform-specific RNA binding of human and mouse fragile X mental retardation proteins","volume":"292","author":"Denman","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2021.01.011_bib15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/acel.12646","article-title":"The emerging role of alternative splicing in senescence and aging","volume":"16","author":"Desch\u00eanes","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.ydbio.2021.01.011_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.molcel.2004.12.025","article-title":"Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPER\u03b1 and CAPER\u03b2","volume":"17","author":"Dowhan","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2021.01.011_bib17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s12264-014-1443-7","article-title":"RNA binding proteins: a common denominator of neuronal function and dysfunction","volume":"30","author":"Doxakis","year":"2014","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ydbio.2021.01.011_bib18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fnmol.2018.00124","article-title":"Modeling fragile X syndrome in Drosophila","volume":"11","author":"Drozd","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/01677060490894522","article-title":"A\u00a0modified minimal hemolymph-like solution, HL3.1, for physiological recordings at the neuromuscular junctions of normal and mutant Drosophila larvae","volume":"18","author":"Feng","year":"2004","journal-title":"J.\u00a0Neurogenet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib20","series-title":"Package \u2018car","author":"Fox","year":"2012"},{"key":"10.1016\/j.ydbio.2021.01.011_bib21","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1242\/dev.022244","article-title":"Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure","volume":"135","author":"Gatto","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2021.01.011_bib22","article-title":"Testosterone reduces the threat premium in competitive resource division","volume":"286","author":"Geniole","year":"2019","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg3813","article-title":"A\u00a0census of human RNA-binding proteins","volume":"15","author":"Gerstberger","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib24","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1016\/j.cub.2019.09.070","article-title":"Polymodal nociception in Drosophila requires alternative splicing of TrpA1","volume":"29","author":"Gu","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep27972","article-title":"Quantifying and predicting Drosophila larvae crawling phenotypes","volume":"6","author":"G\u00fcnther","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2021.01.011_bib26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/nyas.12693","article-title":"Fragile X-associated tremor\/ataxia syndrome","volume":"1338","author":"Hagerman","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib27","series-title":"DHARMa: Residual Diagnostics for Hierarchical (Multi-Level\/Mixed) Regression Models","author":"Hartig","year":"2020"},{"key":"10.1016\/j.ydbio.2021.01.011_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41583-018-0113-1","article-title":"Beyond the neuron\u2013cellular interactions early in Alzheimer disease pathogenesis","author":"Henstridge","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib29","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1158\/0008-5472.CAN-11-1460","article-title":"miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating fas expression","volume":"72","author":"Huang","year":"2012","journal-title":"Canc. Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40478-020-0881-5","article-title":"A\u00a0robust TDP-43 knock-in mouse model of ALS","volume":"8","author":"Huang","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ydbio.2021.01.011_bib31","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41593-019-0486-0","article-title":"Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration","volume":"22","author":"Joshi","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005116","article-title":"CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-\u03b1-gabpa and stress-induced adaptive responses via NF-\u03baB-cMYC","volume":"11","author":"Kang","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aai8133","article-title":"Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome","volume":"10","author":"Kashima","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ydbio.2021.01.011_bib34","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.1074\/jbc.M809506200","article-title":"Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins","volume":"284","author":"Katzenberger","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ydbio.2021.01.011_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41576-018-0083-1","article-title":"The role of sex in the genomics of human complex traits","volume":"20","author":"Khramtsova","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib36","first-page":"1","article-title":"robustlmm: an R package for robust estimation of linear mixed-effects models","volume":"75","author":"Koller","year":"2016","journal-title":"J.\u00a0Stat. Software"},{"key":"10.1016\/j.ydbio.2021.01.011_bib37","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1242\/dev.00792","article-title":"Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1","volume":"130","author":"Lee","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2021.01.011_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07101-4","article-title":"Topoisomerase 3\u03b2 interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2021.01.011_bib39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0166-2236(00)01791-4","article-title":"Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development","volume":"24","author":"Lee","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2010.02.003","article-title":"RNA metabolism and the pathogenesis of motor neuron diseases","author":"Lemmens","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib41","series-title":"Emmeans: Estimated Marginal Means, Aka Least-Squares Means. R Packag. Version 1.1","author":"Lenth","year":"2018"},{"key":"10.1016\/j.ydbio.2021.01.011_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2006.09.017","article-title":"Splicing regulation in neurologic disease","author":"Licatalosi","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2021.01.011_bib43","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature09728","article-title":"The novel gene twenty-four defines a critical translational step in the Drosophila clock","volume":"470","author":"Lim","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2021.01.011_bib44","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1101\/gad.8.15.1787","article-title":"Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion","volume":"8","author":"Luo","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2021.01.011_bib45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.aav9776","article-title":"Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis","volume":"364","author":"Maniatis","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2021.01.011_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003069","article-title":"Tissue-specific regulation of chromatin insulator function","volume":"8","author":"Matzat","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.10.030","article-title":"Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases","author":"Mills","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ydbio.2021.01.011_bib48","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/01677063.2014.936437","article-title":"Alternative splicing in Drosophila neuronal development","volume":"28","author":"Mohr","year":"2014","journal-title":"J.\u00a0Neurogenet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nmeth.1592","article-title":"A\u00a0genome-scale shRNA resource for transgenic RNAi in Drosophila","volume":"8","author":"Ni","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2021.01.011_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004823","article-title":"A\u00a0new Fiji-based algorithm that systematically quantifies nine synaptic parameters provides insights into Drosophila NMJ morphometry","volume":"12","author":"Nijhof","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142836","article-title":"Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein","volume":"10","author":"Novak","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2021.01.011_bib52","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/dvdy.24523","article-title":"The RNA-binding protein caper is required for sensory neuron development in Drosophila melanogaster","volume":"246","author":"Olesnicky","year":"2017","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2021.01.011_bib53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/jdb6030021","article-title":"Drosophila as a model for assessing the function of RNA-binding proteins during neurogenesis and neurological disease","volume":"6","author":"Olesnicky","year":"2018","journal-title":"J.\u00a0Dev. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib54","first-page":"369","article-title":"The impact of sex on gene expression across human tissues","volume":"80","author":"Oliva","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2021.01.011_bib55","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib56","doi-asserted-by":"crossref","first-page":"15974","DOI":"10.1073\/pnas.0407004101","article-title":"Identification of alternative splicing regulators by RNA interference in Drosophila","volume":"101","author":"Park","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ydbio.2021.01.011_bib57","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/dbio.1996.9987","article-title":"Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo","volume":"176","author":"Ranganayakulu","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib58","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib59","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1126\/science.287.5461.2204","article-title":"Comparative genomics of the eukaryotes","volume":"287","author":"Rubin","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2021.01.011_bib60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrg.2015.3","article-title":"RNA mis-splicing in disease","volume":"17","author":"Scotti","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1866-1955-6-23","article-title":"The multiple molecular facets of fragile X-associated tremor\/ataxia syndrome","volume":"6","author":"Sellier","year":"2014","journal-title":"J.\u00a0Neurodev. Disord."},{"key":"10.1016\/j.ydbio.2021.01.011_bib62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/dbio.2001.0411","article-title":"Peripheral glia direct axon guidance across the CNS\/PNS transition zone","volume":"238","author":"Sepp","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib63","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1016\/j.celrep.2020.02.076","article-title":"FMRP control of ribosome translocation promotes chromatin modifications and alternative splicing of neuronal genes linked to autism","volume":"30","author":"Shah","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2021.01.011_bib64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s13402-012-0088-2","article-title":"CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression","volume":"35","author":"Sillars-Hardebol","year":"2012","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib65","series-title":"Afex-Analysis of Factorial EXperiments. R Packag. Version 0.23-0","author":"Singmann","year":"2019"},{"key":"10.1016\/j.ydbio.2021.01.011_bib66","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/hmg\/5.1.95","article-title":"Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms","volume":"5","author":"Sittler","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2021.01.011_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12817","article-title":"Proper splicing contributes to visual function in the aging Drosophila eye","volume":"17","author":"Stegeman","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.ydbio.2021.01.011_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2009.09.029","article-title":"The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)","author":"Strong","year":"2010","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib69","doi-asserted-by":"crossref","first-page":"E99","DOI":"10.1073\/pnas.1309543111","article-title":"FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control","volume":"111","author":"Sudhakaran","year":"2014","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ydbio.2021.01.011_bib70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-62703-556-9_7","article-title":"Aging studies in drosophila melanogaster","volume":"1048","author":"Sun","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib71","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ydbio.2015.12.008","article-title":"Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function","volume":"410","author":"Tan","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027100","article-title":"Elevated levels of the vesicular monoamine transporter and a novel repetitive behavior in the Drosophila model of fragile X syndrome","volume":"6","author":"Tauber","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ydbio.2021.01.011_bib73","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbadis.2008.09.017","article-title":"Alternative splicing and disease","volume":"1792","author":"Tazi","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.ydbio.2021.01.011_bib74","doi-asserted-by":"crossref","first-page":"D759","DOI":"10.1093\/nar\/gky1003","article-title":"FlyBase 2.0: the next generation","volume":"47","author":"Thurmond","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2021.01.011_bib75","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.tem.2017.07.002","article-title":"Sex-specific gene expression and life span regulation","volume":"28","author":"Tower","year":"2017","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib76","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccell.2019.01.010","article-title":"Targeting an RNA-binding protein network in acute myeloid leukemia","volume":"35","author":"Wang","year":"2019","journal-title":"Canc. Cell"},{"issue":"2","key":"10.1016\/j.ydbio.2021.01.011_bib88","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nn1841","article-title":"Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules","volume":"10","author":"Wang","year":"2007","journal-title":"Nature Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib77","doi-asserted-by":"crossref","first-page":"10929","DOI":"10.1038\/s41598-018-29086-2","article-title":"Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2021.01.011_bib78","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.expneurol.2015.05.015","article-title":"Deciphering discord: how Drosophila research has enhanced our understanding of the importance of FMRP in different spatial and temporal contexts","volume":"274","author":"Weisz","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ydbio.2021.01.011_bib79","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-neuro-070918-050306","article-title":"Neuron-glia signaling in synapse elimination","volume":"42","author":"Wilton","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib80","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1074\/jbc.M113.538264","article-title":"U1A regulates 3\u2019 processing of the survival motor neuron mRNA","volume":"289","author":"Workman","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ydbio.2021.01.011_bib81","series-title":"Brain Transcriptome","first-page":"95","article-title":"Chapter five - splicing in the human brain","author":"Zaghlool","year":"2014"},{"key":"10.1016\/j.ydbio.2021.01.011_bib82","article-title":"betareg: beta regression","author":"Zeileis","year":"2016","journal-title":"Comput. Softw. Man"},{"key":"10.1016\/j.ydbio.2021.01.011_bib83","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib84","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0092-8674(01)00589-X","article-title":"Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function","volume":"107","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2021.01.011_bib85","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s11427-014-4647-9","article-title":"RNA-binding proteins in neurological diseases","volume":"57","author":"Zhou","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.ydbio.2021.01.011_bib86","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuroscience.2017.02.044","article-title":"A\u00a0novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14","volume":"349","author":"Zhou","year":"2017","journal-title":"Neuroscience"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160621000233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160621000233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:09:03Z","timestamp":1777392543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160621000233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":87,"alternative-id":["S0012160621000233"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2021.01.011","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2021.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}