{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:16:36Z","timestamp":1777454196966,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214953\/Z\/18\/Z"],"award-info":[{"award-number":["214953\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["UF130182"],"award-info":[{"award-number":["UF130182"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RG140377"],"award-info":[{"award-number":["RG140377"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["191007"],"award-info":[{"award-number":["191007"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.ydbio.2022.06.004","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T01:57:56Z","timestamp":1655171876000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Distinct proliferative and middle ear skeletal-patterning functions for SHH-expressing epithelia in the chick hyoid arch"],"prefix":"10.1016","volume":"489","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-5445","authenticated-orcid":false,"given":"Jenaid M.","family":"Rees","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-3777","authenticated-orcid":false,"given":"J. Andrew","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2022.06.004_bib1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/S0960-9822(00)80052-4","article-title":"Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death","volume":"9","author":"Ahlgren","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib2","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/dvdy.260","article-title":"Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles","volume":"249","author":"Ankamreddy","year":"2020","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2022.06.004_bib3","article-title":"Region-specific Endodermal signals direct neural crest cells to form the three middle Ear ossicles","volume":"vol. 146","author":"Ankamreddy","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/dvdy.20567","article-title":"Hoxa2 knockdown in Xenopus results in hyoid to mandibular homeosis","volume":"234","author":"Baltzinger","year":"2005","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2022.06.004_bib5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/dvdy.24256","article-title":"Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation","volume":"244","author":"Billmyre","year":"2015","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2022.06.004_bib6","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1073\/pnas.0604751103","article-title":"An early role for sonic hedgehog from foregut endoderm in jaw development: ensuring neural crest cell survival","volume":"103","author":"Brito","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2022.06.004_bib7","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1242\/dev.019125","article-title":"Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells","volume":"135","author":"Brito","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib8","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1025302","article-title":"Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened","volume":"16","author":"Chen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2022.06.004_bib9","doi-asserted-by":"crossref","DOI":"10.1242\/dev.165753","article-title":"Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust","volume":"vol. 145","author":"Choi","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1172\/JCI200419596","article-title":"Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes","volume":"114","author":"Cordero","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ydbio.2022.06.004_bib11","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/dev.129.4.1061","article-title":"Interactions between Hox-negative cephalic neural crest cells and the foregut endoderm in patterning the facial skeleton in the vertebrate head","volume":"129","author":"Couly","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib12","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1242\/dev.122.11.3393","article-title":"The regeneration of the cephalic neural crest, a problem revisited: the regenerating cells originate from the contralateral or from the anterior and posterior neural fold","volume":"122","author":"Couly","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1242\/dev.108.4.543","article-title":"Head morphogenesis in embryonic avian chimeras: evidence for a segmental pattern in the ectoderm corresponding to the neuromeres","volume":"108","author":"Couly","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51696","article-title":"Resegmentation is an ancestral feature of the gnathostome vertebral skeleton","volume":"9","author":"Criswell","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2022.06.004_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1242\/dev.100107","article-title":"Multiple developmental mechanisms regulate species-specific jaw size","volume":"141","author":"Fish","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib16","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.133884","article-title":"A\u00a0shared role for sonic hedgehog signalling in patterning chondrichthyan gill arch appendages and tetrapod limbs","volume":"143","author":"Gillis","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib17","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/ncomms2429","article-title":"Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton","volume":"4","author":"Gillis","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2022.06.004_bib18","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1242\/dev.084046","article-title":"Electrosensory ampullary organs are derived from lateral line placodes in cartilaginous fishes","volume":"139","author":"Gillis","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib19","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1073\/pnas.1012968108","article-title":"Holocephalan embryos provide evidence for gill arch appendage reduction and opercular evolution in cartilaginous fishes","volume":"108","author":"Gillis","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2022.06.004_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/1521-1878(200101)23:1<54::AID-BIES1007>3.0.CO;2-5","article-title":"Patterning the pharyngeal arches","volume":"23","author":"Graham","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.ydbio.2022.06.004_bib21","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1242\/dev.127.24.5355","article-title":"Homeotic transformation of branchial arch identity after Hoxa2 overexpression","volume":"127","author":"Grammatopoulos","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ydbio.2011.02.012","article-title":"Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids","volume":"353","author":"Grevellec","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ydbio.2013.11.011","article-title":"Evolution of a developmental mechanism: species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis","volume":"385","author":"Hall","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A\u00a0series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J.\u00a0Morphol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/dbio.2002.0701","article-title":"Zebrafish hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch","volume":"247","author":"Hunter","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib26","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1101\/gad.1190304","article-title":"Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia","volume":"18","author":"Jeong","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2022.06.004_bib27","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1242\/dev.122.10.3229","article-title":"Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny","volume":"122","author":"Kontges","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib28","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/dvdy.23768","article-title":"Fibroblast growth factor and bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program","volume":"241","author":"Kumar","year":"2012","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2022.06.004_bib29","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/dev.01350","article-title":"Neural crest cell plasticity and its limits","volume":"131","author":"Le Douarin","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib30","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1167\/iovs.15-17599","article-title":"A\u00a0novel ImageJ macro for automated cell death quantitation in the retina","volume":"56","author":"Maidana","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ydbio.2022.06.004_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000085950","article-title":"Meckel's cartilage differentiation is dependent on hedgehog signaling","volume":"179","author":"Melnick","year":"2005","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.ydbio.2022.06.004_bib32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0012-1606(83)90318-4","article-title":"The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues","volume":"96","author":"Noden","year":"1983","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib33","series-title":"Chimeras in Developmental Biology","first-page":"241","article-title":"The use of chimeras in analyses of craniofacial development","author":"Noden","year":"1984"},{"key":"10.1016\/j.ydbio.2022.06.004_bib34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ydbio.2006.12.029","article-title":"A\u00a0molecular analysis of neurogenic placode and cranial sensory ganglion development in the shark, Scyliorhinus canicula","volume":"304","author":"O'Neill","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/dbio.2001.0430","article-title":"Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis","volume":"239","author":"Pearse","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/237015","article-title":"Branchial anomalies: diagnosis and management","author":"Prasad","year":"2014","journal-title":"Int. J. Otolaryngol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib37","first-page":"224","article-title":"The presence of an embryonic opercular flap in amniotes","volume":"279","author":"Richardson","year":"2012","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.ydbio.2022.06.004_bib38","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0092-8674(93)90620-6","article-title":"A\u00a0homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene","volume":"75","author":"Rijli","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2022.06.004_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/dvdy.10380","article-title":"Patterning of the hyoid cartilage depends upon signals arising from the ventral foregut endoderm","volume":"228","author":"Ruhin","year":"2003","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2022.06.004_bib40","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.mod.2004.05.012","article-title":"Prospects for transgenesis in the chick","volume":"121","author":"Sang","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2022.06.004_bib41","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1242\/dev.02078","article-title":"Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis","volume":"132","author":"Santagati","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.06.004_bib42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/dbio.2000.9997","article-title":"Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest","volume":"231","author":"Schilling","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib43","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.1077827","article-title":"The cellular and molecular origins of beak morphology","volume":"299","author":"Schneider","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2022.06.004_bib44","first-page":"479","article-title":"Endodermal\/ectodermal interfaces during pharyngeal segmentation in vertebrates","volume":"225","author":"Shone","year":"2014","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.ydbio.2022.06.004_bib45","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.7554\/eLife.60635","article-title":"Embryonic origin and serial homology of gill arches and paired fins in the skate, Leucoraja erinacea","volume":"9","author":"Sleight","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2022.06.004_bib46","first-page":"11","article-title":"The middle ear and columella of birds","volume":"48","author":"Smith","year":"1904","journal-title":"Q.\u00a0J. Microsc. Sci."},{"key":"10.1016\/j.ydbio.2022.06.004_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ydbio.2012.05.032","article-title":"Hh signaling regulates patterning and morphogenesis of the pharyngeal arch-derived skeleton","volume":"369","author":"Swartz","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/35000051","article-title":"Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm","volume":"2","author":"Trainor","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib49","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.1064540","article-title":"Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning","volume":"295","author":"Trainor","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2022.06.004_bib50","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35039056","article-title":"Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity","volume":"1","author":"Trainor","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2022.06.004_bib51","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0960-9822(00)80118-9","article-title":"Pharyngeal arch patterning in the absence of neural crest","volume":"9","author":"Veitch","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0925-4773(95)00453-X","article-title":"Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick","volume":"53","author":"Wall","year":"1995","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2022.06.004_bib53","first-page":"290","article-title":"A\u00a0resegmentation-shift model for vertebral patterning","volume":"230","author":"Ward","year":"2017","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.ydbio.2022.06.004_bib54","first-page":"435","article-title":"Seasonal changes in the lower jaw skeleton in male Atlantic salmon (Salmo salar L.): remodelling and regression of the kype after spawning","volume":"203","author":"Witten","year":"2003","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.ydbio.2022.06.004_bib55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-213X-10-16","article-title":"Analysis of chick (Gallus gallus) middle ear columella formation","volume":"10","author":"Wood","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.06.004_bib56","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/dvdy.23788","article-title":"Induction of the chick columella and its integration with the inner ear","volume":"241","author":"Zou","year":"2012","journal-title":"Dev. Dynam."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160622001191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160622001191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:55:55Z","timestamp":1777380955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160622001191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":56,"alternative-id":["S0012160622001191"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2022.06.004","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct proliferative and middle ear skeletal-patterning functions for SHH-expressing epithelia in the chick hyoid arch","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2022.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}