{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:58:10Z","timestamp":1790272690970,"version":"4.1.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["21\\u201327364S"],"award-info":[{"award-number":["21\\u201327364S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["OP VaVpI CZ.1.05\/2.1.00\/19.0395"],"award-info":[{"award-number":["OP VaVpI CZ.1.05\/2.1.00\/19.0395"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["CZ.1.05\/1.1.00 \/02.0109"],"award-info":[{"award-number":["CZ.1.05\/1.1.00 \/02.0109"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["LM2018126"],"award-info":[{"award-number":["LM2018126"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ydbio.2022.08.006","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T11:55:55Z","timestamp":1661774155000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Multiple roles of Pax6 in postnatal cornea development"],"prefix":"10.1016","volume":"491","author":[{"given":"Sweetu Susan","family":"Sunny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Lachova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Dupacova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbynek","family":"Kozmik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7114","key":"10.1016\/j.ydbio.2022.08.006_bib1","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature05249","article-title":"Corneal avascularity is due to soluble VEGF receptor-1","volume":"443","author":"Ambati","year":"2006","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib2","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1242\/dev.01125","article-title":"Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development","volume":"131","author":"Andl","year":"2004","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.modgep.2003.11.002","article-title":"Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development","volume":"4","author":"Ang","year":"2004","journal-title":"Gene Expr. Patterns"},{"issue":"12","key":"10.1016\/j.ydbio.2022.08.006_bib4","doi-asserted-by":"crossref","first-page":"e1006441","DOI":"10.1371\/journal.pgen.1006441","article-title":"The gene regulatory network of lens induction is wired through meis-dependent shadow enhancers of Pax6","volume":"12","author":"Antosova","year":"2016","journal-title":"PLoS Genet."},{"issue":"21","key":"10.1016\/j.ydbio.2022.08.006_bib5","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1101\/gad.184000","article-title":"Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye","volume":"14","author":"Ashery-Padan","year":"2000","journal-title":"Genes Dev."},{"issue":"24","key":"10.1016\/j.ydbio.2022.08.006_bib6","doi-asserted-by":"crossref","first-page":"11495","DOI":"10.1073\/pnas.88.24.11495","article-title":"The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element","volume":"88","author":"Behrens","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yexcr.2017.03.061","article-title":"Interplay between tight junctions & adherens junctions","volume":"358","author":"Campbell","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1091\/mbc.e06-05-0471","article-title":"Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells","volume":"18","author":"Capaldo","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2022.08.006_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.cellbio.17.1.255","article-title":"Early eye development in vertebrates","volume":"17","author":"Chow","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"17","key":"10.1016\/j.ydbio.2022.08.006_bib10","doi-asserted-by":"crossref","first-page":"9688","DOI":"10.1073\/pnas.161144098","article-title":"Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye","volume":"98","author":"Collinson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib11","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/dvdy.10124","article-title":"Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium","volume":"224","author":"Collinson","year":"2002","journal-title":"Dev. Dynam."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib12","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1167\/iovs.03-1118","article-title":"Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6(+\/-) mouse","volume":"45","author":"Collinson","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","article-title":"Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells","volume":"57","author":"Cotsarelis","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2022.08.006_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exer.2016.04.017","article-title":"PAX6: 25th anniversary and more to learn","volume":"156","author":"Cvekl","year":"2017","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/bies.20009","article-title":"Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases","volume":"26","author":"Cvekl","year":"2004","journal-title":"Bioessays"},{"issue":"7","key":"10.1016\/j.ydbio.2022.08.006_bib16","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1167\/iovs.10-6726","article-title":"Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation","volume":"52","author":"Davis","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Pt 11","key":"10.1016\/j.ydbio.2022.08.006_bib17","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1242\/jcs.00441","article-title":"Requirement for Pax6 in corneal morphogenesis: a role in adhesion","volume":"116","author":"Davis","year":"2003","journal-title":"J.\u00a0Cell Sci."},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib18","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1167\/iovs.07-1057","article-title":"Gene expression of the mouse corneal crystallin Aldh3a1: activation by Pax6, Oct1, and p300","volume":"49","author":"Davis","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.ydbio.2022.08.006_bib19","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1167\/iovs.15-16463","article-title":"Spatiotemporally regulated ablation of Klf4 in adult mouse corneal epithelial cells results in altered epithelial cell identity and disrupted homeostasis","volume":"56","author":"Delp","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib20","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/dvdy.24179","article-title":"The vertebrate corneal epithelium: from early specification to constant renewal","volume":"243","author":"Dhouailly","year":"2014","journal-title":"Dev. Dynam."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib21","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1186\/s13104-018-3812-9","article-title":"A\u00a0conditional Pax6 depletion study with no morphological effect on the adult mouse corneal epithelium","volume":"11","author":"Dora","year":"2018","journal-title":"BMC Res. Notes"},{"issue":"8","key":"10.1016\/j.ydbio.2022.08.006_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071117","article-title":"Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+\/-) mouse model of aniridia","volume":"8","author":"Douvaras","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0039-6257(00)00109-0","article-title":"Limbal stem cells of the corneal epithelium","volume":"44","author":"Dua","year":"2000","journal-title":"Surv. Ophthalmol."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ydbio.2006.07.045","article-title":"Pax6 is required for delta-catenin\/neurojugin expression during retinal, cerebellar and cortical development in mice","volume":"300","author":"Duparc","year":"2006","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ydbio.2006.11.006","article-title":"Pax6 controls the proliferation rate of neuroepithelial progenitors from the mouse optic vesicle","volume":"301","author":"Duparc","year":"2007","journal-title":"Dev. Biol."},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib26","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1167\/iovs.05-0028","article-title":"Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma","volume":"46","author":"Dwivedi","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1242\/dev.129.2.455","article-title":"Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors","volume":"129","author":"Estivill-Torrus","year":"2002","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib28","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ydbio.2008.02.030","article-title":"The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development","volume":"317","author":"Gage","year":"2008","journal-title":"Dev. Biol."},{"issue":"5032","key":"10.1016\/j.ydbio.2022.08.006_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/210209a0","article-title":"Role of the lens in the morphogenesis of the iris and cornea","volume":"210","author":"Genis-Galvez","year":"1966","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0014-4835(67)80053-8","article-title":"Causal factors in corneal development: an experimental analysis in the chick embryo","volume":"6","author":"Genis-Galvez","year":"1967","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ydbio.2022.08.006_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0074-7696(08)61760-X","article-title":"Development of the vertebrate cornea","volume":"63","author":"Hay","year":"1980","journal-title":"Int. Rev. Cytol."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1074\/jbc.271.1.595","article-title":"Mechanisms identified in the transcriptional control of epithelial gene expression","volume":"271","author":"Hennig","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6354","key":"10.1016\/j.ydbio.2022.08.006_bib33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/354522a0","article-title":"Mouse small eye results from mutations in a paired-like homeobox-containing gene","volume":"354","author":"Hill","year":"1991","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib34","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ejhg.2012.100","volume":"20","author":"Hingorani","year":"2012","journal-title":"Aniridia. Eur J Hum Genet"},{"key":"10.1016\/j.ydbio.2022.08.006_bib35","first-page":"95","article-title":"Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse","volume":"97","author":"Hogan","year":"1986","journal-title":"J.\u00a0Embryol. Exp. Morphol."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mcn.2006.10.008","article-title":"Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon","volume":"34","author":"Holm","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib37","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jtos.2015.10.003","article-title":"Congenital aniridia and the ocular surface","volume":"14","author":"Ihnatko","year":"2016","journal-title":"Ocul. Surf."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib38","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1167\/iovs.09-4591","article-title":"Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn","volume":"51","author":"Joo","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"13","key":"10.1016\/j.ydbio.2022.08.006_bib39","first-page":"2572","article-title":"Keratin 12-deficient mice have fragile corneal epithelia","volume":"37","author":"Kao","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib40","doi-asserted-by":"crossref","first-page":"RC132","DOI":"10.1523\/JNEUROSCI.21-05-j0002.2001","article-title":"Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS","volume":"21","author":"Kim","year":"2001","journal-title":"J.\u00a0Neurosci."},{"issue":"6","key":"10.1016\/j.ydbio.2022.08.006_bib41","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1242\/dev.098822","article-title":"Stage-dependent requirement of neuroretinal Pax6 for lens and retina development","volume":"141","author":"Klimova","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2022.08.006_bib42","doi-asserted-by":"crossref","first-page":"d687","DOI":"10.2741\/1018","article-title":"The molecular genetics of the corneal dystrophies--current status","volume":"8","author":"Klintworth","year":"2003","journal-title":"Front. Biosci."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00003226-200001000-00013","article-title":"Amniotic membrane as a substrate for cultivating limbal corneal epithelial cells for autologous transplantation in rabbits","volume":"19","author":"Koizumi","year":"2000","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib44","first-page":"108","article-title":"The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia","volume":"38","author":"Koroma","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2\u20134","key":"10.1016\/j.ydbio.2022.08.006_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.brainresbull.2007.10.046","article-title":"The role of Pax genes in eye evolution","volume":"75","author":"Kozmik","year":"2008","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/dvg.20277","article-title":"Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function","volume":"45","author":"Kreslova","year":"2007","journal-title":"Genesis"},{"issue":"9","key":"10.1016\/j.ydbio.2022.08.006_bib47","first-page":"1903","article-title":"Conjunctival transdifferentiation is due to the incomplete removal of limbal basal epithelium","volume":"31","author":"Kruse","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"11","key":"10.1016\/j.ydbio.2022.08.006_bib48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3109\/02713689409025135","article-title":"Expression of keratins K12, K4 and K14 during development of ocular surface epithelium","volume":"13","author":"Kurpakus","year":"1994","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.ydbio.2022.08.006_bib49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jtos.2021.09.001","article-title":"Pathophysiology of aniridia-associated keratopathy: developmental aspects and unanswered questions","volume":"22","author":"Latta","year":"2021","journal-title":"Ocul. Surf."},{"issue":"6","key":"10.1016\/j.ydbio.2022.08.006_bib50","first-page":"1864","article-title":"Relative proliferative rates of limbal and corneal epithelia. Implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesizing keratinocytes","volume":"32","author":"Lavker","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ydbio.2022.08.006_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108094","article-title":"Corneal epithelial biology: lessons stemming from old to new","volume":"198","author":"Lavker","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib52","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1167\/iovs.08-2812","article-title":"Control of patterns of corneal innervation by Pax6","volume":"50","author":"Leiper","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cr.7310137","article-title":"Niche regulation of corneal epithelial stem cells at the limbus","volume":"17","author":"Li","year":"2007","journal-title":"Cell Res."},{"issue":"12","key":"10.1016\/j.ydbio.2022.08.006_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/genes10121050","article-title":"The spectrum of PAX6 mutations and genotype-phenotype correlations in the eye","volume":"10","author":"Lima Cunha","year":"2019","journal-title":"Genes"},{"issue":"9","key":"10.1016\/j.ydbio.2022.08.006_bib55","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1167\/iovs.12-10725","article-title":"A\u00a0mouse model of limbal stem cell deficiency induced by topical medication with the preservative benzalkonium chloride","volume":"54","author":"Lin","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"40","key":"10.1016\/j.ydbio.2022.08.006_bib56","doi-asserted-by":"crossref","first-page":"24627","DOI":"10.1016\/S0021-9258(17)31438-2","article-title":"Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12","volume":"269","author":"Liu","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/exer.1998.0593","article-title":"Corneal epithelium-specific mouse keratin K12 promoter","volume":"68","author":"Liu","year":"1999","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib58","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/dvdy.10315","article-title":"Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina","volume":"227","author":"Liu","year":"2003","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2022.08.006_bib59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.pmbts.2015.04.003","article-title":"Corneal development: different cells from a common progenitor","volume":"134","author":"Lwigale","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib60","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/dvg.20583","article-title":"Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt\/beta-catenin signaling in the lens surface ectoderm","volume":"48","author":"Machon","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2022.08.006_bib61","first-page":"1215","article-title":"Genetic analysis indicates that transcription factors AP-2alpha and Pax6 cooperate in the normal patterning and morphogenesis of the lens","volume":"13","author":"Makhani","year":"2007","journal-title":"Mol. Vis."},{"issue":"6","key":"10.1016\/j.ydbio.2022.08.006_bib62","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1167\/iovs.05-0745","article-title":"Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling","volume":"47","author":"Mandell","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00295-1","article-title":"Pax6 is required for the multipotent state of retinal progenitor cells","volume":"105","author":"Marquardt","year":"2001","journal-title":"Cell"},{"issue":"7165","key":"10.1016\/j.ydbio.2022.08.006_bib64","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nature06189","article-title":"Purine-mediated signalling triggers eye development","volume":"449","author":"Masse","year":"2007","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ydbio.2022.08.006_bib65","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1167\/iovs.14-15155","article-title":"Eyelid closure in embryogenesis is required for ocular adnexa development","volume":"55","author":"Meng","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ydbio.2022.08.006_bib66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-213X-6-14","article-title":"Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice","volume":"6","author":"Miller","year":"2006","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2022.08.006_bib67","first-page":"793","article-title":"Disruption of eyelid and cornea morphogenesis by epithelial beta-catenin gain-of-function","volume":"21","author":"Mizoguchi","year":"2015","journal-title":"Mol. Vis."},{"issue":"12","key":"10.1016\/j.ydbio.2022.08.006_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028895","article-title":"Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis","volume":"6","author":"Mort","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1432-0436.1996.6010031.x","article-title":"Conjunctival epithelial cells can resurface denuded cornea, but do not transdifferentiate to express cornea-specific keratin 12 following removal of limbal epithelium in mouse","volume":"60","author":"Moyer","year":"1996","journal-title":"Differentiation"},{"issue":"11","key":"10.1016\/j.ydbio.2022.08.006_bib70","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1242\/dev.02381","article-title":"Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium","volume":"133","author":"Mukhopadhyay","year":"2006","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib71","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1167\/iovs.02-0705","article-title":"Centripetal movement of corneal epithelial cells in the normal adult mouse","volume":"44","author":"Nagasaki","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib72","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1128\/MCB.22.3.849-855.2002","article-title":"Structurally normal corneas in aldehyde dehydrogenase 3a1-deficient mice","volume":"22","author":"Nees","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib73","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0002-9394(14)72167-1","article-title":"Ocular surface abnormalities in aniridia","volume":"120","author":"Nishida","year":"1995","journal-title":"Am. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.ydbio.2022.08.006_bib74","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1086\/301650","article-title":"Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy","volume":"61","author":"Nishida","year":"1997","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.ydbio.2022.08.006_bib75","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1074\/jbc.M109.043760","article-title":"Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells","volume":"285","author":"Ooshio","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"issue":"9","key":"10.1016\/j.ydbio.2022.08.006_bib76","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/stem.1176","article-title":"Corneal goblet cells and their niche: implications for corneal stem cell deficiency","volume":"30","author":"Pajoohesh-Ganji","year":"2012","journal-title":"Stem Cell."},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib77","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1073\/pnas.0500344102","article-title":"Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals","volume":"102","author":"Pearton","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib78","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0161-6420(95)30842-1","article-title":"Cytologic evidence of corneal diseases with limbal stem cell deficiency","volume":"102","author":"Puangsricharern","year":"1995","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib79","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1167\/iovs.02-0576","article-title":"Corneal abnormalities in Pax6+\/- small eye mice mimic human aniridia-related keratopathy","volume":"44","author":"Ramaesh","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib80","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.exer.2005.02.002","article-title":"Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+\/- mouse model of aniridia","volume":"81","author":"Ramaesh","year":"2005","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib81","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1167\/iovs.05-1028","article-title":"Increased apoptosis and abnormal wound-healing responses in the heterozygous Pax6+\/- mouse cornea","volume":"47","author":"Ramaesh","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib82","doi-asserted-by":"crossref","first-page":"e1004360","DOI":"10.1371\/journal.pgen.1004360","article-title":"PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF","volume":"10","author":"Raviv","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2022.08.006_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/srep20807","article-title":"PAX6 isoforms, along with reprogramming factors, differentially regulate the induction of cornea-specific genes","volume":"6","author":"Sasamoto","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib84","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12015-008-9029-x","article-title":"Corneal epithelial stem cells: deficiency and regulation","volume":"4","author":"Secker","year":"2008","journal-title":"Stem Cell Rev."},{"issue":"1 Pt 1","key":"10.1016\/j.ydbio.2022.08.006_bib85","first-page":"135","article-title":"Corneal re-epithelialization from the conjunctiva","volume":"21","author":"Shapiro","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib86","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1128\/MCB.24.1.245-257.2004","article-title":"Transcription factors Pax6 and AP-2alpha interact to coordinate corneal epithelial repair by controlling expression of matrix metalloproteinase gelatinase B","volume":"24","author":"Sivak","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib87","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ydbio.2005.07.019","article-title":"The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm","volume":"285","author":"Smith","year":"2005","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib88","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.ydbio.2022.08.006_bib89","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","article-title":"Anatomy of cornea and ocular surface","volume":"66","author":"Sridhar","year":"2018","journal-title":"Indian J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib90","doi-asserted-by":"crossref","first-page":"E239","DOI":"10.1097\/OPX.0b013e3181d39464","article-title":"Dynamic regulation of barrier integrity of the corneal endothelium","volume":"87","author":"Srinivas","year":"2010","journal-title":"Optom. Vis. Sci."},{"issue":"48","key":"10.1016\/j.ydbio.2022.08.006_bib91","doi-asserted-by":"crossref","first-page":"34304","DOI":"10.1074\/jbc.M113.504399","article-title":"The Ets transcription factor EHF as a regulator of cornea epithelial cell identity","volume":"288","author":"Stephens","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib92","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/exer.1996.0175","article-title":"ZO1 in corneal epithelium: association to the zonula occludens and adherens junctions","volume":"64","author":"Sugrue","year":"1997","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib93","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.1038\/s41598-020-65878-1","article-title":"Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea","volume":"10","author":"Sunny","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2022.08.006_bib94","article-title":"Ocular surface development and gene expression","volume":"2013","author":"Swamynathan","year":"2013","journal-title":"J\u00a0Ophthalmol"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib95","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/MCB.00846-06","article-title":"Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells","volume":"27","author":"Swamynathan","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.ydbio.2022.08.006_bib96","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1167\/iovs.08-1811","article-title":"Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea","volume":"49","author":"Swamynathan","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.ydbio.2022.08.006_bib97","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ydbio.2022.08.006_bib98","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1167\/iovs.17-21826","article-title":"KLF4 plays an essential role in corneal epithelial homeostasis by promoting epithelial cell fate and suppressing epithelial-mesenchymal transition","volume":"58","author":"Tiwari","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Pt 2","key":"10.1016\/j.ydbio.2022.08.006_bib99","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/eye.1989.22","article-title":"Concept and application of limbal stem cells","volume":"3","author":"Tseng","year":"1989","journal-title":"Eye"},{"key":"10.1016\/j.ydbio.2022.08.006_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108181","article-title":"Niche regulation of limbal epithelial stem cells: HC-HA\/PTX3 as surrogate matrix niche","volume":"199","author":"Tseng","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"24","key":"10.1016\/j.ydbio.2022.08.006_bib101","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1242\/dev.127.24.5439","article-title":"Dosage requirement and allelic expression of PAX6 during lens placode formation","volume":"127","author":"van Raamsdonk","year":"2000","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib102","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1442-9071.2005.01011.x","article-title":"Inherited corneal disease: the evolving molecular, genetic and imaging revolution","volume":"33","author":"Vincent","year":"2005","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.ydbio.2022.08.006_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108231","article-title":"Corneal development: role of the periocular mesenchyme and bi-directional signaling","volume":"201","author":"Walker","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.ydbio.2022.08.006_bib104","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1242\/dev.113.4.1435","article-title":"Pax-6, a murine paired box gene, is expressed in the developing CNS","volume":"113","author":"Walther","year":"1991","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/dbio.1998.9132","article-title":"AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle","volume":"206","author":"West-Mays","year":"1999","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib106","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1432-0436.2003.710302.x","article-title":"Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface","volume":"71","author":"West-Mays","year":"2003","journal-title":"Differentiation"},{"issue":"Pt 8","key":"10.1016\/j.ydbio.2022.08.006_bib107","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.063321","article-title":"Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea","volume":"123","author":"Zhang","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"issue":"19","key":"10.1016\/j.ydbio.2022.08.006_bib108","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1242\/dev.125393","article-title":"Wnt\/beta-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development","volume":"142","author":"Zhang","year":"2015","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ydbio.2022.08.006_bib109","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41598-018-36392-2","article-title":"Aberrant expression of a stabilized beta-catenin mutant in keratocytes inhibits mouse corneal epithelial stratification","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ydbio.2022.08.006_bib110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1350-9462(99)00018-X","article-title":"Expression of cyclin-dependent kinase inhibitors during corneal wound repair","volume":"19","author":"Zieske","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"issue":"8\u20139","key":"10.1016\/j.ydbio.2022.08.006_bib111","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1387\/ijdb.041860jz","article-title":"Corneal development associated with eyelid opening","volume":"48","author":"Zieske","year":"2004","journal-title":"Int. J. Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160622001580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160622001580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:57:22Z","timestamp":1778626642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160622001580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":111,"alternative-id":["S0012160622001580"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2022.08.006","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.23.493090","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple roles of Pax6 in postnatal cornea development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2022.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}