{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:26:48Z","timestamp":1790342808624,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2019R1F1A1061772"],"award-info":[{"award-number":["2019R1F1A1061772"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2023-00253615"],"award-info":[{"award-number":["RS-2023-00253615"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1F1A1061772"],"award-info":[{"award-number":["NRF-2019R1F1A1061772"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ydbio.2024.03.006","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:38:29Z","timestamp":1711460309000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Loss of function of phosphatidylserine synthase causes muscle atrophy in Drosophila"],"prefix":"10.1016","volume":"511","author":[{"given":"Sangseob","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyunghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-9147","authenticated-orcid":false,"given":"Sang-Hak","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2024.03.006_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1083\/jcb.201602007","article-title":"MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria","volume":"213","author":"Aaltonen","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2024.03.006_bib2","first-page":"116","article-title":"Mitochondria in skeletal muscle: adaptable rheostats of apoptotic susceptibility. Exerc","volume":"36","author":"Adhihetty","year":"2008","journal-title":"Sport Sci. Rev."},{"key":"10.1016\/j.ydbio.2024.03.006_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbagen.2007.11.009","article-title":"N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells","volume":"1780","author":"Amer","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2024.03.006_bib4","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1074\/jbc.M800714200","article-title":"Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice","volume":"283","author":"Arikketh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1203\/PDR.0b013e3181a9eafb","article-title":"Oxygen toxicity and reactive oxygen species: the devil is in the details","volume":"66","author":"Auten","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2024.03.006_bib6","article-title":"An improved method for accurate and rapid measurement of flight performance in Drosophila","volume":"84","author":"Babcock","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2024.03.006_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"issue":"49","key":"10.1016\/j.ydbio.2024.03.006_bib8","doi-asserted-by":"crossref","first-page":"47701","DOI":"10.1074\/jbc.M207734200","article-title":"Defining the importance of phosphatidylserine synthase 2 in mice","volume":"277","author":"Bergo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/dmm.010389","article-title":"Cellular and molecular mechanisms of muscle atrophy","volume":"6","author":"Bonaldo","year":"2013","journal-title":"Dis. Model Mech"},{"key":"10.1016\/j.ydbio.2024.03.006_bib10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative stress and inflammation interactions in human obesity","volume":"68","author":"Bondia-Pons","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0968-0004(01)01958-2","article-title":"Ten years of protein kinase B signalling: a hard Akt to follow","volume":"26","author":"Brazil","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ydbio.2024.03.006_bib12","series-title":"American Association of Physics Teachers (AAPT) Summer Meeting","article-title":"Video modeling: combining dynamic model simulations with traditional video analysis","author":"Brown","year":"2008"},{"key":"10.1016\/j.ydbio.2024.03.006_bib13","article-title":"Mitochondrial dysfunction as an underlying cause of skeletal muscle disorders","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ydbio.2024.03.006_bib14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/dev.027466","article-title":"Integration of Insulin receptor\/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila","volume":"136","author":"Demontis","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2024.03.006_bib15","first-page":"951","article-title":"LysoTracker staining to aid in monitoring autophagy in Drosophila","author":"DeVorkin","year":"2014","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.ydbio.2024.03.006_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/mus.21526","article-title":"Ros-mediated activation of NF-kappaB and Foxo during muscle disuse","volume":"41","author":"Dodd","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ydbio.2024.03.006_bib17","first-page":"225","article-title":"Signaling pathways perturbing muscle mass","volume":"13","author":"Glass","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.ydbio.2024.03.006_bib18","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/ajmg.a.62695","article-title":"De novo loss-of-function variant in PTDSS1 is associated with developmental delay","volume":"188","author":"Gracie","year":"2022","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2024.03.006_bib19","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1177\/002215549704500803","article-title":"Anti-biotin antibodies offer superior organelle-specific labeling of mitochondria over avidin or streptavidin","volume":"45","author":"Hollinshead","year":"1997","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib20","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1083\/jcb.201005100","article-title":"Phosphatidylserine is a critical modulator for Akt activation","volume":"192","author":"Huang","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2024.03.006_bib21","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17495","article-title":"Drosophila larval to pupal switch under nutrient stress requires IP3R\/Ca2+ signalling in glutamatergic interneurons","volume":"5","author":"Jayakumar","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2024.03.006_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fphys.2011.00112","article-title":"The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise","volume":"2","author":"Jensen","year":"2011","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ydbio.2024.03.006_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112486","article-title":"Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in Drosophila","volume":"399","author":"Katti","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2024.03.006_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2014.06.002","article-title":"Phosphatidylserine in the brain: metabolism and function","volume":"56","author":"Kim","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ydbio.2024.03.006_bib25","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.2337\/diabetes.52.10.2603","article-title":"Translocation of glomerular p47phox and p67phox by protein kinase C-\u03b2 activation is required for oxidative stress in diabetic nephropathy","volume":"52","author":"Kitada","year":"2003","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.ydbio.2024.03.006_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ydbio.2011.01.013","article-title":"Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components","volume":"352","author":"Kucherenko","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2024.03.006_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.biophys.093008.131234","article-title":"The distribution and function of phosphatidylserine in cellular membranes","volume":"39","author":"Leventis","year":"2010","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.ydbio.2024.03.006_bib28","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib29","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1126\/science.7939721","article-title":"PHAS-I as a link between mitogen-activated protein kinase and translation initiation","volume":"266","author":"Lin","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2024.03.006_bib30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ydbio.2024.03.006_bib31","doi-asserted-by":"crossref","first-page":"11285","DOI":"10.1073\/pnas.1934283100","article-title":"Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation","volume":"100","author":"Matsuzaki","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2024.03.006_bib32","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1038\/ncomms7670","article-title":"Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy","volume":"6","author":"Milan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2024.03.006_bib33","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.1152\/ajpendo.00543.2005","article-title":"Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle","volume":"291","author":"Nadeau","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ydbio.2024.03.006_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102899","article-title":"Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function","volume":"24","author":"Park","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.ydbio.2024.03.006_bib35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1001\/jama.1995.03520290054029","article-title":"Physical activity and public health: a recommendation from the centers for disease control and prevention and the American College of Sports Medicine","volume":"273","author":"Pate","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ydbio.2024.03.006_bib36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/dvdy.24036","article-title":"Mechanisms of muscle growth and atrophy in mammals and Drosophila","volume":"243","author":"Piccirillo","year":"2014","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.ydbio.2024.03.006_bib37","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1101\/gad.1098703","article-title":"Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway","volume":"17","author":"Puig","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2024.03.006_bib38","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2024.03.006_bib39","article-title":"A direct and simple method to assess Drosophila melanogaster's viability from embryo to adult","volume":"150","author":"Rockwell","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2024.03.006_bib40","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/00003677-200510000-00006","article-title":"Intramuscular triacylglycerol in energy metabolism during exercise in humans","volume":"33","author":"Roepstorff","year":"2005","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.ydbio.2024.03.006_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ng.2829","article-title":"Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome","volume":"46","author":"Sousa","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2024.03.006_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1196\/annals.1427.015","article-title":"The role of mitochondria in reactive oxygen species metabolism and signaling","volume":"1147","author":"Starkov","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ydbio.2024.03.006_bib43","doi-asserted-by":"crossref","first-page":"40032","DOI":"10.1074\/jbc.M506510200","article-title":"Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects","volume":"280","author":"Steenbergen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib44","doi-asserted-by":"crossref","first-page":"34534","DOI":"10.1074\/jbc.M002865200","article-title":"Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes","volume":"275","author":"Stone","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib45","doi-asserted-by":"crossref","first-page":"E1195","DOI":"10.1152\/ajpendo.90958.2008","article-title":"Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis","volume":"296","author":"Takeuchi","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ydbio.2024.03.006_bib46","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1074\/jbc.M112.434183","article-title":"Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology","volume":"288","author":"Tasseva","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2024.03.006_bib47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbalip.2009.10.006","article-title":"Lipid homeostasis, lipotoxicity and the metabolic syndrome","volume":"1801","author":"Unger","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.ydbio.2024.03.006_bib48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.plipres.2005.05.001","article-title":"Metabolism and functions of phosphatidylserine","volume":"44","author":"Vance","year":"2005","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ydbio.2024.03.006_bib49","doi-asserted-by":"crossref","first-page":"9921","DOI":"10.1073\/pnas.86.24.9921","article-title":"Phosphatidylserine translocation to the mitochondrion is an ATP-dependent process in permeabilized animal cells","volume":"86","author":"Voelker","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.ydbio.2024.03.006_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008548","article-title":"Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms","volume":"15","author":"Yang","year":"2019","journal-title":"PLoS Genet."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160624000885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160624000885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T22:51:30Z","timestamp":1762123890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160624000885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":50,"alternative-id":["S0012160624000885"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2024.03.006","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of function of phosphatidylserine synthase causes muscle atrophy in Drosophila","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2024.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}