{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:37:39Z","timestamp":1789709859931,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872288"],"award-info":[{"award-number":["31872288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170511"],"award-info":[{"award-number":["32170511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ydbio.2024.04.008","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:00:32Z","timestamp":1714690832000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["CG9920 is necessary for mitochondrial morphogenesis and individualization during spermatogenesis in Drosophila melanogaster"],"prefix":"10.1016","volume":"512","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2024.04.008_bib1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32943","article-title":"Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility","volume":"7","author":"Al\u00e9got","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2024.04.008_bib2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.cell.2006.05.025","article-title":"Flies without centrioles","volume":"125","author":"Basto","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2024.04.008_bib3","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.25686","article-title":"JAK-STAT signaling in stem cells and their niches in Drosophila","volume":"2","author":"Bausek","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1016\/j.ydbio.2024.04.008_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fmolb.2016.00065","article-title":"Effects of a mutation in the HSPE1 gene encoding the mitochondrial Co-chaperonin HSP10 and its potential association with a neurological and developmental disorder","volume":"3","author":"Bie","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ydbio.2024.04.008_bib5","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.245277","article-title":"Cytochrome c1-like is required for mitochondrial morphogenesis and individualization during spermatogenesis in Drosophila melanogaster","volume":"226","author":"Chen","year":"2023","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182279","article-title":"Drosophila LKB1 is required for the assembly of the polarized actin structure that allows spermatid individualization","volume":"12","author":"Couderc","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2024.04.008_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0015-0282(01)01896-9","article-title":"Members of the Janus kinase\/signal transducers and activators of transcription (JAK\/STAT) pathway are present and active in human sperm","volume":"76","author":"D'Cruz","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ydbio.2024.04.008_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ymeth.2014.04.020","article-title":"Investigating spermatogenesis in Drosophila melanogaster","volume":"68","author":"Demarco","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.ydbio.2024.04.008_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1741-7007-7-19","article-title":"F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testis","volume":"7","author":"Desai","year":"2009","journal-title":"BMC Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib10","first-page":"64","article-title":"Stage and cell-specific expression and intracellular localization of the small heat shock protein Hsp27 during oogenesis and spermatogenesis in the Mediterranean fruit fly","volume":"96","author":"Economou","year":"2017","journal-title":"Ceratitis capitata. J. Insect. Physiol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/ror.0.0040023","article-title":"Role of heat shock protein HSP70-2 in spermatogenesis","volume":"4","author":"Eddy","year":"1999","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.ydbio.2024.04.008_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4161\/spmg.21798","article-title":"Drosophila spermiogenesis: big things come from little packages","volume":"2","author":"Fabian","year":"2012","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.ydbio.2024.04.008_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/genes8070189","article-title":"Developmental expression of HSP60 and HSP10 in the Coilia nasus testis during upstream spawning migration","volume":"8","author":"Fang","year":"2017","journal-title":"Genes"},{"key":"10.1016\/j.ydbio.2024.04.008_bib14","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1242\/jcs.109.12.2779","article-title":"Assembly of ring canals in the male germ line from structural components of the contractile ring","volume":"109","author":"Hime","year":"1996","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2024.04.008_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.126.2.305","article-title":"Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria","volume":"126","author":"H\u00f6hfeld","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib16","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cub.2022.01.052","article-title":"Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility","volume":"32","author":"Horard","year":"2022","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.ydbio.2024.04.008_bib17","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)81286-6","article-title":"Marelle acts downstream of the Drosophila HOP\/JAK kinase and encodes a protein similar to the mammalian STATs","volume":"84","author":"Hou","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2024.04.008_bib18","first-page":"64","article-title":"Mitochondrial dynamics in neurodegeneration. Trends","volume":"23","author":"Itoh","year":"2013","journal-title":"Cell Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1242\/bio.2012646","article-title":"Spermatogenesis arrest caused by conditional deletion of Hsp90\u03b1 in adult mice","volume":"1","author":"Kajiwara","year":"2012","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2024.04.008_bib20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.devcel.2010.06.009","article-title":"Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids","volume":"19","author":"Kaplan","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2024.04.008_bib21","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1095\/biolreprod.111.092379","article-title":"Mediators of the Jak\/STAT signaling pathway in human spermatozoa","volume":"85","author":"Lachance","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ydbio.2024.04.008_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007987","article-title":"Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm","volume":"15","author":"Laurinyecz","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2024.04.008_bib23","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ncb2086","article-title":"Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes","volume":"12","author":"Leatherman","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/jb\/mvz106","article-title":"Mitochondrial division, fusion and degradation","volume":"167","author":"Murata","year":"2020","journal-title":"J. Biochem."},{"key":"10.1016\/j.ydbio.2024.04.008_bib25","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cub.2011.04.016","article-title":"Sustained elongation of sperm tail promoted by local remodeling of giant mitochondria in Drosophila","volume":"21","author":"Noguchi","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ceb.2015.02.001","article-title":"Mitochondrial division and fusion in metabolism","volume":"33","author":"Roy","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jcp.22073","article-title":"Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK\/STAT signaling","volume":"223","author":"Singh","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2022.02.005","article-title":"Fidelity of organellar protein targeting","volume":"75","author":"Song","year":"2022","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/21565562.2015.1041345","article-title":"Separating from the pack: molecular mechanisms of Drosophila spermatid individualization","volume":"5","author":"Steinhauer","year":"2015","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.ydbio.2024.04.008_bib30","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/s41417-021-00316-6","article-title":"Heat shock protein-90alpha (Hsp90\u03b1) stabilizes hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) in support of spermatogenesis and tumorigenesis","volume":"28","author":"Tang","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.ydbio.2024.04.008_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1379\/1466-1268(2001)006<0071:THGODM>2.0.CO;2","article-title":"The hsp60B gene of Drosophila melanogaster is essential for the spermatid individualization process","volume":"6","author":"Timakov","year":"2001","journal-title":"Cell Stress. Chaperones."},{"key":"10.1016\/j.ydbio.2024.04.008_bib32","first-page":"479","article-title":"Dynamics of spermiogenesis in Drosophila melanogaster . I. Individualization process. Z. Zellforsch. Mikrosk","volume":"124","author":"Tokuyasu","year":"1972","journal-title":"Anat."},{"key":"10.1016\/j.ydbio.2024.04.008_bib33","first-page":"492","article-title":"Dynamics of spermiogenesis in Drosophila melanogaster . II. Coiling process. Z. Zellforsch. Mikrosk","volume":"127","author":"Tokuyasu","year":"1972","journal-title":"Anat."},{"key":"10.1016\/j.ydbio.2024.04.008_bib34","article-title":"JAK\/STAT signaling is necessary for cell monosis prior to epithelial cell apoptotic extrusion. Cell Death","volume":"8","author":"Torres","year":"2017","journal-title":"Dis"},{"key":"10.1016\/j.ydbio.2024.04.008_bib35","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1126\/science.1066700","article-title":"Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling","volume":"294","author":"Tulina","year":"2001","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ydbio.2024.04.008_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002536","article-title":"Drosophila Wnt and STAT define apoptosis-resistant epithelial cells for tissue regeneration after irradiation","volume":"14","author":"Verghese","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib37","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1095\/biolreprod.107.066860","article-title":"Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse","volume":"78","author":"Walsh","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ydbio.2024.04.008_bib38","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/PL00012485","article-title":"Structure and function of the GroE chaperone","volume":"59","author":"Walter","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ydbio.2024.04.008_bib39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jgg.2019.05.001","article-title":"RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila","volume":"46","author":"Wang","year":"2019","journal-title":"J. Genet. Genomics."},{"key":"10.1016\/j.ydbio.2024.04.008_bib40","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/antiox10050711","article-title":"Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism, and insulin sensitivity in the hypothalamus","volume":"10","author":"Wardelmann","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ydbio.2024.04.008_bib41","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.jprot.2010.09.002","article-title":"The Drosophila melanogaster sperm proteome-II (DmSPII)","volume":"73","author":"Wasbrough","year":"2010","journal-title":"J. Proteom."},{"key":"10.1016\/j.ydbio.2024.04.008_bib42","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1098\/rstb.2009.0323","article-title":"Evolution and spermatogenesis","volume":"365","author":"White-Cooper","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.ydbio.2024.04.008_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47138","article-title":"Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila","volume":"8","author":"Witt","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.ydbio.2024.04.008_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ydbio.2016.10.007","article-title":"Knockdown of Dynamitin in testes significantly decreased male fertility in Drosophila melanogaster","volume":"420","author":"Wu","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106067","article-title":"Role of human HSPE1 for OPA1 processing independent of HSPD1","volume":"26","author":"Yeung","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ydbio.2024.04.008_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102671","article-title":"Single-cell RNA-sequencing reveals the transcriptional landscape of ND-42 mediated spermatid elongation via mitochondrial derivative maintenance in Drosophila testes","volume":"62","author":"Yu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib47","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/genetics\/151.3.1065","article-title":"Genetic analysis of viable hsp90 alleles reveals a critical role in Drosophila spermatogenesis","volume":"151","author":"Yue","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2024.04.008_bib48","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00018-022-04386-z","article-title":"Mitofusins: from mitochondria to fertility","volume":"79","author":"Zhao","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ydbio.2024.04.008_bib49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41420-021-00452-w","article-title":"Somatic CG6015 mediates cyst stem cell maintenance and germline stem cell differentiation via EGFR signaling in Drosophila testes","volume":"7","author":"Zheng","year":"2021","journal-title":"Cell Death. Discovery"},{"key":"10.1016\/j.ydbio.2024.04.008_bib50","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/imb.12393","article-title":"Ocnus is essential for male germ cell development in Drosophila melanogaster","volume":"27","author":"Zheng","year":"2018","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ydbio.2024.04.008_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12864-023-09386-2","article-title":"Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development","volume":"24","author":"Zheng","year":"2023","journal-title":"BMC Genom."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216062400109X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216062400109X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:01:31Z","timestamp":1777392091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216062400109X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":51,"alternative-id":["S001216062400109X"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2024.04.008","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CG9920 is necessary for mitochondrial morphogenesis and individualization during spermatogenesis in Drosophila melanogaster","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2024.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}