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Biol."},{"issue":"4","key":"10.1016\/j.ydbio.2024.07.015_bib93","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1101\/gad.219202","article-title":"Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling","volume":"16","author":"te Welscher","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2024.07.015_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1152510","article-title":"Integration failure of regenerated limb tissue is associated with incongruencies in positional information in the Mexican axolotl","volume":"11","author":"Vieira","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.ydbio.2024.07.015_bib95","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/jbiol105","article-title":"Limb regeneration revisited","volume":"8","author":"Whited","year":"2009","journal-title":"J. Biol."},{"issue":"34","key":"10.1016\/j.ydbio.2024.07.015_bib96","doi-asserted-by":"crossref","first-page":"24090","DOI":"10.1074\/jbc.C600122200","article-title":"Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells","volume":"281","author":"Wu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.ydbio.2024.07.015_bib97","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2174\/1566523214666140825125138","article-title":"SALL4: engine of cell stemness","volume":"14","author":"Xiong","year":"2014","journal-title":"Curr. Gene Ther."},{"issue":"5","key":"10.1016\/j.ydbio.2024.07.015_bib98","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.201408106","article-title":"Stemness factor Sall4 is required for DNA damage response in embryonic stem cells","volume":"208","author":"Xiong","year":"2015","journal-title":"J. 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