{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:02:49Z","timestamp":1772121769200,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"am","delay-in-days":287,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006734","name":"Princeton University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD110577"],"award-info":[{"award-number":["R01HD110577"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD107026"],"award-info":[{"award-number":["R01HD107026"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007709","name":"Michigan State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ydbio.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T07:56:58Z","timestamp":1746777418000},"page":"105-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development"],"prefix":"10.1016","volume":"524","author":[{"given":"Madeleine","family":"Chalifoux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Avdeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Posfai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.ydbio.2025.05.006_bib1","first-page":"2813","article-title":"Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo","volume":"141","author":"Anani","year":"2014","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.ydbio.2025.05.006_bib2","series-title":"Generative Model for the First Cell Fate Bifurcation in Mammalian Development","author":"Avdeeva","year":"2025"},{"issue":"6238","key":"10.1016\/j.ydbio.2025.05.006_bib3","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.aaa4559","article-title":"Mechanical strain induces E-cadherin\u2013dependent Yap1 and \u03b2-catenin activation to drive cell cycle entry","volume":"348","author":"Benham-Pyle","year":"2015","journal-title":"Science"},{"issue":"7763","key":"10.1016\/j.ydbio.2025.05.006_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-019-1309-x","article-title":"Hydraulic control of mammalian embryo size and cell fate","volume":"571","author":"Chan","year":"2019","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.ydbio.2025.05.006_bib5","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.cub.2013.05.044","article-title":"The Hippo pathway member Nf2 is required for inner cell mass specification","volume":"23","author":"Cockburn","year":"2013","journal-title":"Curr. Biol. CB"},{"issue":"12","key":"10.1016\/j.ydbio.2025.05.006_bib6","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.bpj.2015.05.010","article-title":"Cytoskeletal to nuclear strain transfer regulates YAP signaling in mesenchymal stem cells","volume":"108","author":"Driscoll","year":"2015","journal-title":"Biophys. J."},{"issue":"7350","key":"10.1016\/j.ydbio.2025.05.006_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ydbio.2025.05.006_bib8","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","article-title":"Force triggers YAP nuclear entry by regulating transport across nuclear pores","volume":"171","author":"Elosegui-Artola","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2025.05.006_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42298","article-title":"HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo","volume":"7","author":"Frum","year":"2018","journal-title":"Elife"},{"issue":"17","key":"10.1016\/j.ydbio.2025.05.006_bib11","first-page":"dev179861","article-title":"TEAD4, YAP1 and WWTR1 prevent the premature onset of pluripotency prior to the 16-cell stage","volume":"146","author":"Frum","year":"2019","journal-title":"Dev. Camb. Engl."},{"issue":"1","key":"10.1016\/j.ydbio.2025.05.006_bib12","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210335","article-title":"Live imaging YAP signalling in mouse embryo development","volume":"12","author":"Gu","year":"2022","journal-title":"Open Biol"},{"issue":"13","key":"10.1016\/j.ydbio.2025.05.006_bib13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.cub.2013.05.014","article-title":"Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos","volume":"23","author":"Hirate","year":"2013","journal-title":"Curr. Biol. CB"},{"issue":"8","key":"10.1016\/j.ydbio.2025.05.006_bib14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/dgd.12235","article-title":"Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos","volume":"57","author":"Hirate","year":"2015","journal-title":"Dev. Growth Differ."},{"issue":"16","key":"10.1016\/j.ydbio.2025.05.006_bib15","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1091\/mbc.E19-01-0027","article-title":"Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes","volume":"31","author":"Hoffman","year":"2020","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.ydbio.2025.05.006_bib16","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1038\/ncomms3251","article-title":"Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms","volume":"4","author":"Leung","year":"2013","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.ydbio.2025.05.006_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1006\/dbio.1996.0186","article-title":"Ezrin becomes restricted to outer cells following asymmetrical division in the preimplantation mouse embryo","volume":"177","author":"Louvet","year":"1996","journal-title":"Dev. Biol."},{"issue":"7616","key":"10.1016\/j.ydbio.2025.05.006_bib18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature18958","article-title":"Asymmetric division of contractile domains couples cell positioning and fate specification","volume":"536","author":"Ma\u00eetre","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ydbio.2025.05.006_bib19","first-page":"593","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genes. N. Y. N"},{"issue":"3\u20134","key":"10.1016\/j.ydbio.2025.05.006_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.mod.2007.11.002","article-title":"Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos","volume":"125","author":"Nishioka","year":"2008","journal-title":"Mech. Dev."},{"issue":"3","key":"10.1016\/j.ydbio.2025.05.006_bib21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass","volume":"16","author":"Nishioka","year":"2009","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.ydbio.2025.05.006_bib22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.devcel.2019.10.012","article-title":"A tug-of-war between cell shape and polarity controls division orientation to ensure robust patterning in the mouse blastocyst","volume":"51","author":"Niwayama","year":"2019","journal-title":"Dev. Cell"},{"issue":"21","key":"10.1016\/j.ydbio.2025.05.006_bib23","first-page":"dev202817","article-title":"Nuclear instance segmentation and tracking for preimplantation mouse embryos","volume":"151","author":"Nunley","year":"2024","journal-title":"Dev. Camb. Engl."},{"issue":"12","key":"10.1016\/j.ydbio.2025.05.006_bib24","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in physiology and disease","volume":"18","author":"Panciera","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.ydbio.2025.05.006_bib25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/dbio.2000.9763","article-title":"The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development","volume":"223","author":"Pauken","year":"2000","journal-title":"Dev. Biol."},{"issue":"Pt 3","key":"10.1016\/j.ydbio.2025.05.006_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/jcs.01666","article-title":"Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo","volume":"118","author":"Plusa","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2025.05.006_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22906","article-title":"Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo","volume":"6","author":"Posfai","year":"2017","journal-title":"Elife"},{"issue":"19","key":"10.1016\/j.ydbio.2025.05.006_bib28","doi-asserted-by":"crossref","first-page":"dev189449","DOI":"10.1242\/dev.189449","article-title":"Establishment of a relationship between blastomere geometry and YAP localisation during compaction","volume":"147","author":"Royer","year":"2020","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.ydbio.2025.05.006_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.devcel.2015.07.004","article-title":"Cortical tension allocates the first inner cells of the mammalian embryo","volume":"34","author":"Samarage","year":"2015","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.ydbio.2025.05.006_bib30","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1038\/s41467-023-38770-5","article-title":"The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization","volume":"14","author":"Skory","year":"2023","journal-title":"Nat. Commun."},{"issue":"20","key":"10.1016\/j.ydbio.2025.05.006_bib31","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1242\/dev.050195","article-title":"Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin","volume":"137","author":"Stephenson","year":"2010","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.ydbio.2025.05.006_bib32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.ydbio.2025.05.006_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nmeth.3690","article-title":"Inverted light-sheet microscope for imaging mouse pre-implantation development","volume":"13","author":"Strnad","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2025.05.006_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/srep28040","article-title":"Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs","volume":"6","author":"Tsichlaki","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ydbio.2025.05.006_bib35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ydbio.2005.03.001","article-title":"Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction","volume":"282","author":"Vinot","year":"2005","journal-title":"Dev. Biol."},{"issue":"18","key":"10.1016\/j.ydbio.2025.05.006_bib36","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1242\/dev.070987","article-title":"Hippo pathway regulation by cell morphology and stress fibers","volume":"138","author":"Wada","year":"2011","journal-title":"Development"},{"issue":"10","key":"10.1016\/j.ydbio.2025.05.006_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004618","article-title":"HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst","volume":"10","author":"Wicklow","year":"2014","journal-title":"PLoS Genet."},{"issue":"21","key":"10.1016\/j.ydbio.2025.05.006_bib38","first-page":"3827","article-title":"Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development","volume":"134","author":"Yagi","year":"2007","journal-title":"Dev. Camb. Engl."},{"issue":"3","key":"10.1016\/j.ydbio.2025.05.006_bib39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/cr.2016.20","article-title":"Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse","volume":"26","author":"Yu","year":"2016","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.ydbio.2025.05.006_bib40","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.cell.2018.02.035","article-title":"Expanding actin rings zipper the mouse embryo for blastocyst formation","volume":"173","author":"Zenker","year":"2018","journal-title":"Cell"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160625001290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160625001290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T22:51:53Z","timestamp":1762123913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160625001290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"alternative-id":["S0012160625001290"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.05.006","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.02.27.640568","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}