{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:38:16Z","timestamp":1791509896963,"version":"4.3.4"},"reference-count":134,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"am","delay-in-days":286,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009238","name":"Virginia Commonwealth University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD105144"],"award-info":[{"award-number":["R21HD105144"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R25GM089614"],"award-info":[{"award-number":["R25GM089614"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ydbio.2025.06.009","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T11:27:26Z","timestamp":1749554846000},"page":"216-228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The role of Goldilocks protein kinase DYRK1A in embryonic development"],"prefix":"10.1016","volume":"525","author":[{"given":"H. Katherine","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa L.","family":"Litovchick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-9140","authenticated-orcid":false,"given":"Amanda J.G.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2025.06.009_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pharmthera.2015.03.004","article-title":"DYRK1A in neurodegeneration and cancer: molecular basis and clinical implications","volume":"151","author":"Abbassi","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ydbio.2025.06.009_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/jdb7020009","article-title":"Hedgehog signaling and embryonic craniofacial disorders","volume":"7","author":"Abramyan","year":"2019","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.abb.2010.12.024","article-title":"Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)","volume":"507","author":"Adayev","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ydbio.2025.06.009_bib4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nbd.2005.12.006","article-title":"DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects","volume":"22","author":"Ahn","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40510-016-0148-7","article-title":"Craniofacial features as assessed by lateral cephalometric measurements in children with Down syndrome","volume":"17","author":"Allareddy","year":"2016","journal-title":"Prog. Orthod."},{"key":"10.1016\/j.ydbio.2025.06.009_bib6","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/hmg\/10.18.1915","article-title":"Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome","volume":"10","author":"Altafaj","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2012.11.017","article-title":"Normalization of Dyrk1A expression by AAV2\/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome","volume":"52","author":"Altafaj","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/mrd.23650","article-title":"Structures and functions of cilia during vertebrate embryo development","volume":"89","author":"Amack","year":"2022","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ydbio.2025.06.009_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1277537","article-title":"Insights from the protein interaction Universe of the multifunctional \"Goldilocks\" kinase DYRK1A","volume":"11","author":"Ananthapadmanabhan","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrg.2016.154","article-title":"Down syndrome and the complexity of genome dosage imbalance","volume":"18","author":"Antonarakis","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrg1448","article-title":"Chromosome 21 and down syndrome: from genomics to pathophysiology","volume":"5","author":"Antonarakis","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ydbio.2025.06.009_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41581-019-0116-9","article-title":"Cellular signalling by primary cilia in development, organ function and disease","volume":"15","author":"Anvarian","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12929-015-0138-y","article-title":"Down syndrome: an insight of the disease","volume":"22","author":"Asim","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/genes12111833","article-title":"Dyrk1a from gene function in development and physiology to dosage correction across life span in down syndrome","volume":"12","author":"Atas-Ozcan","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.ydbio.2025.06.009_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj20021535","article-title":"The specificities of protein kinase inhibitors: an update","volume":"371","author":"Bain","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2025.06.009_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.253","article-title":"DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease","volume":"5","author":"Barallobre","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1742-4658.2010.07956.x","article-title":"Activation, regulation, and inhibition of DYRK1A","volume":"278","author":"Becker","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.ydbio.2025.06.009_bib19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/18715273113126660186","article-title":"DYRK1A: a potential drug target for multiple Down syndrome neuropathologies","volume":"13","author":"Becker","year":"2014","journal-title":"CNS Neurol. Disord., Drug Targets"},{"key":"10.1016\/j.ydbio.2025.06.009_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s004410100447","article-title":"Onset and time course of apoptosis in the developing zebrafish retina","volume":"306","author":"Biehlmaier","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2025.06.009_bib21","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1038\/s41436-019-0576-0","article-title":"DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract","volume":"21","author":"Blackburn","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1387\/ijdb.11291854","article-title":"The Spemann-Mangold organizer: the control of fate specification and morphogenetic rearrangements during gastrulation in Xenopus","volume":"45","author":"Bouwmeester","year":"2001","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/jnen\/63.5.429","article-title":"Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration","volume":"63","author":"Branchi","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib24","doi-asserted-by":"crossref","first-page":"R973","DOI":"10.1016\/j.cub.2014.08.047","article-title":"Multiciliated cells","volume":"24","author":"Brooks","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100853","article-title":"A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression","volume":"297","author":"Buchberger","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2025.06.009_bib26","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1056\/NEJMra1706537","article-title":"Down syndrome","volume":"382","author":"Bull","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/wdev.217","article-title":"Specification of anteroposterior axis by combinatorial signaling during Xenopus development","volume":"5","author":"Carron","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1310","article-title":"Single-cell landscape analysis reveals systematic senescence in mammalian Down syndrome","volume":"13","author":"Chen","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib29","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.037044","article-title":"Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish","volume":"12","author":"Cho","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ydbio.2025.06.009_bib134","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1016\/j.cell.2022.06.036","article-title":"A cross-disorder dosage sensitivity map of the human genome","volume":"185","author":"Collins","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2025.06.009_bib30","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.909","article-title":"A copy number variation morbidity map of developmental delay","volume":"43","author":"Cooper","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib31","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1038\/s41436-021-01263-1","article-title":"Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder","volume":"23","author":"Courraud","year":"2021","journal-title":"Genet. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/genes12111800","article-title":"DYRK1A overexpression in mice downregulates the gonadotropic Axis and disturbs early stages of spermatogenesis","volume":"12","author":"Dard","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.ydbio.2025.06.009_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1387\/ijdb.11061420","article-title":"Regulation of primordial germ cell development in the mouse","volume":"44","author":"De Felici","year":"2000","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-444-54299-1.00001-7","article-title":"Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future","volume":"197","author":"de la Torre","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.ydbio.2025.06.009_bib35","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.mod.2009.08.004","article-title":"Spemann's organizer and the self-regulation of embryonic fields","volume":"126","author":"De Robertis","year":"2009","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2025.06.009_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169355","article-title":"The omnipresence of DYRK1A in human diseases","volume":"23","author":"Deboever","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib37","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1100\/tsw.2006.319","article-title":"DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis","volume":"6","author":"Dierssen","year":"2006","journal-title":"Sci. World J."},{"key":"10.1016\/j.ydbio.2025.06.009_bib38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnbeh.2016.00104","article-title":"DYRK1A, a dosage-sensitive gene involved in neurodevelopmental disorders, is a target for drug development in down syndrome","volume":"10","author":"Duchon","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23405","article-title":"Xenopus leads the way: frogs as a pioneering model to understand the human brain","volume":"59","author":"Exner","year":"2021","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2025.06.009_bib40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/cne.20615","article-title":"Cell birth and death in the mouse retinal ganglion cell layer","volume":"489","author":"Farah","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00001665-200111000-00003","article-title":"Surface anatomy of the face in Down's syndrome: anthropometric proportion indices in the craniofacial regions","volume":"12","author":"Farkas","year":"2001","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.ydbio.2025.06.009_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci8100187","article-title":"DYRK1A protein, A promising therapeutic target to improve cognitive deficits in down syndrome","volume":"8","author":"Feki","year":"2018","journal-title":"Brain Sci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib43","article-title":"DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis","volume":"2","author":"Fernandez-Martinez","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib44","article-title":"DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis","volume":"2","author":"Fern\u00e1ndez-Mart\u00ednez","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib45","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ajhg.2009.03.010","article-title":"DECIPHER: database of chromosomal imbalance and phenotype in humans using Ensembl Resources","volume":"84","author":"Firth","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib46","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1128\/MCB.22.18.6636-6647.2002","article-title":"Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice","volume":"22","author":"Fotaki","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106572","article-title":"Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome","volume":"9","author":"Garc\u00eda-Cerro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2025.06.009_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67133-z","article-title":"Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice","volume":"10","author":"Goodlett","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2012.01.007","article-title":"DYRK1A: a master regulatory protein controlling brain growth","volume":"46","author":"Guedj","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41591-018-0279-0","article-title":"Identifying facial phenotypes of genetic disorders using deep learning","volume":"25","author":"Gurovich","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib51","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1460-9568.2008.06092.x","article-title":"The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb\/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development","volume":"27","author":"H\u00e4mmerle","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib52","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1242\/dev.066167","article-title":"Transient expression of Mnb\/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling","volume":"138","author":"Hammerle","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.06.009_bib53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/dbio.2002.0675","article-title":"Mnb\/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions","volume":"246","author":"H\u00e4mmerle","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106359","article-title":"Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model","volume":"190","author":"Hawley","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib55","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ydbio.2006.11.009","article-title":"Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm","volume":"303","author":"Haworth","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib56","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1242\/dmm.029728","article-title":"Rodent models in Down syndrome research: impact and future opportunities","volume":"10","author":"Herault","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ydbio.2025.06.009_bib57","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007955","article-title":"Wnt signaling in vertebrate axis specification","volume":"5","author":"Hikasa","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib58","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"Hildebrandt","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib59","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1242\/jcs.086173","article-title":"Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway","volume":"125","author":"Hong","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264254","article-title":"Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models","volume":"17","author":"Jamal","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2025.06.009_bib61","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/ejhg.2015.71","article-title":"DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies","volume":"23","author":"Ji","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib62","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1093\/hmg\/ddv364","article-title":"Genetic dissection of the Down syndrome critical region","volume":"24","author":"Jiang","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib63","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/brv.12527","article-title":"Causes and effects of haploinsufficiency","volume":"94","author":"Johnson","year":"2019","journal-title":"Biol. Rev. Camb. Phil. Soc."},{"key":"10.1016\/j.ydbio.2025.06.009_bib64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ydbio.2024.04.004","article-title":"Dyrk1a is required for craniofacial development in Xenopus laevis","volume":"511","author":"Johnson","year":"2024","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib65","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.17219\/acem\/112785","article-title":"Down syndrome as a cause of abnormalities in the craniofacial region: a systematic literature review","volume":"28","author":"Kaczorowska","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib66","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.apcsb.2016.07.001","article-title":"Understanding the multifaceted role of human down syndrome kinase DYRK1A","volume":"105","author":"Kay","year":"2016","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib67","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13229-017-0168-2","article-title":"Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism","volume":"8","author":"Kim","year":"2017","journal-title":"Mol. Autism"},{"key":"10.1016\/j.ydbio.2025.06.009_bib68","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/978-0-387-46954-6_7","article-title":"Cranial neural crest and development of the head skeleton","volume":"589","author":"Knight","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib69","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1242\/dev.126.24.5759","article-title":"Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors","volume":"126","author":"Kofron","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.06.009_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/jdb9040047","article-title":"The organizer and its signaling in embryonic development","volume":"9","author":"Kumar","year":"2021","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib71","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.050914","article-title":"Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model","volume":"17","author":"LaCombe","year":"2024","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ydbio.2025.06.009_bib72","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.devcel.2008.10.014","article-title":"The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development","volume":"15","author":"Laguna","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2025.06.009_bib73","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1093\/hmg\/ddt125","article-title":"Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome","volume":"22","author":"Laguna","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib74","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add6883","article-title":"Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome","volume":"16","author":"Lana-Elola","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib75","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11614","article-title":"Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel","volume":"5","author":"Lana-Elola","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2025.06.009_bib76","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102110","article-title":"CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis","volume":"221","author":"Lee","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib77","doi-asserted-by":"crossref","first-page":"33343","DOI":"10.1074\/jbc.M109.042234","article-title":"Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2025.06.009_bib78","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1101\/gad.2034211","article-title":"DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly","volume":"25","author":"Litovchick","year":"2011","journal-title":"Gene Dev."},{"key":"10.1016\/j.ydbio.2025.06.009_bib79","article-title":"Overexpression of DYRK1A, a down syndrome candidate gene, impairs primordial germ cells maintenance and migration in zebrafish","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib80","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s41419-022-05517-x","article-title":"Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib81","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1038\/s41598-022-06984-0","article-title":"A reassessment of Jackson's checklist and identification of two Down syndrome sub-phenotypes","volume":"12","author":"Locatelli","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib82","first-page":"408","article-title":"Craniofacial features and specific oral characteristics of Down syndrome children","volume":"13","author":"Macho","year":"2014","journal-title":"Oral. Health Dent. Manag."},{"key":"10.1016\/j.ydbio.2025.06.009_bib83","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1002\/jcp.24065","article-title":"PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics","volume":"227","author":"Mahajan","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib84","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1038\/s41467-025-57342-3","article-title":"Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility","volume":"16","author":"McCluskey","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.06.009_bib85","first-page":"4856","article-title":"Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome","volume":"25","author":"McElyea","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib86","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.stem.2021.12.002","article-title":"Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors","volume":"29","author":"Meharena","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ydbio.2025.06.009_bib87","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41576-023-00587-9","article-title":"Primary cilia as dynamic and diverse signalling hubs in development and disease","volume":"24","author":"Mill","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib88","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302129","article-title":"Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A","volume":"6","author":"Miyata","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.ydbio.2025.06.009_bib89","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00335-007-9030-8","article-title":"The power of comparative and developmental studies for mouse models of Down syndrome","volume":"18","author":"Moore","year":"2007","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ydbio.2025.06.009_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/jdb8020008","article-title":"Delta-notch signaling: the long and the short of a neuron's influence on progenitor fates","volume":"8","author":"Moore","year":"2020","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1391564","article-title":"Down syndrome and DYRK1A overexpression: relationships and future therapeutic directions","volume":"17","author":"Murphy","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib92","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.euroneuro.2015.03.018","article-title":"Leucettine L41, a DYRK1A-preferential DYRKs\/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric A\u03b225-35 peptide administration in mice","volume":"25","author":"Naert","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib93","doi-asserted-by":"crossref","first-page":"10268","DOI":"10.1073\/pnas.1704143114","article-title":"Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice","volume":"114","author":"Nakano-Kobayashi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2025.06.009_bib94","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.035634","article-title":"Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A","volume":"11","author":"Nguyen","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ydbio.2025.06.009_bib95","article-title":"Whole-exome sequencing identified a novel DYRK1A variant in a patient with intellectual developmental disorder, autosomal dominant 7","volume":"15","author":"Obara","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.ydbio.2025.06.009_bib96","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ncomms1090","article-title":"Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A","volume":"1","author":"Ogawa","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.06.009_bib97","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ajhg.2008.09.010","article-title":"Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome","volume":"83","author":"Ortiz-Abalia","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1462893","article-title":"Skeletal health in DYRK1A syndrome","volume":"18","author":"Otte","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib99","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1007\/s00018-009-0123-2","article-title":"Function and regulation of Dyrk1A: towards understanding Down syndrome","volume":"66","author":"Park","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib100","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","author":"Peng","year":"2003","journal-title":"Gene Dev."},{"key":"10.1016\/j.ydbio.2025.06.009_bib101","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/B978-0-12-804766-8.00017-0","article-title":"Down syndrome","volume":"167","author":"Rafii","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib102","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nbd.2017.12.003","article-title":"DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures","volume":"110","author":"Raveau","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib103","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrg1154","article-title":"Primordial germ-cell development: the zebrafish perspective","volume":"4","author":"Raz","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib104","doi-asserted-by":"crossref","DOI":"10.1242\/dev.201077","article-title":"Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes","volume":"150","author":"Redhead","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.06.009_bib105","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature01178","article-title":"Human chromosome 21 gene expression atlas in the mouse","volume":"420","author":"Reymond","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2025.06.009_bib106","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12915-017-0418-y","article-title":"Dosage-sensitive genes in evolution and disease","volume":"15","author":"Rice","year":"2017","journal-title":"BMC Biol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib107","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14366","article-title":"Dosage sensitivity is a major determinant of human copy number variant pathogenicity","volume":"8","author":"Rice","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.06.009_bib108","article-title":"Notch\/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation","volume":"4","author":"Roese-Koerner","year":"2017","journal-title":"Neurogenesis (Austin)"},{"key":"10.1016\/j.ydbio.2025.06.009_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0020050","article-title":"Understanding the basis for Down syndrome phenotypes","volume":"2","author":"Roper","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mod.2008.11.002","article-title":"A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog","volume":"126","author":"Roper","year":"2009","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2025.06.009_bib111","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrn1221","article-title":"Cranial neural crest and the building of the vertebrate head","volume":"4","author":"Santagati","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib112","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.994256","article-title":"Roles of dual specificity tyrosine-phosphorylation-regulated kinase 2 in nervous system development and disease","volume":"16","author":"Santos-Dur\u00e1n","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib113","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ar.20640","article-title":"Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21","volume":"291","author":"Sebri\u00e9","year":"2008","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ydbio.2025.06.009_bib114","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049927","article-title":"Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice","volume":"16","author":"Sloan","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ydbio.2025.06.009_bib115","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1038\/s41598-019-40328-9","article-title":"Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models","volume":"9","author":"Souchet","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib116","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1038\/s41598-021-83757-1","article-title":"Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome","volume":"11","author":"Starbuck","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib117","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.physbeh.2017.05.003","article-title":"Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes","volume":"177","author":"Stringer","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ydbio.2025.06.009_bib118","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/mgg3.334","article-title":"Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits","volume":"5","author":"Stringer","year":"2017","journal-title":"Mol. Gene.Genomic Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib119","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1038\/s41598-020-61695-8","article-title":"Genetic landscape of autism spectrum disorder in Vietnamese children","volume":"10","author":"Tran","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8050641","article-title":"Cranio-facial characteristics in children with autism spectrum disorders (ASD)","volume":"8","author":"Tripi","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ydbio.2025.06.009_bib121","series-title":"GeneReviews\u00ae [Internet]","first-page":"1993","article-title":"DYRK1A syndrome","author":"van Bon Bwm","year":"2015"},{"key":"10.1016\/j.ydbio.2025.06.009_bib122","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76984-5","article-title":"Craniofacial morphology in down syndrome: a systematic review and meta-analysis","volume":"10","author":"Vicente","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ydbio.2025.06.009_bib123","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2788.2009.01158.x","article-title":"Down syndrome: a cardiovascular perspective","volume":"53","author":"Vis","year":"2009","journal-title":"J. Intellect. Disabil. Res."},{"key":"10.1016\/j.ydbio.2025.06.009_bib124","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1742-4658.2010.07955.x","article-title":"The role of DYRK1A in neurodegenerative diseases","volume":"278","author":"Wegiel","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.ydbio.2025.06.009_bib125","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/dvg.20824","article-title":"Understanding ciliated epithelia: the power of Xenopus","volume":"50","author":"Werner","year":"2012","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2025.06.009_bib126","doi-asserted-by":"crossref","DOI":"10.1242\/bio.032862","article-title":"Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism","volume":"7","author":"Widowati","year":"2018","journal-title":"Biol. Open"},{"key":"10.1016\/j.ydbio.2025.06.009_bib127","doi-asserted-by":"crossref","DOI":"10.1242\/dev.198317","article-title":"The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos","volume":"147","author":"Willsey","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.06.009_bib128","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1093\/hmg\/ddp010","article-title":"Down syndrome--recent progress and future prospects","volume":"18","author":"Wiseman","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2025.06.009_bib129","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.diff.2023.07.002","article-title":"Sonic hedgehog signaling in craniofacial development","volume":"133","author":"Xu","year":"2023","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2025.06.009_bib130","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.4711-09.2010","article-title":"Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells","volume":"30","author":"Yabut","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2025.06.009_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115521","article-title":"Function and inhibition of DYRK1A: emerging roles of treating multiple human diseases","volume":"212","author":"Yang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ydbio.2025.06.009_bib132","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.gendis.2021.12.004","article-title":"New insights into the roles for DYRK family in mammalian development and congenital diseases","volume":"10","author":"Yoshida","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.ydbio.2025.06.009_bib133","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00198-021-06070-7","article-title":"Changes in bone mineral density in Down syndrome individuals: a systematic review and meta-analysis","volume":"33","author":"Zhang","year":"2022","journal-title":"Osteoporos. Int."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216062500168X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216062500168X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:04:58Z","timestamp":1778645098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216062500168X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":134,"alternative-id":["S001216062500168X"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.06.009","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Goldilocks protein kinase DYRK1A in embryonic development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}