{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:06:21Z","timestamp":1787659581405,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC018040"],"award-info":[{"award-number":["R01DC018040"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ydbio.2025.07.006","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T16:02:14Z","timestamp":1752768134000},"page":"133-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse organ of Corti"],"prefix":"10.1016","volume":"526","author":[{"given":"Shubham","family":"Kale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Traenkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellison J.","family":"Goodrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish R.","family":"Ghimire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Coate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-7945","authenticated-orcid":false,"given":"Michael R.","family":"Deans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2025.07.006_bib1","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1523\/JNEUROSCI.4703-12.2013","article-title":"Gata3 is a critical regulator of cochlear wiring","volume":"33","author":"Appler","year":"2013","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19921","article-title":"Fine-tuning of notch signaling sets the boundary of the organ of corti and establishes sensory cell fates","volume":"5","author":"Basch","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2025.07.006_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbamcr.2010.10.015","article-title":"Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein","volume":"1813","author":"Baxter","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2025.07.006_bib4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cne.20944","article-title":"Expression of Prox1 during mouse cochlear development","volume":"496","author":"Bermingham-McDonogh","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib5","doi-asserted-by":"crossref","DOI":"10.1242\/dev.165753","article-title":"Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust","volume":"145","author":"Choi","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.07.006_bib6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.devcel.2006.09.015","article-title":"Prospero acts as a binary switch between self-renewal and differentiation in drosophila neural stem cells","volume":"11","author":"Choksi","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2025.07.006_bib7","article-title":"Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system","volume":"252","author":"Clancy","year":"2025","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.07.006_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(91)90463-9","article-title":"The prospero gene specifies cell fates in the drosophila central nervous system","volume":"65","author":"Doe","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2025.07.006_bib9","doi-asserted-by":"crossref","DOI":"10.1242\/dev.162263","article-title":"Development of the cochlea","volume":"147","author":"Driver","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.07.006_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ng1144","article-title":"Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the Mammalian retina","volume":"34","author":"Dyer","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2025.07.006_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009377","article-title":"Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity","volume":"5","author":"Fritzsch","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2025.07.006_bib12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41586-022-04668-3","article-title":"Tbx2 is a master regulator of inner versus outer hair cell differentiation","volume":"605","author":"Garcia-Anoveros","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2025.07.006_bib13","doi-asserted-by":"crossref","first-page":"8013","DOI":"10.1523\/JNEUROSCI.1740-19.2019","article-title":"Frizzled3 and Frizzled6 cooperate with Vangl2 to direct cochlear innervation by type II spiral ganglion neurons","volume":"39","author":"Ghimire","year":"2019","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib14","article-title":"A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea","volume":"145","author":"Ghimire","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.07.006_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202425","article-title":"Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear","volume":"151","author":"Goodrich","year":"2024","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.07.006_bib16","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ng1642","article-title":"Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity","volume":"37","author":"Harvey","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2025.07.006_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/dvdy.21026","article-title":"Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti","volume":"236","author":"Hayashi","year":"2007","journal-title":"Dev. Dyn. : an official publication of the American Association of Anatomists"},{"key":"10.1016\/j.ydbio.2025.07.006_bib18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10162-010-0211-x","article-title":"CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear","volume":"11","author":"Hertzano","year":"2010","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.ydbio.2025.07.006_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/dvdy.10163","article-title":"Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate","volume":"225","author":"Hong","year":"2002","journal-title":"Dev. Dyn. : an official publication of the American Association of Anatomists"},{"key":"10.1016\/j.ydbio.2025.07.006_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001231","article-title":"Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal","volume":"10","author":"Huh","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib21","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1074\/jbc.RA118.004153","article-title":"PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-beta (TGF-beta) signaling","volume":"294","author":"Ikeno","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2025.07.006_bib22","doi-asserted-by":"crossref","first-page":"21054","DOI":"10.1073\/pnas.1910223116","article-title":"beta-Catenin is required for radial cell patterning and identity in the developing mouse cochlea","volume":"116","author":"Jansson","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ydbio.2025.07.006_bib23","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1038\/s41467-022-35214-4","article-title":"TBX2 specifies and maintains inner hair and supporting cell fate in the organ of corti","volume":"13","author":"Kaiser","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.07.006_bib24","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neuron.2004.12.002","article-title":"Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans","volume":"44","author":"Kantor","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2025.07.006_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2025.07.006_bib26","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1523\/JNEUROSCI.0239-05.2005","article-title":"Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium","volume":"25","author":"Kimura","year":"2005","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.270.5233.96","article-title":"Bax-deficient mice with lymphoid hyperplasia and male germ cell death","volume":"270","author":"Knudson","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2025.07.006_bib28","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1038\/s41467-020-16113-y","article-title":"Characterization of the development of the mouse cochlear epithelium at the single cell level","volume":"11","author":"Kolla","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.07.006_bib29","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033241","article-title":"A functional perspective on the evolution of the cochlea","volume":"9","author":"Koppl","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ydbio.2025.07.006_bib30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2025.07.006_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz114","article-title":"The R package rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2025.07.006_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib33","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s12264-021-00757-x","article-title":"Mapping genome-wide binding sites of Prox1 in mouse cochlea using the CUT&RUN approach","volume":"37","author":"Luo","year":"2021","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ydbio.2025.07.006_bib34","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.neuron.2011.06.009","article-title":"Class 5 transmembrane semaphorins control selective mammalian retinal lamination and function","volume":"71","author":"Matsuoka","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2025.07.006_bib35","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1523\/JNEUROSCI.22-21-09368.2002","article-title":"Fibroblast growth factor signaling regulates pillar cell development in the organ of corti","volume":"22","author":"Mueller","year":"2002","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib36","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1242\/dev.139469","article-title":"Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner","volume":"143","author":"Munnamalai","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2025.07.006_bib37","first-page":"281","article-title":"The acquisition of positional information across the radial axis of the cochlea","volume":"vol. 249","author":"Munnamalai","year":"2020"},{"key":"10.1016\/j.ydbio.2025.07.006_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170568","article-title":"Dynamic expression of Sox2, Gata3, and Prox1 during primary auditory neuron development in the Mammalian cochlea","volume":"12","author":"Nishimura","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2025.07.006_bib39","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1523\/JNEUROSCI.3547-10.2010","article-title":"BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea","volume":"30","author":"Ohyama","year":"2010","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004118","article-title":"FGFR1-Frs2\/3 signalling maintains sensory progenitors during inner ear hair cell formation","volume":"10","author":"Ono","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2025.07.006_bib41","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41592-021-01200-9","article-title":"gEAR: Gene expression analysis resource portal for community-driven, multi-omic data exploration","volume":"18","author":"Orvis","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2025.07.006_bib42","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1038\/s41467-018-06033-3","article-title":"Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system","volume":"9","author":"Petitpre","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.07.006_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47613","article-title":"A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea","volume":"8","author":"Prajapati-DiNubila","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2025.07.006_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107769","article-title":"Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset","volume":"26","author":"Rose","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib45","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2010.02.025","article-title":"Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice","volume":"65","author":"Ross","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2025.07.006_bib46","first-page":"221","article-title":"Development of the inner ear of the mouse: a radioautographic study of terminal mitoses","volume":"220","author":"Ruben","year":"1967","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib47","first-page":"1","article-title":"The embryonic and postnatal development of the inner ear of the mouse","volume":"285","author":"Sher","year":"1971","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.ydbio.2025.07.006_bib48","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2018.07.007","article-title":"Sensory neuron diversity in the inner ear is shaped by activity","volume":"174","author":"Shrestha","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2025.07.006_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ydbio.2011.01.009","article-title":"Non-cell-autonomous planar cell polarity propagation in the auditory sensory epithelium of vertebrates","volume":"352","author":"Sienknecht","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ydbio.2018.02.021","article-title":"Domineering non-autonomy in Vangl1;Vangl2 double mutants demonstrates intercellular PCP signaling in the vertebrate inner ear","volume":"437","author":"Stoller","year":"2018","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib51","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0006-8993(01)02123-0","article-title":"Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss","volume":"894","author":"Takahashi","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.ydbio.2025.07.006_bib52","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0092-8674(91)90367-8","article-title":"Prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in drosophila","volume":"67","author":"Vaessin","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2025.07.006_bib53","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ydbio.2005.07.021","article-title":"Prox1 activity controls pancreas morphogenesis and participates in the production of \"secondary transition\" pancreatic endocrine cells","volume":"286","author":"Wang","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.07.006_bib54","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1523\/JNEUROSCI.18-04-01428.1998","article-title":"Widespread elimination of naturally occurring neuronal death in Bax-deficient mice","volume":"18","author":"White","year":"1998","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.ydbio.2025.07.006_bib55","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/emboj\/21.7.1505","article-title":"An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype","volume":"21","author":"Wigle","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2025.07.006_bib56","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41586-018-0570-8","article-title":"Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1","volume":"563","author":"Wiwatpanit","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2025.07.006_bib57","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160625001976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160625001976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:17:42Z","timestamp":1777105062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160625001976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":57,"alternative-id":["S0012160625001976"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.07.006","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PROX1 is necessary for cellular patterning, innervation and differentiation in the mouse organ of Corti","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}