{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:27:04Z","timestamp":1792618024055,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE024034"],"award-info":[{"award-number":["R01 DE024034"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K99\/R00 DE031349"],"award-info":[{"award-number":["K99\/R00 DE031349"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ydbio.2025.12.002","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:26:48Z","timestamp":1764865608000},"page":"210-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["PRDM paralogs are required for Meckel's cartilage formation during mandibular bone development"],"prefix":"10.1016","volume":"530","author":[{"given":"Qootsvenma","family":"Denipah-Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryanna V.","family":"Saxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin B.","family":"Artinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lomeli C.","family":"Shull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2025.12.002_bib1","unstructured":"Akiyama, H. et al. Interactions Between Sox9 and -catenin Control Chondrocyte Differentiation."},{"key":"10.1016\/j.ydbio.2025.12.002_bib2","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1073\/pnas.0504750102","article-title":"Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors","volume":"102","author":"Akiyama","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ydbio.2025.12.002_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1469-7580.2012.01526.x","article-title":"Evolution of the mammalian middle ear and jaw: adaptations and novel structures","volume":"222","author":"Anthwal","year":"2013","journal-title":"J. Anat."},{"key":"10.1016\/j.ydbio.2025.12.002_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuron.2018.06.031","article-title":"The epigenetic State of PRDM16-Regulated enhancers in radial glia controls cortical neuron position","volume":"99","author":"Baizabal","year":"2018","journal-title":"Neuron."},{"key":"10.1016\/j.ydbio.2025.12.002_bib5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.cellbio.042308.113245","article-title":"Assembling neural crest regulatory circuits into a gene regulatory network","volume":"26","author":"Betancur","year":"2010","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008326","article-title":"Signals and switches in mammalian neural crest cell differentiation","volume":"5","author":"Bhatt","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/hmg\/ddp543","article-title":"Prdm16 is required for normal palatogenesis in mice","volume":"19","author":"Bjork","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2025.12.002_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ydbio.2011.12.042","article-title":"Development and evolution of the neural crest: an overview","volume":"366","author":"Bronner","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/ajmg.a.33702","article-title":"Cranial neural crest cells on the move: their roles in craniofacial development","volume":"155A","author":"Cordero","year":"2011","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2025.12.002_bib10","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115409","article-title":"The development, patterning and evolution of neural crest cell differentiation into cartilage and bone","volume":"137","author":"Dash","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.ydbio.2025.12.002_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","article-title":"Wnt\/Beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis","volume":"8","author":"Day","year":"2005","journal-title":"Dev. Cell."},{"key":"10.1016\/j.ydbio.2025.12.002_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/biology2010107","article-title":"PRDM proteins: molecular mechanisms in signal transduction and transcriptional regulation","volume":"2","author":"Di Zazzo","year":"2013","journal-title":"Biol"},{"key":"10.1016\/j.ydbio.2025.12.002_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/bies.201100107","article-title":"PRDM proteins: important players in differentiation and disease","volume":"34","author":"Fog","year":"2012","journal-title":"Bioessays."},{"key":"10.1016\/j.ydbio.2025.12.002_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.stem.2008.06.002","article-title":"Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells","volume":"3","author":"Goyama","year":"2008","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.ydbio.2025.12.002_bib16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature14436","article-title":"Evolution of vertebrates as viewed from the crest","volume":"520","author":"Green","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2025.12.002_bib17","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.1038\/s41467-024-52154-3","article-title":"PRDM3\/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function","volume":"15","author":"He","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2025.12.002_bib18","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1074\/jbc.M110.165100","article-title":"Lef1\u0394N binds \u03b2-Catenin and increases osteoblast activity and trabecular bone mass","volume":"286","author":"Hoeppner","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2025.12.002_bib19","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1242\/dev.070110","article-title":"The prdm family: expanding roles in stem cells and development","volume":"139","author":"Hohenauer","year":"2012","journal-title":"Development."},{"key":"10.1016\/j.ydbio.2025.12.002_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0925-4773(97)00057-9","article-title":"The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development","volume":"65","author":"Hoyt","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2025.12.002_bib21","doi-asserted-by":"crossref","first-page":"12758","DOI":"10.1074\/jbc.M413367200","article-title":"Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin","volume":"280","author":"Hwang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2025.12.002_bib22","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","article-title":"Wnt\/\u03b2-Catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway","volume":"22","author":"Jho","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011493","article-title":"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from scandinavia","volume":"5","author":"Jugessur","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ydbio.2025.12.002_bib24","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/jcb.20702","article-title":"Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts","volume":"97","author":"Kahler","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ydbio.2025.12.002_bib25","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/dvdy.20341","article-title":"Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation","volume":"233","author":"McKeown","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2025.12.002_bib26","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1242\/dev.040048","article-title":"Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development","volume":"137","author":"Minoux","year":"2010","journal-title":"Develop."},{"key":"10.1016\/j.ydbio.2025.12.002_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","article-title":"Update on wnt signaling in bone cell biology and bone disease","volume":"492","author":"Monroe","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.ydbio.2025.12.002_bib28","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1073\/pnas.1631288100","article-title":"Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest","volume":"100","author":"Mori-Akiyama","year":"2003","journal-title":"Proc Natl Acad Sci U A"},{"key":"10.1016\/j.ydbio.2025.12.002_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2025.12.002_bib30","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1101\/gad.988402","article-title":"The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development","volume":"16","author":"Robledo","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2025.12.002_bib31","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1242\/dev.129.23.5541","article-title":"Regulation of the chondrocyte phenotype by beta-catenin","volume":"129","author":"Ryu","year":"2002","journal-title":"Develop."},{"key":"10.1016\/j.ydbio.2025.12.002_bib32","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrn1221","article-title":"Cranial neural crest and the building of the vertebrate head","volume":"4","author":"Santagati","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ydbio.2025.12.002_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006149","article-title":"Genome-wide association study reveals multiple loci influencing normal human facial morphology","volume":"12","author":"Shaffer","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2025.12.002_bib34","doi-asserted-by":"crossref","DOI":"10.1242\/dev.187997","article-title":"The KMT2D kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology","author":"Shpargel","year":"2020","journal-title":"Development dev"},{"key":"10.1016\/j.ydbio.2025.12.002_bib35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ydbio.2020.02.006","article-title":"The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development","volume":"461","author":"Shull","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib36","article-title":"PRDM paralogs antagonistically balance wnt\/Beta-catenin activity during craniofacial chondrocyte differentiation","volume":"149","author":"Shull","year":"2022","journal-title":"Develop."},{"key":"10.1016\/j.ydbio.2025.12.002_bib37","author":"Shull"},{"key":"10.1016\/j.ydbio.2025.12.002_bib38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1242\/dev.105445","article-title":"Establishing neural crest identity: a gene regulatory recipe","volume":"142","author":"Sim\u00f5es-Costa","year":"2015","journal-title":"Develop."},{"key":"10.1016\/j.ydbio.2025.12.002_bib39","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fcell.2020.00821","article-title":"Diverse fate of an enigmatic structure: 200 years of meckel's cartilage","volume":"8","author":"Svandova","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2025.12.002_bib40","author":"Topol"},{"key":"10.1016\/j.ydbio.2025.12.002_bib41","article-title":"ChIP-seq of multiple histone marks and RNA-seq from e11.5 mouse face subregions","author":"Visel","year":"2017","journal-title":"FaceBase Consort"},{"key":"10.1016\/j.ydbio.2025.12.002_bib42","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1242\/dev.120.5.1109","article-title":"The role of Pax-1 in axial skeleton development","volume":"120","author":"Wallin","year":"1994","journal-title":"Develop."},{"key":"10.1016\/j.ydbio.2025.12.002_bib43","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.bbamcr.2007.03.016","article-title":"PRDM16\/MEL1: a novel smad binding protein, expressed in murine embryonic orofacial tissue","volume":"1773","author":"Warner","year":"2007","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.ydbio.2025.12.002_bib44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00441-012-1525-2","article-title":"Gene expression changes in the secondary palate and mandible of Prdm16(-\/-) mice","volume":"351","author":"Warner","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2025.12.002_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41588-020-00741-7","article-title":"Insights into the genetic architecture of the human face","volume":"53","author":"White","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2025.12.002_bib46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1126\/sciadv.abb0119","article-title":"Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis","volume":"6","author":"Yuan","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160625003331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160625003331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:19:22Z","timestamp":1781511562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160625003331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":46,"alternative-id":["S0012160625003331"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.12.002","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRDM paralogs are required for Meckel's cartilage formation during mandibular bone development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2025.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}