{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:17:25Z","timestamp":1783153045377,"version":"3.54.6"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,5,5]],"date-time":"2027-05-05T00:00:00Z","timestamp":1809475200000},"content-version":"am","delay-in-days":277,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R35GM155195-01"],"award-info":[{"award-number":["1R35GM155195-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2P20GM103432 ( WY INBRE"],"award-info":[{"award-number":["2P20GM103432 ( WY INBRE"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013635","name":"Wyoming Water Research Program, University of Wyoming","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008106","name":"University of Wyoming","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["9445"],"award-info":[{"award-number":["9445"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ydbio.2026.04.014","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:26:04Z","timestamp":1776813964000},"page":"56-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development"],"prefix":"10.1016","volume":"536","author":[{"given":"Shalini","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Florez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Govaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Hawke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-0942","authenticated-orcid":false,"given":"Todd","family":"Schoborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2026.04.014_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/01677063.2014.922558","article-title":"A challenge of numbers and diversity: neurogenesis in the drosophila optic lobe","volume":"28","author":"Apitz","year":"2014","journal-title":"J. Neurogenet."},{"key":"10.1016\/j.ydbio.2026.04.014_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nn.3896","article-title":"A region-specific neurogenesis mode requires migratory progenitors in the drosophila visual system","volume":"18","author":"Apitz","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2026.04.014_bib3","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.21974","article-title":"Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain","volume":"513","author":"Azevedo","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.semcdb.2017.11.033","article-title":"Nuclear migration in Mammalian brain development","volume":"82","author":"Bertipaglia","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng995","article-title":"ASPM is a major determinant of cerebral cortical size","volume":"32","author":"Bond","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2026.04.014_bib6","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/bioinformatics\/btm066","article-title":"NucPred--predicting nuclear localization of proteins","volume":"23","author":"Brameier","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ydbio.2026.04.014_bib7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.neuron.2011.05.016","article-title":"Neural stem cell biology in vertebrates and invertebrates: more alike than different?","volume":"70","author":"Brand","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2026.04.014_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ydbio.2019.10.004","article-title":"Slit neuronal secretion coordinates optic lobe morphogenesis in drosophila","volume":"458","author":"Caipo","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib11","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1038\/ncomms9763","article-title":"ASPM regulates symmetric stem cell division by tuning cyclin E ubiquitination","volume":"6","author":"Capecchi","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2026.04.014_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2144\/000113088","article-title":"Non-lethal PCR genotyping of single Drosophila","volume":"46","author":"Carvalho","year":"2009","journal-title":"Biotechniques"},{"key":"10.1016\/j.ydbio.2026.04.014_bib15","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.celrep.2016.03.061","article-title":"A unique class of neural progenitors in the drosophila optic lobe generates both migrating neurons and glia","volume":"15","author":"Chen","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2026.04.014_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuron.2005.09.019","article-title":"Glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of drosophila","volume":"48","author":"Chotard","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2026.04.014_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fnmol.2019.00140","article-title":"Novel strategies for the generation of neuronal diversity: lessons from the fly visual system","volume":"12","author":"Contreras","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ydbio.2026.04.014_bib19","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/ajmg.a.32312","article-title":"Primary microcephaly with ASPM mutation shows simplified cortical gyration with antero-posterior gradient pre- and post-natally","volume":"146A","author":"Desir","year":"2008","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2026.04.014_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-62703-655-9_1","article-title":"Immunostaining of the developing embryonic and larval Drosophila brain","volume":"1082","author":"Diaper","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib21","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.283.5408.1733","article-title":"Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers","volume":"283","author":"do Carmo Avides","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2026.04.014_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nmeth.1356","article-title":"G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila","volume":"6","author":"Evans","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2026.04.014_bib23","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1073\/pnas.0604066103","article-title":"Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells","volume":"103","author":"Fish","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.ydbio.2026.04.014_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.braindev.2013.10.006","article-title":"Disruption of Aspm causes microcephaly with abnormal neuronal differentiation","volume":"36","author":"Fujimori","year":"2014","journal-title":"Brain Dev."},{"key":"10.1016\/j.ydbio.2026.04.014_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-8104-9-18","article-title":"Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain","volume":"9","author":"Gold","year":"2014","journal-title":"Neural Dev."},{"key":"10.1016\/j.ydbio.2026.04.014_bib27","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s004120050329","article-title":"Interactions between mgr, asp, and polo: asp function modulated by polo and needed to maintain the poles of monopolar and bipolar spindles","volume":"107","author":"Gonzalez","year":"1998","journal-title":"Chromosoma"},{"key":"10.1016\/j.ydbio.2026.04.014_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/genetics\/123.2.371","article-title":"Gross genetic dissection and interaction of the chromosomal region 95E;96F of Drosophila melanogaster","volume":"123","author":"Gonz\u00e1lez","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2026.04.014_bib28","doi-asserted-by":"crossref","DOI":"10.1242\/dev.166207","article-title":"A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis in Drosophila melanogaster","volume":"145","author":"Hakes","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/gene.10137","article-title":"GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps","volume":"34","author":"Hayashi","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2026.04.014_bib30","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1073\/pnas.0611396104","article-title":"Cellular scaling rules for primate brains","volume":"104","author":"Herculano-Houzel","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.ydbio.2026.04.014_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2121-11-85","article-title":"Human ASPM participates in spindle organisation, spindle orientation and cytokinesis","volume":"11","author":"Higgins","year":"2010","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib32","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1242\/dev.080515","article-title":"Drosophila neuroblasts: a model for stem cell biology","volume":"139","author":"Homem","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/gene.10125","article-title":"Analysis of twenty-four Gal4 lines in Drosophila melanogaster","volume":"34","author":"Hrdlicka","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2026.04.014_bib34","article-title":"Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas","volume":"e4347","author":"Hsiao","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2026.04.014_bib37","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.201507001","article-title":"Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle","volume":"211","author":"Ito","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2016.09.056","article-title":"Microcephaly proteins wdr62 and aspm define a mother centriole complex regulating centriole biogenesis, apical complex, and cell fate","volume":"92","author":"Jayaraman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2026.04.014_bib39","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41586-018-0035-0","article-title":"Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size","volume":"556","author":"Johnson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2026.04.014_bib40","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1007\/s00381-021-05284-8","article-title":"Central nervous system vasculopathy and Seckel syndrome: case illustration and systematic review","volume":"37","author":"Khojah","year":"2021","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.ydbio.2026.04.014_bib41","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbrc.2011.05.056","article-title":"The microcephaly gene aspm is involved in brain development in zebrafish","volume":"409","author":"Kim","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2026.04.014_bib43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jcct.2009.07.003","article-title":"What are the basic concepts of temporal, contrast, and spatial resolution in cardiac CT?","volume":"3","author":"Lin","year":"2009","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"10.1016\/j.ydbio.2026.04.014_bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/humu.23381","article-title":"Autosomal recessive primary microcephaly due to ASPM mutations: an update","volume":"39","author":"L\u00e9tard","year":"2018","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ydbio.2026.04.014_bib45","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyad188","article-title":"Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain","volume":"225","author":"Mannino","year":"2023","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2026.04.014_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ydbio.2025.05.027","article-title":"A deep learning model for accurate segmentation of the Drosophila melanogaster brain from Micro-CT imaging","volume":"525","author":"McDaniel","year":"2025","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib47","series-title":"Encyclopedia of Neuroscience","first-page":"843","article-title":"Microcephaly Vera","author":"Mochida","year":"2009"},{"key":"10.1016\/j.ydbio.2026.04.014_bib48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1242\/dev.056069","article-title":"Cell migration in Drosophila optic lobe neurons is controlled by eyeless\/Pax6","volume":"138","author":"Morante","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib49","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S0016672318000046","article-title":"Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH)","volume":"100","author":"Naveed","year":"2018","journal-title":"Genet. Res."},{"key":"10.1016\/j.ydbio.2026.04.014_bib50","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/bs.ctdb.2015.11.032","article-title":"From the eye to the brain: development of the drosophila visual system","volume":"116","author":"N\u00e9riec","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib51","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/s41388-018-0497-4","article-title":"ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-\u03b2-catenin signaling","volume":"38","author":"Pai","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2026.04.014_bib52","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/embr.201438447","article-title":"Neurogenesis during development of the vertebrate central nervous system","volume":"15","author":"Paridaen","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ydbio.2026.04.014_bib53","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cortex.2015.10.010","article-title":"Abnormal spindle-like microcephaly-associated (ASPM) mutations strongly disrupt neocortical structure but spare the hippocampus and long-term memory","volume":"74","author":"Passemard","year":"2016","journal-title":"Cortex"},{"key":"10.1016\/j.ydbio.2026.04.014_bib55","doi-asserted-by":"crossref","first-page":"16595","DOI":"10.1073\/pnas.1010494107","article-title":"Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline","volume":"107","author":"Pulvers","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.ydbio.2026.04.014_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75879","article-title":"A notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla","volume":"11","author":"Ray","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2026.04.014_bib57","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0092-8674(85)80071-4","article-title":"A cell division mutant of Drosophila with a functionally abnormal spindle","volume":"41","author":"Ripoll","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2026.04.014_bib58","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ncb2858","article-title":"The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II","volume":"15","author":"Rujano","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12068","article-title":"A genome-wide resource for the analysis of protein localisation in Drosophila","volume":"5","author":"Sarov","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2026.04.014_bib61","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.137.4.881","article-title":"The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle","volume":"137","author":"Saunders","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib62","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ydbio.2026.04.014_bib65","doi-asserted-by":"crossref","DOI":"10.3791\/61515","article-title":"Whole animal imaging of Drosophila melanogaster using microcomputed tomography","author":"Schoborg","year":"2020","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2026.04.014_bib63","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1083\/jcb.201509054","article-title":"An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells","volume":"211","author":"Schoborg","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib64","doi-asserted-by":"crossref","DOI":"10.1242\/dev.176685","article-title":"Micro-computed tomography as a platform for exploring Drosophila development","volume":"146","author":"Schoborg","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib67","article-title":"Dissection and immunostaining of imaginal discs from Drosophila melanogaster","volume":"51792","author":"Spratford","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ydbio.2026.04.014_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.676911","article-title":"Length of the neurogenic Period-A key determinant for the generation of upper-layer neurons during neocortex Development and evolution","volume":"9","author":"Stepien","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib69","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.celrep.2016.03.056","article-title":"Formation of neuronal circuits by interactions between neuronal populations derived from different origins in the Drosophila visual center","volume":"15","author":"Suzuki","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ydbio.2026.04.014_bib70","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.isci.2018.09.021","article-title":"Netrin signaling defines the regional border in the drosophila visual center","volume":"8","author":"Suzuki","year":"2018","journal-title":"iScience"},{"key":"10.1016\/j.ydbio.2026.04.014_bib71","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1242\/dev.01465","article-title":"Compartmentalization of visual centers in the Drosophila brain requires slit and robo proteins","volume":"131","author":"Tayler","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib72","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.tig.2009.09.011","article-title":"Primary microcephaly: do all roads lead to rome?","volume":"25","author":"Thornton","year":"2009","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2026.04.014_bib75","first-page":"1","article-title":"Two new cases of primary microcephaly with neuronal migration defect caused by truncating mutations in the ASPM gene","author":"T\u00fcrky\u0131lmaz","year":"2021","journal-title":"Mol. Syndromol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib73","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0012-1606(88)90067-X","article-title":"Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster","volume":"125","author":"Truman","year":"1988","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib76","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.153.4.637","article-title":"The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis","volume":"153","author":"Wakefield","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2026.04.014_bib79","first-page":"3921","article-title":"Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice","volume":"142","author":"Williams","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2026.04.014_bib80","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/archdischild-2012-302882","article-title":"Investigating microcephaly","volume":"98","author":"Woods","year":"2013","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ydbio.2026.04.014_bib81","doi-asserted-by":"crossref","first-page":"RP90133","DOI":"10.7554\/eLife.90133","article-title":"Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity","volume":"12","author":"Xu","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.ydbio.2026.04.014_bib84","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.4161\/cc.4.9.2029","article-title":"The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein","volume":"4","author":"Zhong","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ydbio.2026.04.014_bib85","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41467-022-28915-3","article-title":"A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing","volume":"13","author":"Zhu","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160626000953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160626000953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:36:27Z","timestamp":1783150587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160626000953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":70,"alternative-id":["S0012160626000953"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2026.04.014","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.06.27.662046","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2026.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}