{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:55:12Z","timestamp":1790585712564,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012127","name":"Augusta University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY033369"],"award-info":[{"award-number":["R01EY033369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY035683"],"award-info":[{"award-number":["R01EY035683"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY033737"],"award-info":[{"award-number":["R01EY033737"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY031631"],"award-info":[{"award-number":["P30EY031631"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ydbio.2026.07.017","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:09:55Z","timestamp":1785697795000},"page":"5-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fibulin-1 is required for microvascular integrity in the developing brain and retina"],"prefix":"10.1016","volume":"539","author":[{"given":"Xuanyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshit","family":"Singhania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Adeel H.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger I.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth B.","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-745X","authenticated-orcid":false,"given":"Marion A.","family":"Cooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ydbio.2026.07.017_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039336","article-title":"Endothelial expression of TGF\u03b2 type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system","volume":"7","author":"Allinson","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ydbio.2026.07.017_bib3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/sj.embor.7400033","article-title":"Fibulins: physiological and disease perspectives","volume":"4","author":"Argraves","year":"2003","journal-title":"EMBO Rep."},{"issue":"6 Pt 2","key":"10.1016\/j.ydbio.2026.07.017_bib2","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1083\/jcb.111.6.3155","article-title":"Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure","volume":"111","author":"Argraves","year":"1990","journal-title":"J. Cell Biol."},{"issue":"7323","key":"10.1016\/j.ydbio.2026.07.017_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.ydbio.2026.07.017_bib5","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1242\/dev.107193","article-title":"Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking \u03b1V\u03b28-TGF\u03b2 signaling in the brain","volume":"141","author":"Arnold","year":"2014","journal-title":"Development"},{"issue":"28","key":"10.1016\/j.ydbio.2026.07.017_bib6","doi-asserted-by":"crossref","first-page":"20120","DOI":"10.1016\/S0021-9258(19)88674-X","article-title":"Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin","volume":"267","author":"Balbona","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ydbio.2026.07.017_bib7","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCRESAHA.118.314300","article-title":"CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-Dependent KLF4 expression","volume":"124","author":"Castro","year":"2019","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.ydbio.2026.07.017_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.156928","article-title":"Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells","volume":"7","author":"Chen","year":"2022","journal-title":"JCI Insight"},{"issue":"13","key":"10.1016\/j.ydbio.2026.07.017_bib9","first-page":"2364","article-title":"The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and notch signaling","volume":"142","author":"Chintala","year":"2015","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/dvdy.23716","article-title":"Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1\/2 activation, and to attenuate trabecular cardiomyocyte proliferation","volume":"241","author":"Cooley","year":"2012","journal-title":"Dev. Dyn. : an official publication of the American Association of Anatomists"},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ydbio.2008.04.029","article-title":"Fibulin-1 is required for morphogenesis of neural crest-derived structures","volume":"319","author":"Cooley","year":"2008","journal-title":"Dev. Biol."},{"issue":"14","key":"10.1016\/j.ydbio.2026.07.017_bib12","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1073\/pnas.1017192108","article-title":"GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier","volume":"108","author":"Cullen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.ydbio.2026.07.017_bib13","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1096\/fj.15-271775","article-title":"Slow binding kinetics of secreted protein, acidic, rich in cysteine-VEGF interaction limit VEGF activation of VEGF receptor 2 and attenuate angiogenesis","volume":"29","author":"Cydzik","year":"2015","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib14","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1073\/pnas.0805165106","article-title":"Wnt\/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis","volume":"106","author":"Daneman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"7323","key":"10.1016\/j.ydbio.2026.07.017_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood-brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ydbio.2026.07.017_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ydbio.2011.06.045","article-title":"Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development","volume":"358","author":"Darland","year":"2011","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.ydbio.2026.07.017_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/CIRCULATIONAHA.115.017537","article-title":"Targeting NCK-Mediated endothelial cell front-rear polarity inhibits neovascularization","volume":"133","author":"Dubrac","year":"2016","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ydbio.2026.07.017_bib18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.5483\/BMBRep.2023-0156","article-title":"Matricellular proteins in immunometabolism and tissue homeostasis","volume":"57","author":"Eun","year":"2024","journal-title":"BMB Rep."},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nprot.2013.015","article-title":"The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis","volume":"8","author":"Fantin","year":"2013","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.ydbio.2026.07.017_bib20","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood.V88.7.2569.bloodjournal8872569","article-title":"Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen","volume":"88","author":"Godyna","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.ydbio.2026.07.017_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105823","article-title":"The role of basement membrane laminins in vascular function","volume":"127","author":"Hallmann","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6560","key":"10.1016\/j.ydbio.2026.07.017_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/379091a0","article-title":"Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase","volume":"379","author":"Hannigan","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2026.07.017_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mod.2014.12.005","article-title":"Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract","volume":"136","author":"Harikrishnan","year":"2015","journal-title":"Mech. Dev."},{"issue":"3","key":"10.1016\/j.ydbio.2026.07.017_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1083\/jcb.153.3.543","article-title":"Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis","volume":"153","author":"Hellstr\u00f6m","year":"2001","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.ydbio.2026.07.017_bib25","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1242\/dev.01039","article-title":"The neural tube patterns vessels developmentally using the VEGF signaling pathway","volume":"131","author":"Hogan","year":"2004","journal-title":"Development"},{"issue":"10","key":"10.1016\/j.ydbio.2026.07.017_bib26","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200140","article-title":"Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican","volume":"217","author":"Hong","year":"2020","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.ydbio.2026.07.017_bib27","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1161\/ATVBAHA.120.314729","article-title":"Fibulin-1 integrates subendothelial extracellular matrices and contributes to anatomical closure of the ductus arteriosus","volume":"40","author":"Ito","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"50","key":"10.1016\/j.ydbio.2026.07.017_bib28","doi-asserted-by":"crossref","first-page":"38923","DOI":"10.1074\/jbc.M110.172304","article-title":"Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47","volume":"285","author":"Kaur","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.ydbio.2026.07.017_bib29","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1172\/JCI93825","article-title":"YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation","volume":"127","author":"Kim","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"20","key":"10.1016\/j.ydbio.2026.07.017_bib30","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1128\/MCB.21.20.7025-7034.2001","article-title":"Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice","volume":"21","author":"Kostka","year":"2001","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.ydbio.2026.07.017_bib31","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.235762","article-title":"ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis","volume":"133","author":"Lambert","year":"2020","journal-title":"J. Cell Sci."},{"issue":"13","key":"10.1016\/j.ydbio.2026.07.017_bib32","article-title":"Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations","volume":"145","author":"Lavi\u00f1a","year":"2018","journal-title":"Development"},{"issue":"16","key":"10.1016\/j.ydbio.2026.07.017_bib34","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.121.054071","article-title":"Role of venous endothelial cells in developmental and pathologic angiogenesis","volume":"144","author":"Lee","year":"2021","journal-title":"Circulation"},{"issue":"41","key":"10.1016\/j.ydbio.2026.07.017_bib33","doi-asserted-by":"crossref","first-page":"34796","DOI":"10.1074\/jbc.M506980200","article-title":"Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1","volume":"280","author":"Lee","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ydbio.2026.07.017_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.expneurol.2012.06.005","article-title":"An angiogenic role for the \u03b15\u03b21 integrin in promoting endothelial cell proliferation during cerebral hypoxia","volume":"237","author":"Li","year":"2012","journal-title":"Exp. Neurol."},{"issue":"26","key":"10.1016\/j.ydbio.2026.07.017_bib36","doi-asserted-by":"crossref","first-page":"24200","DOI":"10.1074\/jbc.M302028200","article-title":"CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family","volume":"278","author":"Lin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2026.07.017_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcdb.2018.08.007","article-title":"Extracellular matrix scaffolding in angiogenesis and capillary homeostasis","volume":"89","author":"Marchand","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.ydbio.2026.07.017_bib38","doi-asserted-by":"crossref","first-page":"969","DOI":"10.21037\/qims-20-920","article-title":"VasoMetrics: unbiased spatiotemporal analysis of microvascular diameter in multi-photon imaging applications","volume":"11","author":"McDowell","year":"2021","journal-title":"Quant. Imag. Med. Surg."},{"issue":"46","key":"10.1016\/j.ydbio.2026.07.017_bib39","doi-asserted-by":"crossref","first-page":"15260","DOI":"10.1523\/JNEUROSCI.3678-13.2014","article-title":"The extracellular matrix protein laminin alpha2 regulates the maturation and function of the blood-brain barrier","volume":"34","author":"Menezes","year":"2014","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"issue":"12","key":"10.1016\/j.ydbio.2026.07.017_bib40","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1039\/c3ib40085a","article-title":"The mouse retina in 3D: quantification of vascular growth and remodeling","volume":"5","author":"Milde","year":"2013","journal-title":"Integr. Biol."},{"issue":"11","key":"10.1016\/j.ydbio.2026.07.017_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17111822","article-title":"Extracellular Matrix, a hard player in angiogenesis","volume":"17","author":"Mongiat","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ydbio.2026.07.017_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101184","article-title":"A CTGF-YAP regulatory pathway is essential for angiogenesis and barriergenesis in the retina","volume":"23","author":"Moon","year":"2020","journal-title":"iScience"},{"issue":"6","key":"10.1016\/j.ydbio.2026.07.017_bib43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.devcel.2017.02.019","article-title":"Flow-Dependent endothelial YAP regulation contributes to vessel maintenance","volume":"40","author":"Nakajima","year":"2017","journal-title":"Dev. Cell"},{"issue":"26","key":"10.1016\/j.ydbio.2026.07.017_bib44","doi-asserted-by":"crossref","first-page":"14602","DOI":"10.1073\/pnas.94.26.14602","article-title":"Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells","volume":"94","author":"O'Gorman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.ydbio.2026.07.017_bib45","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/cvr\/cvae211","article-title":"Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia","volume":"120","author":"Okumura","year":"2024","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.ydbio.2026.07.017_bib46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00381-025-07089-5","article-title":"Capillary malformation-arteriovenous malformation syndrome (CM-AVM): a systematic review of cerebrovascular manifestations","volume":"41","author":"Palermo","year":"2025","journal-title":"Childs Nerv. Syst."},{"issue":"1","key":"10.1016\/j.ydbio.2026.07.017_bib47","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1038\/s41467-019-13220-3","article-title":"Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy","volume":"10","author":"Park","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ydbio.2026.07.017_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-43612-x","article-title":"Author Correction: endomucin knockdown inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling","volume":"13","author":"Park-Windhol","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ydbio.2026.07.017_bib49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s43152-020-00014-9","article-title":"Pericytes in vascular development","volume":"1","author":"Payne","year":"2020","journal-title":"Curr Tissue Microenviron Rep"},{"issue":"3","key":"10.1016\/j.ydbio.2026.07.017_bib50","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1073\/pnas.96.3.869","article-title":"The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling","volume":"96","author":"Perbal","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.ydbio.2026.07.017_bib51","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1096\/fj.11-200154","article-title":"CCN2\/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators","volume":"26","author":"Pi","year":"2012","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"5","key":"10.1016\/j.ydbio.2026.07.017_bib52","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/ATVBAHA.118.310840","article-title":"Parvins are required for endothelial cell-cell junctions and cell polarity during embryonic blood vessel Formation","volume":"38","author":"Pitter","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.ydbio.2026.07.017_bib53","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/nprot.2010.113","article-title":"Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice","volume":"5","author":"Pitulescu","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ydbio.2026.07.017_bib54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnana.2019.00059","article-title":"Patterned vascularization of Embryonic mouse forebrain, and neuromeric topology of major human subarachnoidal arterial branches: a prosomeric mapping","volume":"13","author":"Puelles","year":"2019","journal-title":"Front. Neuroanat."},{"issue":"9","key":"10.1016\/j.ydbio.2026.07.017_bib55","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1172\/JCI126655","article-title":"Roles of HIFs and VEGF in angiogenesis in the retina and brain","volume":"129","author":"Rattner","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ydbio.2026.07.017_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86978.3","article-title":"Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier","volume":"12","author":"Sadanandan","year":"2024","journal-title":"eLife"},{"issue":"41","key":"10.1016\/j.ydbio.2026.07.017_bib57","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1073\/pnas.1704030114","article-title":"YAP\/TAZ-CDC42 signaling regulates vascular tip cell migration","volume":"114","author":"Sakabe","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"6","key":"10.1016\/j.ydbio.2026.07.017_bib58","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/NEN.0b013e31821bc40e","article-title":"Impairment of tight junctions and glucose transport in endothelial cells of human cerebral cavernous malformations","volume":"70","author":"Schneider","year":"2011","journal-title":"Journal of neuropathology and experimental neurology"},{"issue":"5","key":"10.1016\/j.ydbio.2026.07.017_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252342","article-title":"Venous malformation vessels are improperly specified and hyperproliferative","volume":"16","author":"Schonning","year":"2021","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.ydbio.2026.07.017_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe9716","article-title":"Structural insights into integrin \u03b1(5)\u03b2(1) opening by fibronectin ligand","volume":"7","author":"Schumacher","year":"2021","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.ydbio.2026.07.017_bib61","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1096\/fj.201902888R","article-title":"Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3","volume":"34","author":"Schwefel","year":"2020","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.ydbio.2026.07.017_bib62","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jchemneu.2018.06.001","article-title":"Markers for human brain pericytes and smooth muscle cells","volume":"92","author":"Smyth","year":"2018","journal-title":"J. Chem. Neuroanat."},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib63","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.celrep.2016.09.016","article-title":"VEGF-A\/Notch-Induced podosomes proteolyse basement membrane Collagen-IV during retinal sprouting angiogenesis","volume":"17","author":"Spuul","year":"2016","journal-title":"Cell Rep."},{"issue":"20","key":"10.1016\/j.ydbio.2026.07.017_bib64","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1242\/dev.071381","article-title":"Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis","volume":"138","author":"Stenzel","year":"2011","journal-title":"Development"},{"issue":"10","key":"10.1016\/j.ydbio.2026.07.017_bib65","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1177\/0271678X17722436","article-title":"The vascular basement membrane in the healthy and pathological brain","volume":"37","author":"Thomsen","year":"2017","journal-title":"J. Cerebr. Blood Flow Metabol. : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"4","key":"10.1016\/j.ydbio.2026.07.017_bib66","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1128\/MCB.22.4.1194-1202.2002","article-title":"Deletion of the laminin alpha4 chain leads to impaired microvessel maturation","volume":"22","author":"Thyboll","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"33","key":"10.1016\/j.ydbio.2026.07.017_bib67","doi-asserted-by":"crossref","first-page":"19458","DOI":"10.1074\/jbc.270.33.19458","article-title":"The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis","volume":"270","author":"Tran","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.ydbio.2026.07.017_bib68","doi-asserted-by":"crossref","first-page":"22600","DOI":"10.1074\/jbc.272.36.22600","article-title":"The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains","volume":"272","author":"Tran","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.ydbio.2026.07.017_bib69","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10456-017-9563-8","article-title":"Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion","volume":"20","author":"Turner","year":"2017","journal-title":"Angiogenesis"},{"issue":"Pt 24","key":"10.1016\/j.ydbio.2026.07.017_bib70","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1242\/jcs.114.24.4587","article-title":"Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility","volume":"114","author":"Twal","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2026.07.017_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2025.101387","article-title":"Phenotyping and genotyping FEVR: molecular genetics, clinical and imaging features, and therapeutics","volume":"108","author":"Wang","year":"2025","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib72","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1189\/jlb.0210065","article-title":"CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse","volume":"88","author":"Winnicka","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ydbio.2026.07.017_bib73","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.1038\/ncomms7429","article-title":"Integrin \u03b21 controls VE-cadherin localization and blood vessel stability","volume":"6","author":"Yamamoto","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ydbio.2026.07.017_bib74","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1038\/ncomms4413","article-title":"Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity","volume":"5","author":"Yao","year":"2014","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib75","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2009.07.047","article-title":"Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization","volume":"139","author":"Ye","year":"2009","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.ydbio.2026.07.017_bib76","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.devcel.2021.06.021","article-title":"Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation","volume":"56","author":"Zarkada","year":"2021","journal-title":"Dev. Cell"},{"issue":"8","key":"10.1016\/j.ydbio.2026.07.017_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/biom14080966","article-title":"Neural regulation of vascular development: molecular mechanisms and interactions","volume":"14","author":"Zhang","year":"2024","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.ydbio.2026.07.017_bib78","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.devcel.2014.08.018","article-title":"Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling","volume":"31","author":"Zhou","year":"2014","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.ydbio.2026.07.017_bib79","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1172\/JCI76431","article-title":"Canonical WNT signaling components in vascular development and barrier formation","volume":"124","author":"Zhou","year":"2014","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.ydbio.2026.07.017_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027385","article-title":"A computational tool for quantitative analysis of vascular networks","volume":"6","author":"Zudaire","year":"2011","journal-title":"PLoS One"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160626001636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160626001636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:57:16Z","timestamp":1790582236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160626001636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":80,"alternative-id":["S0012160626001636"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2026.07.017","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibulin-1 is required for microvascular integrity in the developing brain and retina","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2026.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}