{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:14:00Z","timestamp":1761016440588},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.yebeh.2005.07.007","type":"journal-article","created":{"date-parts":[[2005,9,3]],"date-time":"2005-09-03T07:14:26Z","timestamp":1125731666000},"page":"639-651","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacodynamic and\/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: An isobolographic analysis"],"prefix":"10.1016","volume":"7","author":[{"given":"Jarogniew J.","family":"Luszczki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neville","family":"Ratnaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Patsalos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislaw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2005.07.007_bib1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Kwan","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2005.07.007_bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/seiz.2000.0442","article-title":"Epilepsy after the first drug fails: substitution or add-on?","volume":"9","author":"Kwan","year":"2000","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2005.07.007_bib3","first-page":"31","article-title":"Pharmacological principles as a basis for polytherapy","volume":"Suppl. 162","author":"Perucca","year":"1995","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2005.07.007_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1528-1157.2002.13001.x","article-title":"The importance of drug interactions in epilepsy therapy","volume":"43","author":"Patsalos","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2005.07.007_bib5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(03)00409-5","article-title":"Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib6","first-page":"61","article-title":"Use of animal models in developing guiding principles for polypharmacy in epilepsy","volume":"Suppl. 11","author":"L\u00f6scher","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0896-6273(94)90330-1","article-title":"A novel allosteric modulatory site on the GABAA receptor beta subunit","volume":"12","author":"Wafford","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2005.07.007_bib8","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1073\/pnas.91.10.4569","article-title":"The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit","volume":"91","author":"Wingrove","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.yebeh.2005.07.007_bib9","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0028-3908(96)00053-6","article-title":"Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents","volume":"35","author":"Donnelly","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2005.07.007_bib10","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(00)00778-0","article-title":"Loreclezole as a simple functional marker for homomeric rho type GABA(C) receptors","volume":"408","author":"Thomet","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0920-1211(92)90006-F","article-title":"Effects of loreclezole on epileptic activity and on EEG and behaviour in rats with absence seizures","volume":"13","author":"Ates","year":"1992","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib12","first-page":"727","article-title":"Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats","volume":"55","author":"Borowicz","year":"2003","journal-title":"Pol J Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0920-1211(00)00102-9","article-title":"Pharmacokinetic\u2013pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model","volume":"40","author":"Della Paschoa","year":"2000","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib14","first-page":"1148","article-title":"Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures","volume":"290","author":"Gasior","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0920-1211(92)90018-O","article-title":"In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole","volume":"11","author":"Ashton","year":"1992","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib16","first-page":"163","article-title":"Effects of loreclezole on metrazol-induced phenomena in developing rats","volume":"305","author":"Pohl","year":"1990","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.0013-9580.2005.34704.x","article-title":"Pharmacodynamic and pharmacokinetic interaction studies with loreclezole and felbamate, lamotrigine, topiramate and oxcarbazepine in the mouse maximal electroshock seizure model","volume":"46","author":"Luszczki","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2005.07.007_bib18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0920-1211(91)90085-T","article-title":"Efficacy and safety evaluation of loreclezole as add-on treatment in therapy-resistant epilepsy patients","volume":"8","author":"Rentmeester","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0920-1211(91)90047-J","article-title":"A double-blind, placebo-controlled evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures","volume":"9","author":"Rentmeester","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0920-1211(91)90048-K","article-title":"Long-term evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures: a 1-year open follow-up","volume":"9","author":"Rentmeester","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib21","first-page":"93","article-title":"What is synergy?","volume":"41","author":"Berenbaum","year":"1989","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.yebeh.2005.07.007_bib22","first-page":"331","article-title":"The search for synergy: a critical review from a response surface perspective","volume":"47","author":"Greco","year":"1995","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.yebeh.2005.07.007_bib23","series-title":"Drug synergism and dose\u2013effect data analysis","author":"Tallarida","year":"2000"},{"key":"10.1016\/j.yebeh.2005.07.007_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.eplepsyres.2003.08.003","article-title":"Isobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics: a comparative study","volume":"56","author":"Luszczki","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00210-004-0867-z","article-title":"Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study","volume":"369","author":"Luszczki","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0920-1211(88)90054-X","article-title":"Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations","volume":"2","author":"L\u00f6scher","year":"1988","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0920-1211(91)90062-K","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs: III. Pentylenetetrazole seizure models","volume":"8","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib28","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.npp.1300602","article-title":"Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis","volume":"30","author":"Luszczki","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yebeh.2005.07.007_bib29","first-page":"99","article-title":"A simplified method of evaluating dose\u2013effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000134913","article-title":"Une nouvelle m\u00e9thode simple pour explorer l\u2019action tranquilisante: le test de la chemin\u00e9e","volume":"3","author":"Boissier","year":"1960","journal-title":"Med Exp (Basel)"},{"key":"10.1016\/j.yebeh.2005.07.007_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1528-1157.2003.32702.x","article-title":"Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis","volume":"44","author":"Luszczki","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2005.07.007_bib32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1528-1157.2003.10003.x","article-title":"Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis","volume":"44","author":"Luszczki","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2005.07.007_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0014-2999(90)90190-H","article-title":"Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction","volume":"179","author":"Porreca","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0920-1211(91)90041-D","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs: IV. Protective indices","volume":"9","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib35","series-title":"Antiepileptic drugs","first-page":"36","article-title":"Discovery and preclinical development of antiepileptic drugs","author":"White","year":"2002"},{"key":"10.1016\/j.yebeh.2005.07.007_bib36","series-title":"Contemporary diagnosis and management of the patients with epilepsy","first-page":"74","article-title":"Antiepileptic drugs","author":"Leppik","year":"2001"},{"key":"10.1016\/j.yebeh.2005.07.007_bib37","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.410250610","article-title":"Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons","volume":"25","author":"Coulter","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib38","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1124\/mol.60.5.1121","article-title":"Block of cloned human T-type calcium channels by succinimide antiepileptic drugs","volume":"60","author":"Gomora","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib39","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1523\/JNEUROSCI.18-13-04842.1998","article-title":"On the action of the anti-absence drug ethosuximide in the rat and cat thalamus","volume":"18","author":"Leresche","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2005.07.007_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1535-7597.2002.00024.x","article-title":"Block of thalamic T-type Ca2+ channels by ethosuximide is not the whole story","volume":"2","author":"Crunelli","year":"2002","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.yebeh.2005.07.007_bib41","series-title":"Antiepileptic drugs","first-page":"721","article-title":"Benzodiazepines: mechanisms of action","author":"Haefely","year":"1989"},{"key":"10.1016\/j.yebeh.2005.07.007_bib42","series-title":"Antiepileptic drugs","first-page":"179","article-title":"Benzodiazepines. Mechanisms of action","author":"Macdonald","year":"2002"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2005.07.007_bib43","first-page":"227","article-title":"Preclinical profile of interactions between loreclezole and conventional antiepileptics against maximal electroconvulsions in mice: an isobolographic analysis [abstract, 8th Congress of the European Federation of Neurological Societies. Paris, France]","volume":"11","author":"Luszczki","year":"2004","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib44","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2165\/00023210-200216100-00003","article-title":"Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy","volume":"16","author":"L\u00f6scher","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2005.07.007_bib45","first-page":"48","article-title":"Comparative study of the inhibition of GABA aminotransferase by different anticonvulsant drugs","volume":"43","author":"L\u00f6scher","year":"1980","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0028-3908(86)90214-5","article-title":"Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes","volume":"25","author":"Larsson","year":"1986","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2005.07.007_bib47","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/0006-2952(82)90111-3","article-title":"The effects of sodium valproate on gamma-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice","volume":"31","author":"Phillips","year":"1982","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib48","first-page":"654","article-title":"Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouse","volume":"220","author":"Nau","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib49","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI114877","article-title":"Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites: possible mechanism of anticonvulsant and toxic actions","volume":"86","author":"Luder","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yebeh.2005.07.007_bib50","first-page":"1001","article-title":"Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture","volume":"237","author":"McLean","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib51","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(91)90078-A","article-title":"Valproate suppresses N-methyl-d-aspartate-evoked, transient depolarizations in the rat neocortex in vitro","volume":"544","author":"Zeise","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-2999(85)90449-2","article-title":"Antagonism of N-methyl-d,l-aspartic acid-induced convulsions by antiepileptic drugs and other agents","volume":"108","author":"Czuczwar","year":"1985","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib53","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0306-4522(90)90262-3","article-title":"Differential effects of antiepileptic drugs and beta-carbolines on seizures induced by excitatory amino acids","volume":"39","author":"Turski","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2005.07.007_bib54","first-page":"1063","article-title":"Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants","volume":"265","author":"Steppuhn","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2005.07.007_bib55","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0920-1211(98)00022-9","article-title":"Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid [AMPA] binding by the anticonvulsant valproate in clinically relevant concentrations: an autoradiographic investigation in human hippocampus","volume":"31","author":"K\u00fcnig","year":"1998","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib56","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/0006-2952(84)90413-1","article-title":"Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues: a dose-dependent correlation with changes in brain aspartate and GABA levels in DBA\/2 mice","volume":"33","author":"Chapman","year":"1984","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib57","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3940(90)90416-7","article-title":"Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons","volume":"116","author":"Kelly","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2005.07.007_bib58","first-page":"223","article-title":"Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds","volume":"42","author":"Rogawski","year":"1990","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.yebeh.2005.07.007_bib59","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1098\/rspb.1979.0108","article-title":"Phenobarbitone modulation of postsynaptic GABA receptor function on cultured mammalian neurons","volume":"206","author":"Barker","year":"1979","journal-title":"Proc R Soc Lond Ser B"},{"key":"10.1016\/j.yebeh.2005.07.007_bib60","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1113\/jphysiol.1989.sp017814","article-title":"Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture","volume":"417","author":"Macdonald","year":"1989","journal-title":"J Physiol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib61","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ana.410250302","article-title":"Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital","volume":"25","author":"Twyman","year":"1989","journal-title":"Ann Neurol"},{"issue":"Pt. 2","key":"10.1016\/j.yebeh.2005.07.007_bib62","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1113\/jphysiol.1996.sp021784","article-title":"Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons","volume":"497","author":"Rho","year":"1996","journal-title":"J Physiol"},{"key":"10.1016\/j.yebeh.2005.07.007_bib63","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0006-8993(86)90207-6","article-title":"Voltage-dependent block of excitatory amino acid currents by pentobarbital","volume":"376","author":"Miljkovic","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib64","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3940(90)90374-I","article-title":"Phenobarbital protects cerebral cortex neurones against toxicity induced by kainate but not by other excitatory amino acids","volume":"111","author":"Frandsen","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2005.07.007_bib65","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0361-9230(96)00268-7","article-title":"The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus","volume":"42","author":"Ko","year":"1997","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.yebeh.2005.07.007_bib66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1014233102342","article-title":"Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin\u2013theophylline convulsant interaction in rats","volume":"19","author":"Cadart","year":"2002","journal-title":"Pharm Res"},{"key":"10.1016\/j.yebeh.2005.07.007_bib67","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0091-3057(03)00081-9","article-title":"Interactions of tiagabine with some antiepileptics in the maximal electroshock in mice","volume":"75","author":"Luszczki","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2005.07.007_bib68","series-title":"New antiepileptic drugs. (Epilepsy Res. Suppl. 3)","first-page":"125","article-title":"Loreclezole","author":"De Beukelaar","year":"1991"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550500500257X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550500500257X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T05:19:39Z","timestamp":1552972779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152550500500257X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S152550500500257X"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2005.07.007","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}