{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:52Z","timestamp":1790268772230,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.yebeh.2006.09.008","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T07:19:00Z","timestamp":1162019940000},"page":"148-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Effect of lamotrigine on depressive symptoms in adult patients with epilepsy"],"prefix":"10.1016","volume":"10","author":[{"given":"Alan B.","family":"Ettinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Kustra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 140","key":"10.1016\/j.yebeh.2006.09.008_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0404.1992.tb04481.x","article-title":"Affect and mood in epilepsy: an overview with a focus on depression","volume":"86","author":"Robertson","year":"1992","journal-title":"Acta Neurol Scand Suppl"},{"issue":"Suppl. 10","key":"10.1016\/j.yebeh.2006.09.008_bib2","first-page":"S21","article-title":"Depression in epilepsy: etiology, phenomenology, and treatment","volume":"40","author":"Lambert","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2006.09.008_bib3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0006-3223(03)00469-4","article-title":"Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment","volume":"54","author":"Kanner","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.yebeh.2006.09.008_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1528-1157.1998.tb01427.x","article-title":"Symptoms of depression and anxiety in pediatric epilepsy patients","volume":"39","author":"Ettinger","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2006.09.008_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.yebeh.2005.09.014","article-title":"The presence and clinical implications of depression in a community population of adults with epilepsy","volume":"8","author":"Mensah","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2006.09.008_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/01.wco.0000162853.29650.ec","article-title":"Diagnosis and treatment of mood disorders in persons with epilepsy","volume":"18","author":"Gilliam","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.yebeh.2006.09.008_bib7","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1212\/01.WNL.0000138430.11829.61","article-title":"Depression and comorbidity in community-based patients with epilepsy or asthma","volume":"63","author":"Ettinger","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2006.09.008_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/ebeh.2000.0030","article-title":"Depression in epilepsy: a common but often unrecognized comorbid malady","volume":"1","author":"Kanner","year":"2000","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2006.09.008_bib9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.0013-9580.2004.47003.x","article-title":"The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy","volume":"45","author":"Johnson","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2006.09.008_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1212\/WNL.58.8_suppl_5.S9","article-title":"Optimizing health outcomes in active epilepsy","volume":"58","author":"Gilliam","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2006.09.008_bib11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1212\/01.WNL.0000103282.62353.85","article-title":"Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy","volume":"62","author":"Boylan","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2006.09.008_bib12","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/j.0013-9580.2003.28403.x","article-title":"The influence of comorbid depression on seizure severity","volume":"44","author":"Cramer","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2006.09.008_bib13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.yebeh.2004.01.010","article-title":"The impact of comorbid depression on health resource utilization in a community sample of patients with epilepsy","volume":"5","author":"Cramer","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2006.09.008_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/14740338.3.1.1","article-title":"Behavioural effects of the newer antiepileptic drugs: an update","volume":"3","author":"Besag","year":"2004","journal-title":"Expert Opin Drug Saf"},{"issue":"Suppl. 4","key":"10.1016\/j.yebeh.2006.09.008_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1528-1167.2005.463010.x","article-title":"Antiepileptic drugs and the regulation of mood and quality of life (QOL): the evidence from epilepsy","volume":"46","author":"Selai","year":"2005","journal-title":"Epilepsia"},{"issue":"6, Suppl. 1","key":"10.1016\/j.yebeh.2006.09.008_bib16","first-page":"A117","article-title":"Lamotrigine in patients with epilepsy and comorbid depressive symptoms [abstract]","volume":"64","author":"Fakhoury","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2006.09.008_bib17","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.yebeh.2004.07.005","article-title":"Improved mood states with lamotrigine in patients with epilepsy","volume":"5","author":"Cramer","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2006.09.008_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1525-5050(02)00528-0","article-title":"Improvement in depression associated with partial epilepsy in patients treated with lamotrigine","volume":"3","author":"Sackellares","year":"2002","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2006.09.008_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/ebeh.2000.0143","article-title":"Lamotrigine monotherapy improves depressive symptoms in epilepsy: a double-blind comparison with valproate","volume":"2","author":"Edwards","year":"2001","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2006.09.008_bib20","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2165\/00003495-200363190-00009","article-title":"Lamotrigine: a review of its use in bipolar disorder","volume":"63","author":"Goldsmith","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.yebeh.2006.09.008_bib21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4088\/JCP.v65n0321","article-title":"A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder","volume":"65","author":"Goodwin","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.yebeh.2006.09.008_bib22","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1017\/S1092852900010324","article-title":"Lamotrigine augmentation strategy for patients with treatment-resistant depression","volume":"10","author":"Gutierrez","year":"2005","journal-title":"CNS Spectr"},{"key":"10.1016\/j.yebeh.2006.09.008_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jad.2004.01.016","article-title":"Sustained remission with lamotrigine augmentation or monotherapy in female resistant depressives with mixed cyclothymic\u2013dysthymic temperament","volume":"84","author":"Manning","year":"2005","journal-title":"J Affect Disord"},{"key":"10.1016\/j.yebeh.2006.09.008_bib24","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1212\/01.wnl.0000187118.19221.e4","article-title":"Double-blind, placebo-controlled study of lamotrigine in primary generalized tonic\u2013clonic seizures","volume":"65","author":"Biton","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2006.09.008_bib25","doi-asserted-by":"crossref","unstructured":"Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1989;30:389\u201399.","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"10.1016\/j.yebeh.2006.09.008_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1037\/0278-6133.20.2.112","article-title":"Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients","volume":"20","author":"Arnau","year":"2001","journal-title":"Health Psychol"},{"key":"10.1016\/j.yebeh.2006.09.008_bib27","series-title":"Beck Depression Inventory II manual","author":"Beck","year":"1996"},{"key":"10.1016\/j.yebeh.2006.09.008_bib28","series-title":"EITS Manual for the Profile of Mood States","author":"McNair","year":"1971"},{"key":"10.1016\/j.yebeh.2006.09.008_bib29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3928\/0048-5713-19931101-09","article-title":"Measurement of severity and treatment response in dysthymia","volume":"23","author":"Mason","year":"1993","journal-title":"Psychiatr Ann"},{"key":"10.1016\/j.yebeh.2006.09.008_bib30","series-title":"Diagnosis and treatment of chronic depression","article-title":"Assessment of symptoms and change in dysthymic disorder","author":"Mason","year":"1995"},{"key":"10.1016\/j.yebeh.2006.09.008_bib31","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1528-1157.1999.tb00830.x","article-title":"A beneficial effect on mood in partial epilepsy patients treated with gabapentin","volume":"40","author":"Harden","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2006.09.008_bib32","series-title":"Psychopathology in epilepsy: social dimensions","first-page":"5","article-title":"Psychopathology in epilepsy: a multietiologic model","author":"Hermann","year":"1986"},{"key":"10.1016\/j.yebeh.2006.09.008_bib33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1528-1157.1993.tb02417.x","article-title":"Outcomes of add-on treatment with lamotrigine in partial epilepsy","volume":"34","author":"Smith","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2006.09.008_bib34","first-page":"41","article-title":"Lamotrigine add-on therapy in focal epilepsy: electroencephalographic and neuropsychological evaluation","volume":"21","author":"Marciani","year":"1998","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.yebeh.2006.09.008_bib35","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1212\/01.WNL.0000165994.46777.BE","article-title":"Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers","volume":"64","author":"Meador","year":"2005","journal-title":"Neurology"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505006003544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505006003544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:19:08Z","timestamp":1761502748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505006003544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1525505006003544"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2006.09.008","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of lamotrigine on depressive symptoms in adult patients with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2006.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}