{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:23:08Z","timestamp":1761502988788,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["2 P05A 045 28"],"award-info":[{"award-number":["2 P05A 045 28"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["\/11\/2.6\/09\/04\/U\/06\/04","Z\/2.06"],"award-info":[{"award-number":["\/11\/2.6\/09\/04\/U\/06\/04","Z\/2.06"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.yebeh.2007.04.018","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T07:20:29Z","timestamp":1183188029000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock"],"prefix":"10.1016","volume":"11","author":[{"given":"Kinga K.","family":"Borowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Malek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarogniew J.","family":"Luszczki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neville","family":"Ratnaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Patsalos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislaw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2007.04.018_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/seiz.2000.0442","article-title":"Epilepsy after the first drug fails: substitution or add-on?","volume":"9","author":"Kwan","year":"2000","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2007.04.018_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0920-1211(02)00181-X","article-title":"Polytherapy in epilepsy: the experimental evidence","volume":"52","author":"Czuczwar","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1570-0232(03)00605-6","article-title":"Separation methods that are capable of revealing blood-brain barrier permeability","volume":"797","author":"Dash","year":"2003","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.yebeh.2007.04.018_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0920-1211(91)90050-P","article-title":"Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat","volume":"9","author":"Garske","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0920-1211(92)90086-9","article-title":"Biological profile of the metabolites of the anticonvulsant remacemide","volume":"12","author":"Palmer","year":"1992","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0920-1211(90)90050-6","article-title":"Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice","volume":"7","author":"Stagnitto","year":"1990","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1358\/dof.1993.018.11.233082","article-title":"Antiepileptic and neuroprotective potential for remacemide hydrochloride","volume":"18","author":"Palmer","year":"1993","journal-title":"Drug Future"},{"key":"10.1016\/j.yebeh.2007.04.018_bib8","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/0024-3205(94)00845-0","article-title":"Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of antiepileptic drugs and calcium antagonists","volume":"54","author":"Cramer","year":"1994","journal-title":"Life Sci"},{"issue":"Suppl. 6","key":"10.1016\/j.yebeh.2007.04.018_bib9","first-page":"4","article-title":"Update on the mechanism of action of antiepileptic drugs","volume":"37","author":"Meldrum","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2007.04.018_bib10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0028-3908(97)00069-5","article-title":"Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro","volume":"36","author":"Norris","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2007.04.018_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(02)01297-9","article-title":"Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes","volume":"438","author":"Santangeli","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2007.04.018_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0920-1211(95)00053-4","article-title":"Remacemide HCl and its metabolite, FLP 12495AA, limit potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture","volume":"23","author":"Wamil","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0022-3565(25)12245-3","article-title":"Block of the N-methyl-d-aspartate receptor by remacemide and its des-glycine metabolite","volume":"276","author":"Subramaniam","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2007.04.018_bib14","series-title":"Antiepileptic drugs","first-page":"1035","article-title":"Potential antiepileptic drugs: remacemide hydrochloride","author":"Clark","year":"1995"},{"key":"10.1016\/j.yebeh.2007.04.018_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0306-3623(96)00280-7","article-title":"Remacemide hydrochloride: a novel antiepileptic agent","volume":"28","author":"Davies","year":"1997","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.yebeh.2007.04.018_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0920-1211(02)00049-9","article-title":"Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride","volume":"49","author":"Sills","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1046\/j.1471-4159.1996.66030989.x","article-title":"The desglycinyl metabolite of remacemide hydrochloride is neuroprotective in cultured rat cortical neurons","volume":"66","author":"Black","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2007.04.018_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(01)02511-3","article-title":"Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice","volume":"321","author":"Santangeli","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2007.04.018_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/seiz.2002.0588","article-title":"Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg\/day) in a Q.I.D. regimen","volume":"11","author":"Chadwick","year":"2002","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2007.04.018_bib20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1053\/seiz.2002.0589","article-title":"Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg\/day) in a B.I.D. regimen","volume":"11","author":"Jones","year":"2002","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2007.04.018_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/seiz.2001.0669","article-title":"A double-blind, placebo-controlled study of remacemide hydrochloride in patients with refractory epilepsy following pre-surgical assessment","volume":"11","author":"Devinsky","year":"2002","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2007.04.018_bib22","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1528-1157.1996.tb01031.x","article-title":"Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites","volume":"37","author":"Leach","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2007.04.018_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1059-1311(97)80003-9","article-title":"Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients","volume":"6","author":"Leach","year":"1997","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2007.04.018_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose\u2013effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2007.04.018_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000134913","article-title":"Une nouvelle methode simple pour explorer l\u2019action tranquilisante: le test de la cheminee","volume":"3","author":"Boissier","year":"1960","journal-title":"Med Exp (Basel)"},{"key":"10.1016\/j.yebeh.2007.04.018_bib26","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/321864a0","article-title":"Benzodiazepines impair and beta-carbolines enhance performance in learning and memory tasks","volume":"321","author":"Venault","year":"1986","journal-title":"Nature"},{"year":"2000","series-title":"Drug synergism and dose-effect data analysis","author":"Tallarida","key":"10.1016\/j.yebeh.2007.04.018_bib27"},{"key":"10.1016\/j.yebeh.2007.04.018_bib28","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1528-1157.2003.32702.x","article-title":"Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis","volume":"44","author":"Luszczki","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2007.04.018_bib29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0014-2999(90)90190-H","article-title":"Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction","volume":"179","author":"Porreca","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2007.04.018_bib30","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1046\/j.1528-1157.2002.34301.x","article-title":"Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis","volume":"43","author":"Borowicz","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2007.04.018_bib31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00210-004-0867-z","article-title":"Isobolographic profile of interaction between tiagabine and gabapentin: a preclinical study","volume":"369","author":"Luszczki","year":"2004","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.yebeh.2007.04.018_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0920-1211(91)90062-K","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs","volume":"8","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0920-1211(91)90050-P","article-title":"Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat","volume":"9","author":"Garske","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0920-1211(98)00122-3","article-title":"Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat","volume":"34","author":"Halonen","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0920-1211(90)90050-6","article-title":"Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice","volume":"7","author":"Stagnitto","year":"1990","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib36","doi-asserted-by":"crossref","first-page":"PL271","DOI":"10.1016\/0024-3205(94)00845-0","article-title":"Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists","volume":"54","author":"Cramer","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.yebeh.2007.04.018_bib37","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0022-3565(24)35017-7","article-title":"Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures","volume":"290","author":"Gasior","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2007.04.018_bib38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0920-1211(02)00236-X","article-title":"Effects of remacemide in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS","volume":"52","author":"Nehlig","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib39","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1053\/seiz.2000.0447","article-title":"A placebo-controlled, double-blind cross- over trial of adjunctive one month remacemide hydrochloride treatment in patients with refractory epilepsy","volume":"9","author":"Richens","year":"2000","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2007.04.018_bib40","first-page":"CD001900","article-title":"Remacemide for drug-resistant localization related epilepsy","volume":"4","author":"Leach","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.yebeh.2007.04.018_bib41","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/ebeh.2002.0337","article-title":"Efficacy and safety of remacemide versus carbamazepine in newly diagnosed epilepsy: comparison by sequential analysis","volume":"3","author":"Brodie","year":"2002","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2007.04.018_bib42","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1528-1157.2000.tb00111.x","article-title":"Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed","volume":"41","author":"Deckers","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2007.04.018_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-1211(02)00257-7","article-title":"Current limitations of antiepileptic drug therapy: a conference review","volume":"53","author":"Deckers","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2007.04.018_bib44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0165-0173(97)00054-4","article-title":"Sodium channels as molecular targets for antiepileptic drugs","volume":"26","author":"Ragsdale","year":"1998","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.yebeh.2007.04.018_bib45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2165\/00023210-200115050-00001","article-title":"The new generation of GABA enhancers","volume":"15","author":"Czuczwar","year":"2001","journal-title":"CNS Drugs"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505007001618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505007001618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:19:10Z","timestamp":1761502750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505007001618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S1525505007001618"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2007.04.018","relation":{},"ISSN":["1525-5050"],"issn-type":[{"type":"print","value":"1525-5050"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2007.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}