{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:47:55Z","timestamp":1785034075487,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.yebeh.2010.01.001","type":"journal-article","created":{"date-parts":[[2010,2,15]],"date-time":"2010-02-15T09:36:50Z","timestamp":1266226610000},"page":"336-343","source":"Crossref","is-referenced-by-count":36,"title":["Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats"],"prefix":"10.1016","volume":"17","author":[{"given":"Ameer Y.","family":"Taha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Jeffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeen M.Y.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saimir","family":"Bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.M.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2010.01.001_bib1","series-title":"Principles of medical pharmacology","first-page":"223","article-title":"Antiseizure drugs","author":"Burnham","year":"2007"},{"key":"10.1016\/j.yebeh.2010.01.001_bib2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.0013-9580.2005.34204.x","article-title":"Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro","volume":"46","author":"Abdelmalik","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.eplepsyres.2006.06.007","article-title":"Afterdischarge threshold reduction in the kindling model of epilepsy","volume":"72","author":"Ng","year":"2006","journal-title":"Epilepsy Res"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2010.01.001_bib4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1528-1157.1996.tb06027.x","article-title":"The epidemiology and treatment of chronic and refractory epilepsy","volume":"37","author":"Shorvon","year":"1996","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.yebeh.2010.01.001_bib5","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1111\/j.1528-1157.1996.tb06026.x","article-title":"Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids","volume":"37","author":"Prasad","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0065-3101(24)00055-0","article-title":"The ketogenic diet: 1997","volume":"44","author":"Swink","year":"1997","journal-title":"Adv Pediatr"},{"key":"10.1016\/j.yebeh.2010.01.001_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0920-1211(99)00070-4","article-title":"Clinical efficacy of the ketogenic diet","volume":"37","author":"Vining","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-2999(94)90387-5","article-title":"Essential fatty acid preparation (SR-3) raises the seizure threshold in rats","volume":"254","author":"Yehuda","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2010.01.001_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/00207459608986715","article-title":"Essential fatty acid preparation reduces cholesterol and fatty acids in rat cortex","volume":"86","author":"Yehuda","year":"1996","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.yebeh.2010.01.001_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1388-1981(00)00077-9","article-title":"Metabolism of highly unsaturated n-3 and n-6 fatty acids","volume":"1486","author":"Sprecher","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yebeh.2010.01.001_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.eplepsyres.2006.05.011","article-title":"Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats","volume":"71","author":"Taha","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1528-1167.2008.01731.x","article-title":"Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats","volume":"50","author":"Taha","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1528-1167.2008.01723.x","article-title":"Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions","volume":"50","author":"Porta","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib14","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.neuroscience.2009.07.013","article-title":"Chronic omega-3 supplementation in seizure-prone versus seizure-resistant rat strains: a cautionary tale","volume":"163","author":"Gilby","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2010.01.001_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1528-1167.2008.01722.x","article-title":"Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models","volume":"50","author":"Willis","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-2999(97)01467-2","article-title":"Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model","volume":"341","author":"Voskuyl","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2010.01.001_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1528-1157.2002.13601.x","article-title":"Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients","volume":"43","author":"Schlanger","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.yebeh.2007.09.011","article-title":"A randomized trial of polyunsaturated fatty acids for refractory epilepsy","volume":"12","author":"Bromfield","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.01.001_bib19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.yebeh.2008.08.001","article-title":"n-3 fatty acids (fish oil) for epilepsy, cardiac risk factors, and risk of SUDEP: clues from a pilot, double-blind, exploratory study","volume":"13","author":"DeGiorgio","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.01.001_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.yebeh.2005.04.014","article-title":"Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial","volume":"7","author":"Yuen","year":"2005","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.01.001_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yebeh.2008.10.012","article-title":"Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy","volume":"14","author":"Taha","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.01.001_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-0173(89)90003-9","article-title":"Animal models of the epilepsies","volume":"14","author":"Fisher","year":"1989","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.yebeh.2010.01.001_bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1528-1157.1978.tb04507.x","article-title":"Antiepileptic drug development. II. Anticonvulsant drug screening","volume":"19","author":"Krall","year":"1978","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.01.001_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0014-2999(87)90464-X","article-title":"Anticonvulsant efficacy of clonazepam and the beta-carboline ZK 93423 during chronic treatment in amygdala-kindled rats","volume":"143","author":"Loscher","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2010.01.001_bib25","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1159\/000126425","article-title":"Effect of parenteral administration of selected nutrients and central injection of gamma-globulin from antiserum to neuropeptide Y on growth hormone secretory pattern in food-deprived rats","volume":"57","author":"Okada","year":"1993","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.yebeh.2010.01.001_bib26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1460-9568.2007.05348.x","article-title":"Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors","volume":"25","author":"Morris","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.yebeh.2010.01.001_bib27","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/brain\/awn079","article-title":"Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy","volume":"131","author":"Noe","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2010.01.001_bib28","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.peptides.2007.04.003","article-title":"Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats","volume":"28","author":"Obay","year":"2007","journal-title":"Peptides"},{"issue":"\/76","key":"10.1016\/j.yebeh.2010.01.001_bib29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0167-0115(98)00079-2","article-title":"Antiepileptic effects of NPY on pentylenetetrazole seizures","volume":"75","author":"Woldbye","year":"1998","journal-title":"Regul Pept"},{"key":"10.1016\/j.yebeh.2010.01.001_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2760(70)90086-X","article-title":"Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain","volume":"218","author":"Bazan","year":"1970","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yebeh.2010.01.001_bib31","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/j.1471-4159.1971.tb00002.x","article-title":"Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia","volume":"18","author":"Bazan","year":"1971","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2010.01.001_bib32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1471-4159.1983.tb04810.x","article-title":"Changes in free fatty acids and diglycerides in mouse brain at birth and during anoxia","volume":"41","author":"Rodriguez de Turco","year":"1983","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2010.01.001_bib33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/1098-2396(200008)37:2<90::AID-SYN2>3.0.CO;2-Z","article-title":"Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus","volume":"37","author":"Young","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.yebeh.2010.01.001_bib34","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/emboj\/19.8.1784","article-title":"Polyunsaturated fatty acids are potent neuroprotectors","volume":"19","author":"Lauritzen","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.yebeh.2010.01.001_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(99)01997-6","article-title":"Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation","volume":"846","author":"Xiao","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib36","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1073\/pnas.93.22.12559","article-title":"Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons","volume":"93","author":"Vreugdenhil","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.yebeh.2010.01.001_bib37","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MCO.0b013e32802b7030","article-title":"Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection","volume":"10","author":"Bazan","year":"2007","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.yebeh.2010.01.001_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.eplepsyres.2006.06.009","article-title":"The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction","volume":"71","author":"Akarsu","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib39","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.eplepsyres.2009.05.010","article-title":"Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitability","volume":"86","author":"Auvin","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib40","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1358\/mf.2003.25.8.778080","article-title":"Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice","volume":"25","author":"Tandon","year":"2003","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2010.01.001_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-4886(02)00019-5","article-title":"Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex","volume":"179","author":"Tu","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2010.01.001_bib42","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.pnpbp.2006.06.003","article-title":"Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action","volume":"30","author":"Dhir","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.yebeh.2010.01.001_bib43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.eplepsyres.2007.12.008","article-title":"Cyclooxygenase-2\/PGE2 pathway facilitates pentylenetetrazol-induced seizures","volume":"79","author":"Oliveira","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12031-007-0039-y","article-title":"Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-oleic acid tracers","volume":"33","author":"Polozova","year":"2007","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.yebeh.2010.01.001_bib45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0165-0173(92)90016-F","article-title":"A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis","volume":"17","author":"Robinson","year":"1992","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.yebeh.2010.01.001_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-4886(83)90374-6","article-title":"Effects of carbamazepine, clonazepam, and phenytoin on seizure threshold in amygdala and cortex","volume":"79","author":"Albright","year":"1983","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2010.01.001_bib47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.plefa.2006.05.009","article-title":"Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins","volume":"75","author":"Polozova","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.yebeh.2010.01.001_bib48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.plefa.2008.09.003","article-title":"Regulation of brain polyunsaturated fatty acid uptake and turnover","volume":"79","author":"Chen","year":"2008","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.yebeh.2010.01.001_bib49","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.neuint.2009.04.018","article-title":"Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood\u2013brain barrier: an in situ cerebral perfusion study","volume":"55","author":"Ouellet","year":"2009","journal-title":"Neurochem Int"},{"key":"10.1016\/j.yebeh.2010.01.001_bib50","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1194\/jlr.M700386-JLR200","article-title":"The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations","volume":"49","author":"Chen","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.yebeh.2010.01.001_bib51","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.metabol.2005.03.018","article-title":"Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats","volume":"54","author":"Taha","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.yebeh.2010.01.001_bib52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1054\/plef.2002.0409","article-title":"Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet","volume":"67","author":"Cunnane","year":"2002","journal-title":"Prostaglandins Leukot Essent Fatty Acids"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505010000065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505010000065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T01:08:03Z","timestamp":1711242483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505010000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S1525505010000065"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2010.01.001","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}