{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:27:00Z","timestamp":1786998420296,"version":"build-2736575974"},"reference-count":24,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.yebeh.2010.03.016","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T12:04:09Z","timestamp":1273665849000},"page":"100-105","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and safety of levetiracetam as adjunctive therapy in adult patients with uncontrolled partial epilepsy: The Asia SKATE II Study"],"prefix":"10.1016","volume":"18","author":[{"given":"Patrick","family":"Kwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hui","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotin","family":"Chinvarun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Cabral-Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zariah Abdul","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk-Keung","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Tonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Beh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Edrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2010.03.016_bib1","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1073\/pnas.0308208101","article-title":"The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam","volume":"101","author":"Lynch","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.yebeh.2010.03.016_bib2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/35087000","article-title":"SV2 modulates the size of the readily releasable pool of secretory vesicles","volume":"3","author":"Xu","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.yebeh.2010.03.016_bib3","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1528-1157.2000.tb04605.x","article-title":"for the European Levetiracetam Study Group. Efficacy and tolerability of levetiracetam 3000mg\/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy","volume":"41","author":"Ben-Menachem","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1212\/WNL.55.2.236","article-title":"Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial","volume":"55","author":"Cereghino","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2010.03.016_bib5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1528-1157.2000.tb00323.x","article-title":"for the European Levetiracetam Study Group. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures","volume":"41","author":"Shorvon","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib6","unstructured":"Murasaki M, Yagi K, Yamauchi T, et al. Multicentre, double-blind, randomised, placebo-controlled, parallel-group study of add-on levetiracetam in Japanese patients with uncontrolled partial seizures. Presented at the 6th Asian and Oceanian Epilepsy Congress; Kuala Lumpur, Malaysia; 16\u201319 November 2006."},{"key":"10.1016\/j.yebeh.2010.03.016_bib7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1528-1167.2008.01729.x","article-title":"Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in Chinese patients with refractory partial-onset seizures","volume":"50","author":"Wu","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1528-1167.2006.00372.x","article-title":"Efficacy and safety of levetiracetam (up to 2000mg\/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind, placebo-controlled study","volume":"47","author":"Tsai","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.nurt.2006.11.013","article-title":"Clinical development of antiepileptic drugs in adults","volume":"4","author":"Schmidt","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.yebeh.2010.03.016_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.eplepsyres.2008.04.007","article-title":"Reporting and analysis of open-label extension studies of anti-epileptic drugs","volume":"81","author":"Maguire","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.03.016_bib11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.yebeh.2003.09.007","article-title":"Use of levetiracetam in a population of patients aged 65years and older: a subset analysis of the KEEPER trial","volume":"4","author":"Ferrendelli","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.03.016_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0920-1211(03)00080-9","article-title":"The KEEPER\u2122 trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study","volume":"54","author":"Morrell","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.03.016_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.eplepsyres.2003.09.001","article-title":"Corrigendum to \"The KEEPER trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study.\"","volume":"56","author":"Morrell","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.03.016_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.eplepsyres.2007.06.002","article-title":"The SKATE (TM) study: an open-label community-based study of levetiracetam as add-on therapy for adults with uncontrolled partial epilepsy","volume":"76","author":"Steinhoff","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2010.03.016_bib15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.seizure.2007.02.011","article-title":"Efficacy and safety of levetiracetam as adjunctive treatment of refractory partial seizures in a multicentre open-label single-arm trial in Korean patients","volume":"16","author":"Heo","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2010.03.016_bib16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"Proposal for revised clinical and electroencephalographic classification of epileptic seizures","volume":"22","year":"1981","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2165\/00003088-200443110-00002","article-title":"Clinical pharmacokinetics of levetiracetam","volume":"43","author":"Patsalos","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.yebeh.2010.03.016_bib18","series-title":"CPMP\/ICH\/135\/95","year":"2007"},{"key":"10.1016\/j.yebeh.2010.03.016_bib19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.yebeh.2007.06.005","article-title":"Adjunctive therapy of uncontrolled partial seizures with levetiracetam in Australian patients","volume":"11","author":"Somerville","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.03.016_bib20","first-page":"81","article-title":"Antiepileptic drug research in Asia: where do we go from here?","volume":"8","author":"Kwan","year":"2003","journal-title":"Neurol J Southeast Asia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1365-2125.2006.02782.x","article-title":"Single-dose pharmacokinetics of levetiracetam in healthy Chinese male subjects","volume":"63","author":"Zhao","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2010.03.016_bib22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2165\/00003088-200746060-00004","article-title":"Population pharmacokinetics of levetiracetam in Japanese and Western adults","volume":"46","author":"Pigeolet","year":"2007","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.yebeh.2010.03.016_bib23","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/j.1528-1167.2007.01136.x","article-title":"Seizure-free outcome in randomized add-on trials of the new antiepileptic drugs","volume":"48","author":"Gazzola","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.03.016_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1684\/j.1950-6945.2006.tb00170.x","article-title":"Measurement of seizure freedom in adjunctive therapy studies in refractory partial epilepsy: the levetiracetam experience","volume":"8","author":"Leppik","year":"2006","journal-title":"Epileptic Disord"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505010002921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505010002921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T15:43:32Z","timestamp":1740066212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505010002921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":24,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1525505010002921"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2010.03.016","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}