{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:03:12Z","timestamp":1790776992926,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.yebeh.2010.10.002","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T13:22:05Z","timestamp":1289308925000},"page":"20-23","source":"Crossref","is-referenced-by-count":83,"title":["Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: A pharmacodynamic interaction?"],"prefix":"10.1016","volume":"20","author":[{"given":"Jan","family":"Novy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Patsalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay M.","family":"Sisodiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2010.10.002_bb0005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1528-1167.2008.01951.x","article-title":"Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial","volume":"50","author":"Halasz","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0010","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1528-1167.2009.02496.x","article-title":"Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial","volume":"51","author":"Chung","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0015","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1528-1167.2007.01188.x","article-title":"Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures","volume":"48","author":"Ben-Menachem","year":"2007","journal-title":"Epilepsia"},{"issue":"Suppl. 7","key":"10.1016\/j.yebeh.2010.10.002_bb0020","first-page":"188","article-title":"Basic clinical pharmacologic investigations of the new antiepileptic drug SPM 927","volume":"43","author":"Horstmann","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1586\/ern.09.136","article-title":"Drug interactions involving the new second- and third-generation antiepileptic drugs","volume":"10","author":"Johannessen Landmark","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0091270009347675","article-title":"No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteers","volume":"50","author":"Cawello","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mol.107.039867","article-title":"The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels","volume":"73","author":"Errington","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1527-3458.2007.00001.x","article-title":"Lacosamide: a review of preclinical properties","volume":"13","author":"Beyreuther","year":"2007","journal-title":"CNS Drug Rev"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0045","doi-asserted-by":"crossref","first-page":"25296","DOI":"10.1074\/jbc.M110.128801","article-title":"In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein 2 (CRMP-2) identifies a pocket important in modulating sodium channel slow inactivation","volume":"285","author":"Wang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.yebeh.2009.07.043","article-title":"Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany","volume":"16","author":"Wehner","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0055","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/FTD.0b013e3181dcc5fb","article-title":"A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsy","volume":"32","author":"Greenaway","year":"2010","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0060","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1528-1157.1997.tb01142.x","article-title":"Reappraisal of polytherapy in epilepsy: a critical review of drug load and adverse effects","volume":"38","author":"Deckers","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0065","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0026-895X(24)13073-8","article-title":"A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels","volume":"54","author":"Kuo","year":"1998","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0070","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1073\/pnas.0407346102","article-title":"Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin","volume":"102","author":"Tate","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0075","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.neuropharm.2006.02.002","article-title":"Seeking a mechanism of action for the novel anticonvulsant lacosamide","volume":"50","author":"Errington","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1085\/jgp.200308881","article-title":"Molecular motions of the outer ring of charge of the sodium channel","volume":"122","author":"Xiong","year":"2003","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2006.08.070","article-title":"Carbamazepine interacts with a slow inactivation state of NaV1.8-like sodium channels","volume":"408","author":"Cardenas","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2010.10.002_bb0090","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1528-1167.2008.01561.x","article-title":"Antiepileptic drugs\u2014best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies","volume":"49","author":"Patsalos","year":"2008","journal-title":"Epilepsia"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505010006499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505010006499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T18:09:13Z","timestamp":1740679753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505010006499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1525505010006499"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2010.10.002","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}