{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:55:51Z","timestamp":1791158151877,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Vlaamse Interuniversitaire Raad (VLIR)\u2014\u201cPharmacological Characterization of Medicinal Plants from the South of Ecuador\u201d Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.yebeh.2012.02.020","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T23:45:30Z","timestamp":1333583130000},"page":"14-22","source":"Crossref","is-referenced-by-count":103,"title":["Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models"],"prefix":"10.1016","volume":"24","author":[{"given":"Adriana Monserrath","family":"Orellana-Paucar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Sophie K.","family":"Serruys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Afrikanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"De Borggraeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Alen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n","family":"Le\u00f3n-Tamariz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Mar\u00eda","family":"Wilches-Ariz\u00e1bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.M.","family":"de Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila V.","family":"Esguerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2012.02.020_bb0235","series-title":"Atlas: epilepsy care in the world","author":"World Health Organization","year":"2005"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yebeh.2009.02.030","article-title":"Drug treatment of epilepsy: options and limitations","volume":"15","author":"Schmidt","year":"2009","journal-title":"Epilepsy Behav"},{"issue":"1\u20132","key":"10.1016\/j.yebeh.2012.02.020_bb0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0920-1211(01)00306-0","article-title":"Life-threatening adverse events of antiepileptic drugs","volume":"47","author":"Arroyo","year":"2001","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.yebeh.2012.02.020_bb0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.seizure.2005.01.008","article-title":"Complaints associated with the use of antiepileptic drugs: results from a community-based study","volume":"14","author":"Carpay","year":"2005","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0240","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.yebeh.2008.10.017","article-title":"Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugs","volume":"14","author":"Arif","year":"2009","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eplepsyres.2005.09.023","article-title":"Cognitive and memory effects of the new antiepileptic drugs","volume":"68","author":"Meador","year":"2006","journal-title":"Epilepsy Res"},{"issue":"2","key":"10.1016\/j.yebeh.2012.02.020_bb0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nurt.2008.12.004","article-title":"Botanicals and herbs: a traditional approach to treating epilepsy","volume":"6","author":"Schachter","year":"2009","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.yebeh.2012.02.020_bb0245","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/seiz.1999.0378","article-title":"Review on phytotherapy in epilepsy","volume":"9","author":"Nsour","year":"2000","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/1568026053386944","article-title":"New anticonvulsant agents","volume":"5","author":"Malawska","year":"2005","journal-title":"Curr Top Med Chem"},{"issue":"12","key":"10.1016\/j.yebeh.2012.02.020_bb0250","first-page":"1763","volume":"2","author":"Willmore","year":"2001","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0255","series-title":"WHO monographs on selected medicinal plants","author":"World Health Organization","year":"1999"},{"issue":"2","key":"10.1016\/j.yebeh.2012.02.020_bb0060","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.yebeh.2008.11.011","article-title":"Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis","volume":"14","author":"Jyoti","year":"2009","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0260","first-page":"35","article-title":"Protective role of curcumin in maximal electroshock induced seizures, memory impairment and neurotransmitters in rat brain","volume":"2","author":"Jithendra","year":"2008","journal-title":"JPCCR"},{"issue":"16","key":"10.1016\/j.yebeh.2012.02.020_bb0070","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.lfs.2005.08.028","article-title":"Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin","volume":"78","author":"Sumanont","year":"2006","journal-title":"Life Sci"},{"issue":"19\u201322","key":"10.1016\/j.yebeh.2012.02.020_bb0075","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.lfs.2010.09.006","article-title":"Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model","volume":"87","author":"Mehla","year":"2010","journal-title":"Life Sci"},{"issue":"4","key":"10.1016\/j.yebeh.2012.02.020_bb0080","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/0250-474X.44591","article-title":"A pilot cross-over study to evaluate human oral bioavailability of BCM-95\u00aeCG (Biocurcumax\u2122), a novel bioenhanced preparation of curcumin","volume":"70","author":"Antony","year":"2008","journal-title":"Indian J Pharm Sci."},{"issue":"3","key":"10.1016\/j.yebeh.2012.02.020_bb0085","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1078\/0944-7113-00113","article-title":"Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures","volume":"9","author":"Sayyah","year":"2002","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.yebeh.2012.02.020_bb0090","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.phymed.2007.09.018","article-title":"Phytochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents","volume":"15","author":"Quintans-J\u00fanior","year":"2008","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2008.04.020","article-title":"Curcuma oil modulates the nitric oxide system response to cerebral ischemia\/reperfusion injury","volume":"19","author":"Dohare","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1472-6882-8-55","article-title":"Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model","volume":"8","author":"Dohare","year":"2008","journal-title":"BMC Complement Altern Med"},{"issue":"9","key":"10.1016\/j.yebeh.2012.02.020_bb0265","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1007\/s11064-007-9515-6","article-title":"Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain","volume":"33","author":"Rathore","year":"2008","journal-title":"Neurochem Res"},{"issue":"6","key":"10.1016\/j.yebeh.2012.02.020_bb0110","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1055\/s-2008-1034374","article-title":"Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery","volume":"74","author":"Crawford","year":"2008","journal-title":"Planta Med"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0115","first-page":"493","article-title":"Chemical screening in zebrafish for novel biological and therapeutic discovery","volume":"105","author":"Tan","year":"2011","journal-title":"Methods Cell Biol."},{"issue":"3","key":"10.1016\/j.yebeh.2012.02.020_bb0120","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.pbb.2004.01.003","article-title":"Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening","volume":"77","author":"Lockwood","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0270","first-page":"35","article-title":"In vivo drug discovery in the zebrafish","volume":"4","author":"Zon","year":"2005","journal-title":"Nat Rev"},{"issue":"3","key":"10.1016\/j.yebeh.2012.02.020_bb0130","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.neuroscience.2004.11.031","article-title":"Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression","volume":"131","author":"Baraban","year":"2005","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.eplepsyres.2007.03.015","article-title":"Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants","volume":"75","author":"Berghmans","year":"2007","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.yebeh.2012.02.020_bb0140","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.vascn.2008.01.004","article-title":"Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs","volume":"57","author":"Winter","year":"2008","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"7","key":"10.1016\/j.yebeh.2012.02.020_bb0275","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.seizure.2007.05.005","article-title":"Timed pentylenetetrazol infusion test: a comparative analysis with s.c. PTZ and MES models of anticonvulsant screening in mice","volume":"16","author":"Mandhane","year":"2007","journal-title":"Seizure"},{"issue":"5","key":"10.1016\/j.yebeh.2012.02.020_bb0150","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1059-1311(03)00185-7","article-title":"Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models","volume":"13","author":"Sills","year":"2004","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0280","series-title":"Atlas of microscopy of medicinal plants, culinary herbs and spices","first-page":"257 p","author":"Jackson","year":"1990"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0285","series-title":"A guide for the laboratory use of zebrafish (Danio rerio)","article-title":"The zebrafish book","author":"Westerfield","year":"2000"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0021-9673(98)00540-8","article-title":"Liquid chromatography\u2013electrospray mass spectrometric analysis of curcuminoids and sesquiterpenoids in turmeric (Curcuma longa)","volume":"818","author":"He","year":"1998","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0170","series-title":"Current protocols in pharmacology","first-page":"27","article-title":"Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse","author":"Giardina","year":"2009"},{"issue":"1\u20133","key":"10.1016\/j.yebeh.2012.02.020_bb0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuint.2008.12.019","article-title":"vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol","volume":"55","author":"Scallier","year":"2009","journal-title":"Neurochem Int"},{"issue":"11","key":"10.1016\/j.yebeh.2012.02.020_bb0290","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.tetasy.2009.05.006","article-title":"Total synthesis of (R)- and (S)-turmerone and (7S,9R)-bisacumol by an efficient chemoenzymatic approach","volume":"20","author":"Kamal","year":"2009","journal-title":"Tetrahedron Asymmetr"},{"issue":"1","key":"10.1016\/j.yebeh.2012.02.020_bb0185","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1248\/cpb.37.237","article-title":"New bisabolane sesquiterpenoids from the rhizomes of Curcuma xanthorrhiza (Zingiberaceae)","volume":"37","author":"Uehara","year":"1989","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0190","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1021\/jo960894z","article-title":"Preparation of \u03b3,\u03b4\u2010unsaturated \u03b2\u2010ketophosphonates from tertiary \u03b1\u2010allenic alcohols. The synthesis of (+\/\u2212)\u2010(E)\u2010\u03b1\u2010atlantone","volume":"61","author":"Friesen","year":"1996","journal-title":"J Org Chem"},{"issue":"12","key":"10.1016\/j.yebeh.2012.02.020_bb0195","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/ptr.2551","article-title":"Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice","volume":"22","author":"Bharal","year":"2008","journal-title":"Phytother Res"},{"issue":"1\u20133","key":"10.1016\/j.yebeh.2012.02.020_bb0200","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.eplepsyres.2005.08.005","article-title":"alpha-Tocopherol protects against pentylenetetrazol- and methylmalonate-induced convulsions","volume":"66","author":"Ribeiro","year":"2005","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0295","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/BF03177490","article-title":"Regional vulnerability to oxidative stress in a model of experimental epilepsy","volume":"23","author":"Lores Arnaiz","year":"1998","journal-title":"Neurochem Res"},{"issue":"Suppl. 3","key":"10.1016\/j.yebeh.2012.02.020_bb0210","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.yebeh.2005.08.006","article-title":"Antiepileptic drugs and neuroprotection: current status and future roles","volume":"7","author":"Willmore","year":"2005","journal-title":"Epilepsy Behav"},{"issue":"4","key":"10.1016\/j.yebeh.2012.02.020_bb0215","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1528-1167.2011.03024.x","article-title":"Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma","volume":"52","author":"L\u00f6scher","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0300","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/mnfr.200700280","article-title":"New mechanisms and therapeutic potential of curcumin for colorectal cancer","volume":"52","author":"Villegas","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.yebeh.2012.02.020_bb0225","first-page":"1055","article-title":"Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers","volume":"51","author":"Joshi","year":"2003","journal-title":"J Assoc Physicians India"},{"issue":"10","key":"10.1016\/j.yebeh.2012.02.020_bb0230","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1016\/j.fct.2010.07.032","article-title":"Toxicity prediction of compounds from turmeric (Curcuma longa L)","volume":"48","author":"Balaji","year":"2010","journal-title":"Food Chem Toxicol"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505012000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505012000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T03:59:30Z","timestamp":1543031970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505012000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1525505012000868"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2012.02.020","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}