{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:45:55Z","timestamp":1791312355501,"version":"4.3.1"},"reference-count":97,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.yebeh.2012.03.026","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T17:26:11Z","timestamp":1336497971000},"page":"199-206","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate"],"prefix":"10.1016","volume":"24","author":[{"given":"Neveen A.","family":"Noor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S.","family":"Aboul Ezz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Razik","family":"Faraag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser A.","family":"Khadrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2012.03.026_bb0005","series-title":"Harrison's principles of internal medicine","first-page":"2357","article-title":"Seizures and epilepsy","author":"Lowenstein","year":"2008"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0010","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1212\/WNL.31.7.872","article-title":"Amino acid abnormalities in epileptogenic foci","volume":"31","author":"Perry","year":"1981","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0301-0082(95)00030-5","article-title":"Glutamate, GABA and epilepsy","volume":"47","author":"Bradford","year":"1995","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0020","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0306-4522(00)00400-0","article-title":"Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels","volume":"101","author":"Pena","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.eplepsyres.2008.01.005","article-title":"Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats","volume":"79","author":"Khongsombat","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJM199601183340308","article-title":"Antiepileptic drugs","volume":"334","author":"Brodie","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0035","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00967253","article-title":"Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acid in the brain","volume":"18","author":"L\u00f6scher","year":"1993","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0040","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0022-3565(25)32552-8","article-title":"Sodium valproate enhancement of \u03b3-aminobutyric (GABA) inhibition: electrophysiological evidence for anticonvulsant activity","volume":"217","author":"Baldino","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0301-0082(82)90010-7","article-title":"Mechanisms of anticonvulsant action of valproate","volume":"19","author":"Chapman","year":"1982","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0197-0186(00)00013-9","article-title":"Mechanisms of action of valproate: a commentatory","volume":"37","author":"Johannessen","year":"2000","journal-title":"Neurochem Int"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0055","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/0006-2952(85)90645-8","article-title":"In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities","volume":"34","author":"L\u00f6scher","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0060","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0022-3565(25)24966-7","article-title":"Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture","volume":"237","author":"McLean","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0065","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0920-1211(98)00060-6","article-title":"Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons","volume":"32","author":"Taverna","year":"1998","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0070","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0361-9230(94)90202-X","article-title":"Valproic acid suppresses the synaptic response mediated by the NMDA receptors in rat amygdalar slices","volume":"33","author":"Gean","year":"1994","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00213-006-0317-3","article-title":"Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex","volume":"185","author":"Gobbi","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0361-9230(96)00268-7","article-title":"The effects of anticonvulsant drugs on NMDA-EPSP, AMPAEPSP, and GABA-IPSP in the rat hippocampus","volume":"42","author":"Ko","year":"1997","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0085","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neuropharm.2003.10.013","article-title":"Valproate reduced excitatory postsynaptic currents in hippocampal CA1 pyramidal neurons","volume":"46","author":"Martin","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0090","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0306-4522(90)90262-3","article-title":"Differential effects of antiepileptic drugs and beta-carbolines on seizures induced by excitatory amino acids","volume":"39","author":"Turski","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0006-8993(91)90078-A","article-title":"Valproate suppresses N-methyl-d-aspartate-evoked, transient depolarizations in the rat neocortex in vitro","volume":"544","author":"Zeise","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1474-4422(02)00073-X","article-title":"Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy","volume":"1","author":"Pitkanen","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0105","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1023\/A:1007559208599","article-title":"In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy","volume":"17","author":"Lindekens","year":"2000","journal-title":"Pharm Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0110","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1528-1157.1996.tb00639.x","article-title":"Does antiepileptic drug therapy prevent the development of \u201cchronic\u201d epilepsy?","volume":"37","author":"Shinnar","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0115","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1248\/bpb.30.1732","article-title":"Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus","volume":"30","author":"Sumanont","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2007.01.060","article-title":"Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice","volume":"416","author":"Shin","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0125","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/ptr.2551","article-title":"Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice","volume":"22","author":"Bharal","year":"2008","journal-title":"Phytother Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.yebeh.2008.11.011","article-title":"Curcumin protects against electrobehavioral progression of seizures in iron induced experimental model of epileptogenesis","volume":"14","author":"Jyoti","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0505","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.lfs.2010.09.006","article-title":"Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model","volume":"87","author":"Mehla","year":"2010","journal-title":"Life Sci"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0510","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s11064-011-0544-9","article-title":"The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate","volume":"36","author":"Aboul Ezz","year":"2011","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0145","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuropharm.2005.04.004","article-title":"Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice","volume":"49","author":"Ilhan","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0150","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1163\/156939105774647367","article-title":"Suppression of penicillin-induced epileptiform activity by Nigella sativa: possible mediation by neurotransmitters","volume":"19","author":"Guha","year":"2005","journal-title":"Biog Amines"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-8741(03)00157-0","article-title":"Neuropharmacological activity of Nigella sativa L. extracts","volume":"88","author":"Al-Naggar","year":"2003","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0160","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","article-title":"Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures","volume":"32","author":"Cavalheiro","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0165","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","article-title":"Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting","volume":"34","author":"Mello","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0515","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/syn.890030207","article-title":"Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy","volume":"3","author":"Turski","year":"1989","journal-title":"Synapse"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0175","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-4328(83)90136-5","article-title":"Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study","volume":"9","author":"Turski","year":"1983","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0180","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/BF01990130","article-title":"Cholinomimetics produce seizures and brain damage in rats","volume":"39","author":"Turski","year":"1983","journal-title":"Experientia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0185","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1528-1157.1996.tb00541.x","article-title":"The pilocarpine model of epilepsy in mice","volume":"37","author":"Cavalheiro","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0190","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-4886(87)90293-7","article-title":"Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats","volume":"97","author":"Morrisett","year":"1987","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0195","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0165-0173(87)90002-6","article-title":"Only certain antiepileptic drugs prevent seizures induced by pilocarpine","volume":"12","author":"Turski","year":"1987","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1994.tb02905.x","article-title":"Spontaneous recurrent seizures in rats: amino acid and monoamine determination in the hippocampus","volume":"35","author":"Cavalheiro","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0520","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0920-1211(96)00057-5","article-title":"Comparison of seizure-related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy","volume":"26","author":"Wilson","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0210","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/exnr.1994.1158","article-title":"Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine","volume":"129","author":"Williams","year":"1994","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0215","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.euroneuro.2009.02.002","article-title":"Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)","volume":"19","author":"Ishrat","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0220","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s11064-010-0215-2","article-title":"Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice","volume":"35","author":"Abdel-Zaher","year":"2010","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0525","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0378-4347(00)83656-7","article-title":"Determination of 27 dansyl amino acid derivatives in biological fluids by reversed-phase high-performance liquid chromatography","volume":"380","author":"M\u00e0rquez","year":"1986","journal-title":"J Chromatogr"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0230","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0003-2697(81)90534-0","article-title":"Dansylation of amino acids for high-performance liquid chromatography analysis","volume":"115","author":"Tapuhi","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0235","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0920-1211(98)00092-8","article-title":"The course of untreated seizures in the pilocarpine model of epilepsy","volume":"34","author":"Arida","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0240","series-title":"Models of seizures and epilepsy","first-page":"601","article-title":"Behavioral characterization of seizures in rats","author":"Veliskova","year":"2006"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0245","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0301-0082(98)00075-6","article-title":"Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action","volume":"58","author":"L\u00f6scher","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/brain\/93.1.57","article-title":"Alterations in the activity of selected enzymes in the chronic isolated cerebral cortex of cat","volume":"93","author":"Green","year":"1970","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0255","first-page":"468","article-title":"Interictal\u2013ictal interactions and limbic seizure generation","volume":"155","author":"Avoli","year":"1999","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0260","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/sj.npp.1301449","article-title":"Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition","volume":"33","author":"Zhang","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0265","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00979526","article-title":"Contributions of basic neurochemistry towards a novel concept of epilepsy","volume":"12","author":"Van Gelder","year":"1987","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0270","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0896-6273(90)90172-C","article-title":"Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy","volume":"5","author":"Feldblum","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0275","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000081964","article-title":"Choline acetyltransferase, glutamic acid decarboxylase and somatostatin in the kainic acid model for chronic temporal lobe epilepsy","volume":"13","author":"Baran","year":"2004","journal-title":"Neurosignals"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0280","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0306-4522(87)90171-0","article-title":"The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures","volume":"23","author":"Clifford","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0285","series-title":"Recent advances in epilepsy","first-page":"19","article-title":"Cerebral energy metabolism and seizures","author":"Chapman","year":"1985"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0290","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1471-4159.2007.04887.x","article-title":"Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate\/glutamine cycling","volume":"103","author":"Chowdhury","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0295","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10522-006-6495-x","article-title":"Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions","volume":"7","author":"Bala","year":"2006","journal-title":"Biogerontology"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0300","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0305","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.pbb.2007.10.009","article-title":"Protective effect of curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain","volume":"88","author":"Bishnoi","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0310","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00221-005-0068-0","article-title":"Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-d-aspartate-induced intracellular Ca2+ increase","volume":"167","author":"Matteucci","year":"2005","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0315","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-006-9365-6","article-title":"Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling","volume":"298","author":"Suh","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0320","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1471-4159.1978.tb10477.x","article-title":"Glutamine \u2014 a major substrate for nerve endings","volume":"30","author":"Bradford","year":"1978","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0325","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pbb.2010.02.013","article-title":"The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats","volume":"95","author":"Pyrzanowska","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0330","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0047-6374(00)00252-9","article-title":"Endogenous glutamate\u2013taurine interaction in striatum and nucleus accumbens of the freely moving rat: studies during the normal process of aging","volume":"122","author":"Del Arco","year":"2001","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0335","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1014890219513","article-title":"The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis","volume":"27","author":"Foos","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0530","first-page":"398312","article-title":"Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in vitro","volume":"2101","author":"El-Naggar","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0345","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF00169293","article-title":"Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma","volume":"349","author":"L\u00f6scher","year":"1994","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0350","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2010.03.076","article-title":"Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats","volume":"133","author":"Safar","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0355","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0197-0186(03)00148-7","article-title":"Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus","volume":"44","author":"Li","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0360","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0014-2999(95)00589-7","article-title":"Differential effects of phenytoin and sodium valproate on seizure-induced changes in \u03b3-aminobutyric acid and glutamate release in vivo","volume":"294","author":"Rowley","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0365","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/sj.mp.4001087","article-title":"Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity","volume":"7","author":"Farber","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0535","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00964170","article-title":"Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities","volume":"9","author":"Battistin","year":"1984","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0540","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-3940(93)90407-C","article-title":"In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats","volume":"160","author":"L\u00f6scher","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0400","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0924-977X(03)00070-1","article-title":"Effects of chronic lithium and sodium valproate on concentrations of brain amino acids","volume":"13","author":"O'Donnell","year":"2003","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0405","first-page":"48","article-title":"Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain","volume":"46","author":"Guzm\u00e1n","year":"2003","journal-title":"Proc West Pharmacol Soc"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0545","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.eplepsyres.2003.12.002","article-title":"Effects of seven clinically important antiepileptic drugs on inhibitory glycine receptor currents in hippocampal neurons","volume":"58","author":"Karkar","year":"2004","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0415","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0420","first-page":"555","article-title":"GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures","volume":"23","author":"Cavalheiro","year":"1990","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0425","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-1211(02)00099-2","article-title":"Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations","volume":"51","author":"Klitgaard","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0430","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1523\/JNEUROSCI.15-05-03990.1995","article-title":"Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata","volume":"15","author":"Mathern","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0435","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0920-1211(94)90054-X","article-title":"Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures","volume":"17","author":"Liu","year":"1994","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0440","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/107385840200800211","article-title":"Epilepsy as an example of neural plasticity","volume":"8","author":"Scharfman","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0445","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2007.05.071","article-title":"Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats","volume":"1162","author":"Xu","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0450","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1212\/WNL.51.1.41","article-title":"Comparison of valproate and phenobarbital treatment after status epilepticus in rats","volume":"51","author":"Bolanos","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0455","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ana.410290404","article-title":"Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy","volume":"29","author":"Silver","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0460","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1046\/j.0022-3042.2001.00728.x","article-title":"Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation","volume":"80","author":"Hashimoto","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0465","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1471-4159.2004.02725.x","article-title":"The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells","volume":"91","author":"Laeng","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0470","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","article-title":"Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis","volume":"24","author":"Hao","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0550","first-page":"522","article-title":"Decrease of folic acid and cognitive alterations in patients with epilepsy treated with phenytoin or carbamazepine, pilot study","volume":"57","author":"Hernandez","year":"2005","journal-title":"Rev Invest Clin"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0480","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yebeh.2006.11.004","article-title":"Effects of antiepileptic drugs on learning as assessed by a repeated acquisition of response sequences task in rats","volume":"10","author":"Shannon","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0485","first-page":"27","article-title":"Anticonvulsant effects on the memory performance of epileptics","volume":"20","author":"Butlin","year":"1984","journal-title":"Clin Exp Neurol"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0490","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0896-6974(95)00041-B","article-title":"Effects of chronic use of carbamazepine and valproate on cognitive processes","volume":"8","author":"Coenen","year":"1995","journal-title":"J Epilepsy"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0495","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1528-1157.1984.tb05640.x","article-title":"Sodium valproate and cognitive function","volume":"25","author":"Trimble","year":"1984","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0500","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.biopsych.2009.11.008","article-title":"Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment","volume":"67","author":"Sgobio","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.yebeh.2012.03.026_bb0555","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bcp.2008.12.011","article-title":"Curcumin-induced degradation of PKC\u03b4 is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats","volume":"77","author":"Conboy","year":"2009","journal-title":"Biochem Pharmacol"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505012001710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505012001710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T16:06:57Z","timestamp":1743091617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505012001710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":97,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1525505012001710"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2012.03.026","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}