{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:20:08Z","timestamp":1769224808892,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100002782","name":"CURE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Massachusetts General Hospital Department of Anesthesia, Critical Care and Pain Medicine"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.yebeh.2015.02.013","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T15:46:04Z","timestamp":1426261564000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA\/1 mice"],"prefix":"10.1016","volume":"45","author":[{"given":"Chang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Cotten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Solt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl L.","family":"Faingold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Jun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2015.02.013_bb0005","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S1474-4422(08)70202-3","article-title":"Sudden unexpected death in epilepsy: current knowledge and future directions","volume":"7","author":"Tomson","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.yebeh.2008.12.004","article-title":"A review of sudden unexpected death in epilepsy: prediction of patients at risk","volume":"14","author":"Hughes","year":"2009","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0015","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/epi.12666","article-title":"Sudden unexpected death in epilepsy: assessing the public health burden","volume":"55","author":"Thurman","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0020","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S1059-1311(02)00352-7","article-title":"Risk factors for sudden unexpected death in epilepsy: a controlled prospective study based on coroners cases","volume":"12","author":"Opeskin","year":"2003","journal-title":"Seizure"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jnnp.68.2.211","article-title":"Sudden unexpected death in epilepsy: a series of witnessed deaths","volume":"68","author":"Langan","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.yebeh.2015.02.013_bb0030","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.3949\/ccjm.74.Suppl_1.S121","article-title":"Sudden unexplained death in epilepsy: the role of the heart","volume":"74","author":"Schuele","year":"2007","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0035","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.yebeh.2010.02.007","article-title":"DBA\/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest","volume":"17","author":"Faingold","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.yebeh.2011.06.015","article-title":"Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor","volume":"22","author":"Faingold","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0045","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1528-1157.2000.tb00128.x","article-title":"Postictal central apnea as a cause of SUDEP: evidence from near-SUDEP incident","volume":"41","author":"So","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0050","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1113\/jphysiol.2014.277574","article-title":"Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality","volume":"592","author":"Buchanan","year":"2014","journal-title":"J Physiol"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0055","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/j.1528-1167.2010.02594.x","article-title":"Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy","volume":"51","author":"Bateman","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.neuro.26.041002.131103","article-title":"Breathing: rhythmicity, plasticity, chemosensitivity","volume":"26","author":"Feldman","year":"2003","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0065","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1073\/pnas.1004587107","article-title":"Central serotonin neurons are required for arousal to CO2","volume":"107","author":"Buchanan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0070","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1093\/brain\/awn277","article-title":"Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors","volume":"131","author":"Bateman","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0075","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1528-1167.2009.02490.x","article-title":"How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?","volume":"51","author":"Moseley","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1399-6576.1993.tb03697.x","article-title":"Doxapram improves pulmonary function after upper abdominal surgery","volume":"37","author":"Bjork","year":"1993","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0085","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00003246-200201000-00018","article-title":"Oxygen therapy for hypercapnic patients with chronic obstructive pulmonary disease and acute respiratory failure: a randomized, controlled pilot study","volume":"30","author":"Gomersall","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0090","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1213\/ANE.0b013e318284469d","article-title":"TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats","volume":"116","author":"Cotten","year":"2013","journal-title":"Anesth Analg"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cmdc.201100351","article-title":"Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3)","volume":"7","author":"Coburn","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0100","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1021\/jm0210461","article-title":"Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5","volume":"46","author":"Peukert","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","article-title":"A barometric method for measuring ventilation in newborn infants","volume":"16","author":"Drorbaugh","year":"1955","journal-title":"Pediatrics"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/B978-0-444-63274-6.00011-4","article-title":"Serotonin neurons and central respiratory chemoreception: where are we now?","volume":"209","author":"Teran","year":"2014","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0115","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.0013-9580.2004.02304.x","article-title":"Oxygenation prevents sudden death in seizure-prone mice","volume":"45","author":"Venit","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0028-3908(83)90016-3","article-title":"The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats","volume":"22","author":"Albertson","year":"1983","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0125","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2013.04.003","article-title":"Effects of age, sex, and sertraline administration on seizure-induced respiratory arrest in the DBA\/1 mouse model of sudden unexpected death in epilepsy (SUDEP)","volume":"28","author":"Faingold","year":"2013","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0130","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.yebeh.2014.06.028","article-title":"Serotonin and sudden death: differential effects of serotonergic drugs on seizure-induced respiratory arrest in DBA\/1 mice","volume":"37","author":"Faingold","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0135","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0022-3565(25)13254-0","article-title":"McN-5652: a highly potent inhibitor of serotonin uptake","volume":"247","author":"Shank","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/ebeh.2000.0023","article-title":"The postictal state: a neglected entity in the management of epilepsy","volume":"1","author":"Fisher","year":"2000","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0145","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1523\/JNEUROSCI.5271-08.2009","article-title":"Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P","volume":"29","author":"Ptak","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0150","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1523\/JNEUROSCI.4729-07.2008","article-title":"Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons","volume":"28","author":"Hodges","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0155","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1152\/japplphysiol.00019.2002","article-title":"Ventilatory phenotypes among four strains of adult rats","volume":"93","author":"Hodges","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0160","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1096\/fasebj.26.1_supplement.894.5","article-title":"Altered brainstem neuromodulators relevant to central chemoreceptor function in Brown Norway (BN) rats","volume":"26","author":"Hodges","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.resp.2013.02.020","article-title":"Fluoxetine augments ventilatory CO2 sensitivity in Brown Norway but not Sprague Dawley rats","volume":"186","author":"Hodges","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0170","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1177\/0269881109106908","article-title":"Acute and chronic treatment with serotonin reuptake inhibitors exert opposite effects on respiration in rats: possible implications for panic disorder","volume":"24","author":"Annerbrink","year":"2010","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0175","first-page":"356","article-title":"Alterations of central hypercapnic respiratory response induced by acute central administration of serotonin re-uptake inhibitor, fluoxetine","volume":"54","author":"Sahin","year":"2011","journal-title":"Chin J Physiol"},{"issue":"Suppl. 7","key":"10.1016\/j.yebeh.2015.02.013_bb0180","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1097\/00005344-199001001-00006","article-title":"Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists","volume":"15","author":"Blier","year":"1990","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0185","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2011.08.043","article-title":"Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA\/2 vs. DBA\/1 mice","volume":"1418","author":"Faingold","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0190","doi-asserted-by":"crossref","first-page":"e21395","DOI":"10.1371\/journal.pone.0021395","article-title":"Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network","volume":"6","author":"Niebert","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0195","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1601-183X.2010.00586.x","article-title":"Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice","volume":"9","author":"Osipova","year":"2010","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.yebeh.2015.02.013_bb0200","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","article-title":"Tryptophan hydroxylase-2 controls brain serotonin synthesis","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550501500061X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152550501500061X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T23:32:12Z","timestamp":1747783932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152550501500061X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":40,"alternative-id":["S152550501500061X"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2015.02.013","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA\/1 mice","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2015.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}