{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:16Z","timestamp":1777493536062,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.yebeh.2015.04.012","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T21:02:10Z","timestamp":1431464530000},"page":"298-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The potential of sec -butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus"],"prefix":"10.1016","volume":"49","author":[{"given":"Tawfeeq","family":"Shekh-Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz","family":"Mawasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Yagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meir","family":"Bialer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2015.04.012_bb0005","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S0009-9236(97)90194-6","article-title":"Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and epileptic patients","volume":"61","author":"Barel","year":"1997","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0010","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.nurt.2006.11.007","article-title":"Valproic acid \u2014 second generation","volume":"4","author":"Bialer","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0015","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.addr.2011.11.006","article-title":"Chemical properties of antiepileptic drugs (AEDs)","volume":"64","author":"Bialer","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0020","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.eplepsyres.2010.09.001","article-title":"Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X)","volume":"92","author":"Bialer","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0025","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nrd2997","article-title":"Key factors in the discovery and development of new antiepileptic drugs (AEDs)","volume":"9","author":"Bialer","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0030","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1528-1167.2011.03338.x","article-title":"A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage","volume":"53","author":"White","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0035","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.neuroscience.2012.11.005","article-title":"A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.","volume":"231","author":"Pouliot","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0040","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.eplepsyres.2012.10.001","article-title":"Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)","volume":"103","author":"Bialer","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0045","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.eplepsyres.2015.01.001","article-title":"Progress report on new antiepileptic drugs: a summary of the Twelfth Eilat Conference (EILAT XII)","volume":"111","author":"Bialer","year":"2015","journal-title":"Epilepsy Res"},{"issue":"Suppl. 5","key":"10.1016\/j.yebeh.2015.04.012_bb0050","first-page":"98","article-title":"Valnoctamide and sec-propyl-butylacetamide (SPD) for acute seizures and status epilepticus","author":"Shekh-Ahmad","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0055","doi-asserted-by":"publisher","first-page":"6467","DOI":"10.1021\/jm4007565","article-title":"Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus","volume":"56","author":"Hen","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0060","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/epi.12480","article-title":"Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential","volume":"55","author":"Shekh-Ahmad","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0065","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1111\/epi.12838","article-title":"sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats","volume":"55","author":"Bar-Klein","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0070","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin test: an evaluation of the method","volume":"51","author":"Tjolsen","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0075","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.neuropharm.2010.03.004","article-title":"Evaluation of the antiallodynic, teratogenic and pharmacokinetic profile of stereoisomers of valnoctamide, an amide derivative of a chiral isomer of valproic acid","volume":"52","author":"Kaufmann","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0080","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.1111\/epi.12702","article-title":"Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus","volume":"55","author":"Spampanato","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0085","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMoa0803531","article-title":"Cognitive function at 3years of age after fetal exposure to antiepileptic drugs","volume":"360","author":"Meador","year":"2009","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.yebeh.2015.04.012_bb0090","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S1474-4422(11)70107-7","article-title":"EURAP study group. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry","author":"Tomson","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0095","author":"European Medicines Agency (EMA)"},{"key":"10.1016\/j.yebeh.2015.04.012_bb0100","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1517\/13543784.15.6.637","article-title":"New antiepileptic drugs (AEDs) in clinical development which are second generation to existing AEDs","volume":"15","author":"Bialer","year":"2006","journal-title":"Expert Opin Investig Drugs"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505015001602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505015001602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T13:23:35Z","timestamp":1537622615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505015001602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":20,"alternative-id":["S1525505015001602"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2015.04.012","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2015.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}