{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:48:41Z","timestamp":1790718521309,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["308459\/2013-0"],"award-info":[{"award-number":["308459\/2013-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["249\/14"],"award-info":[{"award-number":["249\/14"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"FAPESC","doi-asserted-by":"publisher","award":["1262\/2012-9"],"award-info":[{"award-number":["1262\/2012-9"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INCT \u2014 National Institute of Science and Technology","award":["2010\/01"],"award-info":[{"award-number":["2010\/01"]}]}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.yebeh.2015.12.001","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T16:31:26Z","timestamp":1452702686000},"page":"92-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy"],"prefix":"10.1016","volume":"55","author":[{"given":"Mark William","family":"Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Cristiane","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u00fabia Bonfanti","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Marques","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"de Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Daniel","family":"Prediger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-6888","authenticated-orcid":false,"given":"Rodrigo Bainy","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2015.12.001_bb0005","first-page":"392","article-title":"Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment","volume":"35","author":"Goldenberg","year":"2010","journal-title":"P T"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00019052-200304000-00008","article-title":"The epidemiology of epilepsy revisited","volume":"16","author":"Sander","year":"2003","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0015","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1212\/WNL.59.9_suppl_5.S21","article-title":"Epilepsy after brain insult: targeting epileptogenesis","volume":"59","author":"Herman","year":"2002","journal-title":"Neurology"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2015.12.001_bb0020","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.yebeh.2003.07.002","article-title":"Medical comorbidities in the treatment of epilepsy","volume":"4","author":"Boro","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.yebeh.2005.04.012","article-title":"Psychiatric comorbidity in epilepsy","volume":"7","author":"Swinkels","year":"2005","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2015.12.001_bb0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1528-1167.2006.00685.x","article-title":"Correlation between cognition and behavior in epilepsy","volume":"47","author":"Cornaggia","year":"2006","journal-title":"Epilepsia"},{"issue":"Suppl. 9","key":"10.1016\/j.yebeh.2015.12.001_bb0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1167.2007.01397.x","article-title":"Long-term memory impairment in patients with focal epilepsy","volume":"48","author":"Hoppe","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0040","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.psc.2007.07.005","article-title":"Psychiatric aspects of epilepsy","volume":"30","author":"Marcangelo","year":"2007","journal-title":"Psychiatr Clin North Am"},{"issue":"Suppl. 4","key":"10.1016\/j.yebeh.2015.12.001_bb0045","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.yebeh.2003.10.002","article-title":"Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment","volume":"4","author":"Devinsky","year":"2003","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2015.12.001_bb0050","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.yebeh.2003.07.004","article-title":"Epilepsy and cognition","volume":"4","author":"Motamedi","year":"2003","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2015.12.001_bb0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.0013-9580.2004.452001.x","article-title":"Neurobiology of seizures and behavioral abnormalities","volume":"45","author":"Post","year":"2004","journal-title":"Epilepsia"},{"issue":"Suppl. 1","key":"10.1016\/j.yebeh.2015.12.001_bb0060","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.yebeh.2003.11.012","article-title":"Do seizures cause irreversible cognitive damage? Evidence from animal studies","volume":"5","author":"Majak","year":"2004","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.yebeh.2005.08.009","article-title":"Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms","volume":"8","author":"Heinrichs","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0070","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1528-1157.1991.tb05533.x","article-title":"Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures","volume":"32","author":"Cavalheiro","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0075","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","article-title":"Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting","volume":"34","author":"Mello","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1994.tb02905.x","article-title":"Spontaneous recurrent seizures in rats: amino acid and monoamine determination in the hippocampus","volume":"35","author":"Cavalheiro","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0085","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s11064-011-0544-9","article-title":"The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate","volume":"36","author":"Ezz","year":"2011","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0090","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s11064-012-0797-y","article-title":"Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy","volume":"37","author":"Lopes","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00221-013-3421-8","article-title":"Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy","volume":"226","author":"Lopes","year":"2013","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yebeh.2015.08.037","article-title":"The enigma of the latent period in the development of symptomatic acquired epilepsy \u2014 traditional view versus new concepts","volume":"52","author":"Loscher","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0105","series-title":"Jasper's Basic Mechanisms of the Epilepsies","first-page":"454","article-title":"Abnormal dentate gyrus network circuitry in temporal lobe epilepsy","author":"Sloviter","year":"2012"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2012.01.022","article-title":"Defining \u201cepileptogenesis\u201d and identifying \u201cantiepileptogenic targets\u201d in animal models of acquired temporal lobe epilepsy is not as simple as it might seem","volume":"69","author":"Sloviter","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neulet.2003.11.019","article-title":"Pilocarpine-induced status epilepticus increases glutamate release in rat hippocampal synaptosomes","volume":"356","author":"Costa","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0120","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1528-1157.1998.tb01305.x","article-title":"Status epilepticus causes long-term NMDA receptor-dependent behavioral changes and cognitive deficits","volume":"39","author":"Rice","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0125","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nbd.2011.02.012","article-title":"Pilocarpine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1\/2 mechanisms","volume":"42","author":"Di Maio","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/neuro.02.005.2008","article-title":"Epilepsy, E\/I balance and GABA(A) receptor plasticity","volume":"1","author":"Fritschy","year":"2008","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0135","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.0013-9580.2005.38704.x","article-title":"A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium\u2013pilocarpine model in adult rats","volume":"46","author":"Detour","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0140","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/epi.12219","article-title":"A comprehensive behavioral evaluation in the lithium\u2013pilocarpine model in rats: effects of carisbamate administration during status epilepticus","volume":"54","author":"Faure","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0145","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/epi.12549","article-title":"Attention and executive functions in a rat model of chronic epilepsy","volume":"55","author":"Faure","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0150","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1523\/JNEUROSCI.0633-10.2010","article-title":"Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy","volume":"30","author":"Brandt","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0155","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1203\/01.PDR.0000112032.47575.D1","article-title":"Detrimental effects of the ketogenic diet on cognitive function in rats","volume":"55","author":"Zhao","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0920-1211(01)00321-7","article-title":"Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus","volume":"48","author":"Holmes","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1134\/S0012496615040055","article-title":"Impairment of exploratory behavior and spatial memory in adolescent rats in lithium\u2013pilocarpine model of temporal lobe epilepsy","volume":"463","author":"Kalemenev","year":"2015","journal-title":"Dokl Biol Sci"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.expneurol.2007.06.021","article-title":"Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice","volume":"207","author":"Groticke","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0175","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.expneurol.2008.04.036","article-title":"Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate","volume":"213","author":"Groticke","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0180","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.expneurol.2009.05.035","article-title":"Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL\/6 mice","volume":"219","author":"Muller","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0185","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s00415-012-6741-x","article-title":"Olfactory bulb volume in patients with temporal lobe epilepsy","volume":"260","author":"Hummel","year":"2013","journal-title":"J Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0190","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2011.06.035","article-title":"Oxidative stress in rat striatum after pilocarpine-induced seizures is diminished by alpha-tocopherol","volume":"668","author":"dos Santos","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0195","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neulet.2009.07.037","article-title":"Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine","volume":"462","author":"Freitas","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0200","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbr.2012.01.016","article-title":"Lithium and valproate prevent olfactory discrimination and short-term memory impairments in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rat model of Parkinson's disease","volume":"229","author":"Castro","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0205","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0920-1211(00)00095-4","article-title":"Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy","volume":"39","author":"Bonan","year":"2000","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0210","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuint.2015.05.003","article-title":"Region-specific alterations of AMPA receptor phosphorylation and signaling pathways in the pilocarpine model of epilepsy","volume":"87","author":"Lopes","year":"2015","journal-title":"Neurochem Int"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0215","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.neurobiolaging.2004.08.012","article-title":"Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors","volume":"26","author":"Prediger","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0220","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1037\/h0077266","article-title":"Olfactory recognition of conspecifics by domestic Norway rats","volume":"90","author":"Carr","year":"1976","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.expneurol.2006.07.001","article-title":"The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease","volume":"202","author":"Prediger","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0230","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF00518192","article-title":"Modulation of social memory in male rats by neurohypophyseal peptides","volume":"91","author":"Dantzer","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0235","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2003.11.009","article-title":"Facilitation of short-term social memory by ethanol in rats is mediated by dopaminergic receptors","volume":"153","author":"Prediger","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/01.fbp.0000166825.62130.9a","article-title":"Antagonistic interaction between adenosine A2A and dopamine D2 receptors modulates the social recognition memory in reserpine-treated rats","volume":"16","author":"Prediger","year":"2005","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0245","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0250","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neubiorev.2005.04.017","article-title":"Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20years on","volume":"29","author":"Carobrez","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0255","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2013.01.039","article-title":"Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-beta (Abeta(1-40)) administration in mice","volume":"244","author":"dos Santos","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0260","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1089\/neu.2010.1318","article-title":"Effects of traumatic brain injury of different severities on emotional, cognitive, and oxidative stress-related parameters in mice","volume":"27","author":"Schwarzbold","year":"2010","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0265","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0079-6123(02)35007-6","article-title":"The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus","volume":"135","author":"Dudek","year":"2002","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0079-6123(02)35008-8","article-title":"Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy","volume":"135","author":"Pitkanen","year":"2002","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0280","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11910-007-0053-z","article-title":"The neurobiology of epilepsy","volume":"7","author":"Scharfman","year":"2007","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"Suppl. 9","key":"10.1016\/j.yebeh.2015.12.001_bb0285","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1528-1167.2008.01931.x","article-title":"Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the \u201clatent period\u201d and other concepts","volume":"49","author":"Sloviter","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0290","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1124\/pr.110.003046","article-title":"Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research","volume":"62","author":"Loscher","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0295","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1474-4422(10)70310-0","article-title":"Mechanisms of epileptogenesis and potential treatment targets","volume":"10","author":"Pitkanen","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0300","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.expneurol.2012.11.024","article-title":"Early deficits in social behavior and cortical rhythms in pilocarpine-induced mouse model of temporal lobe epilepsy","volume":"241","author":"Seo","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0305","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0310","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1525-5050(03)00006-4","article-title":"Temporal lobe seizures alter the amplitude and timing of rat behavioral rhythms","volume":"4","author":"Stewart","year":"2003","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0315","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2005.09.037","article-title":"Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy","volume":"1066","author":"Dos Santos","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0320","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-4328(83)90136-5","article-title":"Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study","volume":"9","author":"Turski","year":"1983","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0325","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1523\/JNEUROSCI.22-08-03174.2002","article-title":"Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway","volume":"22","author":"Parent","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0330","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1037\/0735-7044.98.5.908","article-title":"Chemosensory and hormonal mediation of social memory in male rats","volume":"98","author":"Sawyer","year":"1984","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.yebeh.2015.12.001_bb0335","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505015006563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505015006563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T11:52:35Z","timestamp":1567511555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505015006563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":67,"alternative-id":["S1525505015006563"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2015.12.001","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time course evaluation of behavioral impairments in the pilocarpine model of epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2015.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}