{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:57:48Z","timestamp":1773712668838,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","epilepsybehavior.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.yebeh.2016.02.041","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T23:45:27Z","timestamp":1459813527000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["A long-term noninterventional safety study of adjunctive lacosamide therapy in patients with epilepsy and uncontrolled partial-onset seizures"],"prefix":"10.1016","volume":"58","author":[{"given":"Bernhard J.","family":"Steinhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Eckhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Doty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Brunnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schulze-Bonhage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2016.02.041_bb0005","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/WCO.0b013e32833735e7","article-title":"Metabolic consequences of antiepileptic drugs","volume":"23","author":"Mintzer","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0010","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1111\/j.1528-1167.2007.01147.x","article-title":"Reversible effects of antiepileptic drugs on reproductive endocrine function in men and women with epilepsy\u2014a prospective randomized double-blind withdrawal study","volume":"48","author":"Lossius","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/nyas.12213","article-title":"Development of lacosamide for the treatment of partial-onset seizures","volume":"1291","author":"Doty","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/nyas.12513","article-title":"Advances in epilepsy treatment: lacosamide pharmacokinetic profile","volume":"1329","author":"Cawello","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0025","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1528-1167.2007.01188.x","article-title":"Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures","volume":"48","author":"Ben-Menachem","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1528-1167.2008.01951.x","article-title":"Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial","volume":"50","author":"Halasz","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0035","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1528-1167.2009.02496.x","article-title":"Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial","volume":"51","author":"Chung","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0040","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/epi.12681","article-title":"Conversion to lacosamide monotherapy in the treatment of focal epilepsy: results from a historical-controlled, multicenter, double-blind study","volume":"55","author":"Wechsler","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0045","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1528-1167.2009.02463.x","article-title":"Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures","volume":"51","author":"Krauss","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0050","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1528-1167.2012.03543.x","article-title":"Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partial-onset seizures","volume":"54","author":"Fountain","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0055","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1528-1167.2012.03407.x","article-title":"Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a phase III open-label extension trial","volume":"53","author":"Husain","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0060","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1528-1167.2007.01317.x","article-title":"Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures","volume":"49","author":"Biton","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.yebeh.2014.09.074","article-title":"Safety and efficacy of adjunctive lacosamide among patients with partial-onset seizures in a long-term open-label extension trial of up to 8years","volume":"41","author":"Rosenfeld","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0070","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1111\/j.1528-1157.1997.tb06128.x","article-title":"Arrhythmia, heart rate variability, and antiepileptic drugs","volume":"38","author":"Tomson","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1517\/17425255.2012.645535","article-title":"Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects","volume":"8","author":"Jankovic","year":"2012","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0080","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/14656566.3.5.479","article-title":"Psychotropic drugs and the ECG: focus on the QTc interval","volume":"3","author":"Goodnick","year":"2002","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0085","series-title":"Atlas of epilepsies","first-page":"1479","article-title":"Cardiac effects of antiepileptic drugs","author":"Shah","year":"2010"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0090","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yebeh.2014.05.015","article-title":"Factors influencing response to intravenous lacosamide in emergency situations: LACO-IV study","volume":"36","author":"Garces","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.yebeh.2016.02.041_bb0095","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/ane.12414","article-title":"Lacosamide cardiac safety: clinical trials in patients with partial-onset seizures","volume":"132","author":"Rudd","year":"2015","journal-title":"Acta Neurol Scand"},{"issue":"5","key":"10.1016\/j.yebeh.2016.02.041_bb0100","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/ane.12416","article-title":"Lacosamide cardiac safety: a thorough QT\/QTc trial in healthy volunteers","volume":"132","author":"Kropeit","year":"2015","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0105","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1111\/j.1528-1167.2011.03212.x","article-title":"Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy","volume":"52","author":"Nizam","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ebcr.2012.10.001","article-title":"Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy","volume":"1","author":"DeGiorgio","year":"2013","journal-title":"Epilepsy Behav Case Rep"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ebcr.2012.10.006","article-title":"Low-dose lacosamide-induced atrial fibrillation: case analysis with literature review","volume":"1","author":"Kaufman","year":"2013","journal-title":"Epilepsy Behav Case Rep"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0120","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yebeh.2010.04.043","article-title":"Atrial flutter\/atrial fibrillation associated with lacosamide for partial seizures","volume":"18","author":"Degiorgio","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/epi.12108","article-title":"Sinus node dysfunction: an adverse effect of lacosamide","volume":"54","author":"Chinnasami","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0130","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.yebeh.2011.02.006","article-title":"Atrioventricular block following lacosamide intoxication","volume":"20","author":"Krause","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0135","first-page":"165","article-title":"Transient third-degree atrioventricular block following rapid lacosamide titration in a patient with nonconvulsive status epilepticus","volume":"19","author":"Wittstock","year":"2011","journal-title":"Epileptologica"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0140","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1017\/S1047951114001188","article-title":"Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks","volume":"25","author":"Loomba","year":"2015","journal-title":"Cardiol Young"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0145","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00228-013-1594-5","article-title":"Factors associated with pregabalin dispensing at higher than the approved maximum dose","volume":"70","author":"Bod\u00e9n","year":"2014","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0150","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1177\/0269881109359095","article-title":"Evaluation of the subjective and reinforcing effects of diphenhydramine, levetiracetam, and valproic acid","volume":"25","author":"Feltner","year":"2011","journal-title":"J Psychopharmacol"},{"issue":"Suppl. 2","key":"10.1016\/j.yebeh.2016.02.041_bb0155","first-page":"28","article-title":"Benzodiazepine use, abuse, and dependence","volume":"66","author":"O'Brien","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1756285609355850","article-title":"New treatment option for partial-onset seizures: efficacy and safety of lacosamide","volume":"3","author":"Chung","year":"2010","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0165","first-page":"26","article-title":"Managing depressive disorders in patients with epilepsy","volume":"4","author":"Trivedi","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3988\/jcn.2014.10.3.175","article-title":"Depression and anxiety in people with epilepsy","volume":"10","author":"Kwon","year":"2014","journal-title":"J Clin Neurol"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0175","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2147\/DHPS.S13225","article-title":"Antiepileptic drugs and suicidality","volume":"2","author":"Britton","year":"2010","journal-title":"Drug Healthc Patient Saf"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0180","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1535-7511.2005.00056.x","article-title":"Psychotropic effects of antiepileptic drugs","volume":"5","author":"Nadkarni","year":"2005","journal-title":"Epilepsy Curr"},{"issue":"1","key":"10.1016\/j.yebeh.2016.02.041_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2011.03.011","article-title":"Antiepileptic drugs in the treatment of psychiatric disorders","volume":"21","author":"Kaufman","year":"2011","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1517\/14740338.2015.1010506","article-title":"Suicide and epilepsy: do antiepileptic drugs increase the risk?","volume":"14","author":"Mula","year":"2015","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0195","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/npy.11.29","article-title":"Treatment-emergent psychiatric adverse events of antiepileptic drugs in epilepsy: how can we avoid them?","volume":"1","author":"Mula","year":"2011","journal-title":"Neuropsychiatry"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0200","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1528-1167.2012.03688.x","article-title":"Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology","volume":"54","author":"Mula","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0205","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1528-1167.2011.03361.x","article-title":"A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs","volume":"53","author":"Lotufo","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0210","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1212\/WNL.43.11.2284","article-title":"Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures US Lamotrigine Protocol 05 Clinical Trial Group","volume":"43","author":"Matsuo","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0215","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1111\/j.1528-1167.2009.02069.x","article-title":"Cardiac function and antiepileptic drug treatment in the elderly: a comparison between lamotrigine and sustained-release carbamazepine","volume":"50","author":"Saetre","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0220","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1684\/j.1950-6945.2004.tb00043.x","article-title":"The mortality of epilepsy revisited","volume":"6","author":"Gaitatzis","year":"2004","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0225","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1365-2125.2010.03855.x","article-title":"Effect of lamotrigine on the PR interval in healthy subjects","volume":"71","author":"Dixon","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0230","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1528-1157.2002.01702.x","article-title":"A postmarketing surveillance study of gabapentin as add-on therapy for 3,100 patients in England","volume":"43","author":"Wilton","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0235","first-page":"237","article-title":"Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom","volume":"42","author":"Wong","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0240","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2165\/11586830-000000000-00000","article-title":"Examining the clinical utility of lacosamide: pooled analyses of three phase II\/III clinical trials","volume":"24","author":"Chung","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0245","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/pds.1932","article-title":"Antiepileptic drugs and risk of suicide: a nationwide study","volume":"19","author":"Olesen","year":"2010","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0250","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/HRP.0000000000000039","article-title":"Is antiepileptic-induced suicidality a data-based class effect or an exaggeration? A comment on the literature","volume":"22","author":"Siamouli","year":"2014","journal-title":"Harv Rev Psychiatry"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0255","series-title":"Atlas of epilepsies","first-page":"1559","article-title":"Treatment of drug resistant epilepsy","author":"Beghi","year":"2010"},{"key":"10.1016\/j.yebeh.2016.02.041_bb0260","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12991-014-0037-8","article-title":"Depression and attempted suicide under pregabalin therapy","volume":"13","author":"Kustermann","year":"2014","journal-title":"Ann Gen Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/j.yebeh.2016.02.041_bb0265","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/epi.12504","article-title":"Adverse effects and safety profile of perampanel: a review of pooled data","volume":"55","author":"Rugg-Gunn","year":"2014","journal-title":"Epilepsia"}],"container-title":["Epilepsy & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016001153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016001153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:24:12Z","timestamp":1761503052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505016001153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":53,"alternative-id":["S1525505016001153"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.02.041","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A long-term noninterventional safety study of adjunctive lacosamide therapy in patients with epilepsy and uncontrolled partial-onset seizures","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}