{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:31:30Z","timestamp":1787902290784,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PIBIC"},{"DOI":"10.13039\/501100004263","name":"FAPERGS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PROBIC"}],"content-domain":{"domain":["epilepsybehavior.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.yebeh.2016.06.037","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T03:35:00Z","timestamp":1469072100000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice"],"prefix":"10.1016","volume":"62","author":[{"given":"J\u00e9ssica","family":"Grigoletto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa Vasconcelos de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia Beck","family":"Grauncke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00edze Lopes de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naieli Schiefelbein","family":"Souto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara L\u00fctchemeyer de","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via","family":"Furian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adair Roberto Soares","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Schneider","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yebeh.2016.06.037_bb0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0010","series-title":"Epilepsy across the spectrum: promoting health and understanding","author":"England","year":"2012"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/WCO.0b013e3283507e73","article-title":"Evidence-based review on the natural history of the epilepsies","volume":"25","author":"Schmidt","year":"2012","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0020","series-title":"Neurological disorders: public health challenges","article-title":"World Health Organization","author":"WHO","year":"2006"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0025","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1474-4422(07)70215-6","article-title":"Development of new antiepileptic drugs: challenges, incentives, and recent advances","volume":"6","author":"Perucca","year":"2007","journal-title":"Lancet Neurol"},{"issue":"Pt B","key":"10.1016\/j.yebeh.2016.06.037_bb0030","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.yebeh.2015.05.012","article-title":"A pharmacological basis of herbal medicines for epilepsy.","volume":"52","author":"Sucher","year":"2015","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0031-9422(02)00513-7","article-title":"Rosmarinic acid","volume":"62","author":"Petersen","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0040","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00253-015-6395-6","article-title":"Production and applications of rosmarinic acid and structurally related compounds","volume":"99","author":"Kim","year":"2015","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0045","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3945\/an.113.005264","article-title":"Supplemental substances derived from foods as adjunctive therapeutic agents for treatment of neurodegenerative diseases and disorders","volume":"5","author":"Bigford","year":"2014","journal-title":"Adv Nutr"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0050","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2174\/1570159X12666140923205715","article-title":"Antioxidants as a preventive treatment for epileptic process: a review of the current status","volume":"12","author":"Martinc","year":"2014","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1196\/annals.1344.011","article-title":"Brain response to injury and neurodegeneration: endogenous neuroprotective signaling","volume":"1053","author":"Bazan","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0065","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.3109\/13880209.2015.1010738","article-title":"Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: underlying mechanisms","volume":"53","author":"Khamse","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0070","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.lfs.2014.11.009","article-title":"Antiepileptogenic, antioxidant and genotoxic evaluation of rosmarinic acid and its metabolite caffeic acid in mice","volume":"122","author":"Coelho","year":"2015","journal-title":"Life Sci"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0075","series-title":"Models of seizures and epilepsy","author":"Pitk\u00e4nen","year":"2006"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0080","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yebeh.2015.12.040","article-title":"Anticonvulsant activity of beta-caryophyllene against pentylenetetrazol-induced seizures","volume":"56","author":"Oliveira","year":"2016","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0085","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.expneurol.2007.06.021","article-title":"Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice","volume":"207","author":"Groticke","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0090","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/ptr.2712","article-title":"Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity","volume":"23","author":"Awad","year":"2009","journal-title":"Phytother Res"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0095","article-title":"Mechanism of action of vigabatrin: correcting misperceptions","volume":"5-15","author":"Ben-Menachem","year":"2011","journal-title":"Acta Neurol Scand Suppl"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pbb.2009.03.014","article-title":"Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice","volume":"93","author":"Guginski","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0014-2999(02)02037-X","article-title":"Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice","volume":"449","author":"Takeda","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0110","first-page":"306","article-title":"GABA-mediated modification of despair behavior in mice","volume":"339","author":"Aley","year":"1989","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0014-2999(84)90459-X","article-title":"The effect of diazepam and of agents which change GABAergic functions in immobility in mice","volume":"97","author":"Nagatani","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0120","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1523\/JNEUROSCI.0900-05.2005","article-title":"Status epilepticus increases the intracellular accumulation of GABAA receptors","volume":"25","author":"Goodkin","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0125","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/2661","article-title":"Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy","volume":"4","author":"Brooks-Kayal","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0130","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.nbd.2014.12.032","article-title":"Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus","volume":"76","author":"Jiang","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eplepsyres.2015.11.003","article-title":"Network pharmacology for antiepileptogenesis: tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice","volume":"118","author":"Klee","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.yebeh.2016.06.037_bb0140","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat Rev Drug Discov"}],"container-title":["Epilepsy &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016302189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525505016302189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T15:47:07Z","timestamp":1568908027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525505016302189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":28,"alternative-id":["S1525505016302189"],"URL":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.06.037","relation":{},"ISSN":["1525-5050"],"issn-type":[{"value":"1525-5050","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yebeh.2016.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}